General Information of the Compound
Compound ID
CP0268143
Compound Name
5-(2-aminopyrimidin-4-yl)-2-[2,5-bis(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
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Structure
Formula
C17H11F6N5O
Molecular Weight
415.297
Canonical SMILES
NC(=O)c1cc([nH]c1-c1cc(ccc1C(F)(F)F)C(F)(F)F)-c1ccnc(N)n1
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InChI
InChI=1S/C17H11F6N5O/c18-16(19,20)7-1-2-10(17(21,22)23)8(5-7)13-9(14(24)29)6-12(27-13)11-3-4-26-15(25)28-11/h1-6,27H,(H2,24,29)(H2,25,26,28)
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InChIKey
MOMYBDKTKLWNMV-UHFFFAOYSA-N
Physicochemical Property
logP
3.8574
Rotatable Bonds
3
Heavy Atom Count
29
Polar Areas
110.68
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
4
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 66571078
SID: 152228842
ChEMBL ID
CHEMBL3330127
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01214, Tyrosine-protein kinase JAK2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000224 SET-2 Homo sapiens (Human)  1
1
IC50 = 3070 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 21 nM