| Compound ID |
Compound Name |
Compound Formula |
|
CP0388346
|
2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-5-(1-methylsulfonylpiperidin-4-yl)-2,3-dihydrofuro[2,3-c]pyridine
Show/Hide
|
C24H33N5O3S
|
1
|
| 1 |
EC50 = 2 nM
|
|
|
|
CP0481759
|
(2R)-2-[1-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]-5-(1-methylsulfonyl-3,6-dihydro-2H-pyridin-4-yl)-2,3-dihydrofuro[2,3-c]pyridine
Show/Hide
|
C24H26F4N4O3S
|
1
|
| 1 |
EC50 = 2 nM
|
|
|
|
CP0458555
|
US9469631, 40
Show/Hide
|
C23H28FN3O4
|
1
|
| 1 |
EC50 = 2 nM
|
|
|
|
CP0435520
|
(2S)-2-methyl-5-(1-methylsulfonyl-3,6-dihydro-2H-pyridin-4-yl)-2-[1-[5-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl]-3H-furo[2,3-c]pyridine
Show/Hide
|
C24H28F3N5O3S
|
1
|
| 1 |
EC50 = 3 nM
|
|
|
|
CP0511401
|
(2R)-2-[1-(5-cyclopropylpyrimidin-2-yl)piperidin-4-yl]-5-(1-methylsulfonyl-3,6-dihydro-2H-pyridin-4-yl)-2,3-dihydrofuro[2,3-c]pyridine
Show/Hide
|
C25H31N5O3S
|
1
|
| 1 |
EC50 = 3 nM
|
|
|
|
CP0561664
|
US9469631, 46
Show/Hide
|
C24H31N3O4
|
1
|
| 1 |
EC50 = 7 nM
|
|
|
|
CP0458554
|
US9469631, 28
Show/Hide
|
C23H28FN3O4
|
1
|
| 1 |
EC50 = 8 nM
|
|
|
|
CP0866146
|
4-[5-(1-Methanesulfonyl-1,2,3,6-tetrahydropyridin-4-yl)-furo[2,3-c]pyridin-2-yl]piperidine-1-carboxylic acid tert-butyl ester
Show/Hide
|
C23H31N3O5S
|
1
|
| 1 |
EC50 = 9 nM
|
|
|
|
CP0961981
|
4-[5-(2-Fluoro-4-methanesulfonylphenyl)-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester
Show/Hide
|
C24H27FN2O5S
|
1
|
| 1 |
EC50 = 9 nM
|
|
|
|
CP0458545
|
US9469631, 33
Show/Hide
|
C23H27F2N3O4
|
1
|
| 1 |
EC50 = 9 nM
|
|
|
|
CP0951586
|
4-[5-(1-Methanesulfonyl-1,2,3,6-tetrahydropyridin-4-yl)-furo[2,3-c]pyridin-2-yl]piperidine-1-carboxylic acid 1-methyl-cyclopropyl ester
Show/Hide
|
C23H29N3O5S
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0516353
|
US9469631, 130
Show/Hide
|
C23H26F3N3O4
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0961966
|
4-[5-(2-Fluoro-4-methanesulfonylphenyl)-furo[2,3-c]pyridin-2-yl]piperidine-1-carboxylic acid isopropyl ester
Show/Hide
|
C23H25FN2O5S
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
|
CP0859936
|
4-[5-(2-Fluoro-4-methanesulfonylphenyl)-furo[2,3-c]pyridin-2-yl]piperidine-1-carboxylic acid 1-methylcyclopropyl ester
Show/Hide
|
C24H25FN2O5S
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
|
CP0516347
|
US9469631, 2
Show/Hide
|
C24H31N3O4
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0564116
|
US9469631, 45
Show/Hide
|
C24H31N3O5
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0967474
|
5-(1-Methanesulfonyl-1,2,3,6-tetrahydropyridin-4-yl)-2-[1-(5-trifluoromethy1-[1,3,4]thiadiazol-2-yl)-piperidin-4-yl]furo[2,3-c]pyridine
Show/Hide
|
C21H22F3N5O3S2
|
1
|
| 1 |
EC50 = 18 nM
|
|
|
|
CP0866145
|
4-[5-(1-Methanesulfonyl-1,2,3,6-tetrahydropyridin-4-yl)-furo[2,3-c]pyridin-2-yl]piperidine-1-carboxylic acid isopropyl ester
Show/Hide
|
C22H29N3O5S
|
1
|
| 1 |
EC50 = 19 nM
|
|
|
|
CP0516358
|
US9469631, 32
Show/Hide
|
C26H28N4O3
|
1
|
| 1 |
EC50 = 19 nM
|
|
|
|
CP0498036
|
US9469631, 34
Show/Hide
|
C26H29FN4O3
|
1
|
| 1 |
EC50 = 21 nM
|
|
|
|
CP0565332
|
US8772323, 259
Show/Hide
|
C27H34N4O3
|
1
|
| 1 |
EC50 = 22 nM
|
|
|
|
CP0561296
|
US8772323, 260
Show/Hide
|
C24H27N3O3
|
1
|
| 1 |
EC50 = 24 nM
|
|
|
|
CP0516345
|
US9469631, 89
Show/Hide
|
C25H29N3O3S
|
1
|
| 1 |
EC50 = 24 nM
|
|
|
|
CP0567074
|
US8772323, 206
Show/Hide
|
C17H18N4O3
|
1
|
| 1 |
EC50 = 27 nM
|
|
|
|
CP0476691
|
US9469631, 29
Show/Hide
|
C26H30N4O3
|
1
|
| 1 |
EC50 = 27 nM
|
|
|
|
CP0918237
|
5-(1-Methanesulfonyl-1,2,3,6-tetrahydropyridin-4-yl)-2-[1-(1-trifluoromethylcyclopropylmethyl)-piperidin-4-yl]furo[2,3-c]pyridine
Show/Hide
|
C23H28F3N3O3S
|
1
|
| 1 |
EC50 = 28 nM
|
|
|
|
CP0503828
|
US8772323, 193
Show/Hide
|
C22H23N3O3
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0454608
|
US9469631, 41
Show/Hide
|
C23H28FN3O4
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0477848
|
US8772323, 81
Show/Hide
|
C17H13N3O3
|
1
|
| 1 |
EC50 = 31 nM
|
|
|
|
CP0497640
|
US9469631, 6
Show/Hide
|
C23H29N3O3S
|
1
|
| 1 |
EC50 = 32 nM
|
|
|
|
CP0497637
|
US9469631, 53
Show/Hide
|
C23H29N3O4
|
1
|
| 1 |
EC50 = 33 nM
|
|
|
|
CP0498009
|
US9469631, 100
Show/Hide
|
C26H30N4O3
|
1
|
| 1 |
EC50 = 34 nM
|
|
|
|
CP0515223
|
US9469631, 128
Show/Hide
|
C24H29N3O4
|
1
|
| 1 |
EC50 = 34 nM
|
|
|
|
CP0500223
|
US8772323, 57
Show/Hide
|
C27H34N4O3
|
1
|
| 1 |
EC50 = 37 nM
|
|
|
|
CP0572558
|
US8772323, 171
Show/Hide
|
C24H27N3O3
|
1
|
| 1 |
EC50 = 37 nM
|
|
|
|
CP0556686
|
US8772323, 196
Show/Hide
|
C21H21N3O2
|
1
|
| 1 |
EC50 = 39 nM
|
|
|
|
CP0398257
|
US9469631, 102
Show/Hide
|
C27H33N3O4
|
1
|
| 1 |
EC50 = 39 nM
|
|
|
|
CP0951584
|
2-[1-(5-Chloropyrimidin-2-yl)-piperidin-4-yl]-5-(1-methanesulfonyl-1,2,3,6-tetrahydropyridin-4-yl)-furo[2,3-c]pyridine
Show/Hide
|
C22H24ClN5O3S
|
1
|
| 1 |
EC50 = 41 nM
|
|
|
|
CP0419372
|
US8772323, 191
Show/Hide
|
C21H22N4O2
|
1
|
| 1 |
EC50 = 41 nM
|
|
|
|
CP0564968
|
US8772323, 79
Show/Hide
|
C18H15N3O3
|
1
|
| 1 |
EC50 = 41 nM
|
|
|
|
CP0458549
|
US9469631, 70
Show/Hide
|
C25H31N3O3
|
1
|
| 1 |
EC50 = 41 nM
|
|
|
|
CP0484945
|
US8772323, 96
Show/Hide
|
C21H22N4O2
|
1
|
| 1 |
EC50 = 42 nM
|
|
|
|
CP0517227
|
US9469631, 110
Show/Hide
|
C27H33FN2O5S
|
1
|
| 1 |
EC50 = 44 nM
|
|
|
|
