Protein Information

General Information of the Protein

Protein ID	PT02455
Protein Name	Glucose-dependent insulinotropic receptor
Secondarily Protein Name	G-protein coupled receptor 119
Gene Name	GPR119
Sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Lipid-like ligand receptor (family A GPCR)
Function	Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway. Show/Hide
Uniprot ID	Primary ID: Q8TDV5 Secondarily ID: Q495H7 Q4VBN3 Show/Hide
HGNC ID	HGNC:19060
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0462142 Compound Info	tert-butyl (1S,5R)-3-[[4-(2-fluoro-4-methylsulfonylanilino)pyrimido[5,4-d]pyrimidin-8-yl]amino]-8-azabicyclo[3.2.1]octane-8-carboxylate Show/Hide	C25H30FN7O4S	1
1	EC50 = 2.2 nM Bioactivity Info	TI LI LO TS
CP0116940 Compound Info	tert-butyl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)thieno[3,2-d]pyrimidin-4-yl]-methylamino]piperidine-1-carboxylate Show/Hide	C24H29FN4O4S2	1
1	EC50 = 3 nM Bioactivity Info	TI LI LO TS
CP0272880 Compound Info	GSK-1292263A Show/Hide	C23H28N4O4S	1
1	EC50 = 3.4 nM Bioactivity Info	TI LI LO TS
CP0078155 Compound Info	(2-Fluoro-4-methanesulfonyl-phenyl)-{6-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-5-nitropyrimidin-4-yl}-amine Show/Hide	C21H24FN7O5S	1
1	EC50 = 6 nM Bioactivity Info	TI LI LO TS
CP0548546 Compound Info	tert-butyl (1S,5R)-3-[[4-(4-cyano-2-fluoroanilino)pyrimido[5,4-d]pyrimidin-8-yl]amino]-8-azabicyclo[3.2.1]octane-8-carboxylate Show/Hide	C25H27FN8O2	1
1	EC50 = 8.1 nM Bioactivity Info	TI LI LO TS
CP0397597 Compound Info	S-propan-2-yl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carbothioate Show/Hide	C22H27FN4O4S2	1
1	EC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0397673 Compound Info	phenyl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carbodithioate Show/Hide	C25H25FN4O3S3	1
1	EC50 = 12.59 nM Bioactivity Info	TI LI LO TS
CP0523536 Compound Info	1,1,1,3,3,3-hexafluoropropan-2-yl 6-[4-(pyridin-2-ylmethylsulfonylmethyl)phenyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxylate Show/Hide	C30H28F6N2O5S	1
1	EC50 = 17 nM Bioactivity Info	TI LI LO TS
CP0062434 Compound Info	(3E)-3-[[4-[[2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-1,3-thiazol-4-yl]methoxy]-3-methylphenyl]methylidene]pyrrolidine-2,5-dione Show/Hide	C27H29N5O3S	1
1	EC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0541311 Compound Info	tert-butyl 4-[4-[[4-[(E)-(2,5-dioxopyrrolidin-3-ylidene)methyl]-2-methylphenoxy]methyl]-1,3-thiazol-2-yl]piperidine-1-carboxylate Show/Hide	C26H31N3O5S	1
1	EC50 = 19 nM Bioactivity Info	TI LI LO TS
CP0507615 Compound Info	tert-butyl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C23H29FN4O5S	1
1	EC50 = 19.95 nM Bioactivity Info	TI LI LO TS
CP0397608 Compound Info	3-fluoro-4-[[5-fluoro-6-[4-[3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]pyrimidin-4-yl]amino]-N,N-dimethylbenzamide Show/Hide	C23H26F3N7O2	1
1	EC50 = 23.4 nM Bioactivity Info	TI LI LO TS
CP0389508 Compound Info	2-methylpropyl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C23H29FN4O5S	1
1	EC50 = 25.12 nM Bioactivity Info	TI LI LO TS
CP0513071 Compound Info	(1-methylcyclopropyl) 4-[[7-(2-fluoro-4-methylsulfonylphenyl)thieno[3,2-d]pyrimidin-4-yl]-methylamino]piperidine-1-carboxylate Show/Hide	C24H27FN4O4S2	1
1	EC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0460668 Compound Info	3-fluoro-4-[[5-fluoro-6-[4-[3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]pyrimidin-4-yl]amino]-N-methylbenzamide Show/Hide	C22H24F3N7O2	1
1	EC50 = 27 nM Bioactivity Info	TI LI LO TS
CP0508640 Compound Info	3-fluoro-4-[[5-fluoro-6-[4-[3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]pyrimidin-4-yl]amino]benzamide Show/Hide	C21H22F3N7O2	1
1	EC50 = 28.2 nM Bioactivity Info	TI LI LO TS
CP0389493 Compound Info	S-ethyl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carbothioate Show/Hide	C21H25FN4O4S2	1
1	EC50 = 31.62 nM Bioactivity Info	TI LI LO TS
CP0517584 Compound Info	tert-butyl (1R,5S)-3-[8-(4-cyano-2-fluoroanilino)pyrimido[5,4-d]pyrimidin-4-yl]oxy-8-azabicyclo[3.2.1]octane-8-carboxylate Show/Hide	C25H26FN7O3	1
1	EC50 = 36 nM Bioactivity Info	TI LI LO TS
CP0419572 Compound Info	tert-butyl 4-[methyl-[7-(4-methylsulfonylphenyl)thieno[3,2-d]pyrimidin-4-yl]amino]piperidine-1-carboxylate Show/Hide	C24H30N4O4S2	1
1	EC50 = 39 nM Bioactivity Info	TI LI LO TS
CP0500584 Compound Info	2,2-dimethylpropyl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C24H31FN4O5S	1
1	EC50 = 39.81 nM Bioactivity Info	TI LI LO TS
CP0417502 Compound Info	7-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-(5-methylsulfonyl-2,3-dihydroindol-1-yl)furo[3,2-d]pyrimidine Show/Hide	C26H28N6O3S	1
1	EC50 = 41 nM Bioactivity Info	TI LI LO TS
CP0495698 Compound Info	7-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]-4-(5-methylsulfonyl-2,3-dihydroindol-1-yl)furo[3,2-d]pyrimidine Show/Hide	C24H23ClN6O3S	1
1	EC50 = 42 nM Bioactivity Info	TI LI LO TS
CP0562987 Compound Info	tert-butyl 4-[6-[3-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]-5-methylpyrimidin-4-yl]oxypiperidine-1-carboxylate Show/Hide	C25H28N4O6S	1
1	EC50 = 43 nM Bioactivity Info	TI LI LO TS
CP0471846 Compound Info	tert-butyl (1R,5S)-3-[[4-(4-methylsulfonylanilino)pyrimido[5,4-d]pyrimidin-8-yl]amino]-8-azabicyclo[3.2.1]octane-8-carboxylate Show/Hide	C25H31N7O4S	1
1	EC50 = 44 nM Bioactivity Info	TI LI LO TS
CP0377360 Compound Info	tert-butyl 4-[3-[(3-oxo-1,2-dihydroinden-5-yl)amino]propyl]piperidine-1-carboxylate Show/Hide	C22H32N2O3	1
1	EC50 = 46 nM Bioactivity Info	TI LI LO TS
CP0412076 Compound Info	tert-butyl 6-[4-(pyridin-2-ylmethylsulfonylmethyl)phenyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxylate Show/Hide	C31H36N2O5S	1
1	EC50 = 46 nM Bioactivity Info	TI LI LO TS
CP0097714 Compound Info	(3E)-3-[[4-[[2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-1,3-thiazol-4-yl]methoxy]-3-fluorophenyl]methylidene]pyrrolidine-2,5-dione Show/Hide	C26H26FN5O3S	1
1	EC50 = 49 nM Bioactivity Info	TI LI LO TS
CP0559074 Compound Info	tert-butyl (1S,4S,5S)-5-[[4-(4-cyano-2-fluoroanilino)pyrimido[5,4-d]pyrimidin-8-yl]amino]-2-azabicyclo[2.2.2]octane-2-carboxylate Show/Hide	C25H27FN8O2	1
1	EC50 = 49 nM Bioactivity Info	TI LI LO TS
CP0368437 Compound Info	propan-2-yl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C22H27FN4O5S	1
