General Information of the Cell Line
Cell Line ID
CL000714
Cell Line Name
MM1.S
Synonyms
MM.1S
MM1-S
MM-1S
MM1S
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_8792
Tissue Information
Peripheral blood
Disease
Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT01462, Bromodomain-containing protein 4
Compound ID Compound Name Compound Formula
CP0213781
(3R)-4-[[1-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenyl]azetidin-3-yl]methyl]-1,3-dimethylpiperazin-2-one
   Show/Hide
C27H36N8O2
 1
1
IC50 < 1.995 nM
   TI
   LI
   LO
   TS
CP0362338
1-[(3S,5R)-4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]-3,5-dimethylpiperazin-1-yl]ethanone
   Show/Hide
C27H37N7O3
 1
1
IC50 < 1.995 nM
   TI
   LI
   LO
   TS
CP0368533
(3R)-4-[3-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]propyl]-1,3-dimethylpiperazin-2-one
   Show/Hide
C26H35N7O3
 1
1
IC50 = 3.162 nM
   TI
   LI
   LO
   TS
CP0249898
(3R)-4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenyl]ethyl]-1,3-dimethylpiperazin-2-one
   Show/Hide
C25H33N7O2
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0480263
(3R)-1,3-dimethyl-4-[2-[4-[1-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]phenoxy]ethyl]piperazin-2-one
   Show/Hide
C25H30F3N7O2
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0143638
(3R)-4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]-1,3-dimethylpiperazin-2-one
   Show/Hide
C25H33N7O3
 1
1
IC50 = 12.59 nM
   TI
   LI
   LO
   TS
CP0362373
(3R,5R)-4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]-1,3,5-trimethylpiperazin-2-one
   Show/Hide
C26H35N7O3
 1
1
IC50 = 12.59 nM
   TI
   LI
   LO
   TS
CP0236899
(3R)-4-[2-[4-[1-[3-(dimethylamino)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl]phenoxy]ethyl]-1,3-dimethylpiperazin-2-one
   Show/Hide
C26H36N8O2
 1
1
IC50 = 15.85 nM
   TI
   LI
   LO
   TS
CP0213782
(3R)-1,3-dimethyl-4-[2-[4-[1-(3-methylsulfanyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]piperazin-2-one
   Show/Hide
C25H33N7O2S
 1
1
IC50 = 19.95 nM
   TI
   LI
   LO
   TS
CP0259597
(3R)-1,3-dimethyl-4-[2-[4-[1-(3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]piperazin-2-one
   Show/Hide
C25H33N7O2
 1
1
IC50 = 25.12 nM
   TI
   LI
   LO
   TS
CP0191020
(3S)-4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]-1,3-dimethylpiperazin-2-one
   Show/Hide
C25H33N7O3
 1
1
IC50 = 79.43 nM
   TI
   LI
   LO
   TS
CP0236893
(3R)-4-[2-[4-[1-(3-chloro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]-1,3-dimethylpiperazin-2-one
   Show/Hide
C24H30ClN7O2
 1
1
IC50 = 79.43 nM
   TI
   LI
   LO
   TS
CP0180784
(3R)-1,3-dimethyl-4-[2-[4-[1-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]piperazin-2-one
   Show/Hide
C24H31N7O2
 1
1
IC50 = 1258.93 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0015140
N-hydroxy-2-[methyl-[[3-[1-[(4-methylphenyl)methyl]piperidin-4-yl]-1,2,4-oxadiazol-5-yl]methyl]amino]pyrimidine-5-carboxamide
   Show/Hide
C22H27N7O3  1
1
IC50 = 9.8 nM
   TI
   LI
   LO
   TS
CP0041537
5-[6-[(4-methylpiperazin-1-yl)methyl]benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide
   Show/Hide
C27H28F3N5O2S  1
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
CP0044060
4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
   Show/Hide
C28H39N7O3  1
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
CP0204830
(2R)-N-[4-[1-[7-(hydroxyamino)-7-oxoheptyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-2-methylmorpholine-4-carboxamide
   Show/Hide
C28H38N8O5  1
1
IC50 = 7.3 nM
   TI
   LI
   LO
   TS
CP0368533
(3R)-4-[3-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]propyl]-1,3-dimethylpiperazin-2-one
   Show/Hide
C26H35N7O3  1
1
GI50 < 1.585 nM
   TI
   LI
   LO
   TS
CP0855455
N'-(Perchlorocyclopenta-2,4-dien-1-yli-dene)benzohydrazide
   Show/Hide
C12H6Cl4N2O  1
1
IC50 = 800 nM
   TI
   LI
   LO
   TS
CP0948154
2-((3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)methyl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one
   Show/Hide
C17H12F8N4O  1
1
IC50 = 90 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Peripheral blood)
Cell Line Name Organism Disease
SET-2 Homo sapiens (Human) Adult acute megakaryoblastic leukemia
