General Information of the Cell Line
Cell Line ID
CL000494
Cell Line Name
THP1-Dual
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_X599
Tissue Information
Peripheral blood
Disease
Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT05581, Cyclic GMP-AMP synthase
Compound ID Compound Name Compound Formula
CP0549328
[2-[6,7-dichloro-9b-(4-chloro-2-formylanilino)-3,4-dihydro-1H-pyrido[4,3-b]indol-2-yl]-2-oxoethyl] acetate
   Show/Hide
C22H18Cl3N3O4
 1
1
IC50 = 1140 nM
   TI
   LI
   LO
   TS
CP0527944
2-amino-N-[2-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-oxoethyl]acetamide
   Show/Hide
C19H20Cl2N6O2
 1
1
IC50 = 1380 nM
   TI
   LI
   LO
   TS
CP0564585
2-amino-1-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]ethanone
   Show/Hide
C17H17Cl2N5O
 1
1
IC50 = 1870 nM
   TI
   LI
   LO
   TS
CP0547099
1-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-hydroxyethanone
   Show/Hide
C17H16Cl2N4O2
 1
1
IC50 = 2690 nM
   TI
   LI
   LO
   TS
CP0545588
[2-[6,7-dichloro-9b-[2-formyl-4-(trifluoromethyl)anilino]-3,4-dihydro-1H-pyrido[4,3-b]indol-2-yl]-2-oxoethyl] acetate
   Show/Hide
C23H18Cl2F3N3O4
 1
1
IC50 = 2720 nM
   TI
   LI
   LO
   TS
CP0573339
[2-[6,7-dichloro-9b-(3-chloro-2-formylanilino)-3,4-dihydro-1H-pyrido[4,3-b]indol-2-yl]-2-oxoethyl] acetate
   Show/Hide
C22H18Cl3N3O4
 1
1
IC50 = 2870 nM
   TI
   LI
   LO
   TS
CP0527948
1-[9b-[3,5-bis(trifluoromethyl)anilino]-6,7-dichloro-3,4-dihydro-1H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethanone
   Show/Hide
C21H15Cl2F6N3O2
 1
1
IC50 = 3120 nM
   TI
   LI
   LO
   TS
CP0527945
[2-[9b-[3,5-bis(trifluoromethyl)anilino]-6,7-dichloro-3,4-dihydro-1H-pyrido[4,3-b]indol-2-yl]-2-oxoethyl] acetate
   Show/Hide
C23H17Cl2F6N3O3
 1
1
IC50 = 3230 nM
   TI
   LI
   LO
   TS
CP0947460
1-(6,7-Dichloro-9b-(1H-indol-3-yl)-1,3,4,4a,5,9b-hexahydro-2H-pyrido[4,3-b]indol-2-yl)-2-hydroxyethan-1-one
   Show/Hide
C21H19Cl2N3O2
 1
1
IC50 = 4070 nM
   TI
   LI
   LO
   TS
CP0955082
2-(6,7-Dichloro-9b-(1H-indol-3-yl)-1,3,4,4a,5,9b-hexahydro-2H-pyrido[4,3-b]indol-2-yl)-2-oxoethyl Acetate
   Show/Hide
C23H21Cl2N3O3
 1
1
IC50 = 5490 nM
   TI
   LI
   LO
   TS
CP0549843
1-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-(methylamino)ethanone
   Show/Hide
C18H19Cl2N5O
 1
1
IC50 = 6300 nM
   TI
   LI
   LO
   TS
CP0967557
2-(6,7-Dichloro-9b-(1H-indol-3-yl)-1,3,4,9b-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-oxoethyl Acetate
   Show/Hide
C23H19Cl2N3O3
 1
1
IC50 = 6300 nM
   TI
   LI
   LO
   TS
CP0941170
(R)-N-(2-(6,7-Dichloro-9-(1-methyl-1H-pyrazol-3-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2 yl)-2-oxoethyl)-4,4-difluoropyrrolidine-2-carboxamide
   Show/Hide
C22H22Cl2F2N6O2
 1
1
IC50 = 6400 nM
   TI
   LI
   LO
   TS
CP0549330
1-[6,7-dichloro-9b-[4-(trifluoromethyl)anilino]-3,4-dihydro-1H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethanone
   Show/Hide
C20H16Cl2F3N3O2
 1
1
IC50 = 6480 nM
   TI
   LI
   LO
   TS
CP0957294
1-(6,7-Dichloro-9b-(1H-indol-3-yl)-1,3,4,9b-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-hydroxyethan-1-one
   Show/Hide
C21H17Cl2N3O2
 1
1
IC50 = 6950 nM
   TI
   LI
   LO
   TS
CP0555277
N-[2-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-oxoethyl]-2-(furan-2-yl)acetamide
   Show/Hide
C23H21Cl2N5O3
 1
1
IC50 = 7170 nM
   TI
   LI
   LO
   TS
CP0573549
N-[2-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-oxoethyl]-2-piperazin-1-ylacetamide