1	EC50 = 50.12 nM Bioactivity Info	TI LI LO TS
CP0500585 Compound Info	butyl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C23H29FN4O5S	1
1	EC50 = 50.12 nM Bioactivity Info	TI LI LO TS
CP0538951 Compound Info	1-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-4-ol Show/Hide	C10H17N3O2	1
1	EC50 = 50.12 nM Bioactivity Info	TI LI LO TS
CP0852737 Compound Info	(S)-1,1-Dimethylethyl 4-({1-[4-(Methylsulfinyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarboxylate Show/Hide	C22H27FN4O4S	1
1	EC50 = 50.12 nM Bioactivity Info	TI LI LO TS
CP0445388 Compound Info	6-[3-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]propylamino]-2,3-dihydroinden-1-one Show/Hide	C23H30N4O	1
1	EC50 = 51 nM Bioactivity Info	TI LI LO TS
CP0847394 Compound Info	tert-butyl 4-(3-(3-oxo-2,3-dihydrobenzofuran-6-ylamino)propyl)piperidine-1-carboxylate Show/Hide	C21H30N2O4	1
1	EC50 = 52 nM Bioactivity Info	TI LI LO TS
CP0513902 Compound Info	tert-butyl 4-[4-(5-methylsulfonyl-2,3-dihydroindol-1-yl)furo[3,2-d]pyrimidin-7-yl]piperidine-1-carboxylate Show/Hide	C25H30N4O5S	1
1	EC50 = 53 nM Bioactivity Info	TI LI LO TS
CP0482538 Compound Info	tert-butyl 4-[[7-[3-fluoro-4-[methoxy(methyl)carbamoyl]phenyl]thieno[3,2-d]pyrimidin-4-yl]-methylamino]piperidine-1-carboxylate Show/Hide	C26H32FN5O4S	1
1	EC50 = 53 nM Bioactivity Info	TI LI LO TS
CP0359455 Compound Info	[(2R)-1,1,1-trifluoropropan-2-yl] 6-[4-(pyridin-2-ylmethylsulfonylmethyl)phenyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxylate Show/Hide	C30H31F3N2O5S	1
1	EC50 = 54 nM Bioactivity Info	TI LI LO TS
CP0478754 Compound Info	tert-butyl 6-[4-(benzylsulfonylmethyl)phenyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxylate Show/Hide	C32H37NO5S	1
1	EC50 = 56 nM Bioactivity Info	TI LI LO TS
CP0512840 Compound Info	tert-butyl 4-[7-[3-fluoro-4-[methoxy(methyl)carbamoyl]phenyl]thieno[3,2-d]pyrimidin-4-yl]oxypiperidine-1-carboxylate Show/Hide	C25H29FN4O5S	1
1	EC50 = 57 nM Bioactivity Info	TI LI LO TS
CP0423368 Compound Info	6-[3-[1-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-4-yl]propylamino]-2,3-dihydroinden-1-one Show/Hide	C22H30N4O2	1
1	EC50 = 58 nM Bioactivity Info	TI LI LO TS
CP0462603 Compound Info	propan-2-yl 4-[[7-(4-cyano-2-fluorophenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C22H24FN5O3	1
1	EC50 = 63.1 nM Bioactivity Info	TI LI LO TS
CP0544815 Compound Info	tert-butyl 4-[7-[4-[methoxy(methyl)carbamoyl]phenyl]thieno[3,2-d]pyrimidin-4-yl]oxypiperidine-1-carboxylate Show/Hide	C25H30N4O5S	1
1	EC50 = 64 nM Bioactivity Info	TI LI LO TS
CP0534193 Compound Info	propan-2-yl 4-[[7-[3-fluoro-4-[methoxy(methyl)carbamoyl]phenyl]thieno[3,2-d]pyrimidin-4-yl]-methylamino]piperidine-1-carboxylate Show/Hide	C25H30FN5O4S	1
1	EC50 = 67 nM Bioactivity Info	TI LI LO TS
CP0389389 Compound Info	tert-butyl 6-[4-(pyridin-3-ylmethylsulfonylmethyl)phenyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxylate Show/Hide	C31H36N2O5S	1
1	EC50 = 68 nM Bioactivity Info	TI LI LO TS
CP0912750 Compound Info	6-(3-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)propylamino)benzofuran-3(2H)-one Show/Hide	C21H28N4O3	1
1	EC50 = 73 nM Bioactivity Info	TI LI LO TS
CP0482540 Compound Info	tert-butyl 4-[[6-[3-fluoro-4-[methoxy(methyl)carbamoyl]phenyl]pyridin-3-yl]oxymethyl]piperidine-1-carboxylate Show/Hide	C25H32FN3O5	1
1	EC50 = 73 nM Bioactivity Info	TI LI LO TS
CP0552249 Compound Info	2-methylpropyl 4-[6-[4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]-5-methylpyrimidin-4-yl]oxypiperidine-1-carboxylate Show/Hide	C25H28N4O6S	1
1	EC50 = 75.1 nM Bioactivity Info	TI LI LO TS
CP0468704 Compound Info	4-[5-[[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]methoxy]pyridin-2-yl]-2-fluoro-N-methoxy-N-methylbenzamide Show/Hide	C26H30FN5O3	1
1	EC50 = 77 nM Bioactivity Info	TI LI LO TS
CP0417501 Compound Info	1-[2-[4-[4-(5-methylsulfonyl-2,3-dihydroindol-1-yl)furo[3,2-d]pyrimidin-7-yl]piperidin-1-yl]pyrimidin-5-yl]ethanone Show/Hide	C26H26N6O4S	1
1	EC50 = 78 nM Bioactivity Info	TI LI LO TS
CP0478402 Compound Info	tert-butyl 4-[4-(2-fluoro-4-methylsulfonylanilino)thieno[3,2-d]pyrimidin-7-yl]piperidine-1-carboxylate Show/Hide	C23H27FN4O4S2	1
1	EC50 = 79 nM Bioactivity Info	TI LI LO TS
CP0381374 Compound Info	propan-2-yl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]sulfanyl]piperidine-1-carboxylate Show/Hide	C22H27FN4O4S2	1
1	EC50 = 79.43 nM Bioactivity Info	TI LI LO TS
CP0389509 Compound Info	propan-2-yl 4-[[7-[2-fluoro-4-(1,3-thiazol-2-yl)phenyl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C24H26FN5O3S	1
1	EC50 = 79.43 nM Bioactivity Info	TI LI LO TS
CP0499453 Compound Info	propyl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C22H27FN4O5S	1
1	EC50 = 79.43 nM Bioactivity Info	TI LI LO TS
CP0500583 Compound Info	5-[4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidin-1-yl]-3-propan-2-yl-1,2,4-oxadiazole Show/Hide	C23H27FN6O4S	1
1	EC50 = 79.43 nM Bioactivity Info	TI LI LO TS
CP0410630 Compound Info	propan-2-yl 4-[methyl-[7-(4-methylsulfonylphenyl)thieno[3,2-d]pyrimidin-4-yl]amino]piperidine-1-carboxylate Show/Hide	C23H28N4O4S2	1
1	EC50 = 82 nM Bioactivity Info	TI LI LO TS
CP0557640 Compound Info	(3E)-3-[[4-[[2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-1,3-thiazol-4-yl]methoxy]-3-fluorophenyl]methylidene]-1-phenylpyrrolidine-2,5-dione Show/Hide	C32H30FN5O3S	1
1	EC50 = 82 nM Bioactivity Info	TI LI LO TS
CP0489053 Compound Info	tert-butyl 4-[methyl-[7-[4-(phenylmethoxycarbamoyl)phenyl]thieno[3,2-d]pyrimidin-4-yl]amino]piperidine-1-carboxylate Show/Hide	C31H35N5O4S	1
1	EC50 = 83 nM Bioactivity Info	TI LI LO TS
CP0428973 Compound Info	tert-butyl 4-[3-[(1-oxo-2,3-dihydroinden-5-yl)amino]propyl]piperidine-1-carboxylate Show/Hide	C22H32N2O3	1
1	EC50 = 86 nM Bioactivity Info	TI LI LO TS
CP0062435 Compound Info	2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole Show/Hide	C22H24N8OS	1
1	EC50 = 87 nM Bioactivity Info	TI LI LO TS
CP0847395 Compound Info	tert-butyl 4-(3-(3-oxo-2,3-dihydrobenzofuran-5-ylamino)propyl)piperidine-1-carboxylate Show/Hide	C21H30N2O4	1
1	EC50 = 88 nM Bioactivity Info	TI LI LO TS
CP0560133 Compound Info	tert-butyl 4-[6-[4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]-5-methylpyrimidin-4-yl]oxypiperidine-1-carboxylate Show/Hide	C25H28N4O6S	1
1	EC50 = 88 nM Bioactivity Info	TI LI LO TS