Mono-Mac-6 Homo sapiens (Human) Adult acute monocytic leukemia
HL-60 Homo sapiens (Human) Adult acute myeloid leukemia
MOLM-13 Homo sapiens (Human) Adult acute myeloid leukemia
OCI-AML-2 Homo sapiens (Human) Adult acute myeloid leukemia
HL-60/ADR Homo sapiens (Human) Adult acute myeloid leukemia
MOLM-14 Homo sapiens (Human) Adult acute myeloid leukemia
HL60/MDR Homo sapiens (Human) Adult acute myeloid leukemia
HL60/MRP Homo sapiens (Human) Adult acute myeloid leukemia
NALM-6 Homo sapiens (Human) Adult B acute lymphoblastic leukemia
MOLT-4 Homo sapiens (Human) Adult T acute lymphoblastic leukemia
MOLT-4/CCR5 Homo sapiens (Human) Adult T acute lymphoblastic leukemia
Karpas-299 Homo sapiens (Human) Anaplastic large cell lymphoma, ALK-positive
M-07e Homo sapiens (Human) Childhood acute megakaryoblastic leukemia
THP-1 Homo sapiens (Human) Childhood acute monocytic leukemia
MV4-11 Homo sapiens (Human) Childhood acute monocytic leukemia
THP1-Dual Homo sapiens (Human) Childhood acute monocytic leukemia
THP1-Dual KO-STING Homo sapiens (Human) Childhood acute monocytic leukemia
THP1-Blue ISG Homo sapiens (Human) Childhood acute monocytic leukemia
THP1-ASC-GFP Homo sapiens (Human) Childhood acute monocytic leukemia
PMNL Homo sapiens (Human) Childhood acute monocytic leukemia
THP1-Xblue Homo sapiens (Human) Childhood acute monocytic leukemia
SEM Homo sapiens (Human) Childhood B acute lymphoblastic leukemia
SEMK2 Homo sapiens (Human) Childhood B acute lymphoblastic leukemia
Reh Homo sapiens (Human) Childhood B acute lymphoblastic leukemia
Jurkat Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
Jurkat E6.1 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CCRF-CEM Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CCRF/VCR1000 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CEM/VLB100 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CEM/VLB500 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CEM-SS Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
HPB-ALL Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CCRF-SB Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
CEM-T4 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
J-Lat 10.6 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
12D7-MDR1 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
MDR CCRF vcr1000 Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
FGS7 Jurkat Homo sapiens (Human) Childhood T acute lymphoblastic leukemia
EoL-1 Homo sapiens (Human) Chronic eosinophilic leukemia, not otherwise specified
CII Homo sapiens (Human) Chronic lymphocytic leukemia
Ku812 Homo sapiens (Human) Chronic myelogenous leukemia, BCR-ABL1 positive
Ri-1 Homo sapiens (Human) Diffuse large B-cell lymphoma activated B-cell type
Daudi Homo sapiens (Human) EBV-related Burkitt lymphoma
HEL Homo sapiens (Human) Erythroleukemia
UKE-1 Homo sapiens (Human) Essential thrombocythemia
L-1236 Homo sapiens (Human) Hodgkin lymphoma
Granta-519 Homo sapiens (Human) Mantle cell lymphoma
JeKo-1 Homo sapiens (Human) Mantle cell lymphoma
Mino Homo sapiens (Human) Mantle cell lymphoma
HMC-1 Homo sapiens (Human) Mast cell leukemia
NK-92 Homo sapiens (Human) Natural killer cell lymphoblastic leukemia/lymphoma
NK Homo sapiens (Human) Natural killer cell lymphoblastic leukemia/lymphoma
KHYG-1 Homo sapiens (Human) Natural killer cell lymphoblastic leukemia/lymphoma
RPMI-8226 Homo sapiens (Human) Plasma cell myeloma
OPM-2 Homo sapiens (Human) Plasma cell myeloma
U266B1 Homo sapiens (Human) Plasma cell myeloma
KMS-18 Homo sapiens (Human) Plasma cell myeloma
MM1.R Homo sapiens (Human) Plasma cell myeloma
OPM-1 Homo sapiens (Human) Plasma cell myeloma
RPMI-8226/Dox40 Homo sapiens (Human) Plasma cell myeloma
HuT 78 Homo sapiens (Human) Sezary syndrome
H9 Homo sapiens (Human) Sezary syndrome
CREM010i-SS9-1 Homo sapiens (Human) Sickle cell disease
RBL-1 Rattus norvegicus (Rat) Rat leukemia
RBL-2H3 Rattus norvegicus (Rat) Rat leukemia
LCL Orang Asli K28 Homo sapiens (Human) -
JY Homo sapiens (Human) -
C.M.L. Homo sapiens (Human) -
BON Homo sapiens (Human) -
PBMC iPSC #1 Homo sapiens (Human) -
LCL 721 Homo sapiens (Human) -