CP0963529
|
4-[5-(4-Ethylcarbamoylphenyl)-furo[2,3-c]pyridin-2-yl]piperidine-1-carboxylic acid tert-butyl ester
Show/Hide
|
C26H31N3O4
|
1
|
| 1 |
EC50 = 45 nM
|
|
|
|
CP0458553
|
US9469631, 35
Show/Hide
|
C23H28FN3O4
|
1
|
| 1 |
EC50 = 45 nM
|
|
|
|
CP0469771
|
US9469631, 121
Show/Hide
|
C24H31N3O4
|
1
|
| 1 |
EC50 = 45 nM
|
|
|
|
CP0469818
|
US9469631, 125
Show/Hide
|
C23H29N3O4
|
1
|
| 1 |
EC50 = 45 nM
|
|
|
|
CP0479345
|
US8772323, 223
Show/Hide
|
C29H36N4O4
|
1
|
| 1 |
EC50 = 46 nM
|
|
|
|
CP0572562
|
US8772323, 226
Show/Hide
|
C29H34N4O5
|
1
|
| 1 |
EC50 = 47 nM
|
|
|
|
CP0535961
|
US9469631, 113
Show/Hide
|
C26H30N4O3
|
1
|
| 1 |
EC50 = 48 nM
|
|
|
|
CP0517228
|
US9469631, 31
Show/Hide
|
C25H28N4O3
|
1
|
| 1 |
EC50 = 49 nM
|
|
|
|
CP0574691
|
US8772323, 205
Show/Hide
|
C17H18N4O3
|
1
|
| 1 |
EC50 = 50 nM
|
|
|
|
CP0868027
|
5-(2-Fluoro-4-methanesulfonylphenyl)-2-[1-(1-trifluoromethyl-cyclopropylmethyl)-piperidin-4-yl]furo[2,3-c]pyridine
Show/Hide
|
C24H24F4N2O3S
|
1
|
| 1 |
EC50 = 51 nM
|
|
|
|
CP0500218
|
US8772323, 195
Show/Hide
|
C24H25N3O4
|
1
|
| 1 |
EC50 = 51 nM
|
|
|
|
CP0512119
|
US8772323, 67
Show/Hide
|
C30H36N4O5
|
1
|
| 1 |
EC50 = 51 nM
|
|
|
|
CP0444906
|
US9469631, 103
Show/Hide
|
C29H37N3O4
|
1
|
| 1 |
EC50 = 51 nM
|
|
|
|
CP0484954
|
US8772323, 227
Show/Hide
|
C29H34N4O5
|
1
|
| 1 |
EC50 = 52 nM
|
|
|
|
CP0503829
|
US8772323, 200
Show/Hide
|
C28H27N3O3
|
1
|
| 1 |
EC50 = 52 nM
|
|
|
|
CP0469826
|
US9469631, 20
Show/Hide
|
C23H27N3O4
|
1
|
| 1 |
EC50 = 52 nM
|
|
|
|
CP0556685
|
US8772323, 170
Show/Hide
|
C29H38N4O3
|
1
|
| 1 |
EC50 = 53 nM
|
|
|
|
CP0567666
|
US8772323, 184
Show/Hide
|
C20H21N3O2S
|
1
|
| 1 |
EC50 = 53 nM
|
|
|
|
CP0547612
|
US8772323, 246
Show/Hide
|
C27H32N4O4
|
1
|
| 1 |
EC50 = 54 nM
|
|
|
|
CP0561667
|
US9469631, 99
Show/Hide
|
C25H32N4O4
|
1
|
| 1 |
EC50 = 55 nM
|
|
|
|
CP0500212
|
US8772323, 128
Show/Hide
|
C21H21N3O2
|
1
|
| 1 |
EC50 = 56 nM
|
|
|
|
CP0518540
|
US9469631, 37
Show/Hide
|
C28H36N2O5S
|
1
|
| 1 |
EC50 = 57 nM
|
|
|
|
CP0900481
|
4-[5-(4-Methanesulfonylphenyl)-furo[2,3-c]pyridin-2-yl]piperidine-1-carboxylic acid tert-butyl ester
Show/Hide
|
C24H28N2O5S
|
1
|
| 1 |
EC50 = 58 nM
|
|
|
|
CP0477842
|
US8772323, 36
Show/Hide
|
C25H21N3O3
|
1
|
| 1 |
EC50 = 58 nM
|
|
|
|
CP0569530
|
US8772323, 249
Show/Hide
|
C27H34N4O3
|
1
|
| 1 |
EC50 = 58 nM
|
|
|
|
CP0413350
|
US8772323, 99
Show/Hide
|
C22H23N3O3
|
1
|
| 1 |
EC50 = 59 nM
|
|
|
|
CP0458550
|
US9469631, 122
Show/Hide
|
C25H31N3O4
|
1
|
| 1 |
EC50 = 59 nM
|
|
|
|
CP0512664
|
US8772323, 68
Show/Hide
|
C29H34N4O5
|
1
|
| 1 |
EC50 = 60 nM
|
|
|
|
CP0512672
|
US8772323, 78
Show/Hide
|
C18H15N3O3
|
1
|
| 1 |
EC50 = 61 nM
|
|
|
|
CP0900610
|
4-[5-(3-Fluoro-4-methanesulfonylphenyl)-furo[2,3-c]pyridin-2-yl]piperidine-1-carboxylic acid tert-butyl ester
Show/Hide
|
C24H27FN2O5S
|
1
|
| 1 |
EC50 = 62 nM
|
|
|
|
CP0560768
|
US8772323, 247
Show/Hide
|
C25H28N4O3S
|
1
|
| 1 |
EC50 = 62 nM
|
|
|
|
CP0481127
|
US9469631, 118
Show/Hide
|
C22H27N3O4
|
1
|
| 1 |
EC50 = 62 nM
|
|
|
|
CP0965622
|
2-[1-(5-Ethylpyrimidin-2-yl)-piperidin-4-yl]-5-(2-fluoro-4-methanesulfonyl-phenyl)furo[2,3-c]pyridine
Show/Hide
|
C25H25FN4O3S
|
1
|
| 1 |
EC50 = 64 nM
|
|
|
|
CP0484942
|
US8772323, 31
Show/Hide
|
C19H17N3O2
|
1
|
| 1 |
EC50 = 66 nM
|
|
|
|
CP0499812
|
US9469631, 107
Show/Hide
|
C27H33N3O5
|
1
|
| 1 |
EC50 = 66 nM
|
|
|
|
CP0500224
|
US8772323, 95
Show/Hide
|
C25H21N3O3
|
1
|
| 1 |
EC50 = 67 nM
|
|
|
|
CP0517226
|
US9469631, 98
Show/Hide
|
C27H34N2O4
|
1
|
| 1 |
EC50 = 68 nM
|
|
|
|
CP0518571
|
US8772323, 232
Show/Hide
|
C27H32N4O4
|
1
|
| 1 |
EC50 = 69 nM
|
|
|
|
CP0555184
|
US8772323, 33
Show/Hide
|
C26H23N3O3
|
1
|
| 1 |
EC50 = 70 nM
|
|
|
|
CP0469827
|
US9469631, 120
Show/Hide
|
C26H27N3O5
|
1
|
| 1 |
EC50 = 71 nM
|
|
|
|
CP0918238
|
4-[5-(1-Methanesulfonyl-1,2,3,6-tetrahydropyridin-4-yl)furo[2,3-c]pyridin-2-y1]-4-methyl-piperidine-1-carboxylic acid tert-butyl ester
Show/Hide
|
C24H33N3O5S
|
1
|
| 1 |
EC50 = 73 nM
|
|
|
|
CP0490132
|
US8772323, 237
Show/Hide
|
C27H32N4O3
|
1
|
| 1 |
EC50 = 73 nM
|
|
|
|
CP0572478
|
US9469631, 21
Show/Hide
|
C26H33N3O5S
|
1
|
| 1 |
EC50 = 74 nM
|
|
|
|
CP0516348
|
US9469631, 10
Show/Hide
|
C24H31N3O4
|
1
|
| 1 |
EC50 = 75 nM
|
|
|
|
CP0516351
|
US9469631, 78
Show/Hide
|
C27H36N4O5
|
1
|
| 1 |
EC50 = 75 nM
|
|
|
|
CP0554529
|
US8772323, 58
Show/Hide
|
C30H38N4O3
|
1
|
| 1 |
EC50 = 76 nM
|
|
|
|
CP0516357
|
US9469631, 16
Show/Hide
|
C25H32N4O3
|
1
|
| 1 |
EC50 = 76 nM
|
|
|
|
CP0441919
|
US9469631, 7
Show/Hide
|
C23H28N4O6
|
1
|
| 1 |
EC50 = 78 nM
|
|
|
|
CP0497642
|
US9469631, 106
Show/Hide
|
C27H30FN3O3
|
1
|
| 1 |
EC50 = 78 nM
|
|
|
|
CP0967675
|
5-(2-FIuoro-4-methanesuIfonylphenyl)-2-[1-(2-fluoro-2-methylpropyl)-piperidin-4-yl]furo[2,3-c]pyridine
Show/Hide
|
C23H26F2N2O3S
|
1
|
| 1 |
EC50 = 79 nM
|
|
|
|
CP0479342
|
US8772323, 147
Show/Hide
|
C20H19N3O2
|
1
|
| 1 |
EC50 = 79 nM
|
|
|
|
CP0569526
|
US8772323, 190
Show/Hide
|
C20H19N3O3
|
1
|
| 1 |
EC50 = 79 nM
|
|
|
|
CP0498008
|
US9469631, 92
Show/Hide
|
C27H35N3O5S
|
1
|
| 1 |
EC50 = 79 nM
|
|
|
|
CP0413352
|
US8772323, 105
Show/Hide
|
C24H25N3O4
|
1
|
| 1 |
EC50 = 80 nM
|
|
|
|
CP0398239
|
US9469631, 123
Show/Hide
|
C22H27N3O4
|
1
|
| 1 |
EC50 = 80 nM
|
|
|
|
CP0498007
|
US9469631, 24
