Cell Line Information

General Information of the Cell Line

Cell Line ID	CL000224
Cell Line Name	SET-2
Synonyms	Set-2 Set2 SET2
Category	Cancer cell line
Organism	Homo sapiens (Human)
Cellosaurus ID	CVCL_2187
Tissue Information	Peripheral blood
Disease	Adult acute megakaryoblastic leukemia (NCIt: C7965) Acute megakaryoblastic leukemia (ORDO: Orphanet_518)

Map of Molecular Bioactivity Related to the Cell Line

Map of Molecular Bioactivity Related to the Cell Line Cell Line Protein Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Cell Line

Protein ID: PT01214, Tyrosine-protein kinase JAK2

Protein Info

Compound ID	Compound Name	Compound Formula
CP0012129 Compound Info	INCB-018424 Show/Hide	C17H18N6	1
1	IC50 = 1.84 nM Bioactivity Info	TI LI LO TS
CP0084963 Compound Info	5-amino-N-[3-(2,5-dichlorophenyl)-1-methylpyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide Show/Hide	C17H13Cl2N7O	1
1	IC50 = 3.9 nM Bioactivity Info	TI LI LO TS
CP0466385 Compound Info	(E)-4-(dimethylamino)-1-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]but-2-en-1-one Show/Hide	C26H33N7O	1
1	IC50 = 11.7 nM Bioactivity Info	TI LI LO TS
CP0219569 Compound Info	methyl (E)-4-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]but-2-enoate Show/Hide	C25H30N6O2	1
1	IC50 = 13.7 nM Bioactivity Info	TI LI LO TS
CP0136525 Compound Info	(E)-1-(4-methylphenyl)-4-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]but-2-ene-1,4-dione Show/Hide	C31H32N6O2	1
1	IC50 = 14.7 nM Bioactivity Info	TI LI LO TS
CP0143654 Compound Info	(E)-4-(dimethylamino)-1-[7-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]but-2-en-1-one Show/Hide	C26H33N7O	1
1	IC50 = 15.3 nM Bioactivity Info	TI LI LO TS
CP0720081 Compound Info	3-(3-methoxyphenyl)-6-(morpholine-4-carbonyl)-9H-carbazole-1-carboxamide Show/Hide	C25H23N3O4	1
1	IC50 = 16 nM Bioactivity Info	TI LI LO TS
CP0054742 Compound Info	N,N-dicyclopropyl-10-ethyl-3-methyl-7-(1,3-thiazol-2-ylamino)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene-11-carboxamide Show/Hide	C21H23N7OS	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0199204 Compound Info	5-(4-methoxyphenyl)-N-[4-(4-methylpiperazin-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine Show/Hide	C24H26N6O	1
1	IC50 = 21.9 nM Bioactivity Info	TI LI LO TS
CP0176163 Compound Info	4-[[8-(1-cyclopentylpyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]benzoic acid Show/Hide	C21H20N6O2	1
1	IC50 = 23.7 nM Bioactivity Info	TI LI LO TS
CP0054741 Compound Info	N,N-dicyclopropyl-10-ethyl-3-methyl-7-[(5-methyl-1,3-thiazol-2-yl)amino]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene-11-carboxamide Show/Hide	C22H25N7OS	1
1	IC50 = 25 nM Bioactivity Info	TI LI LO TS
CP0561585 Compound Info	(E)-1-(4-methylphenyl)-4-[7-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]but-2-ene-1,4-dione Show/Hide	C31H32N6O2	1
1	IC50 = 25 nM Bioactivity Info	TI LI LO TS
CP0087802 Compound Info	5-amino-N-[3-(3-chlorophenyl)-1-methylpyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide Show/Hide	C17H14ClN7O	1
1	IC50 = 30.4 nM Bioactivity Info	TI LI LO TS
CP0233158 Compound Info	4-[[8-(1-cyclohexylpyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]benzoic acid Show/Hide	C22H22N6O2	1
1	IC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0066169 Compound Info	US8501936, 81 Show/Hide	C24H26N6O2S	1
1	IC50 = 32.9 nM Bioactivity Info	TI LI LO TS
CP0357574 Compound Info	(E)-1-[7-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]-4-phenylbut-2-ene-1,4-dione Show/Hide	C30H30N6O2	1
