Cell Line Information

General Information of the Cell Line

Cell Line ID	CL000300
Cell Line Name	Karpas-299
Synonyms	KARPAS-299 Karpas 299 KARPAS 299 Karpas299 KARPAS299 K299
Category	Cancer cell line
Organism	Homo sapiens (Human)
Cellosaurus ID	CVCL_1324
Tissue Information	Peripheral blood
Disease	Anaplastic large cell lymphoma, ALK-positive (NCIt: C37193) ALK-positive anaplastic large cell lymphoma (ORDO: Orphanet_300895)

Map of Molecular Bioactivity Related to the Cell Line

Map of Molecular Bioactivity Related to the Cell Line Cell Line Protein Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Cell Line

Protein ID: PT01203, ALK tyrosine kinase receptor

Protein Info

Compound ID	Compound Name	Compound Formula
CP0073076 Compound Info	(2R)-2-[5-[6-amino-5-[(1R)-1-[5-fluoro-2-(triazol-2-yl)phenyl]ethoxy]pyridin-3-yl]-4-methyl-1,3-thiazol-2-yl]propane-1,2-diol Show/Hide	C22H23FN6O3S	1
1	IC50 = 1.7 nM Bioactivity Info	TI LI LO TS
CP0019908 Compound Info	BDBM50242742 Show/Hide	C30H40ClN7O3S	1
1	IC50 < 10 nM Bioactivity Info	TI LI LO TS
CP0036509 Compound Info	N-[(1R,2R)-2-[[5-chloro-2-[[7-methoxy-3-(2-methoxyethyl)-1,2,4,5-tetrahydro-3-benzazepin-8-yl]amino]pyrimidin-4-yl]amino]cyclohexyl]-N-methylmethanesulfonamide Show/Hide	C26H39ClN6O4S	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0031719 Compound Info	(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine Show/Hide	C21H22Cl2FN5O	3
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
2	IC50 = 62 nM Bioactivity Info	TI LI LO TS
3	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0346931 Compound Info	2-[[5-chloro-2-[(1-methyl-2-oxo-4,5-dihydro-3H-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]-N-methylbenzenesulfonamide Show/Hide	C22H23ClN6O3S	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0089290 Compound Info	(1S,2S,3R,4R)-3-[[5-chloro-2-[[(7S)-4-methoxy-7-morpholin-4-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide Show/Hide	C28H35ClN6O3	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0389904 Compound Info	(3S)-N-[(3-morpholin-4-ylphenyl)methyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide Show/Hide	C30H38N6O5	1
1	IC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0036597 Compound Info	2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-methyl-benzamide Show/Hide	C23H23ClN6O2	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0336558 Compound Info	7-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-1-ethyl-8-methoxy-4,5-dihydro-3H-1-benzazepin-2-one Show/Hide	C26H30ClN5O4S	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0338834 Compound Info	2-[[5-chloro-2-[(1-ethyl-8-methoxy-2-oxo-4,5-dihydro-3H-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]-N,N-dimethylbenzenesulfonamide Show/Hide	C25H29ClN6O4S	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0081541 Compound Info	2-(7-(5-chloro-4-(2-methoxy-4-morpholinophenylamino)pyrimidin-2-ylamino)-8-methoxy-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-N,N-dimethylacetamide Show/Hide	C30H38ClN7O4	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0507344 Compound Info	(1S,2S,3R,4R)-3-[[5-chloro-2-[[(7R)-4-methoxy-7-(2-methoxyethylamino)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide Show/Hide	C27H35ClN6O3	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0083616 Compound Info	6-[6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]-1'-methylspiro[1H-indole-3,4'-piperidine]-2-one Show/Hide	C26H25Cl2FN4O2	1
