Protein Information

General Information of the Protein

Protein ID	PT00994
Protein Name	Histone deacetylase 4
Gene Name	HDAC4
Secondarily Gene Name	KIAA0288
Sequence	MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLLEQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEEEPPL Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Epigenetic regulator > Eraser > Histone deacetylase > HDAC class IIa
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256). Show/Hide
Uniprot ID	Primary ID: P56524 Secondarily ID: E9PGB9 F5GX36 Q86YH7 Q9UND6 Show/Hide
Ensembl ID	ENSG00000068024
HGNC ID	HGNC:14063
Subcellular Location	Nucleus Cytoplasm

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000023 , BTI-Tn-5B1-4

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0497727 Compound Info	5-cyclopropyl-2-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)-N-(6,6,6-trifluoro-5-oxohexyl)-1,3-thiazole-4-carboxamide Show/Hide	C20H22F3N3O2S2	1
1	IC50 = 23.42 nM Bioactivity Info	TI LI LO TS
CP0424976 Compound Info	5-cyclopropyl-2-(1,3-thiazol-2-yl)-N-(6,6,6-trifluoro-5-oxohexyl)-1,3-thiazole-4-carboxamide Show/Hide	C16H16F3N3O2S2	1
1	IC50 = 31.54 nM Bioactivity Info	TI LI LO TS
CP0424978 Compound Info	5-cyclopropyl-2-(5-methyl-1,3-thiazol-2-yl)-N-(6,6,6-trifluoro-5-oxohexyl)-1,3-thiazole-4-carboxamide Show/Hide	C17H18F3N3O2S2	1
1	IC50 = 32.05 nM Bioactivity Info	TI LI LO TS
CP0388780 Compound Info	5-benzyl-2-(1,3-thiazol-2-yl)-N-(6,6,6-trifluoro-5-oxohexyl)-1,3-thiazole-4-carboxamide Show/Hide	C20H18F3N3O2S2	1
1	IC50 = 68.15 nM Bioactivity Info	TI LI LO TS
CP0483501 Compound Info	5-(2-methylpropyl)-2-(1,3-thiazol-2-yl)-N-(6,6,6-trifluoro-5-oxohexyl)-1,3-thiazole-4-carboxamide Show/Hide	C17H20F3N3O2S2	1
1	IC50 = 120.03 nM Bioactivity Info	TI LI LO TS
CP0406684 Compound Info	5-cyclopropyl-2-(1,3-thiazol-2-yl)-N-(7,7,7-trifluoro-6-oxoheptyl)-1,3-thiazole-4-carboxamide Show/Hide	C17H18F3N3O2S2	1
1	IC50 = 132.88 nM Bioactivity Info	TI LI LO TS
CP0085031 Compound Info	5-cyclopropyl-N-[5-(hydroxyamino)-5-oxopentyl]-2-(1,3-thiazol-2-yl)-1,3-thiazole-4-carboxamide Show/Hide	C15H18N4O3S2	1
1	IC50 = 157.79 nM Bioactivity Info	TI LI LO TS
CP0209171 Compound Info	N-[5-(hydroxyamino)-5-oxopentyl]-5-(2-methylpropyl)-2-(1,3-thiazol-2-yl)-1,3-thiazole-4-carboxamide Show/Hide	C16H22N4O3S2	1
1	IC50 = 184.67 nM Bioactivity Info	TI LI LO TS
CP0003832 Compound Info	N'-hydroxy-N-phenyloctanediamide Show/Hide	C14H20N2O3	1
1	IC50 = 353.78 nM Bioactivity Info	TI LI LO TS
