General Information of the Protein
Protein ID
PT01527
Protein Name
Bifunctional epoxide hydrolase 2
Secondarily
Protein Name
Epoxide hydratase
Soluble epoxide hydrolase
Gene Name
EPHX2
Secondarily
Gene Name
Eph2
Sequence
MALRVAAFDLDGVLALPSIAGAFRRSEEALALPRDFLLGAYQTEFPEGPTEQLMKGKITFSQWVPLMDESYRKSSKACGANLPENFSISQIFSQAMAARSINRPMLQAAIALKKKGFTTCIVTNNWLDDGDKRDSLAQMMCELSQHFDFLIESCQVGMIKPEPQIYNFLLDTLKAKPNEVVFLDDFGSNLKPARDMGMVTILVHNTASALRELEKVTGTQFPEAPLPVPCNPNDVSHGYVTVKPGIRLHFVEMGSGPALCLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSPPEIEEYAMELLCKEMVTFLDKLGIPQAVFIGHDWAGVMVWNMALFYPERVRAVASLNTPFMPPDPDVSPMKVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRASDETGFIAVHKATEIGGILVNTPEDPNLSKITTEEEIEFYIQQFKKTGFRGPLNWYRNTERNWKWSCKGLGRKILVPALMVTAEKDIVLRPEMSKNMEKWIPFLKRGHIEDCGHWTQIEKPTEVNQILIKWLQTEVQNPSVTSKI
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Organism
Mus musculus, Mouse
Protein Classification
Enzyme
>
Protease
>
Serine protease
>
Serine protease SC clan
>
Serine protease S33 family
Function
Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:7840649, PubMed:21217101). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (By similarity).
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Uniprot ID
Primary ID:
P34914

Secondarily ID:
Q8CGV0
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Ensembl ID
ENSG00000120915
Subcellular Location
Cytoplasm
Peroxisome
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000012 , Sf21
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0533291
 Compound Info 
1-(1-acetylpiperidin-4-yl)-3-(4-pentacyclo[7.3.1.14,12.02,7.06,11]tetradecanyl)urea
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C22H33N3O2
  1
1
IC50 = 1.8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0036110
 Compound Info 
US10383835, Compound 1153
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C18H29N3O2
  1
1
IC50 = 3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0564472
 Compound Info 
1-(1-acetylpiperidin-4-yl)-3-(3,7-dimethyl-1-tricyclo[3.3.0.03,7]octanyl)urea
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C18H29N3O2
  1
1
IC50 = 3.3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0421578
 Compound Info 
1-(1-acetylpiperidin-4-yl)-3-(3-pentacyclo[7.3.1.14,12.02,7.06,11]tetradecanyl)urea
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C22H33N3O2
  1
1
IC50 = 5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0036110
 Compound Info 
US10383835, Compound 1153
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C18H29N3O2
  3
1 IC50 = 1.7 nM
2 IC50 = 3 nM
3 IC50 = 9 nM
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT01106 Bifunctional epoxide hydrolase 2 Rattus norvegicus, Rat
 Protein Info 
50% Identity
Protein ID Protein Name Protein Organism
PT01103 Bifunctional epoxide hydrolase 2 Homo sapiens, Human
 Protein Info