General Information of the Compound
Compound ID
CP0578365
Compound Name
tert-butyl N-[1-[[2-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-oxoethyl]amino]-2-methyl-1-oxopropan-2-yl]carbamate
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Structure
Formula
C26H32Cl2N6O4
Molecular Weight
563.486
Canonical SMILES
Cn1ccc(n1)-c1cc(Cl)c(Cl)c2[nH]c3CCN(Cc3c12)C(=O)CNC(=O)C(C)(C)NC(=O)OC(C)(C)C
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InChI
InChI=1S/C26H32Cl2N6O4/c1-25(2,3)38-24(37)31-26(4,5)23(36)29-12-19(35)34-10-8-17-15(13-34)20-14(18-7-9-33(6)32-18)11-16(27)21(28)22(20)30-17/h7,9,11,30H,8,10,12-13H2,1-6H3,(H,29,36)(H,31,37)
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InChIKey
VBNVTZNVHDLHQE-UHFFFAOYSA-N
Physicochemical Property
logP
4.1794
Rotatable Bonds
5
Heavy Atom Count
38
Polar Areas
121.35
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
6
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 166634846
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05581, Cyclic GMP-AMP synthase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000494 THP1-Dual Homo sapiens (Human)  1
1
IC50 = 8210 nM
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