1	IC50 = 42.7 nM Bioactivity Info	TI LI LO TS
CP0357998 Compound Info	(E)-1-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]-4-phenylbut-2-ene-1,4-dione Show/Hide	C30H30N6O2	1
1	IC50 = 52.1 nM Bioactivity Info	TI LI LO TS
CP0258000 Compound Info	[4-[[8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]phenyl]-morpholin-4-ylmethanone Show/Hide	C24H23N5O4S	1
1	IC50 = 53.4 nM Bioactivity Info	TI LI LO TS
CP0229792 Compound Info	5-(3-methoxyphenyl)-N-[4-(4-methylpiperazin-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine Show/Hide	C24H26N6O	1
1	IC50 = 53.6 nM Bioactivity Info	TI LI LO TS
CP0065165 Compound Info	N,N-dicyclopropyl-7-[(4,5-dimethyl-1,3-thiazol-2-yl)amino]-10-ethyl-3-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene-11-carboxamide Show/Hide	C23H27N7OS	1
1	IC50 = 65 nM Bioactivity Info	TI LI LO TS
CP0105468 Compound Info	US8815840, 17 Show/Hide	C25H23ClN4O2	1
1	IC50 = 71 nM Bioactivity Info	TI LI LO TS
CP0466326 Compound Info	methyl (E)-4-[7-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]but-2-enoate Show/Hide	C25H30N6O2	1
1	IC50 = 72 nM Bioactivity Info	TI LI LO TS
CP0054730 Compound Info	N,N-dicyclopropyl-10-ethyl-3-methyl-7-[(4-methyl-1,3-thiazol-2-yl)amino]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene-11-carboxamide Show/Hide	C22H25N7OS	1
1	IC50 = 73 nM Bioactivity Info	TI LI LO TS
CP0158208 Compound Info	US8501936, 82 Show/Hide	C24H26N6O2S	1
1	IC50 = 73.1 nM Bioactivity Info	TI LI LO TS
CP0142408 Compound Info	2-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]acetonitrile Show/Hide	C22H25N7	1
1	IC50 = 73.2 nM Bioactivity Info	TI LI LO TS
CP0718990 Compound Info	(S)-7-(3-(dimethylamino)pyrrolidine-1-carbonyl)-3-(3-methoxyphenyl)-9H-carbazole-1-carboxamide Show/Hide	C27H28N4O3	1
1	IC50 = 80 nM Bioactivity Info	TI LI LO TS
CP0257998 Compound Info	8-(4-methoxyphenyl)-N-[1-(oxan-4-yl)pyrazol-4-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine Show/Hide	C21H22N6O2	1
1	IC50 = 86.9 nM Bioactivity Info	TI LI LO TS
CP0258395 Compound Info	(2R)-2-[4-[[8-(4-methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]pyrazol-1-yl]propan-1-ol Show/Hide	C19H20N6O2	1
1	IC50 = 89 nM Bioactivity Info	TI LI LO TS
CP0085066 Compound Info	N-[3-(3-chlorophenyl)-1-methylpyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide Show/Hide	C17H13ClN6O	1
1	IC50 = 89.8 nM Bioactivity Info	TI LI LO TS
CP0466322 Compound Info	2-[7-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]acetonitrile Show/Hide	C22H25N7	1
1	IC50 = 94.6 nM Bioactivity Info	TI LI LO TS
CP0321647 Compound Info	3-(3-methoxyphenyl)-7-(oxane-4-carbonylamino)-9H-carbazole-1-carboxamide Show/Hide	C26H25N3O4	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0188497 Compound Info	US8815840, 145 Show/Hide	C25H22FN3O4	1
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0285803 Compound Info	[4-[[5-(1-ethylpyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]pyridin-2-yl]methanol Show/Hide	C17H17N7O	1
1	IC50 = 115 nM Bioactivity Info	TI LI LO TS
CP0258001 Compound Info	N,N-dimethyl-4-[[8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]benzamide Show/Hide	C22H21N5O3S	1
1	IC50 = 117 nM Bioactivity Info	TI LI LO TS
CP0368062 Compound Info	[4-[[5-(3-propan-2-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]pyridin-2-yl]methanol Show/Hide	C21H21N5O	1
1	IC50 = 117 nM Bioactivity Info	TI LI LO TS
