Brief Information of the Cell Line and Protein
Cell Line ID: CL000749 , HUVEC-C
Synonyms
HUV-EC-C
HUVEC
Category Finite cell line
Organism
Homo sapiens (Human)
Protein ID: PT01575 , Neprilysin
Gene Name MME
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P08473
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000749  Protein ID: PT01575
 
Compound ID Compound Name Compound Formula
CP0372332
2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-hexanoic acid
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C32H39N2O7P
 1
1
IC50 = 300 nM
   TI
   LI
   LO
   TS
CP0372390
2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-propionic acid
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C29H33N2O7P
 1
1
IC50 = 300 nM
   TI
   LI
   LO
   TS
CP0374939
2-{(R)-2-Benzyl-3-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-5-guanidino-pentanoic acid
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C32H40N5O7P
 1
1
IC50 = 800 nM
   TI
   LI
   LO
   TS
CP0403720
2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-succinic acid
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C30H33N2O9P
 1
1
IC50 = 800 nM
   TI
   LI
   LO
   TS
CP0464192
2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-3-phenyl-propionic acid
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C35H37N2O7P
 1
1
IC50 = 800 nM
   TI
   LI
   LO
   TS
CP0480712
2-[[2-benzyl-3-[hydroxy-[(1R)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphoryl]propanoyl]amino]acetic acid
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C28H31N2O7P
 1
1
IC50 = 900 nM
   TI
   LI
   LO
   TS
CP0480745
2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-3-methyl-pentanoic acid
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C32H39N2O7P
 1
1
IC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0510261
3-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-propionic acid
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C29H33N2O7P
 1
1
IC50 = 2300 nM
   TI
   LI
   LO
   TS
CP0490330
2-[[2-benzyl-3-[hydroxy-[(1R)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphoryl]propanoyl]amino]pentanedioic acid
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C31H35N2O9P
 1
1
IC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0404567
2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-succinamic acid
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C30H34N3O8P
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0463550
2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-3-(1H-imidazol-4-yl)-propionic acid
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C32H35N4O7P
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0930750
2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-3-hydroxy-butyric acid
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C30H35N2O8P
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0430490
(R)-2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-5-guanidino-pentanoic acid
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C32H40N5O7P
 1
1
IC50 > 60000 nM
   TI
   LI
   LO
   TS
CP0480613
(R)-2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-3-phenyl-propionic acid
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C35H37N2O7P
 1
1
IC50 > 60000 nM
   TI
   LI
   LO
   TS
CP0416659
6-Amino-2-{2-benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-hexanoic acid
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C32H40N3O7P
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0439011
(R)-2-{2-Benzyl-3-[((R)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-propionylamino}-pentanedioic acid
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C31H35N2O9P
 1
1
IC50 > 100000 nM
   TI
   LI
   LO
   TS