CP0532358 Compound Info	propan-2-yl 4-[[6-[4-(cyclohexylmethylsulfonyl)piperazin-1-yl]pyridin-3-yl]oxymethyl]piperidine-1-carboxylate Show/Hide	C26H42N4O5S	1
1	EC50 = 90 nM Bioactivity Info	TI LI LO TS
CP0544816 Compound Info	propan-2-yl 4-[[6-[3-fluoro-4-[methoxy(methyl)carbamoyl]phenyl]pyridin-3-yl]oxymethyl]piperidine-1-carboxylate Show/Hide	C24H30FN3O5	1
1	EC50 = 92 nM Bioactivity Info	TI LI LO TS
CP0489058 Compound Info	tert-butyl 4-[[7-[4-[methoxy(methyl)carbamoyl]phenyl]thieno[3,2-d]pyrimidin-4-yl]-methylamino]piperidine-1-carboxylate Show/Hide	C26H33N5O4S	1
1	EC50 = 98 nM Bioactivity Info	TI LI LO TS
CP0536877 Compound Info	tert-butyl 6-[4-(pyridin-4-ylmethylsulfonylmethyl)phenyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxylate Show/Hide	C31H36N2O5S	1
1	EC50 = 98 nM Bioactivity Info	TI LI LO TS
CP0430837 Compound Info	propan-2-yl 4-[[6-(4-butylsulfonylpiperazin-1-yl)pyridin-3-yl]oxymethyl]piperidine-1-carboxylate Show/Hide	C23H38N4O5S	1
1	EC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0389502 Compound Info	propan-2-yl 4-[[7-(2-methyl-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C23H30N4O5S	1
1	EC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0500582 Compound Info	propan-2-yl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-2-methyl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C23H29FN4O5S	1
1	EC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0537782 Compound Info	tert-butyl 4-[7-(4-methylsulfonylphenyl)thieno[3,2-d]pyrimidin-4-yl]oxypiperidine-1-carboxylate Show/Hide	C23H27N3O5S2	1
1	EC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0429715 Compound Info	(3E)-3-[[4-[[2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-1,3-thiazol-4-yl]methoxy]-3-fluorophenyl]methylidene]pyrrolidin-2-one Show/Hide	C26H28FN5O2S	1
1	EC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0412074 Compound Info	(1,1,1-trifluoro-2-methylpropan-2-yl) 6-[4-(pyridin-2-ylmethylsulfonylmethyl)phenyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxylate Show/Hide	C31H33F3N2O5S	1
1	EC50 = 101 nM Bioactivity Info	TI LI LO TS
CP0541309 Compound Info	tert-butyl 4-[4-[[4-(tetrazol-1-yl)phenoxy]methyl]-1,3-thiazol-2-yl]piperidine-1-carboxylate Show/Hide	C21H26N6O3S	1
1	EC50 = 103 nM Bioactivity Info	TI LI LO TS
CP0470487 Compound Info	4-[4-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]oxythieno[3,2-d]pyrimidin-7-yl]-2-fluoro-N-methoxy-N-methylbenzamide Show/Hide	C26H27FN6O3S	1
1	EC50 = 105 nM Bioactivity Info	TI LI LO TS
CP0514788 Compound Info	benzyl 4-[6-[3-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]-5-methylpyrimidin-4-yl]oxypiperidine-1-carboxylate Show/Hide	C28H26N4O6S	1
1	EC50 = 105.7 nM Bioactivity Info	TI LI LO TS
CP0425755 Compound Info	benzyl 4-[6-[4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]pyrimidin-4-yl]oxypiperidine-1-carboxylate Show/Hide	C27H24N4O6S	1
1	EC50 = 107.4 nM Bioactivity Info	TI LI LO TS
CP0883016 Compound Info	6-(3-(1-(5-methoxypyrimidin-2-yl)piperidin-4-yl)propylamino)benzofuran-3(2H)-one Show/Hide	C21H26N4O3	1
1	EC50 = 115 nM Bioactivity Info	TI LI LO TS
CP0883015 Compound Info	6-(3-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)propylamino)benzofuran-3(2H)-one Show/Hide	C22H28N4O2	1
1	EC50 = 117 nM Bioactivity Info	TI LI LO TS
CP0882141 Compound Info	6-(3-(1-(3-isopropyl-1,2,4-thiadiazol-5-yl)piperidin-4-yl)propylamino)benzofuran-3(2H)-one Show/Hide	C21H28N4O2S	1
1	EC50 = 121 nM Bioactivity Info	TI LI LO TS
CP0492299 Compound Info	tert-butyl 4-[6-[3-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]pyrimidin-4-yl]oxypiperidine-1-carboxylate Show/Hide	C24H26N4O6S	1
1	EC50 = 125.3 nM Bioactivity Info	TI LI LO TS
CP0408799 Compound Info	tert-butyl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-2-methyl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C24H31FN4O5S	1
1	EC50 = 125.89 nM Bioactivity Info	TI LI LO TS
CP0441815 Compound Info	propan-2-yl 4-[[7-(5-methylsulfonylpyridin-2-yl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C21H27N5O5S	1
1	EC50 = 125.89 nM Bioactivity Info	TI LI LO TS
CP0507183 Compound Info	propan-2-yl 4-[[7-(4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C22H28N4O5S	1
1	EC50 = 125.89 nM Bioactivity Info	TI LI LO TS
CP0392576 Compound Info	[(2S)-1,1,1-trifluoropropan-2-yl] 6-[4-(pyridin-2-ylmethylsulfonylmethyl)phenyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxylate Show/Hide	C30H31F3N2O5S	1
1	EC50 = 126 nM Bioactivity Info	TI LI LO TS
CP0536878 Compound Info	propan-2-yl 6-[4-(pyridin-2-ylmethylsulfonylmethyl)phenyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxylate Show/Hide	C30H34N2O5S	1
1	EC50 = 128 nM Bioactivity Info	TI LI LO TS
CP0547831 Compound Info	tert-butyl 4-[4-(2-fluoro-4-methylsulfonylanilino)furo[3,2-d]pyrimidin-7-yl]piperidine-1-carboxylate Show/Hide	C23H27FN4O5S	1
1	EC50 = 129 nM Bioactivity Info	TI LI LO TS
CP0560134 Compound Info	tert-butyl 4-[6-[4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]pyrimidin-4-yl]oxypiperidine-1-carboxylate Show/Hide	C24H26N4O6S	1
1	EC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0537779 Compound Info	1-[4-[[7-(2-fluoro-4-methylsulfonylphenyl)thieno[3,2-d]pyrimidin-4-yl]-methylamino]piperidin-1-yl]-2-methylpropan-1-one Show/Hide	C23H27FN4O3S2	1
1	EC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0514151 Compound Info	tert-butyl 6-[4-(propan-2-ylsulfonylmethyl)phenyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxylate Show/Hide	C28H37NO5S	1
1	EC50 = 142 nM Bioactivity Info	TI LI LO TS
CP0409533 Compound Info	tert-butyl 4-[5-[(1,1-dioxo-2,3-dihydro-1-benzothiophen-5-yl)amino]pentyl]piperidine-1-carboxylate Show/Hide	C23H36N2O4S	1
1	EC50 = 145 nM Bioactivity Info	TI LI LO TS
CP0416546 Compound Info	tert-butyl 4-[[4-(4-cyano-2-fluoroanilino)pyrimido[5,4-d]pyrimidin-8-yl]amino]piperidine-1-carboxylate Show/Hide	C23H25FN8O2	1
1	EC50 = 147 nM Bioactivity Info	TI LI LO TS
CP0873797 Compound Info	methyl 2-(4-(3-(3-oxo-2,3-dihydrobenzofuran-6-ylamino)propyl)piperidin-1-yl)pyrimidine-5-carboxylate Show/Hide	C22H26N4O4	1
1	EC50 = 149 nM Bioactivity Info	TI LI LO TS
CP0493089 Compound Info	benzyl 4-[6-[3-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]pyrimidin-4-yl]oxypiperidine-1-carboxylate Show/Hide	C27H24N4O6S	1
1	EC50 = 153.4 nM Bioactivity Info	TI LI LO TS