CP0063378 Compound Info	US8815840, 488 Show/Hide	C23H22N4O2	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0724873 Compound Info	6-(morpholine-4-carbonyl)-3-phenyl-9H-carbazole-1-carboxamide Show/Hide	C24H21N3O3	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0688514 Compound Info	3-(1-methyl-1H-indazol-5-yl)-7-(4-methylpiperazin-1-yl)-9H-carbazole-1-carboxamide Show/Hide	C26H26N6O	1
1	IC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0212500 Compound Info	5-amino-N-[2-(3-chlorophenyl)-5-methylpyrazol-3-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide Show/Hide	C17H14ClN7O	1
1	IC50 = 131 nM Bioactivity Info	TI LI LO TS
CP0779781 Compound Info	(S)-3-(3,4-dichlorophenyl)-6-(3-(dimethylamino)pyrrolidine-1-carbonyl)-9H-carbazole-1-carboxamide Show/Hide	C26H24Cl2N4O2	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0087805 Compound Info	N-[5-(3-chlorophenyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide Show/Hide	C16H11ClN6O	1
1	IC50 = 143 nM Bioactivity Info	TI LI LO TS
CP0375323 Compound Info	4-[[8-(1-propan-2-ylpyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]benzoic acid Show/Hide	C19H18N6O2	1
1	IC50 = 151 nM Bioactivity Info	TI LI LO TS
CP0258394 Compound Info	4-[[8-[1-(2-methylpropyl)pyrazol-4-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]benzoic acid Show/Hide	C20H20N6O2	1
1	IC50 = 156 nM Bioactivity Info	TI LI LO TS
CP0073236 Compound Info	5-amino-N-[3-(3-chlorophenyl)-1,2-oxazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide Show/Hide	C16H11ClN6O2	1
1	IC50 = 158 nM Bioactivity Info	TI LI LO TS
CP0510239 Compound Info	5-[1-(2-methylpropyl)pyrazol-4-yl]-N-(2-methylpyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine Show/Hide	C19H21N7	1
1	IC50 = 165 nM Bioactivity Info	TI LI LO TS
CP0765341 Compound Info	7-(morpholine-4-carbonyl)-3-phenyl-9H-carbazole-1-carboxamide Show/Hide	C24H21N3O3	1
1	IC50 = 170 nM Bioactivity Info	TI LI LO TS
CP0258002 Compound Info	5-(4-methoxyphenyl)-N-(2-methylpyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine Show/Hide	C19H17N5O	1
1	IC50 = 174 nM Bioactivity Info	TI LI LO TS
CP0435978 Compound Info	5-amino-N-[4-(3-chlorophenyl)-2-methyl-1,3-thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide Show/Hide	C17H13ClN6OS	1
1	IC50 = 176 nM Bioactivity Info	TI LI LO TS
CP0199128 Compound Info	N-(2-methylpyridin-4-yl)-5-(3-propan-2-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine Show/Hide	C21H21N5	1
1	IC50 = 190 nM Bioactivity Info	TI LI LO TS
CP0683100 Compound Info	3-(3,4-dichlorophenyl)-6-(morpholine-4-carbonyl)-9H-carbazole-1-carboxamide Show/Hide	C24H19Cl2N3O3	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0217473 Compound Info	5-amino-N-[5-(3-chlorophenyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide Show/Hide	C16H12ClN7O	1
1	IC50 = 205 nM Bioactivity Info	TI LI LO TS
CP0192289 Compound Info	5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-ethylphenyl)-1H-pyrrole-3-carboxamide Show/Hide	C17H16ClN5O	1
1	IC50 = 210 nM Bioactivity Info	TI LI LO TS
CP0704926 Compound Info	3-benzyl-6-(morpholine-4-carbonyl)-9H-carbazole-1-carboxamide Show/Hide	C25H23N3O3	1
1	IC50 = 210 nM Bioactivity Info	TI LI LO TS
CP0724878 Compound Info	3-(3-methoxyphenyl)-7-(morpholine-4-carbonyl)-9H-carbazole-1-carboxamide Show/Hide	C25H23N3O4	1
1	IC50 = 210 nM Bioactivity Info	TI LI LO TS
CP0094596 Compound Info	N,N-dicyclopropyl-10-ethyl-7-(2-methoxyethylcarbamoylamino)-3-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene-11-carboxamide Show/Hide	C22H29N7O3	1
1	IC50 = 210 nM Bioactivity Info	TI LI LO TS
CP0368034 Compound Info	4-[[8-(4-methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]benzoic acid Show/Hide	C20H16N4O3	1
