General Information of the Compound
Compound ID
CP0362371
Compound Name
N-[(3S)-3-(4-fluorophenyl)-3-(4-methylsulfonylphenyl)propyl]-4-hydroxybenzamide
    Show/Hide
Structure
Formula
C23H22FNO4S
Molecular Weight
427.497
Canonical SMILES
CS(=O)(=O)c1ccc(cc1)[C@@H](CCNC(=O)c1ccc(O)cc1)c1ccc(F)cc1
    Show/Hide
InChI
InChI=1S/C23H22FNO4S/c1-30(28,29)21-12-6-17(7-13-21)22(16-2-8-19(24)9-3-16)14-15-25-23(27)18-4-10-20(26)11-5-18/h2-13,22,26H,14-15H2,1H3,(H,25,27)/t22-/m0/s1
    Show/Hide
InChIKey
JJTODBVNBRXJDQ-QFIPXVFZSA-N
Physicochemical Property
logP
3.8868
Rotatable Bonds
7
Heavy Atom Count
30
Polar Areas
83.47
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 70689719
ChEMBL ID
CHEMBL2021549
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01103, Bifunctional epoxide hydrolase 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 1.7 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 6 nM