General Information of the Cell Line
Cell Line ID
CL000864
Cell Line Name
THP1-Xblue
Category
Cancer cell line
Organism
Homo sapiens (Human)
Tissue Information
Peripheral blood
Disease
Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT00821, Interleukin-1 receptor-associated kinase 4
Compound ID Compound Name Compound Formula
CP0067186
(1S,2R,3R,5R)-3-(hydroxymethyl)-5-[[2-[(2-methoxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]cyclopentane-1,2-diol
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C25H26N6O4
 1
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
CP0067182
(1R,2S,3R,5R)-3-[[2-[(2,6-dimethylpyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol
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C26H28N6O3
 1
1
IC50 = 55 nM
   TI
   LI
   LO
   TS
CP0716626
5-(Benzo[d]thiazol-2-yl)-6-(((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)amino)-2-(pyrrolidin-1-yl)pyrimidin-4(3H)-one
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C21H25N5O4S
 1
1
IC50 = 78 nM
   TI
   LI
   LO
   TS
CP0318230
US9169260, 198
   Show/Hide
C21H23N9O
 1
1
IC50 = 83 nM
   TI
   LI
   LO
   TS
CP0095742
(1R,2S,3R,5R)-3-[[2-[(2,6-dimethylpyridin-4-yl)amino]-5-(4-phenyl-1,3-thiazol-2-yl)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol
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C26H28N6O3S
 1
1
IC50 = 87 nM
   TI
   LI
   LO
   TS
CP0272491
(1S,2R,3R,5R)-3-(hydroxymethyl)-5-[[2-[(2-methylpyridin-4-yl)amino]-5-(4-phenyl-1,3-thiazol-2-yl)pyrimidin-4-yl]amino]cyclopentane-1,2-diol
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C25H26N6O3S
 1
1
IC50 = 94 nM
   TI
   LI
   LO
   TS
CP0213894
N-(3-carbamoyl-1-methylpyrazol-4-yl)-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide
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C15H15N7O2
 1
1
IC50 = 138 nM
   TI
   LI
   LO
   TS
CP0659036
5-(Benzo[d]thiazol-2-yl)-2-(3,4-dihydroisoquinolin-2(1H)-yl)-6-(((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)amino)pyrimidin-4(3H)-one
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C26H27N5O4S
 1
1
IC50 = 141 nM
   TI
   LI
   LO
   TS
CP0360603
N-(3-carbamoyl-1-methyl- 1H-pyrazol-4-yl)-5- piperazin-1- ylpyrazolo[1,5- a]pyrimidine-3- carboxamide hydrochloride
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C16H19N9O2
 1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
CP0207365
US9586948, Example 1
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C20H21N7O2
 1
1
IC50 = 169 nM
   TI
   LI
   LO
   TS
CP0673999
(R)-5-(Benzo[d]thiazol-2-yl)-2-morpholino-6-(piperidin-3-ylamino)pyrimidin-4(3H)-one
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C20H24N6O2S
 1
1
IC50 = 187 nM
   TI
   LI
   LO
   TS
CP0536477
US9586948, Example 29
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C16H13ClN6O2
 1
1
IC50 = 202 nM
   TI
   LI
   LO
   TS
CP0184908
(1S,2R,3R,5R)-3-(hydroxymethyl)-5-[[2-[(2-propan-2-yloxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]cyclopentane-1,2-diol
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C27H30N6O4
 1
1
IC50 = 216 nM
   TI
   LI
   LO
   TS
CP0460651
US9586948, Example 6
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C16H15N7O2
 1
1
IC50 = 259 nM
   TI
   LI
   LO
   TS
CP0772723
2-(Azetidin-1-yl)-5-(benzo[d]thiazol-2-yl)-6-(((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)amino)pyrimidin-4(3H)-one
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C20H23N5O4S
 1
1
IC50 = 292 nM
   TI
   LI
   LO
   TS
CP0482724
US9586948, Example 18
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C18H16F3N7O2
 1
1
IC50 = 294 nM
   TI
   LI
   LO
   TS
CP0460650
US9586948, Example 28
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C19H18N6O2
 1
1
IC50 = 307 nM
   TI
   LI
   LO
   TS
CP0724473
5-(benzo[d]thiazol-2-yl)-6-(((3R,5R)-5-hydroxypiperidin-3-yl)amino)-2-morpholinopyrimidin-4(3H)-one
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C20H24N6O3S
 1
1
IC50 = 333 nM
   TI
   LI
   LO
   TS
CP0067192
(1R,2S,3R,5R)-3-[[2-[(2-cyclopropyloxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol
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C27H28N6O4
 1
1
IC50 = 341 nM
   TI
   LI
   LO
   TS
CP0707915
5-(Benzo[d]thiazol-2-yl)-6-(((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)amino)-2-morpholinopyrimidin-4(3H)-one
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C21H25N5O5S
 1
1
IC50 = 375 nM
   TI
   LI
   LO
   TS
CP0528182
US9586948, Example 3
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C21H22N6O2
 1
1
IC50 = 428 nM
   TI
   LI
   LO
   TS
CP0460637
US9586948, Example 42
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C24H28N8O2
 1
1
IC50 = 477 nM
   TI
   LI
   LO
   TS
CP0228766
US9586948, Example 46
   Show/Hide
C26H32N8O3
 1
1
IC50 = 533 nM
   TI
   LI
   LO
   TS
CP0678448