1	IC50 = 212 nM Bioactivity Info	TI LI LO TS
CP0252812 Compound Info	US8815840, 164 Show/Hide	C24H19Cl2N3O3	1
1	IC50 = 216 nM Bioactivity Info	TI LI LO TS
CP0169747 Compound Info	N-[3-(3-chlorophenyl)pyridin-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide Show/Hide	C18H12ClN5O	1
1	IC50 = 250 nM Bioactivity Info	TI LI LO TS
CP0553658 Compound Info	2-(5-chloro-2-methylphenyl)-1-methyl-5-[2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]pyrrole-3-carboxamide Show/Hide	C28H30ClN7O	1
1	IC50 = 250 nM Bioactivity Info	TI LI LO TS
CP0160261 Compound Info	N-[2-(3-chlorophenyl)-5-methylpyrazol-3-yl]-5-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide Show/Hide	C18H16ClN7O	1
1	IC50 = 259 nM Bioactivity Info	TI LI LO TS
CP0147581 Compound Info	3-[3-chloro-4-(morpholin-4-ylmethyl)phenyl]-7-(4-methylpiperazin-1-yl)-9H-carbazole-1-carboxamide Show/Hide	C29H32ClN5O2	1
1	IC50 = 260 nM Bioactivity Info	TI LI LO TS
CP0422129 Compound Info	4-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]butan-1-ol Show/Hide	C24H32N6O	1
1	IC50 = 268 nM Bioactivity Info	TI LI LO TS
CP0007710 Compound Info	2-[[1-[2-fluoro-4-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]phenyl]piperidin-4-yl]-methylamino]ethanol Show/Hide	C25H34FN7O	1
1	IC50 = 270 nM Bioactivity Info	TI LI LO TS
CP0183736 Compound Info	3-(3-methoxyphenyl)-6-(4-methylpiperazine-1-carbonyl)-9H-carbazole-1-carboxamide Show/Hide	C26H26N4O3	1
1	IC50 = 280 nM Bioactivity Info	TI LI LO TS
CP0533189 Compound Info	N-[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]-2-prop-2-enyl-3,4-dihydro-1H-isoquinolin-6-amine Show/Hide	C23H28N6	1
1	IC50 = 288 nM Bioactivity Info	TI LI LO TS
CP0422139 Compound Info	3-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]propanenitrile Show/Hide	C23H27N7	1
1	IC50 = 296 nM Bioactivity Info	TI LI LO TS
CP0466331 Compound Info	3-[6-[[5-fluoro-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]propan-1-ol Show/Hide	C22H27FN6O	1
1	IC50 = 311 nM Bioactivity Info	TI LI LO TS
CP0549517 Compound Info	5-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]pentan-1-ol Show/Hide	C25H34N6O	1
1	IC50 = 312 nM Bioactivity Info	TI LI LO TS
CP0147647 Compound Info	5-(2-aminopyrimidin-4-yl)-2-[2-ethyl-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide Show/Hide	C18H16F3N5O	1
1	IC50 = 320 nM Bioactivity Info	TI LI LO TS
CP0565768 Compound Info	2-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]ethanol Show/Hide	C22H28N6O	1
1	IC50 = 323 nM Bioactivity Info	TI LI LO TS
CP0549513 Compound Info	(E)-N,N-diethyl-4-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]but-2-enamide Show/Hide	C28H37N7O	1
1	IC50 = 329 nM Bioactivity Info	TI LI LO TS
CP0466323 Compound Info	(E)-4-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]but-2-enoic acid Show/Hide	C24H28N6O2	1
1	IC50 = 334 nM Bioactivity Info	TI LI LO TS
CP0426514 Compound Info	2-(2-ethoxyethyl)-N-[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]-3,4-dihydro-1H-isoquinolin-6-amine Show/Hide	C24H32N6O	1
1	IC50 = 339 nM Bioactivity Info	TI LI LO TS
CP0718988 Compound Info	6-(morpholine-4-carbonyl)-3-(3-propoxyphenyl)-9H-carbazole-1-carboxamide Show/Hide	C27H27N3O4	1
1	IC50 = 350 nM Bioactivity Info	TI LI LO TS
CP0094586 Compound Info	N,N-dicyclopropyl-10-ethyl-3-methyl-7-(methylamino)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene-11-carboxamide Show/Hide	C19H24N6O	1
1	IC50 = 350 nM Bioactivity Info	TI LI LO TS
CP0176873 Compound Info	7-(4-methylpiperazin-1-yl)-3-phenyl-9H-carbazole-1-carboxamide Show/Hide	C24H24N4O	1
