General Information of the Compound
Compound ID
CP0490838
Compound Name
2-[5-[1-[2-hydroxy-3-[4-(2-methoxyphenyl)piperidin-1-yl]propyl]-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-3-yl]-2-(trifluoromethyl)phenyl]sulfanyl-1-morpholin-4-ylethanone
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Structure
Formula
C34H42F3N5O4S
Molecular Weight
673.802
Canonical SMILES
COc1ccccc1C1CCN(CC(O)Cn2nc(c3CNCCc23)-c2ccc(c(SCC(=O)N3CCOCC3)c2)C(F)(F)F)CC1
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InChI
InChI=1S/C34H42F3N5O4S/c1-45-30-5-3-2-4-26(30)23-9-12-40(13-10-23)20-25(43)21-42-29-8-11-38-19-27(29)33(39-42)24-6-7-28(34(35,36)37)31(18-24)47-22-32(44)41-14-16-46-17-15-41/h2-7,18,23,25,38,43H,8-17,19-22H2,1H3
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InChIKey
ZUZALNURNUOFEB-UHFFFAOYSA-N
Physicochemical Property
logP
4.4146
Rotatable Bonds
10
Heavy Atom Count
47
Polar Areas
92.09
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
47

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46884506
ChEMBL ID
CHEMBL1091337
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01006, Cathepsin S
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000147 JY Homo sapiens (Human)  1
1
IC50 = 1850 nM
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