CP0543533 Compound Info	propan-2-yl 4-[[6-[4-[methoxy(methyl)carbamoyl]phenyl]pyridin-3-yl]oxymethyl]piperidine-1-carboxylate Show/Hide	C24H31N3O5	1
1	EC50 = 155 nM Bioactivity Info	TI LI LO TS
CP0482539 Compound Info	propan-2-yl 4-[[7-[4-[methoxy(methyl)carbamoyl]phenyl]thieno[3,2-d]pyrimidin-4-yl]-methylamino]piperidine-1-carboxylate Show/Hide	C25H31N5O4S	1
1	EC50 = 156 nM Bioactivity Info	TI LI LO TS
CP0541310 Compound Info	tert-butyl 4-[4-[[4-[(E)-(2,5-dioxopyrrolidin-3-ylidene)methyl]-2-fluorophenoxy]methyl]-1,3-thiazol-2-yl]piperidine-1-carboxylate Show/Hide	C25H28FN3O5S	1
1	EC50 = 157 nM Bioactivity Info	TI LI LO TS
CP0549422 Compound Info	ethyl 4-[6-[4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]-5-methylpyrimidin-4-yl]oxypiperidine-1-carboxylate Show/Hide	C23H24N4O6S	1
1	EC50 = 157.4 nM Bioactivity Info	TI LI LO TS
CP0397674 Compound Info	propan-2-yl 4-[[7-[2-fluoro-4-(1-methylpyrrol-2-yl)phenyl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C26H30FN5O3	1
1	EC50 = 158.49 nM Bioactivity Info	TI LI LO TS
CP0462600 Compound Info	tert-butyl 4-[[1-(4-methylsulfonylphenyl)-2,3-dihydroindol-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C25H32N2O5S	1
1	EC50 = 158.49 nM Bioactivity Info	TI LI LO TS
CP0488622 Compound Info	propan-2-yl 4-[[7-(3-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C22H27FN4O5S	1
1	EC50 = 158.49 nM Bioactivity Info	TI LI LO TS
CP0862997 Compound Info	6-(3-(1-(5-isopropyl-1,2,4-oxadiazol-3-yl)piperidin-4-yl)propylamino)benzofuran-3(2H)-one Show/Hide	C21H28N4O3	1
1	EC50 = 161 nM Bioactivity Info	TI LI LO TS
CP0514153 Compound Info	2,2,2-trifluoroethyl 6-[4-(pyridin-2-ylmethylsulfonylmethyl)phenyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxylate Show/Hide	C29H29F3N2O5S	1
1	EC50 = 169 nM Bioactivity Info	TI LI LO TS
CP0481096 Compound Info	tert-butyl 4-[[6-[4-[methoxy(methyl)carbamoyl]phenyl]pyridin-3-yl]oxymethyl]piperidine-1-carboxylate Show/Hide	C25H33N3O5	1
1	EC50 = 171 nM Bioactivity Info	TI LI LO TS
CP0539742 Compound Info	cyclopropyl-[4-[methyl-[7-(4-methylsulfonylphenyl)thieno[3,2-d]pyrimidin-4-yl]amino]piperidin-1-yl]methanone Show/Hide	C23H26N4O3S2	1
1	EC50 = 173 nM Bioactivity Info	TI LI LO TS
CP0552609 Compound Info	tert-butyl (1S,4S,5S)-5-[[4-(4-methylsulfonylanilino)pyrimido[5,4-d]pyrimidin-8-yl]amino]-2-azabicyclo[2.2.2]octane-2-carboxylate Show/Hide	C25H31N7O4S	1
1	EC50 = 179 nM Bioactivity Info	TI LI LO TS
CP0511664 Compound Info	(3E)-3-[[4-[[2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-1,3-thiazol-4-yl]methoxy]phenyl]methylidene]pyrrolidine-2,5-dione Show/Hide	C26H27N5O3S	1
1	EC50 = 182 nM Bioactivity Info	TI LI LO TS
CP0489054 Compound Info	4-[4-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]oxythieno[3,2-d]pyrimidin-7-yl]-N-methoxy-N-methylbenzamide Show/Hide	C26H28N6O3S	1
1	EC50 = 199 nM Bioactivity Info	TI LI LO TS
CP0498634 Compound Info	propan-2-yl 4-[[6-(4-cyclohexylsulfonylpiperazin-1-yl)pyridin-3-yl]oxymethyl]piperidine-1-carboxylate Show/Hide	C25H40N4O5S	1
1	EC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0441812 Compound Info	5-nitro-6-(4-pyridin-2-ylsulfanylpiperidin-1-yl)-N-[4-(1,2,4-triazol-1-yl)phenyl]pyrimidin-4-amine Show/Hide	C22H21N9O2S	1
1	EC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0483142 Compound Info	7-[1-(5-fluoropyrimidin-2-yl)piperidin-4-yl]-4-(5-methylsulfonyl-2,3-dihydroindol-1-yl)furo[3,2-d]pyrimidine Show/Hide	C24H23FN6O3S	1
1	EC50 = 201 nM Bioactivity Info	TI LI LO TS
CP0377358 Compound Info	tert-butyl 4-[4-[(1,1-dioxo-2,3-dihydro-1-benzothiophen-5-yl)amino]butyl]piperidine-1-carboxylate Show/Hide	C22H34N2O4S	1
1	EC50 = 210 nM Bioactivity Info	TI LI LO TS
CP0404229 Compound Info	(3E)-3-[[4-[[2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-1,3-thiazol-4-yl]methoxy]-3,5-difluorophenyl]methylidene]pyrrolidine-2,5-dione Show/Hide	C26H25F2N5O3S	1
1	EC50 = 211 nM Bioactivity Info	TI LI LO TS
CP0443932 Compound Info	ethyl 6-[4-(pyridin-2-ylmethylsulfonylmethyl)phenyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxylate Show/Hide	C29H32N2O5S	1
1	EC50 = 235 nM Bioactivity Info	TI LI LO TS
CP0419571 Compound Info	4-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]oxy-7-(4-methylsulfonylphenyl)thieno[3,2-d]pyrimidine Show/Hide	C24H25N5O3S2	1
1	EC50 = 240 nM Bioactivity Info	TI LI LO TS
CP0559934 Compound Info	(3E)-3-[[4-[[2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-1,3-thiazol-4-yl]methoxy]-3-fluorophenyl]methylidene]-1-(oxan-4-ylmethyl)pyrrolidine-2,5-dione Show/Hide	C32H36FN5O4S	1
1	EC50 = 240 nM Bioactivity Info	TI LI LO TS
CP0391279 Compound Info	5-[4-[[7-(2-fluoro-4-methylsulfonylphenyl)-2-methyl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidin-1-yl]-3-propan-2-yl-1,2,4-oxadiazole Show/Hide	C24H29FN6O4S	1
1	EC50 = 251.19 nM Bioactivity Info	TI LI LO TS
CP0413836 Compound Info	propan-2-yl 4-[[7-(6-methylsulfonylpyridin-3-yl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C21H27N5O5S	1
1	EC50 = 251.19 nM Bioactivity Info	TI LI LO TS
CP0507182 Compound Info	S-methyl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carbothioate Show/Hide	C20H23FN4O4S2	1
1	EC50 = 251.19 nM Bioactivity Info	TI LI LO TS
CP0544374 Compound Info	ethyl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C21H25FN4O5S	1
1	EC50 = 251.19 nM Bioactivity Info	TI LI LO TS
CP0494082 Compound Info	7-[1-(5-methylpyrimidin-2-yl)piperidin-4-yl]-4-(5-methylsulfonyl-2,3-dihydroindol-1-yl)furo[3,2-d]pyrimidine Show/Hide	C25H26N6O3S	1
1	EC50 = 252 nM Bioactivity Info	TI LI LO TS
CP0445387 Compound Info	tert-butyl 4-[3-[(3,3-dioxo-1,3lambda6-benzoxathiol-6-yl)amino]propyl]piperidine-1-carboxylate Show/Hide	C20H30N2O5S	1
1	EC50 = 254 nM Bioactivity Info	TI LI LO TS
CP0409532 Compound Info	tert-butyl 4-[3-[(1,1-dioxo-2,3-dihydro-1lambda6,2,3-benzothiadiazol-5-yl)amino]propyl]piperidine-1-carboxylate Show/Hide	C19H30N4O4S	1
1	EC50 = 268 nM Bioactivity Info	TI LI LO TS
CP0502941 Compound Info	tert-butyl 4-[3-[(1,1-dioxo-2,3-dihydro-1-benzothiophen-5-yl)amino]propyl]piperidine-1-carboxylate Show/Hide	C21H32N2O4S	1
1	EC50 = 270 nM Bioactivity Info	TI LI LO TS
CP0497650 Compound Info	tert-butyl 4-[3-[(4-oxo-2,3-dihydrochromen-6-yl)amino]propyl]piperidine-1-carboxylate Show/Hide	C22H32N2O4	1
1	EC50 = 272 nM Bioactivity Info	TI LI LO TS