Show/Hide
|
C24H31N3O4
|
1
|
| 1 |
EC50 = 81 nM
|
|
|
|
CP0870013
|
4-[5-(4-Methanesulfonylpiperazin-1-yl)-furo[2,3-c]pyridin-2-yl]piperidine-1-carboxylic acid tert-butyl ester
Show/Hide
|
C22H32N4O5S
|
1
|
| 1 |
EC50 = 82 nM
|
|
|
|
CP0518561
|
US8772323, 176
Show/Hide
|
C24H25N3O3
|
1
|
| 1 |
EC50 = 82 nM
|
|
|
|
CP0566141
|
US8772323, 3
Show/Hide
|
C18H15N3O2
|
1
|
| 1 |
EC50 = 82 nM
|
|
|
|
CP0567699
|
US8772323, 188
Show/Hide
|
C19H19N3O3
|
1
|
| 1 |
EC50 = 83 nM
|
|
|
|
CP0419419
|
US8772323, 220
Show/Hide
|
C27H32N4O4
|
1
|
| 1 |
EC50 = 84 nM
|
|
|
|
CP0516350
|
US9469631, 54
Show/Hide
|
C27H31N3O3
|
1
|
| 1 |
EC50 = 84 nM
|
|
|
|
CP0517230
|
US9469631, 95
Show/Hide
|
C25H33N3O4
|
1
|
| 1 |
EC50 = 85 nM
|
|
|
|
CP0961967
|
4-[5-(1-MethanesuIfonyl-1,2,3,6-tetrahydropyridin-4-yl)-furo[2,3-c]pyridin-2-yl]-5'-trifluoromethyl-3.4,5,6-tetrahydro-2H-[1,2']bipyridinyl
Show/Hide
|
C24H25F3N4O3S
|
1
|
| 1 |
EC50 = 86 nM
|
|
|
|
CP0469825
|
US9469631, 91
Show/Hide
|
C28H33N3O3
|
1
|
| 1 |
EC50 = 86 nM
|
|
|
|
CP0554514
|
US8772323, 186
Show/Hide
|
C20H21N3O2S
|
1
|
| 1 |
EC50 = 88 nM
|
|
|
|
CP0498010
|
US9469631, 124
Show/Hide
|
C25H25N3O4
|
1
|
| 1 |
EC50 = 88 nM
|
|
|
|
CP0398270
|
US9469631, 119
Show/Hide
|
C25H24FN3O4
|
1
|
| 1 |
EC50 = 89 nM
|
|
|
|
CP0572559
|
US8772323, 174
Show/Hide
|
C22H23N3O3
|
1
|
| 1 |
EC50 = 92 nM
|
|
|
|
CP0419363
|
US8772323, 83
Show/Hide
|
C19H17N3O3
|
1
|
| 1 |
EC50 = 94 nM
|
|
|
|
CP0515220
|
US9469631, 84
Show/Hide
|
C30H36N4O3
|
1
|
| 1 |
EC50 = 96 nM
|
|
|
|
CP0571487
|
US8772323, 163
Show/Hide
|
C27H29N5O3
|
1
|
| 1 |
EC50 = 97 nM
|
|
|
|
CP0466132
|
US9469631, 57
Show/Hide
|
C23H29N3O4
|
1
|
| 1 |
EC50 = 99 nM
|
|
|
|
CP0490111
|
US8772323, 87
Show/Hide
|
C17H15N3O2S
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0564122
|
US9469631, 127
Show/Hide
|
C22H25N3O4
|
1
|
| 1 |
EC50 = 102 nM
|
|
|
|
CP0484955
|
US8772323, 235
Show/Hide
|
C27H32N4O3
|
1
|
| 1 |
EC50 = 104 nM
|
|
|
|
CP0516359
|
US9469631, 56
Show/Hide
|
C29H34N4O3
|
1
|
| 1 |
EC50 = 104 nM
|
|
|
|
CP0894567
|
4-[5-(4-Methanesulfonylmethylphenyl)-furo[2,3-c]pyridin-2-yl]piperidine-1-carboxylic acid tert-butyl ester
Show/Hide
|
C25H30N2O5S
|
1
|
| 1 |
EC50 = 105 nM
|
|
|
|
CP0419418
|
US8772323, 215
Show/Hide
|
C26H32N4O3
|
1
|
| 1 |
EC50 = 106 nM
|
|
|
|
CP0859912
|
4-[5-(2-Fluoro-4-aminocarbonyl-phenyl)-furo[2,3-c]pyridin-2-yI]piperidine-1-carboxylic acid tert-butyl ester
Show/Hide
|
C24H26FN3O4
|
1
|
| 1 |
EC50 = 108 nM
|
|
|
|
CP0553902
|
US8772323, 212
Show/Hide
|
C25H27N3O4
|
1
|
| 1 |
EC50 = 108 nM
|
|
|
|
CP0557396
|
US8772323, 252
Show/Hide
|
C20H22N4O2
|
1
|
| 1 |
EC50 = 110 nM
|
|
|
|
CP0535979
|
US9469631, 111
Show/Hide
|
C27H35N3O5S
|
1
|
| 1 |
EC50 = 111 nM
|
|
|
|
CP0503841
|
US8772323, 66
Show/Hide
|
C25H27N3O5
|
1
|
| 1 |
EC50 = 112 nM
|
|
|
|
CP0492898
|
US9469631, 129
Show/Hide
|
C26H31N3O4
|
1
|
| 1 |
EC50 = 113 nM
|
|
|
|
CP0567658
|
US8772323, 49
Show/Hide
|
C26H30N4O3
|
1
|
| 1 |
EC50 = 114 nM
|
|
|
|
CP0567660
|
US8772323, 94
Show/Hide
|
C21H21N3O3
|
1
|
| 1 |
EC50 = 114 nM
|
|
|
|
CP0398251
|
US9469631, 105
Show/Hide
|
C26H33N3O5S
|
1
|
| 1 |
EC50 = 115 nM
|
|
|
|
CP0503825
|
US8772323, 151
Show/Hide
|
C30H38N4O3
|
1
|
| 1 |
EC50 = 116 nM
|
|
|
|
CP0518562
|
US8772323, 182
Show/Hide
|
C21H20FN3O2
|
1
|
| 1 |
EC50 = 116 nM
|
|
|
|
CP0503827
|
US8772323, 165
Show/Hide
|
C30H37N5O5
|
1
|
| 1 |
EC50 = 118 nM
|
|
|
|
CP0413353
|
US8772323, 106
Show/Hide
|
C16H13N3O2S
|
1
|
| 1 |
EC50 = 120 nM
|
|
|
|
CP0500220
|
US8772323, 231
Show/Hide
|
C27H32N4O4
|
1
|
| 1 |
EC50 = 120 nM
|
|
|
|
CP0567069
|
US8772323, 104
Show/Hide
|
C20H19N3O3
|
1
|
| 1 |
EC50 = 120 nM
|
|
|
|
CP0950976
|
4-[5-(4-Methanesulfonylaminophenyl)-furo[2,3-c]pyridin-2-yl]piperidine-1-carboxylic acid tert-butyl ester
Show/Hide
|
C24H29N3O5S
|
1
|
| 1 |
EC50 = 121 nM
|
|
|
|
CP0503832
|
US8772323, 214
Show/Hide
|
C22H23N3O4
|
1
|
| 1 |
EC50 = 122 nM
|
|
|
|
CP0500215
|
US8772323, 160
Show/Hide
|
C29H38N4O3
|
1
|
| 1 |
EC50 = 124 nM
|
|
|
|
CP0458551
|
US9469631, 3
Show/Hide
|
C22H25N3O4
|
1
|
| 1 |
EC50 = 124 nM
|
|
|
|
CP0574690
|
US8772323, 189
Show/Hide
|
C21H23N3O3
|
1
|
| 1 |
EC50 = 127 nM
|
|
|
|
CP0458546
|
US9469631, 101
Show/Hide
|
C30H39N3O4
|
1
|
| 1 |
EC50 = 127 nM
|
|
|
|
CP0497644
|
US9469631, 63
Show/Hide
|
C22H29N5O3
|
1
|
| 1 |
EC50 = 127 nM
|
|
|
|
CP0516352
|
US9469631, 126
Show/Hide
|
C26H27N3O4
|
1
|
| 1 |
EC50 = 128 nM
|
|
|
|
CP0515221
|
US9469631, 96
Show/Hide
|
C26H33N3O4
|
1
|
| 1 |
EC50 = 131 nM
|
|
|
|
CP0503843
|
US8772323, 84
Show/Hide
|
C18H14ClN3O2
|
1
|
| 1 |
EC50 = 132 nM
|
|
|
|
CP0518566
|
US8772323, 202
Show/Hide
|
C18H20N4O2
|
1
|
| 1 |
EC50 = 133 nM
|
|
|
|
CP0567108
|
US8772323, 183
Show/Hide
|
C19H19N3O2S
|
1
|
| 1 |
EC50 = 134 nM
|
|
|
|
CP0567665
|
US8772323, 177
Show/Hide
|
C23H24N4O3
|
1
|
| 1 |
EC50 = 134 nM
|
|
|
|
CP0454612
|
US9469631, 22
Show/Hide
|
C21H30N6O3
|
1
|
| 1 |
EC50 = 137 nM
|
|
|
|
CP0459863
|
US9469631, 85
Show/Hide
|
C27H32N6O3
|
1
|
| 1 |
EC50 = 139 nM
|
|
|
|
CP0942773
|
4-[5-(4-Methanesulfonylphenyl)-furo[2,3-c]pyridin-2-yl]-4-methyl-piperidine-1-carboxylic acid tert-butyl ester
Show/Hide
|
C25H30N2O5S
|
1
|
| 1 |
EC50 = 140 nM
|
|
|
|
CP0556924
|
US8772323, 77
Show/Hide
|
C18H15N3O2S
|
1
|
| 1 |