CP0483503 Compound Info	N-[5-(2-aminoanilino)-5-oxopentyl]-5-cyclopropyl-2-(1,3-thiazol-2-yl)-1,3-thiazole-4-carboxamide Show/Hide	C21H23N5O2S2	1
1	IC50 = 2092.35 nM Bioactivity Info	TI LI LO TS
CP0406683 Compound Info	5-cyclopropyl-2-(1,3-thiazol-2-yl)-N-(6,6,6-trifluoro-5-hydroxyhexyl)-1,3-thiazole-4-carboxamide Show/Hide	C16H18F3N3O2S2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0428637 Compound Info	5-cyclopropyl-N-[4-(hydroxycarbamoylamino)butyl]-2-(1,3-thiazol-2-yl)-1,3-thiazole-4-carboxamide Show/Hide	C15H19N5O3S2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0477243 Compound Info	5-cyclopropyl-2-(1,3-thiazol-2-yl)-N-(5,5,5-trifluoro-4-oxopentyl)-1,3-thiazole-4-carboxamide Show/Hide	C15H14F3N3O2S2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0520377 Compound Info	5-cyclopropyl-2-(1,3-thiazol-2-yl)-N-[5-[[3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzoyl]amino]pentyl]-1,3-thiazole-4-carboxamide Show/Hide	C25H23F3N6O3S2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0003580 Compound Info	Faridak Show/Hide	C21H23N3O2	1
1	IC50 = 10390 nM Bioactivity Info	TI LI LO TS
CP0444962 Compound Info	5-cyclopropyl-N-[(1S)-1-[4-(hydroxycarbamoyl)phenyl]ethyl]-2-(5-phenyl-1,3-thiazol-2-yl)-1,3-thiazole-4-carboxamide Show/Hide	C25H22N4O3S2	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000314 , HEK293T/17

Cell Line Info

Cell Line ID: CL000081 , Jurkat E6.1

Cell Line Info

Cell Line ID: CL000013 , Sf9

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0507132 Compound Info	US9056843, 156 Show/Hide	C21H21F3N4O2	1
1	IC50 = 0.08 nM
CP0008777 Compound Info	JNJ-26481585 Show/Hide	C21H26N6O2	3
1	IC50 = 0.64 nM
2	Ki = 0.3 nM
3	Ki = 6.7 nM
CP0044706 Compound Info	(2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl}phenyl)prop-2-enamide Show/Hide	C22H25N3O3	5
1	IC50 = 1 nM
2	IC50 = 1.2 nM
3	IC50 = 4 nM
4	IC50 = 5.82 nM
5	Ki = 2250 nM
CP0572874 Compound Info	N-[(2R)-1-(3,3-dimethylpiperidin-1-yl)propan-2-yl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide Show/Hide	C20H25F3N4O2	1
1	IC50 = 2 nM
CP0032465 Compound Info	US9056843, 137 Show/Hide	C19H25F3N4O2	2
1	IC50 = 3 nM
2	Kd = 44 nM
CP0534746 Compound Info	N-[(2R)-1-[(3S)-3-(difluoromethoxy)piperidin-1-yl]propan-2-yl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide Show/Hide	C19H21F5N4O3	1
1	IC50 = 3 nM
CP0138894 Compound Info	6-((1S,7R,10S,13R)-2,8,11,26-Tetraoxo-3,9,12,25-tetraaza-tricyclo[11.11.2.03,7]hexacos-10-yl)-hexanoic acid hydroxyamide Show/Hide	C28H47N5O6	1
1	IC50 = 4.5 nM
CP0281997 Compound Info	6-((1S,7R,10S,13R)-2,8,11,25-Tetraoxo-3,9,12,24-tetraaza-tricyclo[11.10.2.03,7]pentacos-10-yl)-hexanoic acid hydroxyamide Show/Hide	C27H45N5O6	1
