Brief Information of the Compound and Protein
Compound Name
(1R,2S,3R,5R)-3-[[2-[(2-cyclopropyloxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol
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PubChem ID
CID: 117885766
Canonical SMILES
OC[C@H]1C[C@@H](Nc2nc(Nc3ccnc(OC4CC4)c3)ncc2-c2ccc3ccccc3n2)[C@H](O)[C@@H]1O
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Compound Formula C27H28N6O4
Compound Structure
Protein Name
Interleukin-1 receptor-associated kinase 4
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase IRAK family
Uniprot ID
Q9NWZ3
Gene Name
IRAK4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000864 THP1-Xblue Homo sapiens (Human)  1
1
IC50 = 341 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 44 nM