   Show/Hide
C23H27Cl2N7O2
 1
1
IC50 = 7860 nM
   TI
   LI
   LO
   TS
CP0578365
tert-butyl N-[1-[[2-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-oxoethyl]amino]-2-methyl-1-oxopropan-2-yl]carbamate
   Show/Hide
C26H32Cl2N6O4
 1
1
IC50 = 8210 nM
   TI
   LI
   LO
   TS
CP0954216
1-(6,7-Dichloro-9b-(6-chloro-1H-indol-3-yl)-1,3,4,9b-tetrahydro-2H-pyrido[4,3 b]indol-2-yl)-2-hydroxyethan-1-one
   Show/Hide
C21H16Cl3N3O2
 1
1
IC50 = 8590 nM
   TI
   LI
   LO
   TS
CP0573341
N-[2-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-oxoethyl]-2-(5-methyl-1,2-oxazol-3-yl)acetamide
   Show/Hide
C23H22Cl2N6O3
 1
1
IC50 = 9450 nM
   TI
   LI
   LO
   TS
CP0577817
[2-[6,7-dichloro-9b-(2-formylanilino)-3,4-dihydro-1H-pyrido[4,3-b]indol-2-yl]-2-oxoethyl] acetate
   Show/Hide
C22H19Cl2N3O4
 1
1
IC50 = 9590 nM
   TI
   LI
   LO
   TS
CP0564586
N-[2-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-oxoethyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide
   Show/Hide
C27H20Cl2F3N7O3
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0953225
(S)-2-Amino-N-(2-(6,7-dichloro-9-(1-methyl-1H-pyrazol-3-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-oxoethyl)-3-(1H-pyrazol-3-yl)propanamide
   Show/Hide
C23H24Cl2N8O2
 1
1
IC50 = 10200 nM
   TI
   LI
   LO
   TS
CP0540310
2-amino-N-[2-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-oxoethyl]-2-methylpropanamide
   Show/Hide
C21H24Cl2N6O2
 1
1
IC50 = 10500 nM
   TI
   LI
   LO
   TS
CP0967965
(S)-2-amino-N-(2-(6,7-dichloro-9-(1-methyl-1H-pyrazol-3-yl)-3,4-dihydro-1H-pyrido[4,3-b]indol-2(5H)-yl)-2-oxoethyl)-2-hydroxyacetamide
   Show/Hide
C19H20Cl2N6O3
 1
1
IC50 = 11000 nM
   TI
   LI
   LO
   TS
CP0969739
1-(6,7-Dichloro 9b-(6-methoxy-1H-indol 3-yl)-1,3,4,9b-tetrahydro-2H-pyrido[4,3 b]indol-2-yl)-2-hydroxyethan-1-one
   Show/Hide
C22H19Cl2N3O3
 1
1
IC50 = 11300 nM
   TI
   LI
   LO
   TS
CP0969860
1-(6,7-Dichloro-9b-(4,6-difluoro-1H-indol-3-yl)-1,3,4,9b-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-hydroxyethan-1-one
   Show/Hide
C21H15Cl2F2N3O2
 1
1
IC50 = 12900 nM
   TI
   LI
   LO
   TS
CP0549327
1-amino-N-[2-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-oxoethyl]cyclopropane-1-carboxamide
   Show/Hide
C21H22Cl2N6O2
 1
1
IC50 = 13500 nM
   TI
   LI
   LO
   TS
CP0941171
1-(6,7-Dichloro-9b-(6-fluoro-1H-indol-3-yl)-1,3,4,9b-tetrahydro-2H-pyrido[4,3 b]indol-2-yl)-2-hydroxyethan-1-one
   Show/Hide
C21H16Cl2FN3O2
 1
1
IC50 = 14100 nM
   TI
   LI
   LO
   TS
CP0564583
N-[2-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-oxoethyl]-2,2-difluoro-2-(4-methylphenoxy)acetamide
   Show/Hide
C26H23Cl2F2N5O3
 1
1
IC50 = 15500 nM
   TI
   LI
   LO
   TS
CP0579667
1,1,1,3,3,3-hexafluoropropan-2-yl 6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carboxylate
   Show/Hide
C19H14Cl2F6N4O2
 1
1
IC50 = 19200 nM
   TI
   LI
   LO
   TS
CP0542853
[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-[3-(difluoromethoxy)cyclobutyl]methanone
   Show/Hide
C21H20Cl2F2N4O2
 1
1
IC50 = 20300 nM
   TI
   LI
   LO
   TS
CP0578363
1-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-(dimethylamino)ethanone
   Show/Hide
C19H21Cl2N5O
 1
1
IC50 = 21000 nM
   TI
   LI
   LO
   TS
CP0967964
(S)-6,7-Dichloro-9-(1-methyl-1H-pyrazol-3-yl)-2-prolyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
   Show/Hide
C20H21Cl2N5O
 1
1
IC50 = 22200 nM
   TI
   LI
   LO
   TS