1	IC50 = 370 nM Bioactivity Info	TI LI LO TS
CP0065167 Compound Info	N,N-dicyclopropyl-10-[(2R)-2-hydroxypropyl]-3-methyl-7-(methylamino)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene-11-carboxamide Show/Hide	C20H26N6O2	1
1	IC50 = 370 nM Bioactivity Info	TI LI LO TS
CP0221794 Compound Info	4-[[8-(2-propan-2-ylpyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]benzoic acid Show/Hide	C21H19N5O2	1
1	IC50 = 379 nM Bioactivity Info	TI LI LO TS
CP0422131 Compound Info	N-[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]-2-prop-2-ynyl-3,4-dihydro-1H-isoquinolin-6-amine Show/Hide	C23H26N6	1
1	IC50 = 382 nM Bioactivity Info	TI LI LO TS
CP0065164 Compound Info	N,N-dicyclopropyl-10-(3-hydroxypropyl)-3-methyl-7-(methylamino)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene-11-carboxamide Show/Hide	C20H26N6O2	1
1	IC50 = 390 nM Bioactivity Info	TI LI LO TS
CP0571801 Compound Info	3-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]propan-1-ol Show/Hide	C23H30N6O	1
1	IC50 = 394 nM Bioactivity Info	TI LI LO TS
CP0314014 Compound Info	5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-1H-pyrrole-3-carboxamide Show/Hide	C16H14ClN5O	1
1	IC50 = 430 nM Bioactivity Info	TI LI LO TS
CP0482571 Compound Info	N-(2-methylpyridin-4-yl)-5-(3-methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine Show/Hide	C19H17N5O2S	1
1	IC50 = 446 nM Bioactivity Info	TI LI LO TS
CP0183696 Compound Info	3-(3-chlorophenyl)-7-(4-methylpiperazin-1-yl)-9H-carbazole-1-carboxamide Show/Hide	C24H23ClN4O	1
1	IC50 = 470 nM Bioactivity Info	TI LI LO TS
CP0013429 Compound Info	5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide Show/Hide	C16H11ClF3N5O	1
1	IC50 = 480 nM Bioactivity Info	TI LI LO TS
CP0314013 Compound Info	5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-N-methyl-1H-pyrrole-3-carboxamide Show/Hide	C17H16ClN5O	1
1	IC50 = 480 nM Bioactivity Info	TI LI LO TS
CP0563063 Compound Info	5-[6-[[5-fluoro-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]pentan-1-ol Show/Hide	C24H31FN6O	1
1	IC50 = 492 nM Bioactivity Info	TI LI LO TS
CP0723230 Compound Info	7-morpholino-3-phenyl-9H-carbazole-1-carboxamide Show/Hide	C23H21N3O2	1
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0426511 Compound Info	(E)-4-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]-N-(2-piperidin-1-ylethyl)but-2-enamide Show/Hide	C31H42N8O	1
1	IC50 = 554 nM Bioactivity Info	TI LI LO TS
CP0565878 Compound Info	1-[6-[[5-fluoro-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]-2-hydroxyethanone Show/Hide	C21H23FN6O2	1
1	IC50 = 574 nM Bioactivity Info	TI LI LO TS
CP0370754 Compound Info	2-methoxyethyl N-[11-(dicyclopropylcarbamoyl)-10-ethyl-3-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-7-yl]carbamate Show/Hide	C22H28N6O4	1
1	IC50 = 580 nM Bioactivity Info	TI LI LO TS
CP0466328 Compound Info	2-butyl-N-[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]-3,4-dihydro-1H-isoquinolin-6-amine Show/Hide	C24H32N6	1
1	IC50 = 592 nM Bioactivity Info	TI LI LO TS
CP0549518 Compound Info	4-[6-[[5-fluoro-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]butan-1-ol Show/Hide	C23H29FN6O	1
1	IC50 = 604 nM Bioactivity Info	TI LI LO TS
CP0553266 Compound Info	(E)-N-tert-butyl-4-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]but-2-enamide Show/Hide	C28H37N7O	1
1	IC50 = 612 nM Bioactivity Info	TI LI LO TS
CP0507670 Compound Info	1-(4-methylphenyl)-4-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]butane-1,4-dione Show/Hide	C31H34N6O2	1
1	IC50 = 626 nM Bioactivity Info	TI LI LO TS
