General Information of the Compound
Compound ID
CP0157342
Compound Name
N-[[4-(4-methylsulfonylphenyl)phenyl]methyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
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Structure
Formula
C23H21F3N2O4S
Molecular Weight
478.492
Canonical SMILES
CS(=O)(=O)c1ccc(cc1)-c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)cc1
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InChI
InChI=1S/C23H21F3N2O4S/c1-33(30,31)20-9-6-18(7-10-20)17-4-2-16(3-5-17)14-28-22(29)19-8-11-21(27-15-19)32-13-12-23(24,25)26/h2-11,15H,12-14H2,1H3,(H,28,29)
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InChIKey
JAJQVZPJXGJHGZ-UHFFFAOYSA-N
Physicochemical Property
logP
4.4133
Rotatable Bonds
8
Heavy Atom Count
33
Polar Areas
85.36
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45487846
ChEMBL ID
CHEMBL567703
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01103, Bifunctional epoxide hydrolase 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
IC50 = 24 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 12 nM