EC50 = 141 nM
|
|
|
|
CP0490113
|
US8772323, 91
Show/Hide
|
C20H18FN3O3
|
1
|
| 1 |
EC50 = 142 nM
|
|
|
|
CP0518563
|
US8772323, 185
Show/Hide
|
C21H20ClN3O2
|
1
|
| 1 |
EC50 = 142 nM
|
|
|
|
CP0518947
|
US8772323, 69
Show/Hide
|
C29H34N4O5
|
1
|
| 1 |
EC50 = 143 nM
|
|
|
|
CP0512662
|
US8772323, 54
Show/Hide
|
C26H29N3O3
|
1
|
| 1 |
EC50 = 145 nM
|
|
|
|
CP0512660
|
US8772323, 35
Show/Hide
|
C26H23N3O3
|
1
|
| 1 |
EC50 = 148 nM
|
|
|
|
CP0561673
|
US9469631, 81
Show/Hide
|
C29H33ClN4O3
|
1
|
| 1 |
EC50 = 148 nM
|
|
|
|
CP0535966
|
US9469631, 43
Show/Hide
|
C24H31N3O4
|
1
|
| 1 |
EC50 = 149 nM
|
|
|
|
CP0441916
|
US9469631, 42
Show/Hide
|
C24H32N4O3
|
1
|
| 1 |
EC50 = 152 nM
|
|
|
|
CP0477838
|
US8772323, 18
Show/Hide
|
C18H12FN3O2
|
1
|
| 1 |
EC50 = 153 nM
|
|
|
|
CP0555226
|
US8772323, 13
Show/Hide
|
C19H15N3O2
|
1
|
| 1 |
EC50 = 153 nM
|
|
|
|
CP0574689
|
US8772323, 181
Show/Hide
|
C23H23N3O4
|
1
|
| 1 |
EC50 = 156 nM
|
|
|
|
CP0571013
|
US8772323, 20
Show/Hide
|
C18H12FN3O2
|
1
|
| 1 |
EC50 = 157 nM
|
|
|
|
CP0572477
|
US9469631, 1
Show/Hide
|
C24H31N3O4
|
1
|
| 1 |
EC50 = 157 nM
|
|
|
|
CP0569260
|
US8772323, 51
Show/Hide
|
C24H21N3O3S
|
1
|
| 1 |
EC50 = 158 nM
|
|
|
|
CP0451378
|
US9469631, 69
Show/Hide
|
C24H30N4O3
|
1
|
| 1 |
EC50 = 158 nM
|
|
|
|
CP0518574
|
US8772323, 248
Show/Hide
|
C26H29FN4O3
|
1
|
| 1 |
EC50 = 159 nM
|
|
|
|
CP0516346
|
US9469631, 97
Show/Hide
|
C30H41N3O5S
|
1
|
| 1 |
EC50 = 161 nM
|
|
|
|
CP0477840
|
US8772323, 26
Show/Hide
|
C19H17N3O2
|
1
|
| 1 |
EC50 = 166 nM
|
|
|
|
CP0564123
|
US9469631, 8
Show/Hide
|
C23H30N4O4
|
1
|
| 1 |
EC50 = 169 nM
|
|
|
|
CP0567659
|
US8772323, 56
Show/Hide
|
C27H31N3O3
|
1
|
| 1 |
EC50 = 170 nM
|
|
|
|
CP0564120
|
US9469631, 30
Show/Hide
|
C27H34N4O4
|
1
|
| 1 |
EC50 = 171 nM
|
|
|
|
CP0479344
|
US8772323, 187
Show/Hide
|
C19H19N3O2S
|
1
|
| 1 |
EC50 = 173 nM
|
|
|
|
CP0516349
|
US9469631, 38
Show/Hide
|
C23H28FN3O4
|
1
|
| 1 |
EC50 = 174 nM
|
|
|
|
CP0451381
|
US9469631, 93
Show/Hide
|
C27H34N2O5S
|
1
|
| 1 |
EC50 = 177 nM
|
|
|
|
CP0479340
|
US8772323, 29
Show/Hide
|
C19H17N3O2
|
1
|
| 1 |
EC50 = 181 nM
|
|
|
|
CP0518573
|
US8772323, 244
Show/Hide
|
C29H36N4O3
|
1
|
| 1 |
EC50 = 181 nM
|
|
|
|
CP0553883
|
US8772323, 240
Show/Hide
|
C27H32N4O3
|
1
|
| 1 |
EC50 = 186 nM
|
|
|
|
CP0413346
|
US8772323, 52
Show/Hide
|
C22H23N3O3
|
1
|
| 1 |
EC50 = 189 nM
|
|
|
|
CP0547611
|
US8772323, 82
Show/Hide
|
C18H15N3O2
|
1
|
| 1 |
EC50 = 189 nM
|
|
|
|
CP0518572
|
US8772323, 241
Show/Hide
|
C27H32N4O3
|
1
|
| 1 |
EC50 = 191 nM
|
|
|
|
CP0486383
|
US9469631, 68
Show/Hide
|
C29H34N4O4
|
1
|
| 1 |
EC50 = 192 nM
|
|
|
|
CP0413341
|
US8772323, 34
Show/Hide
|
C25H21N3O3
|
1
|
| 1 |
EC50 = 193 nM
|
|
|
|
CP0500225
|
US8772323, 101
Show/Hide
|
C18H17N3O2S
|
1
|
| 1 |
EC50 = 194 nM
|
|
|
|
CP0419422
|
US8772323, 243
Show/Hide
|
C27H32N4O3
|
1
|
| 1 |
EC50 = 197 nM
|
|
|
|
CP0492926
|
US9469631, 88
Show/Hide
|
C27H31F3N2O4
|
1
|
| 1 |
EC50 = 203 nM
|
|
|
|
CP0518569
|
US8772323, 221
Show/Hide
|
C26H30N4O4
|
1
|
| 1 |
EC50 = 204 nM
|
|
|
|
CP0512661
|
US8772323, 53
Show/Hide
|
C27H32N4O3
|
1
|
| 1 |
EC50 = 205 nM
|
|
|
|
CP0484952
|
US8772323, 145
Show/Hide
|
C20H19N3O2
|
1
|
| 1 |
EC50 = 209 nM
|
|
|
|
CP0477841
|
US8772323, 28
Show/Hide
|
C18H15N3O3
|
1
|
| 1 |
EC50 = 213 nM
|
|
|
|
CP0451336
|
US9469631, 58
Show/Hide
|
C24H30N2O3S
|
1
|
| 1 |
EC50 = 214 nM
|
|
|
|
CP0484953
|
US8772323, 173
Show/Hide
|
C28H34N4O3
|
1
|
| 1 |
EC50 = 218 nM
|
|
|
|
CP0535968
|
US9469631, 36
Show/Hide
|
C23H27F2N3O4
|
1
|
| 1 |
EC50 = 219 nM
|
|
|
|
CP0451335
|
US9469631, 117
Show/Hide
|
C21H25N3O4
|
1
|
| 1 |
EC50 = 222 nM
|
|
|
|
CP0567066
|
US8772323, 50
Show/Hide
|
C25H25N5O4
|
1
|
| 1 |
EC50 = 223 nM
|
|
|
|
CP0571012
|
US8772323, 17
Show/Hide
|
C18H12FN3O2
|
1
|
| 1 |
EC50 = 223 nM
|
|
|
|
CP0458548
|
US9469631, 26
Show/Hide
|
C22H32N6O3
|
1
|
| 1 |
EC50 = 224 nM
|
|
|
|
CP0503847
|
US8772323, 97
Show/Hide
|
C18H17N3O2S
|
1
|
| 1 |
EC50 = 225 nM
|
|
|
|
CP0477844
|
US8772323, 47
Show/Hide
|
C25H22N4O3
|
1
|
| 1 |
EC50 = 226 nM
|
|
|
|
CP0391301
|
(3,3-difluoroazetidin-1-yl)-[4-[2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-5-yl]phenyl]methanone
Show/Hide
|
C29H30F2N4O2
|
1
|
| 1 |
EC50 = 228 nM
|
|
|
|
CP0441917
|
US9469631, 90
Show/Hide
|
C24H30N2O4
|
1
|
| 1 |
EC50 = 228 nM
|
|
|
|
CP0498038
|
US9469631, 114
Show/Hide
|
C27H36N4O3
|
1
|
| 1 |
EC50 = 229 nM
|
|
|
|
CP0564972
|
US8772323, 225
Show/Hide
|
C29H34N4O3
|
1
|
| 1 |
EC50 = 231 nM
|
|
|
|
CP0904329
|
4-[5-(3-Fluoropyridin-4-yl)-furo[2,3-c]pyridin-2-yl]piperidine-1-carboxylic acid tertbutyl ester
Show/Hide
|
C22H24FN3O3
|
1
|
| 1 |
EC50 = 233 nM
|
|
|
|
CP0458559
|
US9469631, 76
Show/Hide
|
C25H34N6O4S
|
1
|
| 1 |
EC50 = 233 nM
|
|
|
|
CP0553884
|
US8772323, 250
Show/Hide
|
C27H32N4O3
|
1
|
| 1 |
EC50 = 235 nM
|
|
|
|
CP0516355
|
US9469631, 23
Show/Hide
|
C24H30N4O3
|
1
|
| 1 |
EC50 = 236 nM
|
|
|
|
CP0571485
|
US8772323, 64
Show/Hide
|
C25H28N4O4
|
1
|
| 1 |
EC50 = 237 nM
|
|
|
|
CP0454605
|
US9469631, 25
Show/Hide
|
C22H28N4O4
|
1
|
| 1 |
EC50 = 238 nM
|
|
|
|
CP0567067
|
US8772323, 74
Show/Hide
|
C26H30N4O5S
|
1
|
| 1 |
EC50 = 240 nM
|
|
|
|
CP0486382
|
US9469631, 12
Show/Hide
|
C23H30N4O3
|
1
|
| 1 |
EC50 = 240 nM
|
|
|
|
CP0553482
|
US8772323, 213
