General Information of the Compound
Compound ID
CP0062141
Compound Name
1-(1-(3-(3-(3-(2-(4-methylpiperazin-1-yl)ethylthio)-4-(trifluoromethyl)phenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)pyrrolidin-2-one
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Structure
Formula
C33H48F3N7O3S2
Molecular Weight
711.921
Canonical SMILES
CN1CCN(CCSc2cc(ccc2C(F)(F)F)-c2nn(CCCN3CCC(CC3)N3CCCC3=O)c3CCN(Cc23)S(C)(=O)=O)CC1
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InChI
InChI=1S/C33H48F3N7O3S2/c1-38-17-19-40(20-18-38)21-22-47-30-23-25(6-7-28(30)33(34,35)36)32-27-24-41(48(2,45)46)16-10-29(27)43(37-32)13-4-11-39-14-8-26(9-15-39)42-12-3-5-31(42)44/h6-7,23,26H,3-5,8-22,24H2,1-2H3
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InChIKey
HXLZKNXUQROSDU-UHFFFAOYSA-N
Physicochemical Property
logP
3.703
Rotatable Bonds
11
Heavy Atom Count
48
Polar Areas
85.23
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
9
Complexity
48

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25102859
SID: 56424275
ChEMBL ID
CHEMBL1093949
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01006, Cathepsin S
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000147 JY Homo sapiens (Human)  1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1060 nM