1	IC50 = 5.5 nM
CP0005479 Compound Info	CHEBI:46024 Show/Hide	C17H22N2O3	19
1	IC50 = 8 nM
2	IC50 = 12 nM
3	IC50 = 12.07 nM
4	IC50 = 12.1 nM
5	IC50 = 29 nM
6	IC50 = 34 nM
7	IC50 = 34.8 nM
8	IC50 = 44 nM
9	IC50 = 85 nM
10	IC50 = 122 nM
11	IC50 = 3800 nM
12	IC50 = 6600 nM
13	IC50 = 7690 nM
14	IC50 = 8439 nM
15	IC50 = 9100 nM
16	Ki = 400 nM
17	Ki = 980 nM
18	Ki = 1400 nM
19	Ki = 14547 nM
CP0080252 Compound Info	1-(5-(3-((4-(1,3,4-oxadiazol-2-yl)phenoxy)methyl)-1,2,4-oxadiazol-5-yl)thiophen-2-yl)-2,2,2-trifluoroethanone Show/Hide	C17H9F3N4O4S	1
1	IC50 = 10 nM
CP0822716 Compound Info	(1R,2R,3R)-N-hydroxy-2-(2-methylbenzo[d]thiazol-5-yl)-3-phenylcyclopropanecarboxamide Show/Hide	C18H16N2O2S	1
1	IC50 = 10 nM
CP0021456 Compound Info	(1S,2S,3S)-1-fluoro-2-[4-(5-fluoropyrimidin-2-yl)phenyl]-N-hydroxy-3-phenylcyclopropane-1-carboxamide Show/Hide	C20H15F2N3O2	2
1	IC50 = 10 nM
2	Kd = 20 nM
CP0179950 Compound Info	(1S,2S,3S)-1-fluoro-N-hydroxy-2-[4-(1,3-oxazol-5-yl)phenyl]-3-phenylcyclopropane-1-carboxamide Show/Hide	C19H15FN2O3	1
1	IC50 = 10 nM
CP0033555 Compound Info	N-[(2R)-1-[(2S)-2-methylpyrrolidin-1-yl]propan-2-yl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide Show/Hide	C18H21F3N4O2	1
1	IC50 = 10 nM
CP0264084 Compound Info	US9056843, 131 Show/Hide	C18H21F3N4O2	1
1	IC50 = 10 nM
CP0426261 Compound Info	US9056843, 130 Show/Hide	C17H19F3N4O2	1
1	IC50 = 10 nM
CP0572873 Compound Info	(R)-N-(1-(Azepan-1-yl)propan-2-yl)-4- (5-(trifluoromethyl)-1,2,4-oxadiazol-3- yl)benzamide Show/Hide	C19H23F3N4O2	1
1	IC50 = 10 nM
CP0281994 Compound Info	6-((5S,8R,11S,13aR)-4,7,10,13-Tetraoxo-5,8-dipentyl-tetradecahydro-3a,6,9,12-tetraaza-cyclopentacyclododecen-11-yl)-hexanoic acid hydroxyamide Show/Hide	C27H47N5O6	1
1	IC50 = 12 nM
CP0070342 Compound Info	(1R,2R,3R)-N-hydroxy-2-phenyl-3-quinoxalin-6-ylcyclopropane-1-carboxamide Show/Hide	C18H15N3O2	1
1	IC50 = 20 nM
CP0070355 Compound Info	(1R,2R,3R)-2-(5-chloro-2,3-dihydro-1,4-benzodioxin-7-yl)-N-hydroxy-3-phenylcyclopropane-1-carboxamide Show/Hide	C18H16ClNO4	1
1	IC50 = 20 nM
CP0071108 Compound Info	(1R,2R,3R)-N-hydroxy-2-[4-(1,3-oxazol-5-yl)phenyl]-3-phenylcyclopropane-1-carboxamide Show/Hide	C19H16N2O3	2
1	IC50 = 20 nM
2	IC50 = 30 nM
CP0155515 Compound Info	(1R,2R,3R)-2-(2-cyclopropylpyridin-4-yl)-N-hydroxy-3-phenylcyclopropane-1-carboxamide Show/Hide	C18H18N2O2	1
1	IC50 = 20 nM
CP0738094 Compound Info	(1R,2R,3R)-2-(3-cyclopropylquinoxalin-6-yl)-3-phenylcyclopropanecarbohydroxamicAcid Show/Hide	C21H19N3O2	1
1	IC50 = 20 nM