CP0466324 Compound Info	2-[6-[[5-fluoro-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]ethanol Show/Hide	C21H25FN6O	1
1	IC50 = 651 nM Bioactivity Info	TI LI LO TS
CP0565766 Compound Info	2-[5-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-1,3-dihydroisoindol-2-yl]ethanol Show/Hide	C21H26N6O	1
1	IC50 = 692 nM Bioactivity Info	TI LI LO TS
CP0523440 Compound Info	5-(2-aminopyrimidin-4-yl)-2-(2,5-dichlorophenyl)-1H-pyrrole-3-carboxamide Show/Hide	C15H11Cl2N5O	1
1	IC50 = 700 nM Bioactivity Info	TI LI LO TS
CP0094582 Compound Info	N,N-dicyclopropyl-10-[(2S)-2,3-dihydroxypropyl]-3-methyl-7-(methylamino)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene-11-carboxamide Show/Hide	C20H26N6O3	1
1	IC50 = 720 nM Bioactivity Info	TI LI LO TS
CP0396887 Compound Info	5-(2-aminopyrimidin-4-yl)-2-[2-methyl-5-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide Show/Hide	C17H14F3N5O	1
1	IC50 = 760 nM Bioactivity Info	TI LI LO TS
CP0549512 Compound Info	2-but-2-ynyl-N-[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]-3,4-dihydro-1H-isoquinolin-6-amine Show/Hide	C24H28N6	1
1	IC50 = 794 nM Bioactivity Info	TI LI LO TS
CP0466327 Compound Info	4-(dimethylamino)-1-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]butan-1-one Show/Hide	C26H35N7O	1
1	IC50 = 985 nM Bioactivity Info	TI LI LO TS
CP0396886 Compound Info	2-(5-chloro-2-methylphenyl)-5-[2-(methylamino)pyrimidin-4-yl]-1H-pyrrole-3-carboxamide Show/Hide	C17H16ClN5O	1
1	IC50 = 1010 nM Bioactivity Info	TI LI LO TS
CP0466377 Compound Info	methyl 4-[6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]butanoate Show/Hide	C25H32N6O2	1
1	IC50 = 1040 nM Bioactivity Info	TI LI LO TS
CP0171413 Compound Info	N-[5-(3-chlorophenyl)-2-methylpyridin-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide Show/Hide	C19H14ClN5O	1
1	IC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0243878 Compound Info	N-[2-(3-chlorophenyl)-5-methylpyrazol-3-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide Show/Hide	C17H13ClN6O	1
1	IC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0145839 Compound Info	5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethoxy)phenyl]-1H-pyrrole-3-carboxamide Show/Hide	C16H11ClF3N5O2	1
1	IC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0065166 Compound Info	N,N-dicyclopropyl-10-ethyl-7-(3-methoxypropylamino)-3-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene-11-carboxamide Show/Hide	C22H30N6O2	1
1	IC50 = 1300 nM Bioactivity Info	TI LI LO TS
CP0304505 Compound Info	(2S)-3-[11-(1-cyclopropyltetrazol-5-yl)-3-methyl-7-(methylamino)-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-10-yl]propane-1,2-diol Show/Hide	C17H21N9O2	1
1	IC50 = 1300 nM Bioactivity Info	TI LI LO TS
CP0368047 Compound Info	N-(4-methylpyridin-2-yl)-5-(3-propan-2-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine Show/Hide	C21H21N5	1
1	IC50 = 1400 nM Bioactivity Info	TI LI LO TS
CP0426508 Compound Info	6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-N-propyl-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C24H31N7O	1
1	IC50 = 1760 nM Bioactivity Info	TI LI LO TS
CP0199126 Compound Info	N-(3-methylphenyl)-5-(3-propan-2-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine Show/Hide	C22H22N4	1
1	IC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0425707 Compound Info	3-[2-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-7,8-dihydro-5H-1,6-naphthyridin-6-yl]propan-1-ol Show/Hide	C22H29N7O	1
1	IC50 = 2180 nM Bioactivity Info	TI LI LO TS
