General Information of the Compound
Compound ID
CP0491465
Compound Name
US8772323, 216
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Structure
Formula
C27H32N4O4
Molecular Weight
476.577
Canonical SMILES
CCC1CC(=O)NN=C1c1ccc2nc(oc2c1)-c1cccc(OCCN2CC(C)OC(C)C2)c1
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InChI
InChI=1S/C27H32N4O4/c1-4-19-14-25(32)29-30-26(19)20-8-9-23-24(13-20)35-27(28-23)21-6-5-7-22(12-21)33-11-10-31-15-17(2)34-18(3)16-31/h5-9,12-13,17-19H,4,10-11,14-16H2,1-3H3,(H,29,32)
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InChIKey
IVGAHYCVLKVANO-UHFFFAOYSA-N
Physicochemical Property
logP
4.233
Rotatable Bonds
7
Heavy Atom Count
35
Polar Areas
89.19
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 67465153
ChEMBL ID
CHEMBL3903079
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000613 MIN6 Mus musculus (Mouse)  1
1
EC50 = 639 nM
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