Brief Information of the Compound and Protein
Compound Name
1-(5-Chloro-2-trifluoromethyl-benzyl)-7-(2-piperazin-1-yl-pyridin-4-yl)-1,2,3,4-tetrahydro-pyrido[2,3-b]pyrazine
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PubChem ID
CID: 46871653
SID: 99311272
Canonical SMILES
FC(F)(F)c1ccc(Cl)cc1CN1CCNc2ncc(cc12)-c1ccnc(c1)N1CCNCC1
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Compound Formula C24H24ClF3N6
Compound Structure
Protein Name
ALK tyrosine kinase receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase STKR family
>
TKL protein kinase STKR Type 1 subfamily
Uniprot ID
Q9UM73
Gene Name
ALK
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000300 Karpas-299 Homo sapiens (Human)  1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 10 nM