CP0422128 Compound Info	N-ethyl-6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C23H29N7O	1
1	IC50 = 2350 nM Bioactivity Info	TI LI LO TS
CP0268143 Compound Info	5-(2-aminopyrimidin-4-yl)-2-[2,5-bis(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide Show/Hide	C17H11F6N5O	1
1	IC50 = 3070 nM Bioactivity Info	TI LI LO TS
CP0553269 Compound Info	N-(3-chlorophenyl)-6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinoline-2-carboxamide Show/Hide	C27H28ClN7O	1
1	IC50 = 3450 nM Bioactivity Info	TI LI LO TS
CP0532772 Compound Info	2-[5-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-2,3-dihydroindol-1-yl]ethanol Show/Hide	C21H26N6O	1
1	IC50 = 3790 nM Bioactivity Info	TI LI LO TS
CP0466383 Compound Info	2-[7-fluoro-6-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-isoquinolin-2-yl]ethanol Show/Hide	C22H27FN6O	1
1	IC50 = 4460 nM Bioactivity Info	TI LI LO TS
CP0092903 Compound Info	5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-N-(1-methylpiperidin-4-yl)-1H-pyrrole-3-carboxamide Show/Hide	C22H25ClN6O	1
1	IC50 > 3000 nM Bioactivity Info	TI LI LO TS
CP0147634 Compound Info	5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-N-[2-(methylamino)ethyl]-1H-pyrrole-3-carboxamide Show/Hide	C19H21ClN6O	1
1	IC50 > 3000 nM Bioactivity Info	TI LI LO TS

Cell Viability or Cytotoxicity Assay

Compound ID	Compound Name	Compound Formula
CP0007710 Compound Info	2-[[1-[2-fluoro-4-[[5-methyl-4-(1-propan-2-ylpyrazol-4-yl)pyrimidin-2-yl]amino]phenyl]piperidin-4-yl]-methylamino]ethanol Show/Hide	C25H34FN7O	1
1	IC50 = 270 nM	TI LI LO TS
CP0026231 Compound Info	ONX-0803 Show/Hide	C28H32N4O3	1
1	IC50 = 915.7 nM	TI LI LO TS
CP0520990 Compound Info	2-(6-(((1R,2S)-2-((E)-1-phenylbut-1-en-2-yl)cyclopropyl)amino)-2-azaspiro[3.3]heptan-2-yl)ethanol Show/Hide	C21H30N2O	1
1	GI50 = 37 nM	TI LI LO TS

Protein family and CMB statistics Related to the Cell Line

Cell Lines Derived from the same Tissue Source (Peripheral blood)

Cell Line Name		Organism	Disease
Mono-Mac-6	Cell Line Info	Homo sapiens (Human)	Adult acute monocytic leukemia
HL-60	Cell Line Info	Homo sapiens (Human)	Adult acute myeloid leukemia
MOLM-13	Cell Line Info	Homo sapiens (Human)	Adult acute myeloid leukemia
OCI-AML-2	Cell Line Info	Homo sapiens (Human)	Adult acute myeloid leukemia
HL-60/ADR	Cell Line Info	Homo sapiens (Human)	Adult acute myeloid leukemia
MOLM-14	Cell Line Info	Homo sapiens (Human)	Adult acute myeloid leukemia
HL60/MDR	Cell Line Info	Homo sapiens (Human)	Adult acute myeloid leukemia
HL60/MRP	Cell Line Info	Homo sapiens (Human)	Adult acute myeloid leukemia
NALM-6	Cell Line Info	Homo sapiens (Human)	Adult B acute lymphoblastic leukemia
MOLT-4	Cell Line Info	Homo sapiens (Human)	Adult T acute lymphoblastic leukemia
MOLT-4/CCR5	Cell Line Info	Homo sapiens (Human)	Adult T acute lymphoblastic leukemia
Karpas-299	Cell Line Info	Homo sapiens (Human)	Anaplastic large cell lymphoma, ALK-positive
M-07e	Cell Line Info	Homo sapiens (Human)	Childhood acute megakaryoblastic leukemia
THP-1	Cell Line Info	Homo sapiens (Human)	Childhood acute monocytic leukemia
MV4-11	Cell Line Info	Homo sapiens (Human)	Childhood acute monocytic leukemia
THP1-Dual	Cell Line Info	Homo sapiens (Human)	Childhood acute monocytic leukemia
THP1-Dual KO-STING	Cell Line Info	Homo sapiens (Human)	Childhood acute monocytic leukemia
THP1-Blue ISG	Cell Line Info	Homo sapiens (Human)	Childhood acute monocytic leukemia
THP1-ASC-GFP	Cell Line Info	Homo sapiens (Human)	Childhood acute monocytic leukemia
PMNL	Cell Line Info	Homo sapiens (Human)	Childhood acute monocytic leukemia