CP0953224
3-(1-(6,7-dichloro-1H-benzo[d]imidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl)isobenzofuran-1(3H)-one
   Show/Hide
C19H12Cl2N4O3
 1
1
IC50 = 32900 nM
   TI
   LI
   LO
   TS
CP0545587
N-[2-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-oxoethyl]acetamide
   Show/Hide
C19H19Cl2N5O2
 1
1
IC50 = 37700 nM
   TI
   LI
   LO
   TS
CP0527947
2-hydroxy-1-[(1R,9S,13R,14R)-5,6,17-trichloro-22-oxa-8,11,21-triazahexacyclo[12.7.1.01,9.02,7.09,13.015,20]docosa-2(7),3,5,15(20),16,18-hexaen-11-yl]ethanone
   Show/Hide
C20H16Cl3N3O3
 1
1
IC50 = 38200 nM
   TI
   LI
   LO
   TS
CP0552809
ethyl 4-[[6,7-dichloro-2-(2-hydroxyacetyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-9b-yl]amino]benzoate
   Show/Hide
C22H21Cl2N3O4
 1
1
IC50 = 39400 nM
   TI
   LI
   LO
   TS
CP0527943
1-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-morpholin-4-ylethanone
   Show/Hide
C21H23Cl2N5O2
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0547098
[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-(3-hydroxycyclobutyl)methanone
   Show/Hide
C20H20Cl2N4O2
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0554221
1-[(1R,9S,13R,14R)-5,6-dichloro-22-oxa-8,11,21-triazahexacyclo[12.7.1.01,9.02,7.09,13.015,20]docosa-2(7),3,5,15,17,19-hexaen-11-yl]-2-hydroxyethanone
   Show/Hide
C20H17Cl2N3O3
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0564584
1-[6,7-dichloro-9b-(2-methoxyanilino)-3,4-dihydro-1H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethanone
   Show/Hide
C20H19Cl2N3O3
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0573340
1-[6,7-dichloro-9b-(3,5-difluoroanilino)-3,4-dihydro-1H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethanone
   Show/Hide
C19H15Cl2F2N3O2
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0573554
1-(6,7,9b-trichloro-3,5-dihydro-1H-pyrido[4,3-b]indol-2-yl)-2-hydroxyethanone
   Show/Hide
C13H11Cl3N2O2
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0577822
1-(5,6-dichloro-11,14-dimethoxy-8,16,18-triazapentacyclo[7.7.4.01,9.02,7.010,15]icosa-2(7),3,5,10,12,14-hexaen-18-yl)-2-hydroxyethanone
   Show/Hide
C21H21Cl2N3O4
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0578362
(3-aminooxetan-3-yl)-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]methanone
   Show/Hide
C19H19Cl2N5O2
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0955863
(3S,4R,5S)-N-(2-(6,7-Dichloro-9-(1-methyl-1H-pyrazol-3-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-oxoethyl)-3,4,5-trihydroxycyclohex-1-ene-1-carboxamide
   Show/Hide
C24H25Cl2N5O5
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Peripheral blood)
Cell Line Name Organism Disease
SET-2 Homo sapiens (Human) Adult acute megakaryoblastic leukemia
Mono-Mac-6 Homo sapiens (Human) Adult acute monocytic leukemia
HL-60 Homo sapiens (Human) Adult acute myeloid leukemia
MOLM-13 Homo sapiens (Human) Adult acute myeloid leukemia
OCI-AML-2 Homo sapiens (Human) Adult acute myeloid leukemia
HL-60/ADR Homo sapiens (Human) Adult acute myeloid leukemia
MOLM-14 Homo sapiens (Human) Adult acute myeloid leukemia
HL60/MDR Homo sapiens (Human) Adult acute myeloid leukemia
HL60/MRP Homo sapiens (Human) Adult acute myeloid leukemia
NALM-6 Homo sapiens (Human) Adult B acute lymphoblastic leukemia
MOLT-4 Homo sapiens (Human) Adult T acute lymphoblastic leukemia
MOLT-4/CCR5 Homo sapiens (Human) Adult T acute lymphoblastic leukemia
