Brief Information of the Compound and Protein
Compound Name
3-(4-methyl-1,2,3-thiadiazol-5-yl)-4-((1-methyl-4-(pyridin-4-ylmethoxy)-1H-indol-3-yl)methylene)-1H-pyrazol-5(4H)-one
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PubChem ID
CID: 136202975
Canonical SMILES
Cc1nnsc1C1=NNC(=O)/C1=C\c1cn(C)c2cccc(OCc3ccncc3)c12
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Compound Formula C22H18N6O2S
Compound Structure
Protein Name
ALK tyrosine kinase receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase STKR family
>
TKL protein kinase STKR Type 1 subfamily
Uniprot ID
Q9UM73
Gene Name
ALK
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000300 Karpas-299 Homo sapiens (Human)  1
1
IC50 = 1600 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 55 nM