1	IC50 = 39 nM Bioactivity Info	TI LI LO TS
CP0271214 Compound Info	(1S,2S,3R,4R)-3-[[5-chloro-2-[(1-ethyl-8-methoxy-2-oxo-4,5-dihydro-3H-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide Show/Hide	C25H29ClN6O3	1
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0338383 Compound Info	2-[[5-chloro-2-[(1-ethyl-8-methoxy-2-oxo-4,5-dihydro-3H-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]-N-methylbenzamide Show/Hide	C25H27ClN6O3	1
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0050160 Compound Info	(1S,2S,3R,4R)-3-[[5-chloro-2-[(1-ethyl-6-methoxy-2-oxo-4,5-dihydro-3H-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide Show/Hide	C25H29ClN6O3	2
1	IC50 = 45 nM Bioactivity Info	TI LI LO TS
2	IC50 = 225 nM Bioactivity Info	TI LI LO TS
CP0338378 Compound Info	7-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-1-ethyl-6-methoxy-4,5-dihydro-3H-1-benzazepin-2-one Show/Hide	C26H30ClN5O4S	1
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0432571 Compound Info	(3S)-N-[[3-(trifluoromethoxy)phenyl]methyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide Show/Hide	C27H30F3N5O5	1
1	IC50 = 59 nM Bioactivity Info	TI LI LO TS
CP0251297 Compound Info	N-[(1R,2R)-2-[[5-chloro-2-[(3-ethyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]cyclohexyl]methanesulfonamide Show/Hide	C23H33ClN6O2S	1
1	IC50 = 60 nM Bioactivity Info	TI LI LO TS
CP0444303 Compound Info	methyl 3-[[[(3S)-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carbonyl]amino]methyl]benzoate Show/Hide	C28H33N5O6	1
1	IC50 = 61 nM Bioactivity Info	TI LI LO TS
CP0038262 Compound Info	N-[(1R,2R)-2-[[5-chloro-2-[[7-methoxy-3-(2-methoxyethyl)-1,2,4,5-tetrahydro-3-benzazepin-8-yl]amino]pyrimidin-4-yl]amino]cyclohexyl]methanesulfonamide Show/Hide	C25H37ClN6O4S	1
1	IC50 = 65 nM Bioactivity Info	TI LI LO TS
CP0071846 Compound Info	N-[(1R,2R)-2-[[5-chloro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]cyclohexyl]methanesulfonamide Show/Hide	C22H31ClN6O4S	1
1	IC50 = 65 nM Bioactivity Info	TI LI LO TS
CP0140927 Compound Info	N-[(1R,2R)-2-[[5-chloro-2-[(3-ethyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]cyclohexyl]acetamide Show/Hide	C24H33ClN6O	1
1	IC50 = 65 nM Bioactivity Info	TI LI LO TS
CP0346930 Compound Info	2-[[5-chloro-2-[(1-ethyl-6-methoxy-2-oxo-4,5-dihydro-3H-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]-N,N-dimethylbenzenesulfonamide Show/Hide	C25H29ClN6O4S	1
1	IC50 = 65 nM Bioactivity Info	TI LI LO TS
CP0544606 Compound Info	(1S,2S,3R,4R)-3-[[5-chloro-2-[[(7S)-4-methoxy-7-(2-methoxyethylamino)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide Show/Hide	C27H35ClN6O3	1
1	IC50 = 65 nM Bioactivity Info	TI LI LO TS
CP0152147 Compound Info	N-[(1R,2R)-2-[[5-chloro-2-[[3-(2-methoxyethyl)-1,2,4,5-tetrahydro-3-benzazepin-7-yl]amino]pyrimidin-4-yl]amino]cyclohexyl]methanesulfonamide Show/Hide	C24H35ClN6O3S	1