CP0179947 Compound Info	US9505736, (1S,2S,3S)-1-Fluoro-N-hydroxy-2-(4-(5- methylpyrimidin-2-yl)phenyl)-3- phenylcyclopropanecarboxamide Show/Hide	C21H18FN3O2	1
1	IC50 = 20 nM
CP0561036 Compound Info	N-[(2R)-1-[(3R)-3-(difluoromethoxy)piperidin-1-yl]propan-2-yl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide Show/Hide	C19H21F5N4O3	1
1	IC50 = 20 nM
CP0003580 Compound Info	Faridak Show/Hide	C21H23N3O2	8
1	IC50 = 26.7 nM
2	IC50 = 203 nM
3	IC50 = 338 nM
4	IC50 = 480 nM
5	IC50 < 300 nM
6	Ki = 0.6 nM
7	Ki = 170 nM
8	Ki = 550 nM
CP0054198 Compound Info	(1R,2R,3R)-N-hydroxy-2-[1-oxo-2-(2,2,2-trifluoroethyl)-3H-isoindol-5-yl]-3-phenylcyclopropane-1-carboxamide Show/Hide	C20H17F3N2O3	1
1	IC50 = 30 nM
CP0210247 Compound Info	(1R,2R,3R)-N-hydroxy-2-[4-(2-methyl-1,3-oxazol-5-yl)phenyl]-3-phenylcyclopropane-1-carboxamide Show/Hide	C20H18N2O3	1
1	IC50 = 30 nM
CP0709433 Compound Info	(1R,2R,3R)-2-(2-Cyclopropylquinoxalin-6-yl)-3-phenylcyclopropanecarbohydroxamicAcid Show/Hide	C21H19N3O2	1
1	IC50 = 30 nM
CP0848205 Compound Info	(1R,2R,3R)-2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-N-hydroxy-3-phenylcyclopropanecarboxamide Show/Hide	C18H17NO4	1
1	IC50 = 30 nM
CP0191871 Compound Info	(1S,2S,3S)-2-[4-[5-(difluoromethoxy)pyrimidin-2-yl]phenyl]-1-fluoro-N-hydroxy-3-phenylcyclopropane-1-carboxamide Show/Hide	C21H16F3N3O3	2
1	IC50 = 30 nM
2	Kd = 80 nM
CP0032464 Compound Info	N-(2-pyrrolidin-1-ylethyl)-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide Show/Hide	C16H17F3N4O2	1
1	IC50 = 30 nM
CP0357105 Compound Info	N-[(2R)-1-(4-fluoropiperidin-1-yl)propan-2-yl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide Show/Hide	C18H20F4N4O2	1
1	IC50 = 30 nM
CP0053685 Compound Info	(1R,2R,3R)-2-[4-(2-cyclopropyl-1,3-oxazol-5-yl)phenyl]-N-hydroxy-3-phenylcyclopropane-1-carboxamide Show/Hide	C22H20N2O3	1
1	IC50 = 40 nM
CP0433054 Compound Info	US9765054, Compound 41A Show/Hide	C19H16N2O3	1
1	IC50 = 40 nM
CP0709432 Compound Info	(1R,2R,3R)-2-(8-Chloro-3,3-dimethyl-2,3-dihydrobenzo[b]-[1,4]dioxin-6-yl)-N-hydroxy-3-phenylcyclopropanecarboxamide Show/Hide	C20H20ClNO4	1
1	IC50 = 40 nM
CP0717466 Compound Info	(1R,2R,3R)-2-(8-Chloro-1,2,3,4-tetrahydroquinolin-6-yl)-N-hydroxy-3-phenylcyclopropanecarboxamide Show/Hide	C19H19ClN2O2	1
1	IC50 = 40 nM
CP0822681 Compound Info	(1R,2R,3R)-2-(2-cyclopropylbenzo[d]oxazol-5-yl)-N-hydroxy-3-phenylcyclopropanecarboxamide Show/Hide	C20H18N2O3	1
1	IC50 = 40 nM
CP0179948 Compound Info	(1S,2S,3S)-2-[4-(5-chloropyrimidin-2-yl)phenyl]-1-fluoro-N-hydroxy-3-phenylcyclopropane-1-carboxamide Show/Hide	C20H15ClFN3O2	1