Show/Hide
|
C22H21N3O3
|
1
|
| 1 |
EC50 = 241 nM
|
|
|
|
CP0547606
|
US8772323, 5
Show/Hide
|
C18H13N3O2
|
1
|
| 1 |
EC50 = 243 nM
|
|
|
|
CP0477847
|
US8772323, 76
Show/Hide
|
C27H25N3O2
|
1
|
| 1 |
EC50 = 245 nM
|
|
|
|
CP0571482
|
US8772323, 12
Show/Hide
|
C19H15N3O2
|
1
|
| 1 |
EC50 = 246 nM
|
|
|
|
CP0419416
|
US8772323, 156
Show/Hide
|
C29H38N4O3
|
1
|
| 1 |
EC50 = 248 nM
|
|
|
|
CP0469824
|
US9469631, 87
Show/Hide
|
C28H36N2O4
|
1
|
| 1 |
EC50 = 256 nM
|
|
|
|
CP0503844
|
US8772323, 88
Show/Hide
|
C18H14ClN3O2
|
1
|
| 1 |
EC50 = 260 nM
|
|
|
|
CP0968901
|
4-[5-(4-Cyano-3-fluorophenyl)-furo[2,3-c]pyridin-2-yl]piperidine-1-carboxylic acid tert-butyl ester
Show/Hide
|
C24H24FN3O3
|
1
|
| 1 |
EC50 = 263 nM
|
|
|
|
CP0503837
|
US8772323, 14
Show/Hide
|
C20H17N3O2
|
1
|
| 1 |
EC50 = 264 nM
|
|
|
|
CP0484946
|
US8772323, 107
Show/Hide
|
C16H13N3O2S
|
1
|
| 1 |
EC50 = 267 nM
|
|
|
|
CP0413343
|
US8772323, 40
Show/Hide
|
C24H21N5O3
|
1
|
| 1 |
EC50 = 275 nM
|
|
|
|
CP0535970
|
US9469631, 64
Show/Hide
|
C24H31N3O3
|
1
|
| 1 |
EC50 = 278 nM
|
|
|
|
CP0942774
|
4-[5-(4-Cyano-2-fluorophenyl)-furo[2,3-c]pyridin-2-yl]piperidine-1-carboxylic acid tert-butyl ester
Show/Hide
|
C24H24FN3O3
|
1
|
| 1 |
EC50 = 281 nM
|
|
|
|
CP0419371
|
US8772323, 180
Show/Hide
|
C22H23N3O3
|
1
|
| 1 |
EC50 = 290 nM
|
|
|
|
CP0469823
|
US9469631, 83
Show/Hide
|
C30H36N4O3
|
1
|
| 1 |
EC50 = 291 nM
|
|
|
|
CP0503826
|
US8772323, 161
Show/Hide
|
C27H32N4O3
|
1
|
| 1 |
EC50 = 293 nM
|
|
|
|
CP0567068
|
US8772323, 98
Show/Hide
|
C20H18FN3O3
|
1
|
| 1 |
EC50 = 294 nM
|
|
|
|
CP0500221
|
US8772323, 242
Show/Hide
|
C25H28N4O3
|
1
|
| 1 |
EC50 = 296 nM
|
|
|
|
CP0518575
|
US8772323, 251
Show/Hide
|
C22H23N3O4
|
1
|
| 1 |
EC50 = 296 nM
|
|
|
|
CP0444907
|
US9469631, 44
Show/Hide
|
C23H29N3O4
|
1
|
| 1 |
EC50 = 298 nM
|
|
|
|
CP0419420
|
US8772323, 222
Show/Hide
|
C25H30N4O3
|
1
|
| 1 |
EC50 = 299 nM
|
|
|
|
CP0557004
|
US8772323, 253
Show/Hide
|
C18H21N3O2
|
1
|
| 1 |
EC50 = 299 nM
|
|
|
|
CP0419367
|
US8772323, 133
Show/Hide
|
C18H17N3O2
|
1
|
| 1 |
EC50 = 300 nM
|
|
|
|
CP0500211
|
US8772323, 126
Show/Hide
|
C20H19N3O2
|
1
|
| 1 |
EC50 = 306 nM
|
|
|
|
CP0572563
|
US8772323, 234
Show/Hide
|
C26H30N4O3
|
1
|
| 1 |
EC50 = 306 nM
|
|
|
|
CP0863198
|
4-(5-Pyridin-4-yl-furo[2,3-c]pyridin-2-yl)-piperidine-1-carboxylic acid tert-butyl ester
Show/Hide
|
C22H25N3O3
|
1
|
| 1 |
EC50 = 310 nM
|
|
|
|
CP0518567
|
US8772323, 209
Show/Hide
|
C26H30N4O3
|
1
|
| 1 |
EC50 = 311 nM
|
|
|
|
CP0553489
|
US8772323, 16
Show/Hide
|
C17H13N3O2
|
1
|
| 1 |
EC50 = 314 nM
|
|
|
|
CP0560760
|
US8772323, 102
Show/Hide
|
C20H19N3O3
|
1
|
| 1 |
EC50 = 316 nM
|
|
|
|
CP0458547
|
US9469631, 109
Show/Hide
|
C27H35N3O4
|
1
|
| 1 |
EC50 = 316 nM
|
|
|
|
CP0565769
|
US9469631, 67
Show/Hide
|
C23H30N4O4
|
1
|
| 1 |
EC50 = 316 nM
|
|
|
|
CP0535965
|
US9469631, 94
Show/Hide
|
C27H31N3O3
|
1
|
| 1 |
EC50 = 317 nM
|
|
|
|
CP0567085
|
US8772323, 224
Show/Hide
|
C29H36N4O3
|
1
|
| 1 |
EC50 = 319 nM
|
|
|
|
CP0571484
|
US8772323, 63
Show/Hide
|
C23H20N4O4
|
1
|
| 1 |
EC50 = 324 nM
|
|
|
|
CP0556700
|
US8772323, 39
Show/Hide
|
C19H17N3O3
|
1
|
| 1 |
EC50 = 329 nM
|
|
|
|
CP0516356
|
US9469631, 59
Show/Hide
|
C23H29N3O3S
|
1
|
| 1 |
EC50 = 332 nM
|
|
|
|
CP0490130
|
US8772323, 194
Show/Hide
|
C24H25N3O4
|
1
|
| 1 |
EC50 = 333 nM
|
|
|
|
CP0535971
|
US9469631, 104
Show/Hide
|
C29H37N3O4
|
1
|
| 1 |
EC50 = 333 nM
|
|
|
|
CP0484943
|
US8772323, 85
Show/Hide
|
C19H17N3O3
|
1
|
| 1 |
EC50 = 334 nM
|
|
|
|
CP0503840
|
US8772323, 61
Show/Hide
|
C26H28N4O4
|
1
|
| 1 |
EC50 = 342 nM
|
|
|
|
CP0477843
|
US8772323, 46
Show/Hide
|
C25H22N4O3
|
1
|
| 1 |
EC50 = 345 nM
|
|
|
|
CP0458561
|
US9469631, 80
Show/Hide
|
C24H30N2O3S
|
1
|
| 1 |
EC50 = 345 nM
|
|
|
|
CP0413354
|
US8772323, 108
Show/Hide
|
C16H13N3O3
|
1
|
| 1 |
EC50 = 346 nM
|
|
|
|
CP0499880
|
US9469631, 60
Show/Hide
|
C23H30N4O4
|
1
|
| 1 |
EC50 = 347 nM
|
|
|
|
CP0547608
|
US8772323, 48
Show/Hide
|
C24H21N3O3S
|
1
|
| 1 |
EC50 = 348 nM
|
|
|
|
CP0569254
|
US8772323, 10
Show/Hide
|
C19H15N3O2
|
1
|
| 1 |
EC50 = 365 nM
|
|
|
|
CP0413356
|
US8772323, 121
Show/Hide
|
C21H20ClN5O3
|
1
|
| 1 |
EC50 = 379 nM
|
|
|
|
CP0564967
|
US8772323, 75
Show/Hide
|
C27H23N3O2
|
1
|
| 1 |
EC50 = 384 nM
|
|
|
|
CP0477849
|
US8772323, 135
Show/Hide
|
C17H16N4O2
|
1
|
| 1 |
EC50 = 391 nM
|
|
|
|
CP0451380
|
US9469631, 77
Show/Hide
|
C24H31N5O4S
|
1
|
| 1 |
EC50 = 394 nM
|
|
|
|
CP0556932
|
US8772323, 211
Show/Hide
|
C22H23N3O4
|
1
|
| 1 |
EC50 = 395 nM
|
|
|
|
CP0413349
|
US8772323, 93
Show/Hide
|
C20H18FN3O3
|
1
|
| 1 |
EC50 = 397 nM
|
|
|
|
CP0500213
|
US8772323, 143
Show/Hide
|
C16H12N4O2
|
1
|
| 1 |
EC50 = 397 nM
|
|
|
|
CP0419421
|
US8772323, 229
Show/Hide
|
C27H32N4O3
|
1
|
| 1 |
EC50 = 398 nM
|
|
|
|
CP0561665
|
US9469631, 86
Show/Hide
|
C27H34N2O4
|
1
|
| 1 |
EC50 = 401 nM
|
|
|
|
CP0498037
|
US9469631, 82
Show/Hide
|
C24H32N6O4S
|
1
|
| 1 |
EC50 = 402 nM
|
|
|
|
CP0490131
|
US8772323, 204
Show/Hide
|
C17H11N3O2
|
1
|
| 1 |
EC50 = 414 nM
|
|
|
|
CP0484944
|
US8772323, 89
Show/Hide
|
C18H14ClN3O2
|
1
|
| 1 |
EC50 = 415 nM
|
|
|
|
CP0451377
|
US9469631, 13
Show/Hide
|
C24H32N4O3
|
1
|
| 1 |
EC50 = 423 nM
|
|
|
|
CP0557763
|
US8772323, 154
Show/Hide
|
C27H34N4O3
|
1
|
| 1 |
EC50 = 424 nM
|
|
|