1	IC50 = 73 nM Bioactivity Info	TI LI LO TS
CP0236924 Compound Info	(4Z)-4-[[4-[(2,3-difluorophenyl)methoxy]-1-methylindol-3-yl]methylidene]-3-(1,3-thiazol-2-yl)-1H-pyrazol-5-one Show/Hide	C23H16F2N4O2S	1
1	IC50 = 90 nM Bioactivity Info	TI LI LO TS
CP0347900 Compound Info	N-[(1R,2R)-2-[[5-chloro-2-[[3-(2-methoxyethyl)-1,2,4,5-tetrahydro-3-benzazepin-7-yl]amino]pyrimidin-4-yl]amino]cyclohexyl]-2,2,2-trifluoroacetamide Show/Hide	C25H32ClF3N6O2	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0252857 Compound Info	(4Z)-4-[[4-[(2,6-difluorophenyl)methoxy]-1-methylindol-3-yl]methylidene]-3-(1,3-thiazol-2-yl)-1H-pyrazol-5-one Show/Hide	C23H16F2N4O2S	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0346929 Compound Info	(1S,2S,3R,4R)-3-[[5-chloro-2-[(1-methyl-2-oxo-4,5-dihydro-3H-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide Show/Hide	C23H25ClN6O2	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0069842 Compound Info	(4Z)-4-[[4-[(3-fluorophenyl)methoxy]-1-methylindol-3-yl]methylidene]-3-(1,3-thiazol-2-yl)-1H-pyrazol-5-one Show/Hide	C23H17FN4O2S	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0523034 Compound Info	(1S,2S,3R,4R)-3-[[5-chloro-2-[[(7R)-4-methoxy-7-morpholin-4-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide Show/Hide	C28H35ClN6O3	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0227700 Compound Info	3-[1-[(3-fluorophenyl)methyl]pyrazol-4-yl]-5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C21H17FN6	2
1	IC50 = 138.5 nM Bioactivity Info	TI LI LO TS
2	IC50 = 219.5 nM Bioactivity Info	TI LI LO TS
CP0035364 Compound Info	1-(5-Chloro-2-trifluoromethyl-benzyl)-7-(2-piperazin-1-yl-pyridin-4-yl)-1,2,3,4-tetrahydro-pyrido[2,3-b]pyrazine Show/Hide	C24H24ClF3N6	1
1	IC50 = 150 nM Bioactivity Info	TI LI LO TS
CP0290762 Compound Info	N-[(1R,2R)-2-[[5-chloro-2-[[7-methoxy-3-(2-methoxyethyl)-1,2,4,5-tetrahydro-3-benzazepin-8-yl]amino]pyrimidin-4-yl]amino]cyclohexyl]-N-ethylmethanesulfonamide Show/Hide	C27H41ClN6O4S	1
1	IC50 = 150 nM Bioactivity Info	TI LI LO TS
CP0439722 Compound Info	(1S,2S,3R,4R)-3-[[5-chloro-2-[[3-methoxy-7-(4-methylpiperazin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide Show/Hide	C29H38ClN7O2	1
1	IC50 = 150 nM Bioactivity Info	TI LI LO TS
CP0066087 Compound Info	1-(2,5-Difluoro-benzyl)-7-[6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-1,2,3,4-tetrahydro-pyrido[2,3-b]pyrazine Show/Hide	C24H26F2N6	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0140924 Compound Info	N-[(1R,2R)-2-[[5-chloro-2-[(3-ethyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]cyclohexyl]-2,2,2-trifluoroacetamide Show/Hide	C24H30ClF3N6O	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0167905 Compound Info	(4Z)-4-[[4-[(2,5-difluorophenyl)methoxy]-1-methylindol-3-yl]methylidene]-3-(1,3-thiazol-2-yl)-1H-pyrazol-5-one Show/Hide	C23H16F2N4O2S	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0209390 Compound Info	(4Z)-4-[[4-[(2-chloro-6-fluorophenyl)methoxy]-1-methylindol-3-yl]methylidene]-3-(1,3-thiazol-2-yl)-1H-pyrazol-5-one Show/Hide	C23H16ClFN4O2S	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0672164 Compound