1	IC50 = 40 nM
CP0179949 Compound Info	(1S,2S,3S)-1-fluoro-N-hydroxy-2-phenyl-3-[4-[4-(trifluoromethyl)pyrimidin-2-yl]phenyl]cyclopropane-1-carboxamide Show/Hide	C21H15F4N3O2	1
1	IC50 = 40 nM
CP0357108 Compound Info	N-[1-(pyrrolidin-1-ylmethyl)cyclopropyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide Show/Hide	C18H19F3N4O2	1
1	IC50 = 40 nM
CP0021455 Compound Info	(1R,2R,3R)-2-[4-(5-fluoropyrimidin-2-yl)phenyl]-N-hydroxy-3-phenylcyclopropane-1-carboxamide Show/Hide	C20H16FN3O2	2
1	IC50 = 50 nM
2	Kd = 110 nM
CP0173000 Compound Info	US9765054, Compound 58 Show/Hide	C19H16N2O3	1
1	IC50 = 50 nM
CP0376927 Compound Info	(1R,2S,3S)-N-hydroxy-1-methyl-2-[4-(5-methylpyrimidin-2-yl)phenyl]-3-phenylcyclopropane-1-carboxamide Show/Hide	C22H21N3O2	1
1	IC50 = 50 nM
CP0264086 Compound Info	N-[(2S)-1-pyrrolidin-1-ylpropan-2-yl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide Show/Hide	C17H19F3N4O2	1
1	IC50 = 50 nM
CP0003832 Compound Info	N'-hydroxy-N-phenyloctanediamide Show/Hide	C14H20N2O3	34
1	IC50 = 54.3 nM
2	IC50 = 63.2 nM
3	IC50 = 100.9 nM
4	IC50 = 113 nM
5	IC50 = 150 nM
6	IC50 = 177.81477 nM
7	IC50 = 210 nM
8	IC50 = 300 nM
9	IC50 = 340 nM
10	IC50 = 490 nM
11	IC50 = 493 nM
12	IC50 = 1140 nM
13	IC50 = 2139 nM
14	IC50 = 6200 nM
15	IC50 = 6860.1 nM
16	IC50 = 7800 nM
17	IC50 = 8800 nM
18	IC50 = 37090 nM
19	IC50 = 41000 nM
20	IC50 = 48300 nM
21	IC50 = 74000 nM
22	IC50 = 76000 nM
23	IC50 > 200 nM
24	IC50 > 1000 nM
25	IC50 > 5000 nM
26	IC50 > 10000 nM
27	IC50 > 33000 nM
28	IC50 > 33330 nM
29	IC50 > 50000 nM
30	IC50 > 100000 nM
31	Ki = 16 nM
32	Ki = 20 nM
33	Ki = 14000 nM
34	Ki = 28400 nM
CP0257542 Compound Info	US9765054, Compound 50h Show/Hide	C20H17N3O2	1
1	IC50 = 60 nM
CP0717881 Compound Info	(1R,2R,3R)-N-Hydroxy-2-(4-(oxazol-4-yl)phenyl)-3-phenylcyclopropanecarboxamide Show/Hide	C19H16N2O3	1
1	IC50 = 60 nM
CP0749497 Compound Info	(1R,2R,3R)-2-(3-Fluoro-4-(5-methyl-1H-imidazol-2-yl)-phenyl)-N-hydroxy-3-phenylcyclopropanecarboxamide Show/Hide	C20H18FN3O2	1
1	IC50 = 60 nM
CP0357107 Compound Info	N-[(2R)-1-[(2R)-2-methylpyrrolidin-1-yl]propan-2-yl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide Show/Hide	C18H21F3N4O2	1
1	IC50 = 70 nM
CP0157174 Compound Info	US9765054, Compound 50f Show/Hide	C20H17N3O2	1
1	IC50 = 80 nM
CP0911613 Compound Info	(1R,2R,3R)-N-Hydroxy-2-phenyl-3-(3-(trifluoromethyl)-quinoxalin-6-yl)cyclopropanecarboxamide Show/Hide	C19H14F3N3O2	1
1	IC50 = 80 nM
CP0046564 Compound Info	(1R,2R,3R)-N-hydroxy-2-phenyl-3-[4-[4-(trifluoromethyl)pyrimidin-2-yl]phenyl]cyclopropane-1-carboxamide Show/Hide	C21H16F3N3O2	1