THP1-Xblue	Cell Line Info	Homo sapiens (Human)	Childhood acute monocytic leukemia
SEM	Cell Line Info	Homo sapiens (Human)	Childhood B acute lymphoblastic leukemia
SEMK2	Cell Line Info	Homo sapiens (Human)	Childhood B acute lymphoblastic leukemia
Reh	Cell Line Info	Homo sapiens (Human)	Childhood B acute lymphoblastic leukemia
Jurkat	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
Jurkat E6.1	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
CCRF-CEM	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
CCRF/VCR1000	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
CEM/VLB100	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
CEM/VLB500	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
CEM-SS	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
HPB-ALL	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
CCRF-SB	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
CEM-T4	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
J-Lat 10.6	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
12D7-MDR1	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
MDR CCRF vcr1000	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
FGS7 Jurkat	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
EoL-1	Cell Line Info	Homo sapiens (Human)	Chronic eosinophilic leukemia, not otherwise specified
CII	Cell Line Info	Homo sapiens (Human)	Chronic lymphocytic leukemia
Ku812	Cell Line Info	Homo sapiens (Human)	Chronic myelogenous leukemia, BCR-ABL1 positive
Ri-1	Cell Line Info	Homo sapiens (Human)	Diffuse large B-cell lymphoma activated B-cell type
Daudi	Cell Line Info	Homo sapiens (Human)	EBV-related Burkitt lymphoma
HEL	Cell Line Info	Homo sapiens (Human)	Erythroleukemia
UKE-1	Cell Line Info	Homo sapiens (Human)	Essential thrombocythemia
L-1236	Cell Line Info	Homo sapiens (Human)	Hodgkin lymphoma
Granta-519	Cell Line Info	Homo sapiens (Human)	Mantle cell lymphoma
JeKo-1	Cell Line Info	Homo sapiens (Human)	Mantle cell lymphoma
Mino	Cell Line Info	Homo sapiens (Human)	Mantle cell lymphoma
HMC-1	Cell Line Info	Homo sapiens (Human)	Mast cell leukemia
NK-92	Cell Line Info	Homo sapiens (Human)	Natural killer cell lymphoblastic leukemia/lymphoma
NK	Cell Line Info	Homo sapiens (Human)	Natural killer cell lymphoblastic leukemia/lymphoma
KHYG-1	Cell Line Info	Homo sapiens (Human)	Natural killer cell lymphoblastic leukemia/lymphoma
RPMI-8226	Cell Line Info	Homo sapiens (Human)	Plasma cell myeloma
OPM-2	Cell Line Info	Homo sapiens (Human)	Plasma cell myeloma
U266B1	Cell Line Info	Homo sapiens (Human)	Plasma cell myeloma
KMS-18	Cell Line Info	Homo sapiens (Human)	Plasma cell myeloma
MM1.S	Cell Line Info	Homo sapiens (Human)	Plasma cell myeloma
MM1.R	Cell Line Info	Homo sapiens (Human)	Plasma cell myeloma
OPM-1	Cell Line Info	Homo sapiens (Human)	Plasma cell myeloma
RPMI-8226/Dox40	Cell Line Info	Homo sapiens (Human)	Plasma cell myeloma
HuT 78	Cell Line Info	Homo sapiens (Human)	Sezary syndrome
H9	Cell Line Info	Homo sapiens (Human)	Sezary syndrome
CREM010i-SS9-1	Cell Line Info	Homo sapiens (Human)	Sickle cell disease
RBL-1	Cell Line Info	Rattus norvegicus (Rat)	Rat leukemia
RBL-2H3	Cell Line Info	Rattus norvegicus (Rat)	Rat leukemia
LCL Orang Asli K28	Cell Line Info	Homo sapiens (Human)	-
JY	Cell Line Info	Homo sapiens (Human)	-
C.M.L.	Cell Line Info	Homo sapiens (Human)	-
BON	Cell Line Info	Homo sapiens (Human)	-
PBMC iPSC #1	Cell Line Info	Homo sapiens (Human)	-
LCL 721	Cell Line Info	Homo sapiens (Human)	-

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han