Info	4-((4-(2-chloro-6-fluorobenzyloxy)-1-methyl-1H-indol-3-yl)methylene)-3-(4-methyl-1,2,3-thiadiazol-5-yl)-1H-pyrazol-5(4H)-one Show/Hide	C23H17ClFN5O2S	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0756199 Compound Info	4-((4-(2,4-difluorobenzyloxy)-1-methyl-1H-indol-3-yl)methylene)-3-(4-methyl-1,2,3-thiadiazol-5-yl)-1H-pyrazol-5(4H)-one Show/Hide	C23H17F2N5O2S	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0480102 Compound Info	2-[[5-chloro-2-[(1-ethyl-6-methoxy-2-oxo-4,5-dihydro-3H-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]-N-methylbenzamide Show/Hide	C25H27ClN6O3	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0432990 Compound Info	(3S)-N-[(3-phenylphenyl)methyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide Show/Hide	C32H35N5O4	1
1	IC50 = 224 nM Bioactivity Info	TI LI LO TS
CP0416087 Compound Info	(3S)-N-[(3-chlorophenyl)methyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide Show/Hide	C26H30ClN5O4	1
1	IC50 = 226 nM Bioactivity Info	TI LI LO TS
CP0037714 Compound Info	[4-[1-[[5-chloro-2-(trifluoromethyl)phenyl]methyl]-3,4-dihydro-2H-pyrido[2,3-b]pyrazin-7-yl]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone Show/Hide	C31H33ClF3N5O	1
1	IC50 = 250 nM Bioactivity Info	TI LI LO TS
CP0039200 Compound Info	1-[4-(4-{1-[5-Chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydro-pyrido[2,3-b]pyrazin-7-yl}pyridin-2-yl)piperazin-1-yl]ethanone Show/Hide	C26H26ClF3N6O	1
1	IC50 = 250 nM Bioactivity Info	TI LI LO TS
CP0206735 Compound Info	N-[(1R,2R)-2-[[5-chloro-2-[[3-(2-methoxyethyl)-1,2,4,5-tetrahydro-3-benzazepin-7-yl]amino]pyrimidin-4-yl]amino]cyclohexyl]-2,2,2-trifluoroethanesulfonamide Show/Hide	C25H34ClF3N6O3S	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0209391 Compound Info	(4Z)-4-[(1-methyl-4-phenylmethoxyindol-3-yl)methylidene]-3-(1,3-thiazol-2-yl)-1H-pyrazol-5-one Show/Hide	C23H18N4O2S	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0645613 Compound Info	4-((4-ethoxy-1-methyl-1H-indol-3-yl)methylene)-3-(4-methyl-1,2,3-thiadiazol-5-yl)-1H-pyrazol-5(4H)-one Show/Hide	C18H17N5O2S	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0704217 Compound Info	4-((4-(2,6-difluorobenzyloxy)-1-methyl-1H-indol-3-yl)methylene)-3-(4-methyl-1,2,3-thiadiazol-5-yl)-1H-pyrazol-5(4H)-one Show/Hide	C23H17F2N5O2S	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0737082 Compound Info	4-((4-(2-chloro-3,6-difluorobenzyloxy)-1-methyl-1H-indol-3-yl)methylene)-3-(4-methyl-1,2,3-thiadiazol-5-yl)-1H-pyrazol-5(4H)-one Show/Hide	C23H16ClF2N5O2S	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0065822 Compound Info	(3S)-N-[(4-methylphenyl)methyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide Show/Hide	C27H33N5O4	1
1	IC50 = 384 nM Bioactivity Info	TI LI LO TS
CP0081119 Compound Info	(4Z)-4-[[4-[(2-fluorophenyl)methoxy]-1-methylindol-3-yl]methylidene]-3-(1,3-thiazol-2-yl)-1H-pyrazol-5-one Show/Hide	C23H17FN4O2S	1
1	IC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0715174 Compound Info	4-((4-(2-fluorobenzyloxy)-1-methyl-1H-indol-3-yl)methylene)-3-(4-methyl-1,2,3-thiadiazol-5-yl)-1H-pyrazol-5(4H)-one Show/Hide	C23H18FN5O2S	1