1	IC50 = 80 nM
CP0073141 Compound Info	(1R,2R,3R)-2-[3-(5-fluoropyrimidin-2-yl)phenyl]-N-hydroxy-3-phenylcyclopropane-1-carboxamide Show/Hide	C20H16FN3O2	1
1	IC50 = 100 nM
CP0123522 Compound Info	US9765054, Compound 50l Show/Hide	C20H19N3O2	1
1	IC50 = 100 nM
CP0157173 Compound Info	US9765054, Compound 50i Show/Hide	C20H17N3O2	1
1	IC50 = 100 nM
CP0767204 Compound Info	(1R,2R,3S)-N-hydroxy-2-(2-methylthiazol-5-yl)-3-phenylcyclopropanecarboxamide Show/Hide	C14H14N2O2S	1
1	IC50 = 100 nM
CP0108591 Compound Info	(1S,2S,3S)-1-chloro-N-hydroxy-2-[4-(5-methylpyrimidin-2-yl)phenyl]-3-phenylcyclopropane-1-carboxamide Show/Hide	C21H18ClN3O2	1
1	IC50 = 110 nM
CP0344868 Compound Info	N-[(2R)-1-(4,4-difluoropiperidin-1-yl)propan-2-yl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide Show/Hide	C18H19F5N4O2	1
1	IC50 = 130 nM
CP0108592 Compound Info	(1R,2R,3R)-2-[4-(5-chloropyrimidin-2-yl)phenyl]-N-hydroxy-3-phenylcyclopropane-1-carboxamide Show/Hide	C20H16ClN3O2	1
1	IC50 = 140 nM
CP0173001 Compound Info	US9765054, Compound 56c Show/Hide	C20H20F2N2O2	1
1	IC50 = 150 nM
CP0389573 Compound Info	US9765054, Compound 56e Show/Hide	C21H22N2O3	1
1	IC50 = 150 nM
CP0652800 Compound Info	(1R,2R,3R)-2-(4-(5-(difluoromethoxy)pyrimidin-2-yl)phenyl)-N-hydroxy-3-phenylcyclopropanecarboxamide Show/Hide	C21H17F2N3O3	1
1	IC50 = 150 nM
CP0204867 Compound Info	(1R,2R,3R)-N-hydroxy-2-[4-(5-methylpyrimidin-2-yl)phenyl]-3-phenylcyclopropane-1-carboxamide Show/Hide	C21H19N3O2	1
1	IC50 = 180 nM
CP0003676 Compound Info	N-hydroxy-2-[[2-(6-methoxypyridin-3-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl-methylamino]pyrimidine-5-carboxamide Show/Hide	C23H24N8O4S	2
1	IC50 = 191 nM
2	IC50 = 409 nM
CP0761918 Compound Info	(1R,2R,3R)-N-Hydroxy-2-phenyl-3-(6-(trifluoromethyl)-imidazo[2,1-b]thiazol-2-yl)cyclopropanecarboxamide Show/Hide	C16H12F3N3O2S	1
1	IC50 = 200 nM
CP0066173 Compound Info	N-hydroxy-2,2-diphenylacetamide Show/Hide	C14H13NO2	2
1	IC50 = 220 nM
2	IC50 = 250 nM
CP0210248 Compound Info	US9765054, Compound 68 Show/Hide	C16H13F3N2O2	1
1	IC50 = 230 nM
CP0357106 Compound Info	N-[(2R)-1-(3,3-difluoropyrrolidin-1-yl)propan-2-yl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide Show/Hide	C17H17F5N4O2	1
1	IC50 = 230 nM
CP0717468 Compound Info	(1R,2R,3R)-2-(6-Cyclopropylpyridazin-4-yl)-N-hydroxy-3-phenylcyclopropanecarboxamide Show/Hide	C17H17N3O2	1
1	IC50 = 280 nM
CP0357109 Compound Info	N-(2-methyl-1-pyrrolidin-1-ylpropan-2-yl)-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide Show/Hide	C18H21F3N4O2	1
