General Information of the Compound
Compound ID
CP0229792
Compound Name
5-(3-methoxyphenyl)-N-[4-(4-methylpiperazin-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine
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Structure
Formula
C24H26N6O
Molecular Weight
414.513
Canonical SMILES
COc1cccc(c1)-c1cccc2nc(Nc3ccc(cc3)N3CCN(C)CC3)nn12
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InChI
InChI=1S/C24H26N6O/c1-28-13-15-29(16-14-28)20-11-9-19(10-12-20)25-24-26-23-8-4-7-22(30(23)27-24)18-5-3-6-21(17-18)31-2/h3-12,17H,13-16H2,1-2H3,(H,25,27)
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InChIKey
WBJPWZBTANRGTP-UHFFFAOYSA-N
Physicochemical Property
logP
3.9003
Rotatable Bonds
5
Heavy Atom Count
31
Polar Areas
57.93
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 59186487
ChEMBL ID
CHEMBL2414546
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01214, Tyrosine-protein kinase JAK2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000224 SET-2 Homo sapiens (Human)  1
1
IC50 = 53.6 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 0.9 nM