General Information of the Compound
Compound ID
CP0504290
Compound Name
2-[5-[1-[2-hydroxy-3-[4-(2-methoxyphenyl)piperidin-1-yl]propyl]-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanyl-1-pyrrolidin-1-ylethanone
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Structure
Formula
C34H42F3N5O3S
Molecular Weight
657.803
Canonical SMILES
COc1ccccc1C1CCN(CC(O)Cn2nc(c3CNCCc23)-c2ccc(c(SCC(=O)N3CCCC3)c2)C(F)(F)F)CC1
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InChI
InChI=1S/C34H42F3N5O3S/c1-45-30-7-3-2-6-26(30)23-11-16-40(17-12-23)20-25(43)21-42-29-10-13-38-19-27(29)33(39-42)24-8-9-28(34(35,36)37)31(18-24)46-22-32(44)41-14-4-5-15-41/h2-3,6-9,18,23,25,38,43H,4-5,10-17,19-22H2,1H3
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InChIKey
QUUKJTUMCJOCFF-UHFFFAOYSA-N
Physicochemical Property
logP
5.1782
Rotatable Bonds
10
Heavy Atom Count
46
Polar Areas
82.86
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
46

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46884505
ChEMBL ID
CHEMBL1091336
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01006, Cathepsin S
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000147 JY Homo sapiens (Human)  1
1
IC50 = 120 nM
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