|
CP0547610
|
US8772323, 65
Show/Hide
|
C25H22N4O3
|
1
|
| 1 |
EC50 = 426 nM
|
|
|
|
CP0571492
|
US8772323, 245
Show/Hide
|
C31H38N4O3
|
1
|
| 1 |
EC50 = 434 nM
|
|
|
|
CP0518568
|
US8772323, 219
Show/Hide
|
C25H30N4O3
|
1
|
| 1 |
EC50 = 438 nM
|
|
|
|
CP0512673
|
US8772323, 100
Show/Hide
|
C22H23N3O3
|
1
|
| 1 |
EC50 = 442 nM
|
|
|
|
CP0512116
|
US8772323, 27
Show/Hide
|
C18H15N3O3
|
1
|
| 1 |
EC50 = 444 nM
|
|
|
|
CP0565331
|
US8772323, 257
Show/Hide
|
C15H9N3O2S
|
1
|
| 1 |
EC50 = 456 nM
|
|
|
|
CP0560759
|
US8772323, 92
Show/Hide
|
C21H21N3O4
|
1
|
| 1 |
EC50 = 460 nM
|
|
|
|
CP0486384
|
US9469631, 108
Show/Hide
|
C25H31N3O4
|
1
|
| 1 |
EC50 = 461 nM
|
|
|
|
CP0413358
|
US8772323, 175
Show/Hide
|
C22H23N3O2
|
1
|
| 1 |
EC50 = 462 nM
|
|
|
|
CP0413340
|
US8772323, 19
Show/Hide
|
C19H14FN3O2
|
1
|
| 1 |
EC50 = 469 nM
|
|
|
|
CP0469820
|
US9469631, 27
Show/Hide
|
C25H32N4O3
|
1
|
| 1 |
EC50 = 469 nM
|
|
|
|
CP0547609
|
US8772323, 55
Show/Hide
|
C23H26N4O3
|
1
|
| 1 |
EC50 = 486 nM
|
|
|
|
CP0569525
|
US8772323, 137
Show/Hide
|
C24H24N4O4
|
1
|
| 1 |
EC50 = 497 nM
|
|
|
|
CP0451379
|
US9469631, 73
Show/Hide
|
C24H32N6O4S
|
1
|
| 1 |
EC50 = 500 nM
|
|
|
|
CP0535960
|
US9469631, 61
Show/Hide
|
C23H30N4O4
|
1
|
| 1 |
EC50 = 513 nM
|
|
|
|
CP0454614
|
US9469631, 11
Show/Hide
|
C24H29N3O5
|
1
|
| 1 |
EC50 = 516 nM
|
|
|
|
CP0556704
|
US8772323, 142
Show/Hide
|
C17H14N4O2
|
1
|
| 1 |
EC50 = 539 nM
|
|
|
|
CP0503833
|
US8772323, 228
Show/Hide
|
C27H32N4O3
|
1
|
| 1 |
EC50 = 549 nM
|
|
|
|
CP0419370
|
US8772323, 164
Show/Hide
|
C27H30N4O3
|
1
|
| 1 |
EC50 = 552 nM
|
|
|
|
CP0574685
|
US8772323, 62
Show/Hide
|
C24H28N4O3
|
1
|
| 1 |
EC50 = 552 nM
|
|
|
|
CP0965662
|
4-[5-(4-Benzyloxycarbonylphenyl)-furo[2,3-c]pyridin-2-yl]piperidine-1-carboxylic acid tert-butyl ester
Show/Hide
|
C31H32N2O5
|
1
|
| 1 |
EC50 = 567 nM
|
|
|
|
CP0503824
|
US8772323, 149
Show/Hide
|
C27H32N4O3
|
1
|
| 1 |
EC50 = 567 nM
|
|
|
|
CP0556931
|
US8772323, 207
Show/Hide
|
C17H18N4O3
|
1
|
| 1 |
EC50 = 578 nM
|
|
|
|
CP0491464
|
US8772323, 210
Show/Hide
|
C26H30N4O3
|
1
|
| 1 |
EC50 = 590 nM
|
|
|
|
CP0967871
|
4-(5-Oxazol-5-yl-furo[2,3-c]pyridin-2-yl)-piperidine-1-carboxylic acid tert-butyl ester
Show/Hide
|
C20H23N3O4
|
1
|
| 1 |
EC50 = 592 nM
|
|
|
|
CP0547605
|
US8772323, 4
Show/Hide
|
C18H15N3O2
|
1
|
| 1 |
EC50 = 596 nM
|
|
|
|
CP0413359
|
US8772323, 258
Show/Hide
|
C27H34N4O3
|
1
|
| 1 |
EC50 = 605 nM
|
|
|
|
CP0574686
|
US8772323, 80
Show/Hide
|
C18H15N3O3
|
1
|
| 1 |
EC50 = 615 nM
|
|
|
|
CP0490116
|
US8772323, 166
Show/Hide
|
C29H37N5O3
|
1
|
| 1 |
EC50 = 621 nM
|
|
|
|
CP0553897
|
US8772323, 159
Show/Hide
|
C25H28N4O3
|
1
|
| 1 |
EC50 = 623 nM
|
|
|
|
CP0497643
|
US9469631, 39
Show/Hide
|
C23H28FN3O4
|
1
|
| 1 |
EC50 = 634 nM
|
|
|
|
CP0413342
|
US8772323, 37
Show/Hide
|
C19H17N3O3
|
1
|
| 1 |
EC50 = 636 nM
|
|
|
|
CP0535967
|
US9469631, 71
Show/Hide
|
C23H30N4O3
|
1
|
| 1 |
EC50 = 637 nM
|
|
|
|
CP0477845
|
US8772323, 60
Show/Hide
|
C25H22N4O3
|
1
|
| 1 |
EC50 = 639 nM
|
|
|
|
CP0491465
|
US8772323, 216
Show/Hide
|
C27H32N4O4
|
1
|
| 1 |
EC50 = 639 nM
|
|
|
|
CP0451376
|
US9469631, 9
Show/Hide
|
C24H31N3O5
|
1
|
| 1 |
EC50 = 650 nM
|
|
|
|
CP0535964
|
US9469631, 62
Show/Hide
|
C22H28N4O4
|
1
|
| 1 |
EC50 = 650 nM
|
|
|
|
CP0469822
|
US9469631, 75
Show/Hide
|
C25H31N3O3
|
1
|
| 1 |
EC50 = 651 nM
|
|
|
|
CP0497638
|
US9469631, 65
Show/Hide
|
C24H30N2O4
|
1
|
| 1 |
EC50 = 659 nM
|
|
|
|
CP0477836
|
US8772323, 1
Show/Hide
|
C18H15N3O2
|
1
|
| 1 |
EC50 = 660 nM
|
|
|
|
CP0569255
|
US8772323, 15
Show/Hide
|
C24H24N4O2
|
1
|
| 1 |
EC50 = 701 nM
|
|
|
|
CP0419369
|
US8772323, 153
Show/Hide
|
C27H29N5O3
|
1
|
| 1 |
EC50 = 735 nM
|
|
|
|
CP0571488
|
US8772323, 172
Show/Hide
|
C29H36N4O3
|
1
|
| 1 |
EC50 = 755 nM
|
|
|
|
CP0490112
|
US8772323, 90
Show/Hide
|
C20H17N3O4
|
1
|
| 1 |
EC50 = 763 nM
|
|
|
|
CP0555225
|
US8772323, 2
Show/Hide
|
C18H15N3O2
|
1
|
| 1 |
EC50 = 787 nM
|
|
|
|
CP0413345
|
US8772323, 45
Show/Hide
|
C25H22N4O3
|
1
|
| 1 |
EC50 = 807 nM
|
|
|
|
CP0560764
|
US8772323, 130
Show/Hide
|
C18H17N3O2
|
1
|
| 1 |
EC50 = 814 nM
|
|
|
|
CP0398271
|
US9469631, 4
Show/Hide
|
C23H28IN3O4
|
1
|
| 1 |
EC50 = 816 nM
|
|
|
|
CP0571489
|
US8772323, 199
Show/Hide
|
C28H27N3O3
|
1
|
| 1 |
EC50 = 832 nM
|
|
|
|
CP0444908
|
US9469631, 52
Show/Hide
|
C23H30N4O3
|
1
|
| 1 |
EC50 = 832 nM
|
|
|
|
CP0503836
|
US8772323, 9
Show/Hide
|
C20H19N3O2
|
1
|
| 1 |
EC50 = 834 nM
|
|
|
|
CP0554515
|
US8772323, 218
Show/Hide
|
C26H32N4O3
|
1
|
| 1 |
EC50 = 840 nM
|
|
|
|
CP0574698
|
US8772323, 233
Show/Hide
|
C26H30N4O3
|
1
|
| 1 |
EC50 = 848 nM
|
|
|
|
CP0561666
|
US9469631, 47
Show/Hide
|
C24H31N3O4
|
1
|
| 1 |
EC50 = 855 nM
|
|
|
|
CP0512118
|
US8772323, 32
Show/Hide
|
C20H19N3O2
|
1
|
| 1 |
EC50 = 869 nM
|
|
|
|
CP0571481
|
US8772323, 8
Show/Hide
|
C20H19N3O2
|
1
|
| 1 |
EC50 = 874 nM
|
|
|
|
CP0469819
|
US9469631, 66
Show/Hide
|
C22H29N5O3S
|
1
|
| 1 |
EC50 = 875 nM
|
|
|
|
CP0445047
|
US9469631, 5
Show/Hide
|
C24H31N3O4
|
1
|
| 1 |
EC50 = 884 nM
|
|
|
|
CP0517225
|
US9469631, 74
Show/Hide
|
C24H31N5O4S
|
1
|
| 1 |
EC50 = 886 nM
|
|
|
|
CP0547607
|
US8772323, 38
Show/Hide
|
C18H15N3O3
|
1
|
| 1 |
EC50 = 890 nM
|
|
|
|
CP0512115
|
US8772323, 7
Show/Hide
|
C20H17N3O2
|
1
|
| 1 |
EC50 = 892 nM
|
|