5-(benzo[d]thiazol-2-yl)-6-(((3R,6R)-6-methylpiperidin-3-yl)amino)-2-morpholinopyrimidin-4(3H)-one
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C21H26N6O2S
 1
1
IC50 = 580 nM
   TI
   LI
   LO
   TS
CP0093353
US9169260, 18
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C23H25N7O3S
 1
1
IC50 = 2400 nM
   TI
   LI
   LO
   TS
CP0184906
(1R,2S,3R,5R)-3-[[5-(1,3-benzothiazol-2-yl)-2-[(2,6-dimethylpyridin-4-yl)amino]pyridin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol
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C25H27N5O3S
 1
1
IC50 = 3452 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Peripheral blood)
Cell Line Name Organism Disease
SET-2 Homo sapiens (Human) Adult acute megakaryoblastic leukemia
Mono-Mac-6 Homo sapiens (Human) Adult acute monocytic leukemia
HL-60 Homo sapiens (Human) Adult acute myeloid leukemia
MOLM-13 Homo sapiens (Human) Adult acute myeloid leukemia
OCI-AML-2 Homo sapiens (Human) Adult acute myeloid leukemia
HL-60/ADR Homo sapiens (Human) Adult acute myeloid leukemia
MOLM-14 Homo sapiens (Human) Adult acute myeloid leukemia
HL60/MDR Homo sapiens (Human) Adult acute myeloid leukemia
HL60/MRP Homo sapiens (Human) Adult acute myeloid leukemia
NALM-6 Homo sapiens (Human) Adult B acute lymphoblastic leukemia
MOLT-4 Homo sapiens (Human) Adult T acute lymphoblastic leukemia
MOLT-4/CCR5 Homo sapiens (Human) Adult T acute lymphoblastic leukemia
Karpas-299 Homo sapiens (Human) Anaplastic large cell lymphoma, ALK-positive
M-07e Homo sapiens (Human) Childhood acute megakaryoblastic leukemia
THP-1 Homo sapiens (Human) Childhood acute monocytic leukemia
MV4-11 Homo sapiens (Human) Childhood acute monocytic leukemia
THP1-Dual Homo sapiens (Human) Childhood acute monocytic leukemia
THP1-Dual KO-STING Homo sapiens (Human) Childhood acute monocytic leukemia
THP1-Blue ISG Homo sapiens (Human) Childhood acute monocytic leukemia
THP1-ASC-GFP Homo sapiens (Human) Childhood acute monocytic leukemia
PMNL Homo sapiens (Human) Childhood acute monocytic leukemia
SEM Homo sapiens (Human) Childhood B acute lymphoblastic leukemia
SEMK2 Homo sapiens (Human) Childhood B acute lymphoblastic leukemia
Reh Homo sapiens (Human) Childhood B acute lymphoblastic leukemia
Jurkat Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
Jurkat E6.1 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CCRF-CEM Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CCRF/VCR1000 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CEM/VLB100 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CEM/VLB500 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CEM-SS Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
HPB-ALL Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CCRF-SB Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CEM-T4 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
J-Lat 10.6 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
12D7-MDR1 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
MDR CCRF vcr1000 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
FGS7 Jurkat Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
EoL-1 Homo sapiens (Human) Chronic eosinophilic leukemia, not otherwise specified
CII Homo sapiens (Human) Chronic lymphocytic leukemia
Ku812 Homo sapiens (Human) Chronic myelogenous leukemia, BCR-ABL1 positive
Ri-1 Homo sapiens (Human) Diffuse large B-cell lymphoma activated B-cell type
Daudi Homo sapiens (Human) EBV-related Burkitt lymphoma
HEL Homo sapiens (Human) Erythroleukemia
UKE-1 Homo sapiens (Human) Essential thrombocythemia
L-1236 Homo sapiens (Human) Hodgkin lymphoma
Granta-519 Homo sapiens (Human) Mantle cell lymphoma
JeKo-1 Homo sapiens (Human) Mantle cell lymphoma
Mino Homo sapiens (Human) Mantle cell lymphoma
HMC-1 Homo sapiens (Human) Mast cell leukemia
NK-92 Homo sapiens (Human) Natural killer cell lymphoblastic leukemia/lymphoma
NK Homo sapiens (Human) Natural killer cell lymphoblastic leukemia/lymphoma
KHYG-1 Homo sapiens (Human) Natural killer cell lymphoblastic leukemia/lymphoma
RPMI-8226 Homo sapiens (Human) Plasma cell myeloma
OPM-2 Homo sapiens (Human) Plasma cell myeloma
U266B1 Homo sapiens (Human) Plasma cell myeloma
KMS-18 Homo sapiens (Human) Plasma cell myeloma
MM1.S Homo sapiens (Human) Plasma cell myeloma
MM1.R Homo sapiens (Human) Plasma cell myeloma
OPM-1 Homo sapiens (Human) Plasma cell myeloma
RPMI-8226/Dox40 Homo sapiens (Human) Plasma cell myeloma
HuT 78 Homo sapiens (Human) Sezary syndrome
H9 Homo sapiens (Human) Sezary syndrome
CREM010i-SS9-1 Homo sapiens (Human) Sickle cell disease
RBL-1 Rattus norvegicus (Rat) Rat leukemia
RBL-2H3 Rattus norvegicus (Rat) Rat leukemia
LCL Orang Asli K28 Homo sapiens (Human) -
JY Homo sapiens (Human) -
C.M.L. Homo sapiens (Human) -
BON Homo sapiens (Human) -
PBMC iPSC #1 Homo sapiens (Human) -
LCL 721 Homo sapiens (Human) -