1	IC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0715175 Compound Info	4-((4-(3-chloro-2,6-difluorobenzyloxy)-1-methyl-1H-indol-3-yl)methylene)-3-(4-methyl-1,2,3-thiadiazol-5-yl)-1H-pyrazol-5(4H)-one Show/Hide	C23H16ClF2N5O2S	1
1	IC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0734366 Compound Info	4-((4-(4-fluorobenzyloxy)-1-methyl-1H-indol-3-yl)methylene)-3-(4-methyl-1,2,3-thiadiazol-5-yl)-1H-pyrazol-5(4H)-one Show/Hide	C23H18FN5O2S	1
1	IC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0037704 Compound Info	[4-[1-[[5-chloro-2-(trifluoromethyl)phenyl]methyl]-3,4-dihydro-2H-pyrido[2,3-b]pyrazin-7-yl]phenyl]-(4-methoxypiperidin-1-yl)methanone Show/Hide	C28H28ClF3N4O2	1
1	IC50 = 450 nM Bioactivity Info	TI LI LO TS
CP0204513 Compound Info	(4Z)-4-[[1-methyl-4-(1-phenylethoxy)indol-3-yl]methylidene]-3-(1,3-thiazol-2-yl)-1H-pyrazol-5-one Show/Hide	C24H20N4O2S	1
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0043422 Compound Info	4-[6-amino-7-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]furo[3,2-c]pyridin-3-yl]-3,6-dihydro-2H-pyridine-1-carboxamide Show/Hide	C21H19Cl2FN4O3	1
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0734367 Compound Info	4-((4-(benzyloxy)-1-methyl-1H-indol-3-yl)methylene)-3-(4-methyl-1,2,3-thiadiazol-5-yl)-1H-pyrazol-5(4H)-one Show/Hide	C23H19N5O2S	1
1	IC50 = 650 nM Bioactivity Info	TI LI LO TS
CP0262545 Compound Info	3-[1-[(2,5-difluorophenyl)methyl]pyrazol-4-yl]-5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C21H16F2N6	2
1	IC50 = 900 nM Bioactivity Info	TI LI LO TS
2	IC50 = 1592 nM Bioactivity Info	TI LI LO TS
CP0076949 Compound Info	3-[1-[(3-chlorophenyl)methyl]pyrazol-4-yl]-5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C21H17ClN6	2
1	IC50 = 985.6 nM Bioactivity Info	TI LI LO TS
2	IC50 = 3121 nM Bioactivity Info	TI LI LO TS
CP0149386 Compound Info	3-[1-[(3,4-difluorophenyl)methyl]pyrazol-4-yl]-5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C21H16F2N6	2
1	IC50 = 985.6 nM Bioactivity Info	TI LI LO TS
2	IC50 = 3300 nM Bioactivity Info	TI LI LO TS
CP0777159 Compound Info	4-((4-(3-fluorobenzyloxy)-1-methyl-1H-indol-3-yl)methylene)-3-(4-methyl-1,2,3-thiadiazol-5-yl)-1H-pyrazol-5(4H)-one Show/Hide	C23H18FN5O2S	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0340900 Compound Info	(1S,2R)-2-[[5-chloro-2-[(1-methyl-2-oxo-4,5-dihydro-3H-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]cyclohexane-1-carboxamide Show/Hide	C22H27ClN6O2	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0672163 Compound Info	3-(4-methyl-1,2,3-thiadiazol-5-yl)-4-((1-methyl-4-(pyridin-4-ylmethoxy)-1H-indol-3-yl)methylene)-1H-pyrazol-5(4H)-one Show/Hide	C22H18N6O2S	1
1	IC50 = 1600 nM Bioactivity Info	TI LI LO TS
CP0715173 Compound Info	3-(4-methyl-1,2,3-thiadiazol-5-yl)-4-((1-methyl-4-(pyridin-3-ylmethoxy)-1H-indol-3-yl)methylene)-1H-pyrazol-5(4H)-one Show/Hide	C22H18N6O2S	1
1	IC50 = 2500 nM Bioactivity Info	TI LI LO TS
CP0101960 Compound Info	3-[1-[(4-fluorophenyl)methyl]pyrazol-4-yl]-5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine Show/Hide	C21H17FN6	2
1	IC50 = 3011 nM Bioactivity Info	TI LI LO TS
2	IC50 = 3914 nM Bioactivity Info	TI LI LO TS

