General Information of the Compound
Compound ID
CP0516351
Compound Name
US9469631, 78
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Structure
Formula
C27H36N4O5
Molecular Weight
496.608
Canonical SMILES
CCOC(=O)c1cnn(c1C)-c1ccc(cc1)C(=O)N(C1CC1)C1CCN(CC1)C(=O)OC(C)(C)C
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InChI
InChI=1S/C27H36N4O5/c1-6-35-25(33)23-17-28-31(18(23)2)22-9-7-19(8-10-22)24(32)30(20-11-12-20)21-13-15-29(16-14-21)26(34)36-27(3,4)5/h7-10,17,20-21H,6,11-16H2,1-5H3
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InChIKey
RUFINHDSFASABG-UHFFFAOYSA-N
Physicochemical Property
logP
4.36152
Rotatable Bonds
6
Heavy Atom Count
36
Polar Areas
93.97
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
7
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 89995533
ChEMBL ID
CHEMBL3920834
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000613 MIN6 Mus musculus (Mouse)  1
1
EC50 = 75 nM
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