General Information of the Protein
Protein ID
PT01533
Protein Name
Mitogen-activated protein kinase kinase kinase 5
Secondarily
Protein Name
Apoptosis signal-regulating kinase 1
MAPK/ERK kinase kinase 5
Gene Name
MAP3K5
Secondarily
Gene Name
ASK1
MAPKKK5
MEKK5
Sequence
MSTEADEGITFSVPPFAPSGFCTIPEGGICRRGGAAAVGEGEEHQLPPPPPGSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGSRRTTVAYVINEASQGQLVVAESEALQSLREACETVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHFVKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNEYLRSISLPVPVLVEDTSSSSEYGSVSPDTELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKQT
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
STE protein kinase group
>
STE protein kinase STE11 family
Function
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).
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Uniprot ID
Primary ID:
Q99683

Secondarily ID:
A6NIA0
B4DGB2
Q5THN3
Q99461
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Ensembl ID
ENSG00000197442
HGNC ID
HGNC:6857
Subcellular Location
Cytoplasm
Endoplasmic reticulum
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000927 , 293/AP1-luc
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0478996
 Compound Info 
4-methoxy-6-methyl-3-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzene-1,3-dicarboxamide
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C20H22N6O3
  1
1
IC50 = 28 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0559576
 Compound Info 
5-(ethylsulfonylamino)-2-methoxy-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzamide
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C20H24N6O4S
  1
1
IC50 = 41 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0446241
 Compound Info 
2-methoxy-4-methyl-5-methylsulfonyl-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzamide
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C20H23N5O4S
  1
1
IC50 = 73 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0536528
 Compound Info 
2-methoxy-4-methyl-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-5-sulfamoylbenzamide
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C19H22N6O4S
  1
1
IC50 = 84 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0458126
 Compound Info 
4-methoxy-3-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzene-1,3-dicarboxamide
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C19H20N6O3
  1
1
IC50 = 94 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0446235
 Compound Info 
2-methoxy-5-methylsulfonyl-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzamide
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C19H21N5O4S
  1
1
IC50 = 140 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0559567
 Compound Info 
4-methoxy-1-N-methyl-3-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzene-1,3-dicarboxamide
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C20H22N6O3
  1
1
IC50 = 272 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0401740
 Compound Info 
2-methoxy-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-5-sulfamoylbenzamide
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C18H20N6O4S
  1
1
IC50 = 736 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Cell Line ID: CL000012 , Sf21
 Cell Line Info 
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0176880
 Compound Info 
3-methoxy-1-methyl-N-[6-[4-[1-(trifluoromethyl)cyclopropyl]-1,2,4-triazol-3-yl]pyridin-2-yl]pyrazole-4-carboxamide
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C17H16F3N7O2
  1
1 IC50 = 1 nM
CP0416385
 Compound Info 
1-[5-(dimethylamino)pyridin-3-yl]-3-methoxy-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]pyrazole-4-carboxamide