CP0400301 Compound Info	propan-2-yl 4-[[6-(4-propylsulfonylpiperazin-1-yl)pyridin-3-yl]oxymethyl]piperidine-1-carboxylate Show/Hide	C22H36N4O5S	1
1	EC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0458941 Compound Info	propan-2-yl 4-[[6-[4-(2-methoxyethylsulfonyl)piperazin-1-yl]pyridin-3-yl]oxymethyl]piperidine-1-carboxylate Show/Hide	C22H36N4O6S	1
1	EC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0498631 Compound Info	propan-2-yl 4-[[6-(4-propan-2-ylsulfonylpiperazin-1-yl)pyridin-3-yl]oxymethyl]piperidine-1-carboxylate Show/Hide	C22H36N4O5S	1
1	EC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0417503 Compound Info	7-[1-(5-methoxypyrimidin-2-yl)piperidin-4-yl]-4-(5-methylsulfonyl-2,3-dihydroindol-1-yl)furo[3,2-d]pyrimidine Show/Hide	C25H26N6O4S	1
1	EC50 = 310 nM Bioactivity Info	TI LI LO TS
CP0381375 Compound Info	4-hydroxypiperidine-1-carbonitrile Show/Hide	C6H10N2O	1
1	EC50 = 316.23 nM Bioactivity Info	TI LI LO TS
CP0389494 Compound Info	methyl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C20H23FN4O5S	1
1	EC50 = 316.23 nM Bioactivity Info	TI LI LO TS
CP0507614 Compound Info	2-methoxyethyl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C22H27FN4O6S	1
1	EC50 = 316.23 nM Bioactivity Info	TI LI LO TS
CP0512841 Compound Info	4-[5-[[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]methoxy]pyridin-2-yl]-N-methoxy-N-methylbenzamide Show/Hide	C26H31N5O3	1
1	EC50 = 319 nM Bioactivity Info	TI LI LO TS
CP0475366 Compound Info	tert-butyl 4-[[6-[4-(oxazinane-2-carbonyl)phenyl]pyridin-3-yl]oxymethyl]piperidine-1-carboxylate Show/Hide	C27H35N3O5	1
1	EC50 = 321 nM Bioactivity Info	TI LI LO TS
CP0514152 Compound Info	3-[[4-[1'-[(2-methylpropan-2-yl)oxycarbonyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-6-yl]phenyl]methylsulfonylmethyl]benzoic acid Show/Hide	C33H37NO7S	1
1	EC50 = 321 nM Bioactivity Info	TI LI LO TS
CP0443933 Compound Info	2-[[4-[1'-[(2-methylpropan-2-yl)oxycarbonyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-6-yl]phenyl]methylsulfonylmethyl]benzoic acid Show/Hide	C33H37NO7S	1
1	EC50 = 334 nM Bioactivity Info	TI LI LO TS
CP0517583 Compound Info	tert-butyl 4-[[4-(4-methylsulfonylanilino)pyrimido[5,4-d]pyrimidin-8-yl]amino]piperidine-1-carboxylate Show/Hide	C23H29N7O4S	1
1	EC50 = 345 nM Bioactivity Info	TI LI LO TS
CP0494084 Compound Info	tert-butyl 4-[7-(2-fluoro-4-methylsulfonylanilino)-[1,2]oxazolo[4,5-d]pyrimidin-3-yl]piperidine-1-carboxylate Show/Hide	C22H26FN5O5S	1
1	EC50 = 353 nM Bioactivity Info	TI LI LO TS
CP0412075 Compound Info	4-[[4-[1'-[(2-methylpropan-2-yl)oxycarbonyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-6-yl]phenyl]methylsulfonylmethyl]benzoic acid Show/Hide	C33H37NO7S	1
1	EC50 = 360 nM Bioactivity Info	TI LI LO TS
CP0440217 Compound Info	tert-butyl 6-[4-(methylsulfonylmethyl)phenyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxylate Show/Hide	C26H33NO5S	1
1	EC50 = 369 nM Bioactivity Info	TI LI LO TS
CP0408601 Compound Info	2-[4-[4-(5-methylsulfonyl-2,3-dihydroindol-1-yl)furo[3,2-d]pyrimidin-7-yl]piperidin-1-yl]pyrimidin-5-ol Show/Hide	C24H24N6O4S	1
1	EC50 = 391 nM Bioactivity Info	TI LI LO TS
CP0389505 Compound Info	propan-2-yl 4-[[7-(4-cyano-3-fluorophenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C22H24FN5O3	1
1	EC50 = 398.11 nM Bioactivity Info	TI LI LO TS
CP0441814 Compound Info	propan-2-yl 4-[[7-(3-fluoro-4-methylsulfanylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C22H27FN4O3S	1
1	EC50 = 398.11 nM Bioactivity Info	TI LI LO TS
CP0462601 Compound Info	4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]-N,N-dimethylpiperidine-1-sulfonamide Show/Hide	C20H26FN5O5S2	1
1	EC50 = 398.11 nM Bioactivity Info	TI LI LO TS
CP0552608 Compound Info	tert-butyl (1S,5R)-3-[[4-(2-fluoro-4-methylsulfonylanilino)pyrimido[5,4-d]pyrimidin-8-yl]amino]-8-azabicyclo[3.2.1]octane-8-carboxylate Show/Hide	C25H30FN7O4S	1
1	EC50 = 452 nM Bioactivity Info	TI LI LO TS
CP0389499 Compound Info	propan-2-yl 4-[[1-(4-methylsulfonylphenyl)-2,3-dihydroindol-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C24H30N2O5S	1
1	EC50 = 501.19 nM Bioactivity Info	TI LI LO TS
CP0397598 Compound Info	propan-2-yl 4-[[7-(4-dimethylsulfinamoylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C23H31N5O4S	1
1	EC50 = 501.19 nM Bioactivity Info	TI LI LO TS
CP0462599 Compound Info	2-fluoroethyl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C21H24F2N4O5S	1
1	EC50 = 501.19 nM Bioactivity Info	TI LI LO TS
CP0470607 Compound Info	tert-butyl 4-[3-[(4,4-dioxo-2,3-dihydro-1,4lambda6-benzoxathiin-7-yl)amino]propyl]piperidine-1-carboxylate Show/Hide	C21H32N2O5S	1
1	EC50 = 511 nM Bioactivity Info	TI LI LO TS
CP0478401 Compound Info	4-(5-methylsulfonyl-2,3-dihydroindol-1-yl)-7-(1-pyrimidin-2-ylpiperidin-4-yl)furo[3,2-d]pyrimidine Show/Hide	C24H24N6O3S	1
1	EC50 = 512 nM Bioactivity Info	TI LI LO TS
CP0377359 Compound Info	tert-butyl 4-[3-[(1-oxo-2,3-dihydroisoindol-5-yl)amino]propyl]piperidine-1-carboxylate Show/Hide	C21H31N3O3	1
1	EC50 = 550 nM Bioactivity Info	TI LI LO TS
CP0483141 Compound Info	1-[2-[4-[4-(5-methylsulfonyl-2,3-dihydroindol-1-yl)furo[3,2-d]pyrimidin-7-yl]piperidin-1-yl]pyrimidin-5-yl]ethanol Show/Hide	C26H28N6O4S	1
1	EC50 = 586 nM Bioactivity Info	TI LI LO TS
CP0389496 Compound Info	tert-butyl 4-[1-(4-methylsulfonylphenyl)indol-4-yl]oxypiperidine-1-carboxylate Show/Hide	C25H30N2O5S	1
1	EC50 = 630.96 nM Bioactivity Info	TI LI LO TS
CP0427709 Compound Info	propan-2-yl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]-methylamino]piperidine-1-carboxylate Show/Hide	C23H30FN5O4S	1
1	EC50 = 630.96 nM Bioactivity Info	TI LI LO TS
CP0852738 Compound Info	(R)-1,1-Dimethylethyl 4-({1-[4-(Methylsulfinyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarboxylate Show/Hide	C22H27FN4O4S	1
1	EC50 = 630.96 nM Bioactivity Info	TI LI LO TS
CP0447587 Compound Info	propan-2-yl 4-[2-[6-(4-propylsulfonylpiperazin-1-yl)pyridin-3-yl]oxyethyl]piperidine-1-carboxylate Show/Hide	C23H38N4O5S	1
1	EC50 = 700 nM Bioactivity Info	TI LI LO TS
CP0862996 Compound Info	6-(3-(1-(5-isopropyl-1,3,4-oxadiazol-2-yl)piperidin-4-yl)propylamino)benzofuran-3(2H)-one Show/Hide	C21H28N4O3	1
1	EC50 = 704 nM Bioactivity Info	TI LI LO TS
CP0389391 Compound Info	1'-(5-chloropyrimidin-2-yl)-6-[4-(pyridin-2-ylmethylsulfonylmethyl)phenyl]spiro[3,4-dihydrochromene-2,4'-piperidine] Show/Hide	C30H29ClN4O3S	1
1	EC50 = 716 nM Bioactivity Info	TI LI LO TS