Karpas-299 Homo sapiens (Human) Anaplastic large cell lymphoma, ALK-positive
M-07e Homo sapiens (Human) Childhood acute megakaryoblastic leukemia
THP-1 Homo sapiens (Human) Childhood acute monocytic leukemia
MV4-11 Homo sapiens (Human) Childhood acute monocytic leukemia
THP1-Dual KO-STING Homo sapiens (Human) Childhood acute monocytic leukemia
THP1-Blue ISG Homo sapiens (Human) Childhood acute monocytic leukemia
THP1-ASC-GFP Homo sapiens (Human) Childhood acute monocytic leukemia
PMNL Homo sapiens (Human) Childhood acute monocytic leukemia
THP1-Xblue Homo sapiens (Human) Childhood acute monocytic leukemia
SEM Homo sapiens (Human) Childhood B acute lymphoblastic leukemia
SEMK2 Homo sapiens (Human) Childhood B acute lymphoblastic leukemia
Reh Homo sapiens (Human) Childhood B acute lymphoblastic leukemia
Jurkat Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
Jurkat E6.1 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CCRF-CEM Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CCRF/VCR1000 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CEM/VLB100 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CEM/VLB500 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CEM-SS Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
HPB-ALL Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CCRF-SB Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CEM-T4 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
J-Lat 10.6 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
12D7-MDR1 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
MDR CCRF vcr1000 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
FGS7 Jurkat Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
EoL-1 Homo sapiens (Human) Chronic eosinophilic leukemia, not otherwise specified
CII Homo sapiens (Human) Chronic lymphocytic leukemia
Ku812 Homo sapiens (Human) Chronic myelogenous leukemia, BCR-ABL1 positive
Ri-1 Homo sapiens (Human) Diffuse large B-cell lymphoma activated B-cell type
Daudi Homo sapiens (Human) EBV-related Burkitt lymphoma
HEL Homo sapiens (Human) Erythroleukemia
UKE-1 Homo sapiens (Human) Essential thrombocythemia
L-1236 Homo sapiens (Human) Hodgkin lymphoma
Granta-519 Homo sapiens (Human) Mantle cell lymphoma
JeKo-1 Homo sapiens (Human) Mantle cell lymphoma
Mino Homo sapiens (Human) Mantle cell lymphoma
HMC-1 Homo sapiens (Human) Mast cell leukemia
NK-92 Homo sapiens (Human) Natural killer cell lymphoblastic leukemia/lymphoma
NK Homo sapiens (Human) Natural killer cell lymphoblastic leukemia/lymphoma
KHYG-1 Homo sapiens (Human) Natural killer cell lymphoblastic leukemia/lymphoma
RPMI-8226 Homo sapiens (Human) Plasma cell myeloma
OPM-2 Homo sapiens (Human) Plasma cell myeloma
U266B1 Homo sapiens (Human) Plasma cell myeloma
KMS-18 Homo sapiens (Human) Plasma cell myeloma
MM1.S Homo sapiens (Human) Plasma cell myeloma
MM1.R Homo sapiens (Human) Plasma cell myeloma
OPM-1 Homo sapiens (Human) Plasma cell myeloma
RPMI-8226/Dox40 Homo sapiens (Human) Plasma cell myeloma
HuT 78 Homo sapiens (Human) Sezary syndrome
H9 Homo sapiens (Human) Sezary syndrome
CREM010i-SS9-1 Homo sapiens (Human) Sickle cell disease
RBL-1 Rattus norvegicus (Rat) Rat leukemia
RBL-2H3 Rattus norvegicus (Rat) Rat leukemia
LCL Orang Asli K28 Homo sapiens (Human) -
JY Homo sapiens (Human) -
C.M.L. Homo sapiens (Human) -
BON Homo sapiens (Human) -
PBMC iPSC #1 Homo sapiens (Human) -
LCL 721 Homo sapiens (Human) -