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C22H25N9O2
  1
1 IC50 = 1.9 nM
CP0176881
 Compound Info 
1-ethyl-3-methoxy-N-[6-[4-[(2S)-1,1,1-trifluoropropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]pyrazole-4-carboxamide
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C17H18F3N7O2
  1
1 IC50 = 2 nM
CP0419295
 Compound Info 
1-(cyclopropylmethyl)-3-methoxy-N-[6-[4-[(2S)-1,1,1-trifluoropropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]pyrazole-4-carboxamide
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C19H20F3N7O2
  1
1 IC50 = 2 nM
CP0555055
 Compound Info 
3-methoxy-1-(2-methoxyethyl)-N-[6-[4-[(2S)-1,1,1-trifluoropropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]pyrazole-4-carboxamide
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C18H20F3N7O3
  1
1 IC50 = 2 nM
CP0565299
 Compound Info 
N-[6-[4-[(2S)-1,1,1-trifluoropropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]quinoline-8-carboxamide
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C20H15F3N6O
  1
1 IC50 = 2 nM
CP0354745
 Compound Info 
3-methoxy-1-methyl-N-[6-(3-propan-2-ylimidazol-4-yl)pyridin-2-yl]pyrazole-4-carboxamide
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C17H20N6O2
  1
1 IC50 = 2.4 nM
CP0217203
 Compound Info 
GS-4997
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C24H24FN7O
  7
1 IC50 = 3 nM
2 IC50 = 5 nM
3 IC50 = 5.5 nM
4 IC50 = 5.9 nM
5 IC50 = 6 nM
6 IC50 = 12.9 nM
7 IC50 = 24.4 nM
CP0444649
 Compound Info 
3-methoxy-1-pyrazin-2-yl-N-[6-[4-[(2S)-1,1,1-trifluoropropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]pyrazole-4-carboxamide
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C19H16F3N9O2
  1
1 IC50 = 3 nM
CP0546434
 Compound Info 
3-methoxy-1-(2,2,2-trifluoroethyl)-N-[6-[4-[(2S)-1,1,1-trifluoropropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]pyrazole-4-carboxamide
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C17H15F6N7O2
  1
1 IC50 = 3 nM
CP0546435
 Compound Info 
2-methoxy-N-[6-[4-[(2S)-1,1,1-trifluoropropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]benzamide
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C18H16F3N5O2
  1
1 IC50 = 3 nM
CP0555056
 Compound Info 
2-methoxy-5-methyl-N-[6-[4-[(2S)-1,1,1-trifluoropropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]pyridine-3-carboxamide
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C18H17F3N6O2
  1
1 IC50 = 3 nM
CP0561697
 Compound Info 
3-methoxy-1-pyridazin-3-yl-N-[6-[4-[(2S)-1,1,1-trifluoropropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]pyrazole-4-carboxamide
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C19H16F3N9O2
  1
1 IC50 = 3 nM
CP0564283
 Compound Info 
3-methoxy-1-methyl-N-[6-[4-[(2S)-1,1,1-trifluoropropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]pyrazole-4-carboxamide
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C16H16F3N7O2
  1
1 IC50 = 3 nM
CP0570837
 Compound Info 
N-[6-[4-[(2S)-1,1,1-trifluoropropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]quinoxaline-5-carboxamide
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C19H14F3N7O
  1
1 IC50 = 3 nM
CP0368689
 Compound Info 
3-methoxy-1-methyl-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]pyrazole-4-carboxamide
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C16H19N7O2
  2
1 IC50 = 3.9 nM
2 IC50 = 6 nM
CP0326338
 Compound Info 
15-(4-methylimidazol-1-yl)-11-oxa-3,4,6,19,24-pentazatetracyclo[18.3.1.02,6.012,17]tetracosa-1(24),2,4,12(17),13,15,20,22-octaen-18-one
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C22H21N7O2
  1
1 IC50 = 4 nM
CP0402031
 Compound Info 
(7S)-7-methyl-11-oxa-3,4,6,19,24-pentazatetracyclo[18.3.1.02,6.012,17]tetracosa-1(24),2,4,12,14,16,20,22-octaen-18-one
