General Information of the Compound
Compound ID
CP0199126
Compound Name
N-(3-methylphenyl)-5-(3-propan-2-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine
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Structure
Formula
C22H22N4
Molecular Weight
342.446
Canonical SMILES
CC(C)c1cccc(c1)-c1cccc2nc(Nc3cccc(C)c3)nn12
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InChI
InChI=1S/C22H22N4/c1-15(2)17-8-5-9-18(14-17)20-11-6-12-21-24-22(25-26(20)21)23-19-10-4-7-16(3)13-19/h4-15H,1-3H3,(H,23,25)
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InChIKey
GQCZJJYSVZVQLZ-UHFFFAOYSA-N
Physicochemical Property
logP
5.57172
Rotatable Bonds
4
Heavy Atom Count
26
Polar Areas
42.22
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 59186442
ChEMBL ID
CHEMBL2414552
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01214, Tyrosine-protein kinase JAK2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000224 SET-2 Homo sapiens (Human)  1
1
IC50 = 2000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 9.1 nM