Protein ID: PT00821, Interleukin-1 receptor-associated kinase 4

Protein Info

Cell Viability or Cytotoxicity Assay

Compound ID	Compound Name	Compound Formula
CP0019908 Compound Info	BDBM50242742 Show/Hide	C30H40ClN7O3S	1
1	IC50 = 2 nM	TI LI LO TS
CP0056941 Compound Info	5-chloro-2-N-(2-cyclobutyloxy-5-methyl-4-piperidin-4-ylphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine Show/Hide	C29H36ClN5O3S	1
1	IC50 = 13.1 nM	TI LI LO TS
CP0375885 Compound Info	5-chloro-2-N-[4-(1-ethylpiperidin-4-yl)-5-methyl-2-propan-2-yloxyphenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine Show/Hide	C30H40ClN5O3S	1
1	IC50 = 11.1 nM	TI LI LO TS
CP0442082 Compound Info	5-chloro-2-N-[5-methyl-4-[1-(1-methylpiperidin-4-yl)piperidin-4-yl]-2-propan-2-yloxyphenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine Show/Hide	C34H47ClN6O3S	1
1	IC50 = 100.3 nM	TI LI LO TS
CP0444678 Compound Info	N-[2-[[5-chloro-2-[[2-(piperidin-1-ylmethyl)-3H-benzimidazol-5-yl]amino]pyrimidin-4-yl]amino]phenyl]methanesulfonamide Show/Hide	C24H27ClN8O2S	1
1	IC50 = 68 nM	TI LI LO TS
CP0557255 Compound Info	N-[2-[[5-chloro-2-[[2-[(4-methylpiperazin-1-yl)methyl]-3H-benzimidazol-5-yl]amino]pyrimidin-4-yl]amino]phenyl]methanesulfonamide Show/Hide	C24H28ClN9O2S	1
1	IC50 = 53 nM	TI LI LO TS
CP0639837 Compound Info	8-[2-methoxy-5-(4-methylpiperazin-1-yl)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide Show/Hide	C23H28N8O2	1
1	IC50 = 5 nM	TI LI LO TS

Protein family and CMB statistics Related to the Cell Line

Cell Lines Derived from the same Tissue Source (Peripheral blood)