|
|
CP0518565
|
US8772323, 198
Show/Hide
|
C21H19N3O2
|
1
|
| 1 |
EC50 = 896 nM
|
|
|
|
CP0560763
|
US8772323, 123
Show/Hide
|
C19H14N4O2
|
1
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| 1 |
EC50 = 902 nM
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CP0469821
|
US9469631, 55
Show/Hide
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C25H34N4O3
|
1
|
| 1 |
EC50 = 927 nM
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CP0503830
|
US8772323, 203
Show/Hide
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C21H21N3O3
|
1
|
| 1 |
EC50 = 962 nM
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CP0484947
|
US8772323, 111
Show/Hide
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C15H11N3O2S
|
1
|
| 1 |
EC50 = 967 nM
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CP0549759
|
US8772323, 144
Show/Hide
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C18H16N4O2
|
1
|
| 1 |
EC50 = 987 nM
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CP0535978
|
US9469631, 18
Show/Hide
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C23H31N5O3
|
1
|
| 1 |
EC50 = 1002 nM
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CP0517229
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US9469631, 79
Show/Hide
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C28H38N4O5
|
1
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| 1 |
EC50 = 1014 nM
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CP0554513
|
US8772323, 167
Show/Hide
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C25H26N4O4
|
1
|
| 1 |
EC50 = 1032 nM
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CP0560766
|
US8772323, 169
Show/Hide
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C29H38N4O3
|
1
|
| 1 |
EC50 = 1035 nM
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CP0556701
|
US8772323, 43
Show/Hide
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C22H22N4O4
|
1
|
| 1 |
EC50 = 1075 nM
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CP0567071
|
US8772323, 152
Show/Hide
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C27H32N4O3
|
1
|
| 1 |
EC50 = 1075 nM
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CP0497641
|
US9469631, 14
Show/Hide
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C25H31N3O5
|
1
|
| 1 |
EC50 = 1081 nM
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CP0481128
|
US9469631, 115
Show/Hide
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C26H31N3O5
|
1
|
| 1 |
EC50 = 1088 nM
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CP0503839
|
US8772323, 44
Show/Hide
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C26H31N5O3
|
1
|
| 1 |
EC50 = 1093 nM
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CP0491466
|
US8772323, 236
Show/Hide
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C27H32N4O3
|
1
|
| 1 |
EC50 = 1097 nM
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CP0491463
|
US8772323, 197
Show/Hide
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C22H23N3O2
|
1
|
| 1 |
EC50 = 1114 nM
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CP0560761
|
US8772323, 115
Show/Hide
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C17H20N4O2
|
1
|
| 1 |
EC50 = 1130 nM
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|
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CP0490110
|
US8772323, 86
Show/Hide
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C19H17N3O3
|
1
|
| 1 |
EC50 = 1146 nM
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CP0458557
|
US9469631, 72
Show/Hide
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C25H34N6O4S
|
1
|
| 1 |
EC50 = 1172 nM
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CP0518570
|
US8772323, 230
Show/Hide
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C27H32N4O3
|
1
|
| 1 |
EC50 = 1187 nM
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CP0413351
|
US8772323, 103
Show/Hide
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C20H16F3N3O3
|
1
|
| 1 |
EC50 = 1208 nM
|
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CP0419368
|
US8772323, 150
Show/Hide
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C25H22N4O3
|
1
|
| 1 |
EC50 = 1263 nM
|
|
|
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CP0484951
|
US8772323, 138
Show/Hide
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C19H20N4O2
|
1
|
| 1 |
EC50 = 1306 nM
|
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|
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CP0500209
|
US8772323, 112
Show/Hide
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C15H11N3O3
|
1
|
| 1 |
EC50 = 1324 nM
|
|
|
|
CP0479341
|
US8772323, 120
Show/Hide
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C17H12Cl2N4O2
|
1
|
| 1 |
EC50 = 1342 nM
|
|
|
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CP0567065
|
US8772323, 23
Show/Hide
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C28H31N5O4
|
1
|
| 1 |
EC50 = 1346 nM
|
|
|
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CP0503849
|
US8772323, 109
Show/Hide
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C17H15N5O2
|
1
|
| 1 |
EC50 = 1412 nM
|
|
|
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CP0413344
|
US8772323, 41
Show/Hide
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C23H24N4O4
