Brief Information of the Compound and Protein
| Compound Name |
INCB-018424
Show/Hide
|
PubChem ID | |||||
|
Compound Structure |
|
|||||
| Protein Name |
Non-receptor tyrosine-protein kinase TYK2
|
Protein Classification |
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase JakB family
|
||||
| Uniprot ID | Gene Name | TYK2 |
|||||
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
| Cell Line ID | Cell Line Name | Cell Line Organism | |
| CL000012 | Sf21 | Spodoptera frugiperda (Fall armyworm) | 1 |
| 1 |
IC50 = 19 nM
|
TI
LI
LO
TS
|
|
|---|---|---|---|
Biochemical Assays
| 1 | IC50 = 0.4 nM | ||
|---|---|---|---|
| 2 | IC50 = 0.72 nM | ||
| 3 | IC50 = 10.3 nM | ||
| 4 | IC50 = 11 nM | ||
| 5 | IC50 = 19 nM | ||
| 6 | IC50 = 30 nM | ||
| 7 | IC50 = 30.1 nM | ||
| 8 | Kd = 0.9 nM | ||
| 9 | Kd = 1400 nM | ||
| 10 | Ki = 0.5 nM | ||
| 11 | Ki = 0.55 nM | ||