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C19H19N5O2
  1
1 IC50 = 4 nM
CP0368691
 Compound Info 
1-ethyl-3-methoxy-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]pyrazole-4-carboxamide
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C17H21N7O2
  1
1 IC50 = 4.1 nM
CP0519313
 Compound Info 
15-(1-methylpyrazol-4-yl)-11-oxa-3,4,6,19,24-pentazatetracyclo[18.3.1.02,6.012,17]tetracosa-1(24),2,4,12(17),13,15,20,22-octaen-18-one
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C22H21N7O2
  1
1 IC50 = 5 nM
CP0561696
 Compound Info 
3-methoxy-1-methyl-N-[6-[4-[(3R)-oxolan-3-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]pyrazole-4-carboxamide
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C17H19N7O3
  1
1 IC50 = 5 nM
CP0569729
 Compound Info 
N-[6-[4-(2,2-difluorocyclobutyl)-1,2,4-triazol-3-yl]pyridin-2-yl]-3-methoxy-1-methylpyrazole-4-carboxamide
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C17H17F2N7O2
  1
1 IC50 = 5 nM
CP0163184
 Compound Info 
3-methoxy-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-1-pyridin-3-ylpyrazole-4-carboxamide
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C20H20N8O2
  1
1 IC50 = 5.3 nM
CP0354744
 Compound Info 
1-(5-cyclopropylpyridin-3-yl)-3-methoxy-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]pyrazole-4-carboxamide
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C23H24N8O2
  1
1 IC50 = 5.6 nM
CP0402034
 Compound Info 
15-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]-11-oxa-3,4,6,19,24-pentazatetracyclo[18.3.1.02,6.012,17]tetracosa-1(24),2,4,12(17),13,15,20,22-octaen-18-one
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C25H28N8O2
  1
1 IC50 = 6 nM
CP0355865
 Compound Info 
N-[6-[4-[(2S)-1,1-difluoropropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]-3-methoxy-1-methylpyrazole-4-carboxamide
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C16H17F2N7O2
  1
1 IC50 = 6 nM
CP0356980
 Compound Info 
N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-4-oxo-1-propan-2-ylquinoline-3-carboxamide
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C30H27N3O5
  2
1 IC50 = 6 nM
2 IC50 = 9 nM
CP0125432
 Compound Info 
(7S)-7,14-dimethyl-11-oxa-3,4,6,13,14,18,23-heptazatetracyclo[17.3.1.02,6.012,16]tricosa-1(23),2,4,12,15,19,21-heptaen-17-one
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C17H19N7O2
  1
1 IC50 = 6.8 nM
CP0125694
 Compound Info 
1-(cyclopropylmethyl)-3-methoxy-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]pyrazole-4-carboxamide
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C19H23N7O2
  1
1 IC50 = 6.9 nM
CP0402033
 Compound Info 
(7S)-14-fluoro-7-methyl-11-oxa-3,4,6,19,24-pentazatetracyclo[18.3.1.02,6.012,17]tetracosa-1(24),2,4,12(17),13,15,20,22-octaen-18-one
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C19H18FN5O2
  1
1 IC50 = 7 nM
CP0176878
 Compound Info 
2-methoxy-N-[6-[4-[(2S)-1,1,1-trifluoropropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]pyridine-3-carboxamide
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C17H15F3N6O2
  1
1 IC50 = 7 nM
CP0176879
 Compound Info 
5-fluoro-2-methoxy-N-[6-[4-[(2S)-1,1,1-trifluoropropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]pyridine-3-carboxamide
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C17H14F4N6O2
  1
1 IC50 = 7 nM
CP0355864
 Compound Info 
N-[6-[4-(1-hydroxypropan-2-yl)-1,2,4-triazol-3-yl]pyridin-2-yl]-3-methoxy-1-methylpyrazole-4-carboxamide
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C16H19N7O3
  1
1 IC50 = 7 nM
CP0552416
 Compound Info 
4-methyl-N-[6-[4-[(2S)-1,1,1-trifluoropropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]-2,3-dihydro-1,4-benzoxazine-8-carboxamide