|
1
|
| 1 |
EC50 = 1523 nM
|
|
|
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CP0560765
|
US8772323, 139
Show/Hide
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C16H13N3O2S
|
1
|
| 1 |
EC50 = 1557 nM
|
|
|
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CP0500214
|
US8772323, 148
Show/Hide
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C26H30N4O3
|
1
|
| 1 |
EC50 = 1559 nM
|
|
|
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CP0515222
|
US9469631, 116
Show/Hide
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C20H23N3O4
|
1
|
| 1 |
EC50 = 1571 nM
|
|
|
|
CP0566142
|
US8772323, 59
Show/Hide
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C24H21N5O3
|
1
|
| 1 |
EC50 = 1588 nM
|
|
|
|
CP0490115
|
US8772323, 125
Show/Hide
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C19H18N4O2
|
1
|
| 1 |
EC50 = 1600 nM
|
|
|
|
CP0556927
|
US8772323, 134
Show/Hide
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C18H17N3O2
|
1
|
| 1 |
EC50 = 1627 nM
|
|
|
|
CP0574699
|
US8772323, 239
Show/Hide
|
C24H26N4O3
|
1
|
| 1 |
EC50 = 1649 nM
|
|
|
|
CP0553521
|
US8772323, 6
Show/Hide
|
C19H15N3O2
|
1
|
| 1 |
EC50 = 1702 nM
|
|
|
|
CP0564125
|
US9469631, 112
Show/Hide
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C29H39N3O3
|
1
|
| 1 |
EC50 = 1742 nM
|
|
|
|
CP0571483
|
US8772323, 22
Show/Hide
|
C23H22N4O3
|
1
|
| 1 |
EC50 = 1750 nM
|
|
|
|
CP0516354
|
US9469631, 19
Show/Hide
|
C26H31N3O5S
|
1
|
| 1 |
EC50 = 1768 nM
|
|
|
|
CP0477846
|
US8772323, 72
Show/Hide
|
C24H26N4O3
|
1
|
| 1 |
EC50 = 1814 nM
|
|
|
|
CP0490114
|
US8772323, 113
Show/Hide
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C16H18N4O2S
|
1
|
| 1 |
EC50 = 1899 nM
|
|
|
|
CP0567073
|
US8772323, 158
Show/Hide
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C27H25N3O5S
|
1
|
| 1 |
EC50 = 1963 nM
|
|
|
|
CP0477850
|
US8772323, 136
Show/Hide
|
C19H15N3O2
|
1
|
| 1 |
EC50 = 2016 nM
|
|
|
|
CP0564970
|
US8772323, 157
Show/Hide
|
C29H37N5O3
|
1
|
| 1 |
EC50 = 2031 nM
|
|
|
|
CP0558644
|
US9469631, 17
Show/Hide
|
C23H31N5O3
|
1
|
| 1 |
EC50 = 2222 nM
|
|
|
|
CP0553898
|
US8772323, 114
Show/Hide
|
C19H23N5O4
|
1
|
| 1 |
EC50 = 2288 nM
|
|
|
|
CP0503838
|
US8772323, 25
Show/Hide
|
C19H17N3O2
|
1
|
| 1 |
EC50 = 2370 nM
|
|
|
|
CP0572560
|
US8772323, 217
Show/Hide
|
C25H30N4O3
|
1
|
| 1 |
EC50 = 2414 nM
|
|
|
|
CP0519544
|
US8772323, 127
Show/Hide
|
C20H19N3O2
|
1
|
| 1 |
EC50 = 2590 nM
|
|
|
|
CP0490133
|
US8772323, 238
Show/Hide
|
C24H26N4O3
|
1
|
| 1 |
EC50 = 2953 nM
|
|
|
|
CP0494896
|
US8772323, 168
Show/Hide
|
C28H35N5O3
|
1
|
| 1 |
EC50 = 3011 nM
|
|
|
|
CP0571490
|
US8772323, 201
Show/Hide
|
C25H28N4O3
|
1
|
| 1 |
EC50 = 3033 nM
|
|
|
|
CP0484948
|
US8772323, 116
Show/Hide
|
C16H18N4O3
|
1
|
| 1 |
EC50 = 3446 nM
|
|
|
|
CP0512674
|
US8772323, 119
Show/Hide
|
C15H16N4O2S
|
1
|
| 1 |
EC50 = 3464 nM
|
|
|
|
CP0569522
|
US8772323, 118
Show/Hide
|
C16H18N4O2
|
1
|
| 1 |
EC50 = 3741 nM
|
|
|
|
CP0479343
|
US8772323, 179
Show/Hide
|
C23H25N3O3
|
1
|
| 1 |
EC50 = 3841 nM
|
|
|
|
CP0503842
|
US8772323, 70
Show/Hide
|
C21H19N3O5
|
1
|
| 1 |
EC50 = 3911 nM
|
|
|
|
CP0484949
|
US8772323, 122
Show/Hide
|
C19H14N4O2
|
1
|
| 1 |
EC50 = 3997 nM
|
|
|
|
CP0419366
|
US8772323, 132
Show/Hide
|
C18H17N3O2
|
1
|
| 1 |
EC50 = 4158 nM
|
|
|
|
CP0557762
|
US8772323, 42
Show/Hide
|
C24H23N5O3
|
1
|
| 1 |
EC50 = 4176 nM
|
|
|
|
CP0458552
|
US9469631, 15
Show/Hide
|
C23H29N3O5
|
1
|
| 1 |
EC50 = 4463 nM
|
|
|
|
CP0503850
|
US8772323, 110
Show/Hide
|
C17H14N4O2
|
1
|
| 1 |
EC50 = 4544 nM
|
|
|
|
CP0479339
|
US8772323, 24
Show/Hide
|
C18H17N3O2S
|
1
|
| 1 |
EC50 = 5100 nM
|
|
|
|
CP0518564
|
US8772323, 192
Show/Hide
|
C22H23N3O3
|
1
|
| 1 |
EC50 = 6057 nM
|
|
|
|
CP0484950
|
US8772323, 129
Show/Hide
|
C21H21N3O2
|
1
|
| 1 |
EC50 = 6721 nM
|
|
|
|
CP0572552
|
US8772323, 73
Show/Hide
|
C24H26N4O3
|
1
|
| 1 |
EC50 = 6773 nM
|
|
|
|
CP0419373
|
US8772323, 255
Show/Hide
|
C19H13N3O4
|
1
|
| 1 |
EC50 = 7238 nM
|
|
|
|
CP0516838
|
US8772323, 141
Show/Hide
|
C17H15N3O2S
|
1
|
| 1 |
EC50 = 7333 nM
|
|
|
|
CP0413357
|
US8772323, 131
Show/Hide
|
C18H17N3O2
|
1
|
| 1 |
EC50 = 7705 nM
|
|
|
|
CP0567072
|
US8772323, 155
Show/Hide
|
C30H37N5O5
|
1
|
| 1 |
EC50 = 7748 nM
|
|
|
|
CP0419365
|
US8772323, 124
Show/Hide
|
C19H18N4O2
|
1
|
| 1 |
EC50 = 8716 nM
|
|
|
|
CP0504069
|
US8772323, 146
Show/Hide
|
C20H19N3O2
|
1
|
| 1 |
EC50 = 8851 nM
|
|
|
|
CP0556929
|
US8772323, 254
Show/Hide
|
C20H15N3O4
|
1
|
| 1 |
EC50 = 8952 nM
|
|
|
|
CP0571486
|
US8772323, 162
Show/Hide
|
C27H31N5O4
|
1
|
| 1 |
EC50 = 9119 nM
|
|
|
|
CP0517877
|
US8772323, 256
Show/Hide
|
C16H11N3O2S
|
1
|
| 1 |
EC50 = 9384 nM
|
|
|
|
CP0413355
|
US8772323, 117
Show/Hide
|
C16H19N5O2
|
1
|
| 1 |
EC50 = 9388 nM
|
|
|
|
CP0477837
|
US8772323, 11
Show/Hide
|
C19H15N3O2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0477839
|
US8772323, 21
Show/Hide
|
C19H17N3O2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0512117
|
US8772323, 30
Show/Hide
|
C19H17N3O2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0512671
|
US8772323, 71
Show/Hide
|
C25H28N4O3
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0556703
|
US8772323, 140
Show/Hide
|
C19H19N3O2S
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
