Brief Information of the Cell Line and Protein
Cell Line ID: CL000749 , HUVEC-C
Synonyms
HUV-EC-C
HUVEC
Category Finite cell line
Organism
Homo sapiens (Human)
Protein ID: PT01554 , Integrin alpha-L
Gene Name ITGAL
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P20701
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000749  Protein ID: PT01554
 
Compound ID Compound Name Compound Formula
CP0094004
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)benzo[d]thiazole-7-carboxylic Acid
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C28H19Cl2N5O4S
 1
1
IC50 = 1.8 nM
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CP0365998
4-((5S,9R)-7-(5-(1H-Tetrazol-5-yl)pyridin-2-yl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-9-yl)-benzonitrile
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C26H19Cl2N9O2
 1
1
IC50 = 1.8 nM
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CP0003162
6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic Acid
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C26H19Cl2N5O4
 1
1
IC50 = 2.5 nM
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CP0300919
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)isonicotinic Acid
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C26H19Cl2N5O4
 1
1
IC50 = 3.6 nM
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CP0150410
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)benzo[d]oxazole-5-carboxylic Acid
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C28H19Cl2N5O5
 1
1
IC50 = 4 nM
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CP0065983
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)benzo[d]thiazole-6-carboxylic Acid
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C28H19Cl2N5O4S
 1
1
IC50 = 4.4 nM
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CP0297450
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)benzo[d]oxazole-7-carboxylic Acid
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C28H19Cl2N5O5
 1
1
IC50 = 4.8 nM
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CP0265379
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)thiazole-5-carboxylicAcid
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C24H17Cl2N5O4S
 1
1
IC50 = 5 nM
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CP0047191
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)benzo[d]oxazole-6-carboxylic Acid
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C28H19Cl2N5O5
 1
1
IC50 = 6 nM
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CP0203549
6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)pyrimidine-4-carboxylic Acid
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C25H18Cl2N6O4
 1
1
IC50 = 8 nM
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CP0115736
6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)-4-methylnicotinic Acid
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C27H21Cl2N5O4
 1
1
IC50 = 11 nM
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CP0128627
6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinonitrile
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C26H18Cl2N6O2
 1
1
IC50 = 11 nM
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CP0315923
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)pyrimidine-5-carboxylic Acid
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C25H18Cl2N6O4
 1
1
IC50 = 11 nM
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CP0325337
4-((5S,9R)-3-(3,5-Dichlorophenyl)-1-methyl-2,4-dioxo-7-(pyridin-2-yl)-1,3,7-triazaspiro[4.4]nonan-9-yl)benzonitrile
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C25H19Cl2N5O2
 1
1
IC50 = 11 nM
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CP0270351
6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)-2-methylnicotinic Acid
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C27H21Cl2N5O4
 1
1
IC50 = 12 nM
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CP0325338
5-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)picolinonitrile
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C26H18Cl2N6O2
 1
1
IC50 = 12 nM
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CP0316221
6-((5S,9R)-3-(3,5-Dichlorophenyl)-1-methyl-2,4-dioxo-9-phenyl-1,3,7-triazaspiro[4.4]nonan-7-yl)pyridazine-3-carboxylic Acid
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C25H18Cl2N6O4
 1
1
IC50 = 13 nM
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CP0009606
5-[(5S,9R)-9-(4-CYANOPHENYL)-3-(3,5-DICHLOROPHENYL)-1-METHYL-2,4-DIOXO-1,3,7-TRIAZASPIRO [4.4]NON-7-YL]METHYL]-3-THIOPHENECARBOXYLICACID
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C26H20Cl2N4O4S
 1
1
IC50 = 18 nM
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CP0106878
5-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)pyrazine-2-carboxylic Acid
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C25H18Cl2N6O4
 1
1
IC50 = 19 nM
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CP0150409
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)pyrimidine-4-carboxylic Acid
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C25H18Cl2N6O4
 1
1
IC50 = 26 nM
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CP0065984
4-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)picolinic Acid
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C26H19Cl2N5O4
 1
1
IC50 = 56 nM
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CP0115737
2-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)oxazole-4-carboxylic Acid
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C24H17Cl2N5O5
 1
1
IC50 = 58 nM
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CP0150411
4,4'-((5S,9R)-3-(3,5-Dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,9-diyl)dibenzonitrile
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C27H19Cl2N5O2
 1
1
IC50 = 60 nM
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