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C20H19F3N6O2
  1
1 IC50 = 7 nM
CP0354743
 Compound Info 
3-methoxy-1-(2-methoxyethyl)-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]pyrazole-4-carboxamide
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C18H23N7O3
  1
1 IC50 = 7.3 nM
CP0096219
 Compound Info 
BDBM50505948
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C18H16FN5O2
  1
1 IC50 = 8 nM
CP0188713
 Compound Info 
15-methylsulfonyl-11-oxa-3,4,6,19,24-pentazatetracyclo[18.3.1.02,6.012,17]tetracosa-1(24),2,4,12(17),13,15,20,22-octaen-18-one
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C19H19N5O4S
  1
1 IC50 = 8 nM
CP0233898
 Compound Info 
(8R)-14-fluoro-8-methyl-11-oxa-3,4,6,19,24-pentazatetracyclo[18.3.1.02,6.012,17]tetracosa-1(24),2,4,12(17),13,15,20,22-octaen-18-one
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C19H18FN5O2
  1
1 IC50 = 8 nM
CP0259270
 Compound Info 
15-morpholin-4-yl-11-oxa-3,4,6,19,24-pentazatetracyclo[18.3.1.02,6.012,17]tetracosa-1(24),2,4,12(17),13,15,20,22-octaen-18-one
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C22H24N6O3
  2
1 IC50 = 8 nM
2 IC50 <= 100 nM
CP0326339
 Compound Info 
(8R)-15-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]-14-fluoro-8-methyl-11-oxa-3,4,6,19,24-pentazatetracyclo[18.3.1.02,6.012,17]tetracosa-1(24),2,4,12(17),13,15,20,22-octaen-18-one
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C26H29FN8O2
  1
1 IC50 = 8 nM
CP0561695
 Compound Info 
3-methoxy-1-methyl-N-[6-[4-[(3S)-oxolan-3-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]pyrazole-4-carboxamide
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C17H19N7O3
  1
1 IC50 = 8 nM
CP0558673
 Compound Info 
3-methoxy-1-methyl-N-[6-[4-(1,1,1-trifluoropropan-2-yl)-1,2,4-triazol-3-yl]pyridin-2-yl]pyrazole-4-carboxamide
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C16H16F3N7O2
  1
1 IC50 = 9 nM
CP0326335
 Compound Info 
11-oxa-3,4,6,19,24-pentazatetracyclo[18.3.1.02,6.012,17]tetracosa-1(24),2,4,12,14,16,20,22-octaen-18-one
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C18H17N5O2
  1
1 IC50 = 11 nM
CP0384160
 Compound Info 
(9R)-9-methyl-11-oxa-3,4,6,19,24-pentazatetracyclo[18.3.1.02,6.012,17]tetracosa-1(24),2,4,12,14,16,20,22-octaen-18-one
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C19H19N5O2
  2
1 IC50 = 13 nM
2 IC50 <= 100 nM
CP0188712
 Compound Info 
(8R)-8-methyl-11-oxa-3,4,6,19,24-pentazatetracyclo[18.3.1.02,6.012,17]tetracosa-1(24),2,4,12,14,16,20,22-octaen-18-one
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C19H19N5O2
  1
1 IC50 = 14 nM
CP0125433
 Compound Info 
3-methoxy-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-1-pyrimidin-5-ylpyrazole-4-carboxamide
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C19H19N9O2
  1
1 IC50 = 16 nM
CP0356982
 Compound Info 
BDBM50505947
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C18H16FN5O2
  1
1 IC50 = 17 nM
CP0540783
 Compound Info 
3-methoxy-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-1-pyridin-2-ylpyrazole-4-carboxamide
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C20H20N8O2
  1
1 IC50 = 17 nM
CP0570802
 Compound Info 
4-methoxy-N-[6-[4-[(2S)-1,1,1-trifluoropropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]pyrimidine-5-carboxamide
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C16H14F3N7O2
  1
1 IC50 = 17 nM
CP0096218
 Compound Info 
N-[4-(6,7-dimethoxycinnolin-4-yl)oxyphenyl]-4-oxo-1-propan-2-ylquinoline-3-carboxamide
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C29H26N4O5
  1
1 IC50 = 18 nM
CP0561313
 Compound Info 
1-methyl-2-oxo-N-[6-[4-[(2S)-1,1,1-trifluoropropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]pyridine-3-carboxamide
