Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(2R)-2-[5-[6-amino-5-[(1R)-1-[5-fluoro-2-(triazol-2-yl)phenyl]ethoxy]pyridin-3-yl]-4-methyl-1,3-thiazol-2-yl]propane-1,2-diol
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 PubChem ID
CID: 72710568
Canonical SMILES
C[C@@H](Oc1cc(cnc1N)-c1sc(nc1C)[C@](C)(O)CO)c1cc(F)ccc1-n1nccn1
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Compound Formula C22H23FN6O3S
Compound Structure
Protein Name
 Protein Info 
ALK tyrosine kinase receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase STKR family
>
TKL protein kinase STKR Type 1 subfamily
Uniprot ID
Q9UM73
Gene Name
ALK
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000300 Karpas-299
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 1.7 nM
   TI
   LI
   LO
   TS
CL000320 NCI-H3122
 Cell Line Info 
Homo sapiens (Human)  3
1
IC50 = 1.3 nM
   TI
   LI
   LO
   TS
2
IC50 = 21 nM
   TI
   LI
   LO
   TS
3
IC50 = 24 nM
   TI
   LI
   LO
   TS
CL000035 NIH 3T3
 Cell Line Info 
Mus musculus (Mouse)  8
1
IC50 = 0.2 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.6 nM
   TI
   LI
   LO
   TS
3
IC50 = 0.76 nM
   TI
   LI
   LO
   TS
4
IC50 = 0.8 nM
   TI
   LI
   LO
   TS
5
IC50 = 3.5 nM
   TI
   LI
   LO
   TS
6
IC50 = 4.5 nM
   TI
   LI
   LO
   TS
7
IC50 = 6.6 nM
   TI
   LI
   LO
   TS
8
IC50 = 9 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.2 nM