Brief Information of the Compound and Protein
Compound Name
4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-6-(1-methyltriazol-4-yl)pyrido[4,3-d]pyrimidin-5-one
    Show/Hide
PubChem ID
CID: 168281588
Canonical SMILES
CN1CCC(CC1)n1cc(Nc2nc(NC3(C)CC3)c3c(ccn(-c4cn(C)nn4)c3=O)n2)cn1
    Show/Hide
Compound Formula C23H29N11O
Compound Structure
Protein Name
Interleukin-1 receptor-associated kinase 4
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase IRAK family
Uniprot ID
Q9NWZ3
Gene Name
IRAK4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000300 Karpas-299 Homo sapiens (Human)  1
1
IC50 = 180 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 6 nM