Brief Information of the Compound and Protein
Compound Name
 Compound Info 
INCB-018424
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 PubChem ID
CID: 25126798
SID: 81071277
Canonical SMILES
N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
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Compound Formula C17H18N6
Compound Structure
Protein Name
 Protein Info 
Tyrosine-protein kinase JAK2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase JakB family
Uniprot ID
O60674
Gene Name
JAK2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000131 HEK293-F
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 3800 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.4 nM
   TI
   LI
   LO
   TS
CL000082 HEL
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 274 nM
   TI
   LI
   LO
   TS
CL000224 SET-2
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 1.84 nM
   TI
   LI
   LO
   TS
CL000012 Sf21
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  2
1
IC50 = 2.8 nM
   TI
   LI
   LO
   TS
2
IC50 = 4.1 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  2
1
IC50 = 0.6 nM
   TI
   LI
   LO
   TS
2
Kd = 28.2 nM
   TI
   LI
   LO
   TS
CL000128 TF-1
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 12 nM
   TI
   LI
   LO
   TS
2
IC50 = 6.85 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.056 nM
2 IC50 = 0.12 nM
3 IC50 = 0.2 nM
4 IC50 < 0.3 nM
5 IC50 = 0.7 nM
6 IC50 < 1 nM
7 IC50 = 2.7 nM
8 IC50 = 2.8 nM
9 IC50 = 2.9 nM
10 IC50 = 3 nM
11 IC50 = 6 nM
12 IC50 = 8.8 nM
13 IC50 = 9 nM
14 IC50 = 60 nM
15 IC50 = 677 nM
16 IC50 = 4982 nM
17 Kd = 0.036 nM
18 Ki = 0.1 nM
19 Ki = 0.24 nM