| Compound ID |
Compound Name |
Compound Formula |
|
CP0566245
|
(1s,3s)-3-(Cyanomethyl)-3-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutane-1-carbonitrile
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|
C20H17N9
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0564988
|
2,2′-(3-(4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)azetidine-1,3-diyl)diacetonitrile
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|
C20H18N10
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0488932
|
2,2′-((1s,3s)-1-(4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutane-1,3-diyl)diacetonitrile (cis isomer)
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|
C21H19N9
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0962463
|
(cis)-3-(4-(6-(1H-Pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)-3-(cyanomethyl)cyclobutane-1-carbonitrile
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|
C19H15N9
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0958819
|
(cis)-3-(4-(6-(1H-Pyrazol-5-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)-3-(cyanomethyl)cyclobutane-1-carbonitrile
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|
C19H15N9
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0424951
|
2-[3-[4-[6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]pyrazol-1-yl]-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile
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|
C20H18F3N9
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0540114
|
3-(cyanomethyl)-3-[4-[6-(1-methylpyrazol-3-yl)pyrazolo[1,5-a]pyrazin-4-yl]pyrazol-1-yl]cyclobutane-1-carbonitrile
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|
C20H17N9
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0008407
|
(1r,3r)-3-(Cyanomethyl)-3-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutane-1-carbonitrile
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|
C20H17N9
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0570337
|
2-((1s,3r)-3-Methoxy-1-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutyl)acetonitrile (cis isomer)
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|
C20H20N8O
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0012129
|
INCB-018424
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|
C17H18N6
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0565115
|
2-((1r,3s)-3-Methoxy-1-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutyl)acetonitrile (trans isomer)
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|
C20H20N8O
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0532287
|
2,2′-((1r,3r)-1-(4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutane-1,3-diyl)diacetonitrile (trans isomer)
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|
C21H19N9
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0962462
|
(trans)-3-(4-(6-(1H-Pyrazol-5-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)-3-(cyanomethyl)cyclobutane-1-carbonitrile
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|
C19H15N9
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0532286
|
2-[1-(cyclopropylmethyl)-3-[4-[6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]pyrazol-1-yl]azetidin-3-yl]acetonitrile
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|
C22H23N9
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0956013
|
(trans)-3-(4-(6-(1H-Pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)-3-(cyanomethyl)cyclobutane-1-carbonitrile
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|
C19H15N9
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0564747
|
2-[1-ethyl-3-[4-[6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]pyrazol-1-yl]azetidin-3-yl]acetonitrile
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|
C20H21N9
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0565112
|
3-(cyanomethyl)-3-[4-[6-(1-methylpyrazol-3-yl)pyrazolo[1,5-a]pyrazin-4-yl]pyrazol-1-yl]cyclobutane-1-carbonitrile
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|
C20H17N9
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0424954
|
2-[1-(2-hydroxyethyl)-3-[4-[6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]pyrazol-1-yl]azetidin-3-yl]acetonitrile
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|
C20H21N9O
|
1
|
| 1 |
IC50 = 189 nM
|
|
|
|
CP0540115
|
2-[3-[4-[7-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyridin-5-yl]pyrazol-1-yl]-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile
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|
C21H19F3N8
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0424950
|
2-[3-[4-[7-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-5-yl]pyrazol-1-yl]-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile
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|
C20H18F3N9
|
1
|
| 1 |
IC50 = 476 nM
|
|
|
|
CP0570336
|
2-[1-acetyl-3-[4-[6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]pyrazol-1-yl]azetidin-3-yl]acetonitrile
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|
C20H19N9O
|
1
|
| 1 |
IC50 = 678 nM
|
|
|
|
CP0113672
|
1-[(3aR,7aR)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin-6-yl]prop-2-en-1-one
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|
C16H19N5O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0181229
|
N-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]prop-2-enamide
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|
C15H12N4O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0479784
|
1-[(3aR,7aR)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin-6-yl]ethanone
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|
C15H19N5O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0670126
|
1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
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|
C15H19N5O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0729829
|
1-((3R,4R)-4-Methyl-3-(methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)prop-2-en-1-one
Show/Hide
|
C16H21N5O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0729830
|
(R,E)-1-(3-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-amino)piperidin-1-yl)but-2-en-1-one
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|
C15H19N5O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0756898
|
(R)-1-(3-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-amino)piperidin-1-yl)prop-2-en-1-one
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|
C14H17N5O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0760534
|
(R)-1-(3-(Methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-piperidin-1-yl)prop-2-en-1-one
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|
C15H19N5O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0566244
|
2-[3-[4-[7-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-5-yl]pyrazol-1-yl]-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile
Show/Hide
|
C20H18F3N9
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