CP0511759 Compound Info	2-methylpropyl 4-[6-[3-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]pyrimidin-4-yl]oxypiperidine-1-carboxylate Show/Hide	C24H26N4O6S	1
1	EC50 = 720 nM Bioactivity Info	TI LI LO TS
CP0409535 Compound Info	tert-butyl 4-[3-[(3-oxo-1,2-dihydroisoindol-5-yl)amino]propyl]piperidine-1-carboxylate Show/Hide	C21H31N3O3	1
1	EC50 = 734 nM Bioactivity Info	TI LI LO TS
CP0502942 Compound Info	tert-butyl 4-[3-[(1,1-dioxo-2,3-dihydro-1-benzothiophen-5-yl)oxy]propyl]piperidine-1-carboxylate Show/Hide	C21H31NO5S	1
1	EC50 = 736 nM Bioactivity Info	TI LI LO TS
CP0532856 Compound Info	2-methylpropyl 4-[6-[4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]pyrimidin-4-yl]oxypiperidine-1-carboxylate Show/Hide	C24H26N4O6S	1
1	EC50 = 745 nM Bioactivity Info	TI LI LO TS
CP0489884 Compound Info	tert-butyl 4-[3-[(5-oxo-6,7,8,9-tetrahydrobenzo[7]annulen-2-yl)amino]propyl]piperidine-1-carboxylate Show/Hide	C24H36N2O3	1
1	EC50 = 770 nM Bioactivity Info	TI LI LO TS
CP0548544 Compound Info	(5Z)-5-[[4-[[2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-1,3-thiazol-4-yl]methoxy]-3-fluorophenyl]methylidene]-1,3-thiazolidine-2,4-dione Show/Hide	C25H24FN5O3S2	1
1	EC50 = 780 nM Bioactivity Info	TI LI LO TS
CP0508165 Compound Info	2-methyl-1-[4-[methyl-[7-(4-methylsulfonylphenyl)thieno[3,2-d]pyrimidin-4-yl]amino]piperidin-1-yl]propan-1-one Show/Hide	C23H28N4O3S2	1
1	EC50 = 781 nM Bioactivity Info	TI LI LO TS
CP0425649 Compound Info	ethyl 4-[6-[4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]pyrimidin-4-yl]oxypiperidine-1-carboxylate Show/Hide	C22H22N4O6S	1
1	EC50 = 790 nM Bioactivity Info	TI LI LO TS
CP0463409 Compound Info	tert-butyl 4-[4-(6-methylsulfonyl-3,4-dihydro-2H-quinolin-1-yl)furo[3,2-d]pyrimidin-7-yl]piperidine-1-carboxylate Show/Hide	C26H32N4O5S	1
1	EC50 = 793 nM Bioactivity Info	TI LI LO TS
CP0413754 Compound Info	propan-2-yl 4-[[2-amino-7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C22H28FN5O5S	1
1	EC50 = 794.33 nM Bioactivity Info	TI LI LO TS
CP0486968 Compound Info	propan-2-yl 4-[[7-(5-cyanopyridin-2-yl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C21H24N6O3	1
1	EC50 = 794.33 nM Bioactivity Info	TI LI LO TS
CP0532359 Compound Info	N-tert-butyl-4-[[6-(4-propylsulfonylpiperazin-1-yl)pyridin-3-yl]oxymethyl]piperidine-1-carboxamide Show/Hide	C23H39N5O4S	1
1	EC50 = 800 nM Bioactivity Info	TI LI LO TS
CP0549421 Compound Info	benzyl 4-[6-[4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]-5-methylpyrimidin-4-yl]oxypiperidine-1-carboxylate Show/Hide	C28H26N4O6S	1
1	EC50 = 805 nM Bioactivity Info	TI LI LO TS
CP0552845 Compound Info	ethyl 4-[6-[3-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]pyrimidin-4-yl]oxypiperidine-1-carboxylate Show/Hide	C22H22N4O6S	1
1	EC50 = 819 nM Bioactivity Info	TI LI LO TS
CP0452227 Compound Info	N-(4-propan-2-ylphenyl)-4-[[6-(4-propylsulfonylpiperazin-1-yl)pyridin-3-yl]oxymethyl]piperidine-1-carboxamide Show/Hide	C28H41N5O4S	1
1	EC50 = 900 nM Bioactivity Info	TI LI LO TS
CP0506167 Compound Info	propan-2-yl 4-[[6-(4-piperidin-1-ylsulfonylpiperazin-1-yl)pyridin-3-yl]oxymethyl]piperidine-1-carboxylate Show/Hide	C24H39N5O5S	1
1	EC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0533386 Compound Info	N-propan-2-yl-4-[[6-(4-propylsulfonylpiperazin-1-yl)pyridin-3-yl]oxymethyl]piperidine-1-carboxamide Show/Hide	C22H37N5O4S	1
1	EC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0500587 Compound Info	propan-2-yl 4-[[1-(2-fluoro-4-methylsulfonylphenyl)-2,3-dihydroindol-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C24H29FN2O5S	1
1	EC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0552610 Compound Info	tert-butyl 4-[8-(4-cyano-2-fluoroanilino)pyrimido[5,4-d]pyrimidin-4-yl]oxypiperidine-1-carboxylate Show/Hide	C23H24FN7O3	1
1	EC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0377361 Compound Info	tert-butyl 4-[3-[(1,1-dioxo-2,3-dihydro-1-benzothiophen-6-yl)amino]propyl]piperidine-1-carboxylate Show/Hide	C21H32N2O4S	1
1	EC50 = 1029 nM Bioactivity Info	TI LI LO TS
CP0400302 Compound Info	propan-2-yl 4-[[6-[4-(diethylsulfamoyl)piperazin-1-yl]pyridin-3-yl]oxymethyl]piperidine-1-carboxylate Show/Hide	C23H39N5O5S	1
1	EC50 = 1200 nM Bioactivity Info	TI LI LO TS
CP0504560 Compound Info	propan-2-yl 4-[2-[6-(4-ethylsulfonylpiperazin-1-yl)pyridin-3-yl]oxyethyl]piperidine-1-carboxylate Show/Hide	C22H36N4O5S	1
1	EC50 = 1200 nM Bioactivity Info	TI LI LO TS
CP0537781 Compound Info	N-methyl-7-(4-methylsulfonylphenyl)-N-(1-propan-2-ylsulfonylpiperidin-4-yl)thieno[3,2-d]pyrimidin-4-amine Show/Hide	C22H28N4O4S3	1
1	EC50 = 1200 nM Bioactivity Info	TI LI LO TS
CP0537783 Compound Info	N-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-N-methyl-7-(4-methylsulfonylphenyl)thieno[3,2-d]pyrimidin-4-amine Show/Hide	C25H28N6O2S2	1
1	EC50 = 1200 nM Bioactivity Info	TI LI LO TS
CP0507617 Compound Info	7-(2-fluoro-4-methylsulfonylphenyl)-4-(1-propan-2-ylsulfonylpiperidin-4-yl)oxy-5,6-dihydropyrrolo[2,3-d]pyrimidine Show/Hide	C21H27FN4O5S2	1
1	EC50 = 1258.93 nM Bioactivity Info	TI LI LO TS
CP0496118 Compound Info	propan-2-yl 4-[[6-(4-ethylsulfonylpiperazin-1-yl)pyridin-3-yl]oxymethyl]piperidine-1-carboxylate Show/Hide	C21H34N4O5S	1
1	EC50 = 1300 nM Bioactivity Info	TI LI LO TS
CP0548545 Compound Info	tert-butyl (1R,5S)-3-[[4-(4-methylsulfonylanilino)pyrimido[5,4-d]pyrimidin-8-yl]amino]-8-azabicyclo[3.2.1]octane-8-carboxylate Show/Hide	C25H31N7O4S	1
1	EC50 = 1400 nM Bioactivity Info	TI LI LO TS
CP0425648 Compound Info	methyl 4-[6-[4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]-5-methylpyrimidin-4-yl]oxypiperidine-1-carboxylate Show/Hide	C22H22N4O6S	1
1	EC50 = 1414 nM Bioactivity Info	TI LI LO TS
CP0462083 Compound Info	4-(1-ethylsulfonylpiperidin-4-yl)oxy-7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidine Show/Hide	C20H25FN4O5S2	1
1	EC50 = 1584.89 nM Bioactivity Info	TI LI LO TS
CP0498633 Compound Info	3-methyl-1-(4-((6-(4-(propylsulfonyl)piperazin-1-yl)pyridin-3-yloxy)methyl)piperidin-1-yl)butan-1-one Show/Hide	C23H38N4O4S	1
1	EC50 = 1600 nM Bioactivity Info	TI LI LO TS
CP0547027 Compound Info	tert-butyl (1S,5R)-3-[[4-(4-cyano-2-fluoroanilino)pyrimido[5,4-d]pyrimidin-8-yl]amino]-8-azabicyclo[3.2.1]octane-8-carboxylate Show/Hide	C25H27FN8O2	1
1	EC50 = 1700 nM Bioactivity Info	TI LI LO TS
