General Information of the Compound
Compound ID
CP0480712
Compound Name
2-[[2-benzyl-3-[hydroxy-[(1R)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphoryl]propanoyl]amino]acetic acid
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Structure
Formula
C28H31N2O7P
Molecular Weight
538.537
Canonical SMILES
OC(=O)CNC(=O)C(Cc1ccccc1)CP(O)(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1
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InChI
InChI=1S/C28H31N2O7P/c31-26(32)18-29-27(33)24(16-21-10-4-1-5-11-21)20-38(35,36)25(17-22-12-6-2-7-13-22)30-28(34)37-19-23-14-8-3-9-15-23/h1-15,24-25H,16-20H2,(H,29,33)(H,30,34)(H,31,32)(H,35,36)/t24?,25-/m1/s1
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InChIKey
JXKBBAIJUNLZHP-WUBHUQEYSA-N
Physicochemical Property
logP
3.8117
Rotatable Bonds
13
Heavy Atom Count
38
Polar Areas
142.03
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
5
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44275916
ChEMBL ID
CHEMBL282158
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01982, Endothelin-converting enzyme 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000749 HUVEC-C Homo sapiens (Human)  1
1
IC50 = 80000 nM
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   LI
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Protein ID: PT01575, Neprilysin
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000749 HUVEC-C Homo sapiens (Human)  1
1
IC50 = 900 nM
   TI
   LI
   LO
   TS