| Compound ID |
Compound Name |
Compound Formula |
|
CP0067186
|
(1S,2R,3R,5R)-3-(hydroxymethyl)-5-[[2-[(2-methoxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]cyclopentane-1,2-diol
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|
C25H26N6O4
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0067182
|
(1R,2S,3R,5R)-3-[[2-[(2,6-dimethylpyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol
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|
C26H28N6O3
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0716626
|
5-(Benzo[d]thiazol-2-yl)-6-(((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)amino)-2-(pyrrolidin-1-yl)pyrimidin-4(3H)-one
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|
C21H25N5O4S
|
1
|
| 1 |
IC50 = 78 nM
|
|
|
|
CP0318230
|
US9169260, 198
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|
C21H23N9O
|
1
|
| 1 |
IC50 = 83 nM
|
|
|
|
CP0095742
|
(1R,2S,3R,5R)-3-[[2-[(2,6-dimethylpyridin-4-yl)amino]-5-(4-phenyl-1,3-thiazol-2-yl)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol
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|
C26H28N6O3S
|
1
|
| 1 |
IC50 = 87 nM
|
|
|
|
CP0272491
|
(1S,2R,3R,5R)-3-(hydroxymethyl)-5-[[2-[(2-methylpyridin-4-yl)amino]-5-(4-phenyl-1,3-thiazol-2-yl)pyrimidin-4-yl]amino]cyclopentane-1,2-diol
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|
C25H26N6O3S
|
1
|
| 1 |
IC50 = 94 nM
|
|
|
|
CP0213894
|
N-(3-carbamoyl-1-methylpyrazol-4-yl)-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide
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|
C15H15N7O2
|
1
|
| 1 |
IC50 = 138 nM
|
|
|
|
CP0659036
|
5-(Benzo[d]thiazol-2-yl)-2-(3,4-dihydroisoquinolin-2(1H)-yl)-6-(((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)amino)pyrimidin-4(3H)-one
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|
C26H27N5O4S
|
1
|
| 1 |
IC50 = 141 nM
|
|
|
|
CP0360603
|
N-(3-carbamoyl-1-methyl- 1H-pyrazol-4-yl)-5- piperazin-1- ylpyrazolo[1,5- a]pyrimidine-3- carboxamide hydrochloride
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|
C16H19N9O2
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0207365
|
US9586948, Example 1
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|
C20H21N7O2
|
1
|
| 1 |
IC50 = 169 nM
|
|
|
|
CP0673999
|
(R)-5-(Benzo[d]thiazol-2-yl)-2-morpholino-6-(piperidin-3-ylamino)pyrimidin-4(3H)-one
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|
C20H24N6O2S
|
1
|
| 1 |
IC50 = 187 nM
|
|
|
|
CP0536477
|
US9586948, Example 29
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|
C16H13ClN6O2
|
1
|
| 1 |
IC50 = 202 nM
|
|
|
|
CP0184908
|
(1S,2R,3R,5R)-3-(hydroxymethyl)-5-[[2-[(2-propan-2-yloxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]cyclopentane-1,2-diol
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|
C27H30N6O4
|
1
|
| 1 |
IC50 = 216 nM
|
|
|
|
CP0460651
|
US9586948, Example 6
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|
C16H15N7O2
|
1
|
| 1 |
IC50 = 259 nM
|
|
|
|
CP0772723
|
2-(Azetidin-1-yl)-5-(benzo[d]thiazol-2-yl)-6-(((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)amino)pyrimidin-4(3H)-one
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|
C20H23N5O4S
|
1
|
| 1 |
IC50 = 292 nM
|
|
|
|
CP0482724
|
US9586948, Example 18
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|
C18H16F3N7O2
|
1
|
| 1 |
IC50 = 294 nM
|
|
|
|
CP0460650
|
US9586948, Example 28
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|
C19H18N6O2
|
1
|
| 1 |
IC50 = 307 nM
|
|
|
|
CP0724473
|
5-(benzo[d]thiazol-2-yl)-6-(((3R,5R)-5-hydroxypiperidin-3-yl)amino)-2-morpholinopyrimidin-4(3H)-one
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|
C20H24N6O3S
|
1
|
| 1 |
IC50 = 333 nM
|
|
|
|
CP0067192
|
(1R,2S,3R,5R)-3-[[2-[(2-cyclopropyloxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol
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|
C27H28N6O4
|
1
|
| 1 |
IC50 = 341 nM
|
|
|
|
CP0707915
|
5-(Benzo[d]thiazol-2-yl)-6-(((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)amino)-2-morpholinopyrimidin-4(3H)-one
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|
C21H25N5O5S
|
1
|
| 1 |
IC50 = 375 nM
|
|
|
|
CP0528182
|
US9586948, Example 3
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|
C21H22N6O2
|
1
|
| 1 |
IC50 = 428 nM
|
|
|
|
CP0460637
|
US9586948, Example 42
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|
C24H28N8O2
|
1
|
| 1 |
IC50 = 477 nM
|
|
|
|
CP0228766
|
US9586948, Example 46
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|
C26H32N8O3
|
1
|
| 1 |
IC50 = 533 nM
|
|
|
|
CP0678448
|
5-(benzo[d]thiazol-2-yl)-6-(((3R,6R)-6-methylpiperidin-3-yl)amino)-2-morpholinopyrimidin-4(3H)-one
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|
C21H26N6O2S
|
1
|
| 1 |
IC50 = 580 nM
|
|
|
|
CP0093353
|
US9169260, 18
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|
C23H25N7O3S
|
1
|
| 1 |
IC50 = 2400 nM
|
|
|
|
CP0184906
|
(1R,2S,3R,5R)-3-[[5-(1,3-benzothiazol-2-yl)-2-[(2,6-dimethylpyridin-4-yl)amino]pyridin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol
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|
C25H27N5O3S
|
1
|
| 1 |
IC50 = 3452 nM
|
|
|