CP0430679 Compound Info	propan-2-yl 4-[[6-(4-thiophen-2-ylsulfonylpiperazin-1-yl)pyridin-3-yl]oxymethyl]piperidine-1-carboxylate Show/Hide	C23H32N4O5S2	1
1	EC50 = 1800 nM Bioactivity Info	TI LI LO TS
CP0492298 Compound Info	methyl 4-[6-[3-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]pyrimidin-4-yl]oxypiperidine-1-carboxylate Show/Hide	C21H20N4O6S	1
1	EC50 = 1870 nM Bioactivity Info	TI LI LO TS
CP0498630 Compound Info	propan-2-yl 4-[[6-[4-(furan-2-carbonyl)piperazin-1-yl]pyridin-3-yl]oxymethyl]piperidine-1-carboxylate Show/Hide	C24H32N4O5	1
1	EC50 = 1900 nM Bioactivity Info	TI LI LO TS
CP0396591 Compound Info	propan-2-yl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]amino]piperidine-1-carboxylate Show/Hide	C22H28FN5O4S	1
1	EC50 = 1995.26 nM Bioactivity Info	TI LI LO TS
CP0507181 Compound Info	7-(2-fluoro-4-methylsulfonylphenyl)-4-[1-(1,4,5,6-tetrahydropyrimidin-2-yl)piperidin-4-yl]oxy-5,6-dihydropyrrolo[2,3-d]pyrimidine Show/Hide	C22H27FN6O3S	1
1	EC50 = 1995.26 nM Bioactivity Info	TI LI LO TS
CP0447590 Compound Info	furan-2-yl-[4-[[6-(4-propylsulfonylpiperazin-1-yl)pyridin-3-yl]oxymethyl]piperidin-1-yl]methanone Show/Hide	C23H32N4O5S	1
1	EC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0498632 Compound Info	propan-2-yl 4-[[6-(4-pyridin-3-ylsulfonylpiperazin-1-yl)pyridin-3-yl]oxymethyl]piperidine-1-carboxylate Show/Hide	C24H33N5O5S	1
1	EC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0430680 Compound Info	propan-2-yl 4-[6-(4-ethylsulfonylpiperazin-1-yl)pyridin-3-yl]oxypiperidine-1-carboxylate Show/Hide	C20H32N4O5S	1
1	EC50 = 2100 nM Bioactivity Info	TI LI LO TS
CP0477488 Compound Info	2,2-difluoro-1-(4-((6-(4-(propylsulfonyl)piperazin-1-yl)pyridin-3-yloxy)methyl)piperidin-1-yl)ethanone Show/Hide	C20H30F2N4O4S	1
1	EC50 = 2100 nM Bioactivity Info	TI LI LO TS
CP0547029 Compound Info	tert-butyl (1S,4S,5R)-5-[[4-(2-fluoro-4-methylsulfonylanilino)pyrimido[5,4-d]pyrimidin-8-yl]amino]-2-azabicyclo[2.2.2]octane-2-carboxylate Show/Hide	C25H30FN7O4S	1
1	EC50 = 2100 nM Bioactivity Info	TI LI LO TS
CP0532357 Compound Info	propan-2-yl 4-[[6-[4-(2-methoxyethyl)piperazin-1-yl]pyridin-3-yl]oxymethyl]piperidine-1-carboxylate Show/Hide	C22H36N4O4	1
1	EC50 = 2600 nM Bioactivity Info	TI LI LO TS
CP0489448 Compound Info	tert-butyl 4-[4-[(1,1-dioxo-2,3-dihydro-1-benzothiophen-5-yl)amino]-4-oxobutyl]piperidine-1-carboxylate Show/Hide	C22H32N2O5S	1
1	EC50 = 2610 nM Bioactivity Info	TI LI LO TS
CP0447588 Compound Info	3,3-dimethyl-1-(4-((6-(4-(propylsulfonyl)piperazin-1-yl)pyridin-3-yloxy)methyl)piperidin-1-yl)butan-1-one Show/Hide	C24H40N4O4S	1
1	EC50 = 2800 nM Bioactivity Info	TI LI LO TS
CP0438908 Compound Info	propan-2-yl 4-[[6-[4-(dimethylcarbamoyl)piperazin-1-yl]pyridin-3-yl]oxymethyl]piperidine-1-carboxylate Show/Hide	C22H35N5O4	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0447589 Compound Info	N-cyclohexyl-4-[[6-(4-propylsulfonylpiperazin-1-yl)pyridin-3-yl]oxymethyl]piperidine-1-carboxamide Show/Hide	C25H41N5O4S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0452108 Compound Info	propan-2-yl 4-[[6-[4-[2-oxo-2-(propan-2-ylamino)ethyl]piperazin-1-yl]pyridin-3-yl]oxymethyl]piperidine-1-carboxylate Show/Hide	C24H39N5O4	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0470415 Compound Info	morpholin-4-yl-[4-[[6-(4-propylsulfonylpiperazin-1-yl)pyridin-3-yl]oxymethyl]piperidin-1-yl]methanone Show/Hide	C23H37N5O5S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0498642 Compound Info	propan-2-yl 4-[[6-(4-acetylpiperazin-1-yl)pyridin-3-yl]oxymethyl]piperidine-1-carboxylate Show/Hide	C21H32N4O4	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0389506 Compound Info	propan-2-yl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-6-methyl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C23H29FN4O5S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0389507 Compound Info	propan-2-yl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]sulfonyl]piperidine-1-carboxylate Show/Hide	C22H27FN4O6S2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0397672 Compound Info	propan-2-yl 4-[[7-(5-fluoropyridin-2-yl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C20H24FN5O3	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0462082 Compound Info	propan-2-yl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)-2-(methylamino)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C23H30FN5O5S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0507616 Compound Info	2-[4-[[7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidin-1-yl]-N,N-dimethylacetamide Show/Hide	C22H28FN5O4S	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0553352 Compound Info	propan-2-yl 4-[[7-(2-methylpyridin-3-yl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate Show/Hide	C21H27N5O3	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0547031 Compound Info	tert-butyl (1R,5S)-3-[8-(4-cyano-2-fluoroanilino)pyrimido[5,4-d]pyrimidin-4-yl]oxy-8-azabicyclo[3.2.1]octane-8-carboxylate Show/Hide	C25H26FN7O3	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0552607 Compound Info	tert-butyl (1S,4S,5R)-5-[[4-(4-cyano-2-fluoroanilino)pyrimido[5,4-d]pyrimidin-8-yl]amino]-2-azabicyclo[2.2.2]octane-2-carboxylate Show/Hide	C25H27FN8O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0408600 Compound Info	tert-butyl 4-[4-(2-fluoro-N-methyl-4-methylsulfonylanilino)furo[3,2-d]pyrimidin-7-yl]piperidine-1-carboxylate Show/Hide	C24H29FN4O5S	1
1	EC50 > 1000 nM Bioactivity Info	TI LI LO TS
CP0460783 Compound Info	tert-butyl 4-[4-(2-fluoro-4-methylsulfonylanilino)-5-methylpyrrolo[3,2-d]pyrimidin-7-yl]piperidine-1-carboxylate Show/Hide	C24H30FN5O4S	1
1	EC50 > 1000 nM Bioactivity Info	TI LI LO TS
CP0478405 Compound Info	tert-butyl 4-[4-(2-fluoro-4-methylsulfonylanilino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl]piperidine-1-carboxylate Show/Hide	C23H28FN5O4S	1
1	EC50 > 1000 nM Bioactivity Info	TI LI LO TS
CP0426564 Compound Info	tert-butyl 6-[4-(2-methylsulfonylethyl)phenyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxylate Show/Hide	C27H35NO5S	1
1	EC50 > 1000 nM Bioactivity Info	TI LI LO TS
CP0426566 Compound Info	tert-butyl 6-(4-methylsulfonylphenyl)spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxylate Show/Hide	C25H31NO5S	1
1	EC50 > 1000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000011 , CHO

