General Information of the Compound
Compound ID
CP0951584
Compound Name
2-[1-(5-Chloropyrimidin-2-yl)-piperidin-4-yl]-5-(1-methanesulfonyl-1,2,3,6-tetrahydropyridin-4-yl)-furo[2,3-c]pyridine
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Structure
Formula
C22H24ClN5O3S
Molecular Weight
473.986
Canonical SMILES
CS(=O)(=O)N1CC=C(c2cc3cc(C4CCN(c5ncc(Cl)cn5)CC4)oc3cn2)CC1
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InChI
InChI=1S/C22H24ClN5O3S/c1-32(29,30)28-8-4-15(5-9-28)19-10-17-11-20(31-21(17)14-24-19)16-2-6-27(7-3-16)22-25-12-18(23)13-26-22/h4,10-14,16H,2-3,5-9H2,1H3
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InChIKey
UPPSRUSVDADRLX-UHFFFAOYSA-N
Physicochemical Property
logP
3.7039
Rotatable Bonds
4
Heavy Atom Count
32
Polar Areas
92.43
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
7
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 86694584
ChEMBL ID
CHEMBL3715366
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000613 MIN6 Mus musculus (Mouse)  1
1
EC50 = 41 nM
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