General Information of the Protein
Protein ID
PT02367
Protein Name
Tumor necrosis factor receptor superfamily member 1A
Secondarily
Protein Name
Tumor necrosis factor receptor 1
Tumor necrosis factor receptor type I
p55
p60
Gene Name
TNFRSF1A
Secondarily
Gene Name
TNFAR
TNFR1
Sequence
MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLELLGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR
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Organism
Homo sapiens, Human
Protein Classification
Membrane receptor
Function
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
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Uniprot ID
Primary ID:
P19438

Secondarily ID:
A8K4X3
B2RDE4
B3KPQ1
B4DQB7
B4E309
B5M0B5
D3DUR1
Q9UCA4
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Ensembl ID
ENSG00000067182
HGNC ID
HGNC:11916
Subcellular Location
Cell membrane
Golgi apparatus membrane
Secreted
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000870 , HEK-Blue Null1-v
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0001611
 Compound Info 
2-(2,4-dichlorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide
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C16H10Cl2N4O2S
  1
1
IC50 = 770 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000864 , THP1-Xblue
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( Tumor necrosis factor receptor type I (TNF-R1) )
Target Type Clinical trial Target