General Information of the Compound
Compound ID
CP0397674
Compound Name
propan-2-yl 4-[[7-[2-fluoro-4-(1-methylpyrrol-2-yl)phenyl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate
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Structure
Formula
C26H30FN5O3
Molecular Weight
479.556
Canonical SMILES
CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)-c1cccn1C
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InChI
InChI=1S/C26H30FN5O3/c1-17(2)34-26(33)31-12-8-19(9-13-31)35-25-20-10-14-32(24(20)28-16-29-25)23-7-6-18(15-21(23)27)22-5-4-11-30(22)3/h4-7,11,15-17,19H,8-10,12-14H2,1-3H3
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InChIKey
CBBJTAPLBBGMKR-UHFFFAOYSA-N
Physicochemical Property
logP
4.7036
Rotatable Bonds
5
Heavy Atom Count
35
Polar Areas
72.72
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
7
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 58017038
SID: 163539572
ChEMBL ID
CHEMBL2177784
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
EC50 = 158.49 nM
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