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C17H15F3N6O2
  1
1 IC50 = 18 nM
CP0356981
 Compound Info 
12-oxa-3,4,6,20,25-pentazatetracyclo[19.3.1.02,6.013,18]pentacosa-1(25),2,4,13,15,17,21,23-octaen-19-one
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C19H19N5O2
  2
1 IC50 = 20 nM
2 IC50 <= 100 nM
CP0517075
 Compound Info 
N-[6-[4-(3,3-difluorocyclobutyl)-1,2,4-triazol-3-yl]pyridin-2-yl]-3-methoxy-1-methylpyrazole-4-carboxamide
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C17H17F2N7O2
  1
1 IC50 = 20 nM
CP0163191
 Compound Info 
3-methoxy-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-1-pyrazin-2-ylpyrazole-4-carboxamide
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C19H19N9O2
  1
1 IC50 = 21 nM
CP0343393
 Compound Info 
3-[3-[1-(methoxymethyl)pyrazol-4-yl]phenyl]-5-(4-propan-2-yl-1,2,4-triazol-3-yl)-1H-indazole
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C23H23N7O
  1
1 IC50 = 26.9 nM
CP0326337
 Compound Info 
15-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-11-oxa-3,4,6,19,24-pentazatetracyclo[18.3.1.02,6.012,17]tetracosa-1(24),2,4,12(17),13,15,20,22-octaen-18-one
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C23H24N6O3
  1
1 IC50 = 28 nM
CP0127753
 Compound Info 
1-methyl-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]pyrazole-3-carboxamide
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C15H17N7O
  1
1 IC50 = 29 nM
CP0748625
 Compound Info 
3-(3-(1-(1-ethoxyethyl)-1H-pyrazol-4-yl)phenyl)-5-(4-isopropyl-4H-1,2,4-triazol-3-yl)-1H-indazole
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C25H27N7O
  1
1 IC50 = 29.9 nM
CP0564282
 Compound Info 
3-methoxy-N-[6-[4-[(2R)-1-methoxypropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]-1-methylpyrazole-4-carboxamide
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C17H21N7O3
  1
1 IC50 = 31 nM
CP0176831
 Compound Info 
4-[2-(4-cyclopropylimidazol-1-yl)-4-[5-(4-propan-2-yl-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl]morpholine
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C28H30N8O
  1
1 IC50 = 31.8 nM
CP0562338
 Compound Info 
3-[3-(3-cyclopropyl-1,2,4-triazol-1-yl)phenyl]-5-(4-propan-2-yl-1,2,4-triazol-3-yl)-1H-indazole
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C23H22N8
  1
1 IC50 = 37 nM
CP0517074
 Compound Info 
N-[6-[4-[(2R)-1,1-difluoropropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]-3-methoxy-1-methylpyrazole-4-carboxamide
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C16H17F2N7O2
  1
1 IC50 = 37 nM
CP0534062
 Compound Info 
3-methoxy-N-[6-[4-[(2S)-1-methoxypropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]-1-methylpyrazole-4-carboxamide
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C17H21N7O3
  1
1 IC50 = 44 nM
CP0471097
 Compound Info 
3-[3-(4-cyclopropylimidazol-1-yl)-5-methoxyphenyl]-5-(4-propan-2-yl-1,2,4-triazol-3-yl)-1H-indazole
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C25H25N7O
  1
1 IC50 = 48.6 nM
CP0558777
 Compound Info 
3-[3-(4-cyclopropylimidazol-1-yl)phenyl]-5-(4-cyclopropyl-1,2,4-triazol-3-yl)-1H-indazole
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C24H21N7
  1
1 IC50 = 50 nM
CP0271586
 Compound Info 
3-[3-[1-(oxan-4-yl)pyrazol-4-yl]phenyl]-5-(4-propan-2-yl-1,2,4-triazol-3-yl)-1H-indazole
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C26H27N7O
  1
1 IC50 = 50.1 nM
CP0487471
 Compound Info 
5-(4-cyclopentyl-1,2,4-triazol-3-yl)-3-[3-(4-cyclopropylimidazol-1-yl)phenyl]-1H-indazole
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C26H25N7
  1
1 IC50 = 54.1 nM
CP0181251
 Compound Info 
2-fluoro-4-methyl-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzamide
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C18H18FN5O