Cell Line Info

Cell Line ID: CL000460 , Flp-In-T-REx-293

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000524 , HEK293-FT

Cell Line Info

Cell Line ID: CL000107 , HEK293S

Cell Line Info

Cell Line ID: CL000613 , MIN6

Cell Line Info

Cell Line ID: CL000012 , Sf21

Cell Line Info

Cell Line ID: CL000043 , U2OS

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0062435 Compound Info	2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole Show/Hide	C22H24N8OS	1
1	EC50 = 3.9 nM
CP0204778 Compound Info	6-[[2-fluoro-3-[1-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-4-yl]propyl]amino]-2,3-dihydroinden-1-one Show/Hide	C22H29FN4O2	1
1	EC50 = 33 nM
CP0359455 Compound Info	[(2R)-1,1,1-trifluoropropan-2-yl] 6-[4-(pyridin-2-ylmethylsulfonylmethyl)phenyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-1'-carboxylate Show/Hide	C30H31F3N2O5S	1
1	EC50 = 54 nM
CP0035557 Compound Info	(Z)-N-(2-hydroxyethyl)octadec-9-enamide Show/Hide	C20H39NO2	2
1	EC50 = 930 nM
2	EC50 = 3200 nM
CP0215429 Compound Info	tert-butyl 4-[(3-pyridin-4-yl-1,2,4-oxadiazol-5-yl)methoxy]piperidine-1-carboxylate Show/Hide	C18H24N4O4	1
1	EC50 = 5130 nM
CP0310370 Compound Info	4-[(4-cyano-2-fluorophenoxy)methyl]-2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]pyrazole-3-carbonitrile Show/Hide	C23H22FN7O	1
1	Ki = 9.25 nM
CP0282904 Compound Info	2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(tetrazol-1-yl)phenoxy]methyl]pyrazole-3-carbonitrile Show/Hide	C23H24N10O	1
1	Ki = 14.9 nM
CP0388345 Compound Info	(1-methylcyclopropyl) 4-[5-cyano-4-[[4-(tetrazol-1-yl)phenoxy]methyl]pyrazol-1-yl]piperidine-1-carboxylate Show/Hide	C22H24N8O3	1
1	Ki = 29.8 nM
CP0210924 Compound Info	(1-methylcyclopropyl) 4-[5-cyano-4-[(4-cyano-2-fluorophenoxy)methyl]pyrazol-1-yl]piperidine-1-carboxylate Show/Hide	C22H22FN5O3	1
1	Ki = 36.5 nM
CP0210925 Compound Info	(1-methylcyclopropyl) 4-[5-cyano-4-[[2-fluoro-4-(1-methyltetrazol-5-yl)phenoxy]methyl]pyrazol-1-yl]piperidine-1-carboxylate Show/Hide	C23H25FN8O3	1
1	Ki = 99 nM

Clinical Information about the Protein

Target 1 ( Glucose-dependent insulinotropic receptor (GPR119) )

Target Type	Successful Target
Disease	2 Target-related Diseases				2
1	Attention deficit hyperactivity disorder [ICD-11: 6A05.Z]
2	Type-2 diabetes [ICD-11: 5A11]
Approved Drug(s)	1 Approved Drug				1
1	Guanfacine extended release	Drug Info	Approved	Attention deficit hyperactivity disorder
Clinical Trial Drug(s)	4 Clinical Trial Drugs				4
1	GSK1292263	Drug Info	Phase 2	Type-2 diabetes
2	SAR-260093	Drug Info	Phase 2	Type-2 diabetes
3	APD-597	Drug Info	Phase 1	Type-2 diabetes
4	BMS-903452	Drug Info	Phase 1	Type-2 diabetes
Discontinued Drug(s)	1 Discontinued Drug				1
1	APD668	Drug Info	Discontinued in Phase 1	Type-2 diabetes

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT01297	Glucose-dependent insulinotropic receptor	Rattus norvegicus, Rat	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han