Brief Information of the Compound and Protein
Compound Name
(4Z)-4-[[4-[(2,5-difluorophenyl)methoxy]-1-methylindol-3-yl]methylidene]-3-(1,3-thiazol-2-yl)-1H-pyrazol-5-one
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PubChem ID
CID: 57403117
Canonical SMILES
Cn1cc(\C=C2/C(=O)NN=C2c2nccs2)c2c(OCc3cc(F)ccc3F)cccc12
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Compound Formula C23H16F2N4O2S
Compound Structure
Protein Name
ALK tyrosine kinase receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase STKR family
>
TKL protein kinase STKR Type 1 subfamily
Uniprot ID
Q9UM73
Gene Name
ALK
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000300 Karpas-299 Homo sapiens (Human)  1
1
IC50 = 200 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 17 nM