  1
1 IC50 = 55 nM
CP0419108
 Compound Info 
3-[3-(4-cyclopropylimidazol-1-yl)-4-methylphenyl]-5-(4-propan-2-yl-1,2,4-triazol-3-yl)-1H-indazole
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C25H25N7
  1
1 IC50 = 56.9 nM
CP0258310
 Compound Info 
3-[3-(1-methylpyrazol-4-yl)phenyl]-5-(4-propan-2-yl-1,2,4-triazol-3-yl)-1H-indazole
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C22H21N7
  1
1 IC50 = 63.6 nM
CP0228880
 Compound Info 
5-(4-cyclobutyl-1,2,4-triazol-3-yl)-3-[3-(4-cyclopropylimidazol-1-yl)phenyl]-1H-indazole
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C25H23N7
  1
1 IC50 = 70 nM
CP0188711
 Compound Info 
2-fluoro-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzamide
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C17H16FN5O
  2
1 IC50 = 76 nM
2 IC50 = 100 nM
CP0247995
 Compound Info 
N-[5-(cyclopropylamino)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]pyridine-3-carboxamide
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C16H13F3N6O
  3
1 IC50 = 90 nM
2 IC50 = 93 nM
3 IC50 = 131 nM
CP0491476
 Compound Info 
2-methoxy-N-[6-(4-methyl-1,2,4-triazol-3-yl)pyridin-2-yl]benzamide
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C16H15N5O2
  1
1 IC50 = 92 nM
CP0565298
 Compound Info 
3-methoxy-1-methyl-N-[6-[4-[(2R)-1,1,1-trifluoropropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]pyrazole-4-carboxamide
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C16H16F3N7O2
  1
1 IC50 = 94 nM
CP0197534
 Compound Info 
US11168095, Example 42
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C23H23N7O2
  1
1 IC50 <= 100 nM
CP0204700
 Compound Info 
US11168095, Example 18
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C19H19N5O2
  1
1 IC50 <= 100 nM
CP0416537
 Compound Info 
1-methyl-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]pyrazole-4-carboxamide
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C15H17N7O
  1
1 IC50 = 108 nM
CP0557069
 Compound Info 
3-methoxy-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-1-pyridin-4-ylpyrazole-4-carboxamide
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C20H20N8O2
  1
1 IC50 = 134 nM
CP0326334
 Compound Info 
10-oxa-3,4,6,18,23-pentazatetracyclo[17.3.1.02,6.011,16]tricosa-1(23),2,4,11,13,15,19,21-octaen-17-one
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C17H15N5O2
  1
1 IC50 = 161 nM
CP0450705
 Compound Info 
(10S)-10-methyl-11-oxa-3,4,6,19,24-pentazatetracyclo[18.3.1.02,6.012,17]tetracosa-1(24),2,4,12,14,16,20,22-octaen-18-one
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C19H19N5O2
  1
1 IC50 = 165 nM
CP0469369
 Compound Info 
(7R)-7-methyl-11-oxa-3,4,6,19,24-pentazatetracyclo[18.3.1.02,6.012,17]tetracosa-1(24),2,4,12,14,16,20,22-octaen-18-one
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C19H19N5O2
  1
1 IC50 = 350 nM
CP0559851
 Compound Info 
N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzamide
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C17H17N5O
  1
1 IC50 = 607 nM
CP0154571
 Compound Info 
5-(4-cyclopropylimidazol-1-yl)-2-fluoro-4-methyl-N-pyridin-2-ylbenzamide
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C19H17FN4O
  1
1 IC50 = 6000 nM
CP0339225
 Compound Info 
3-methoxy-1-methyl-N-[3-(4-propan-2-yl-1,2,4-triazol-3-yl)phenyl]pyrazole-4-carboxamide
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C17H20N6O2
  1
1 IC50 = 6164 nM
Clinical Information about the Protein
Target 1 ( Apoptosis signal-regulating kinase 1 (MAP3K5) )
Target Type Clinical trial Target
Disease 1 Target-related Disease  1
1 Diabetic nephropathy [ICD-11: GB61.Z]
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 GS-4997
 Drug Info 
Phase 2
Diabetic nephropathy