General Information of the Compound
Compound ID
CP0518574
Compound Name
US8772323, 248
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Structure
Formula
C26H29FN4O3
Molecular Weight
464.541
Canonical SMILES
CCC1CC(=O)NN=C1c1ccc2nc(oc2c1)-c1ccc(OCCN2CCC(F)CC2)cc1
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InChI
InChI=1S/C26H29FN4O3/c1-2-17-16-24(32)29-30-25(17)19-5-8-22-23(15-19)34-26(28-22)18-3-6-21(7-4-18)33-14-13-31-11-9-20(27)10-12-31/h3-8,15,17,20H,2,9-14,16H2,1H3,(H,29,32)
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InChIKey
JFEPSLUISUHLTI-UHFFFAOYSA-N
Physicochemical Property
logP
4.5577
Rotatable Bonds
7
Heavy Atom Count
34
Polar Areas
79.96
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 67464592
ChEMBL ID
CHEMBL3975234
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000613 MIN6 Mus musculus (Mouse)  1
1
EC50 = 159 nM
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