Cell Line Name		Organism	Disease
SET-2	Cell Line Info	Homo sapiens (Human)	Adult acute megakaryoblastic leukemia
Mono-Mac-6	Cell Line Info	Homo sapiens (Human)	Adult acute monocytic leukemia
HL-60	Cell Line Info	Homo sapiens (Human)	Adult acute myeloid leukemia
MOLM-13	Cell Line Info	Homo sapiens (Human)	Adult acute myeloid leukemia
OCI-AML-2	Cell Line Info	Homo sapiens (Human)	Adult acute myeloid leukemia
HL-60/ADR	Cell Line Info	Homo sapiens (Human)	Adult acute myeloid leukemia
MOLM-14	Cell Line Info	Homo sapiens (Human)	Adult acute myeloid leukemia
HL60/MDR	Cell Line Info	Homo sapiens (Human)	Adult acute myeloid leukemia
HL60/MRP	Cell Line Info	Homo sapiens (Human)	Adult acute myeloid leukemia
NALM-6	Cell Line Info	Homo sapiens (Human)	Adult B acute lymphoblastic leukemia
MOLT-4	Cell Line Info	Homo sapiens (Human)	Adult T acute lymphoblastic leukemia
MOLT-4/CCR5	Cell Line Info	Homo sapiens (Human)	Adult T acute lymphoblastic leukemia
M-07e	Cell Line Info	Homo sapiens (Human)	Childhood acute megakaryoblastic leukemia
THP-1	Cell Line Info	Homo sapiens (Human)	Childhood acute monocytic leukemia
MV4-11	Cell Line Info	Homo sapiens (Human)	Childhood acute monocytic leukemia
THP1-Dual	Cell Line Info	Homo sapiens (Human)	Childhood acute monocytic leukemia
THP1-Dual KO-STING	Cell Line Info	Homo sapiens (Human)	Childhood acute monocytic leukemia
THP1-Blue ISG	Cell Line Info	Homo sapiens (Human)	Childhood acute monocytic leukemia
THP1-ASC-GFP	Cell Line Info	Homo sapiens (Human)	Childhood acute monocytic leukemia
PMNL	Cell Line Info	Homo sapiens (Human)	Childhood acute monocytic leukemia
THP1-Xblue	Cell Line Info	Homo sapiens (Human)	Childhood acute monocytic leukemia
SEM	Cell Line Info	Homo sapiens (Human)	Childhood B acute lymphoblastic leukemia
SEMK2	Cell Line Info	Homo sapiens (Human)	Childhood B acute lymphoblastic leukemia
Reh	Cell Line Info	Homo sapiens (Human)	Childhood B acute lymphoblastic leukemia
Jurkat	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
Jurkat E6.1	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
CCRF-CEM	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
CCRF/VCR1000	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
CEM/VLB100	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
CEM/VLB500	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
CEM-SS	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
HPB-ALL	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
CCRF-SB	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
CEM-T4	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
J-Lat 10.6	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
12D7-MDR1	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
MDR CCRF vcr1000	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
FGS7 Jurkat	Cell Line Info	Homo sapiens (Human)	Childhood T acute lymphoblastic leukemia
EoL-1	Cell Line Info	Homo sapiens (Human)	Chronic eosinophilic leukemia, not otherwise specified
CII	Cell Line Info	Homo sapiens (Human)	Chronic lymphocytic leukemia
Ku812	Cell Line Info	Homo sapiens (Human)	Chronic myelogenous leukemia, BCR-ABL1 positive
Ri-1	Cell Line Info	Homo sapiens (Human)	Diffuse large B-cell lymphoma activated B-cell type
Daudi	Cell Line Info	Homo sapiens (Human)	EBV-related Burkitt lymphoma
HEL	Cell Line Info	Homo sapiens (Human)	Erythroleukemia
UKE-1	Cell Line Info	Homo sapiens (Human)	Essential thrombocythemia
L-1236	Cell Line Info	Homo sapiens (Human)	Hodgkin lymphoma
Granta-519	Cell Line Info	Homo sapiens (Human)	Mantle cell lymphoma
JeKo-1	Cell Line Info	Homo sapiens (Human)	Mantle cell lymphoma
Mino	Cell Line Info	Homo sapiens (Human)	Mantle cell lymphoma
HMC-1	Cell Line Info	Homo sapiens (Human)	Mast cell leukemia
NK-92	Cell Line Info	Homo sapiens (Human)	Natural killer cell lymphoblastic leukemia/lymphoma
NK	Cell Line Info	Homo sapiens (Human)	Natural killer cell lymphoblastic leukemia/lymphoma
KHYG-1	Cell Line Info	Homo sapiens (Human)	Natural killer cell lymphoblastic leukemia/lymphoma
RPMI-8226	Cell Line Info	Homo sapiens (Human)	Plasma cell myeloma
OPM-2	Cell Line Info	Homo sapiens (Human)	Plasma cell myeloma
U266B1	Cell Line Info	Homo sapiens (Human)	Plasma cell myeloma
KMS-18	Cell Line Info	Homo sapiens (Human)	Plasma cell myeloma
MM1.S	Cell Line Info	Homo sapiens (Human)	Plasma cell myeloma
MM1.R	Cell Line Info	Homo sapiens (Human)	Plasma cell myeloma
OPM-1	Cell Line Info	Homo sapiens (Human)	Plasma cell myeloma
RPMI-8226/Dox40	Cell Line Info	Homo sapiens (Human)	Plasma cell myeloma
HuT 78	Cell Line Info	Homo sapiens (Human)	Sezary syndrome
H9	Cell Line Info	Homo sapiens (Human)	Sezary syndrome
CREM010i-SS9-1	Cell Line Info	Homo sapiens (Human)	Sickle cell disease
RBL-1	Cell Line Info	Rattus norvegicus (Rat)	Rat leukemia
RBL-2H3	Cell Line Info	Rattus norvegicus (Rat)	Rat leukemia
LCL Orang Asli K28	Cell Line Info	Homo sapiens (Human)	-
JY	Cell Line Info	Homo sapiens (Human)	-
C.M.L.	Cell Line Info	Homo sapiens (Human)	-
BON	Cell Line Info	Homo sapiens (Human)	-
PBMC iPSC #1	Cell Line Info	Homo sapiens (Human)	-
LCL 721	Cell Line Info	Homo sapiens (Human)	-

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han