1	IC50 = 280 nM
CP0256853 Compound Info	US9765054, Compound 60 Show/Hide	C20H19N3O2	1
1	IC50 = 290 nM
CP0407436 Compound Info	US9765054, Compound 28G Show/Hide	C16H13F3N2O2	1
1	IC50 = 300 nM
CP0124688 Compound Info	N-hydroxy-9H-fluorene-9-carboxamide Show/Hide	C14H11NO2	2
1	IC50 = 310 nM
2	IC50 = 330 nM
CP0256854 Compound Info	US9765054, Compound 56d Show/Hide	C21H24N2O2	1
1	IC50 = 330 nM
CP0070387 Compound Info	(2R,3R)-N-hydroxy-2,3-diphenylcyclopropane-1-carboxamide Show/Hide	C16H15NO2	1
1	IC50 = 340 nM
CP0172999 Compound Info	US9765054, Compound 28f Show/Hide	C16H13F3N2O2	1
1	IC50 = 340 nM
CP0921509 Compound Info	(1R,2R,3R)-2-(2-Cyclopropylpyrimidin-5-yl)-N-hydroxy-3-phenylcyclopropanecarboxamide Show/Hide	C17H17N3O2	1
1	IC50 = 500 nM
CP0004988 Compound Info	pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate Show/Hide	C21H20N4O3	7
1	IC50 = 510 nM
2	IC50 = 3017 nM
3	IC50 = 10700 nM
4	IC50 = 48700 nM
5	IC50 > 10000 nM
6	IC50 > 50000 nM
7	IC50 > 100000 nM
CP0085832 Compound Info	(1R,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone Show/Hide	C24H36N4O6S2	2
1	IC50 = 510 nM
2	IC50 = 647 nM
CP0822679 Compound Info	(1R,2R,3S)-N-Hydroxy-2-(5-methylthiazol-2-yl)-3-phenylcyclopropanecarboxamide Show/Hide	C14H14N2O2S	1
1	IC50 = 530 nM
CP0070386 Compound Info	(1R,2R,3R)-N-hydroxy-2-(1-methylpyrazol-4-yl)-3-phenylcyclopropane-1-carboxamide Show/Hide	C14H15N3O2	1
1	IC50 = 540 nM
CP0749492 Compound Info	(1R,2R,3R)-N-Hydroxy-2-phenyl-3-(pyrazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide Show/Hide	C17H15N3O2	1
1	IC50 = 670 nM
CP0309948 Compound Info	tert-butyl N-[(2S)-1-(cycloheptylamino)-1-oxo-7-sulfanylheptan-2-yl]carbamate Show/Hide	C19H36N2O3S	1
1	IC50 = 840 nM
CP0264089 Compound Info	4-[5-(difluoromethyl)-1,2,4-oxadiazol-3-yl]-N-[(2R)-1-(dipropylamino)propan-2-yl]benzamide Show/Hide	C19H26F2N4O2	1
1	IC50 = 890 nM
CP0115609 Compound Info	N-hydroxy-2-[2-[6-(6-methoxypyridin-3-yl)-4-methylquinazolin-8-yl]oxyethyl-methylamino]pyrimidine-5-carboxamide Show/Hide	C23H23N7O4	1
1	IC50 = 972 nM
CP0132313 Compound Info	tert-butyl N-[(2S)-1-(cyclopentylamino)-1-oxo-7-sulfanylheptan-2-yl]carbamate Show/Hide	C17H32N2O3S	1
1	IC50 = 1030 nM
CP0247003 Compound Info	US9765054, Compound 28A Show/Hide	C14H13N3O2	1
1	IC50 = 1100 nM
CP0221541 Compound Info	tert-butyl N-[(2S)-1-(cyclohexylamino)-1-oxo-7-sulfanylheptan-2-yl]carbamate Show/Hide	C18H34N2O3S	1
1	IC50 = 1140 nM
CP0717467 Compound Info	(1R,2R,3R)-N-Hydroxy-2-(imidazo[1,2-a]pyridin-2-yl)-3-phenylcyclopropanecarboxamide Show/Hide	C17H15N3O2	1
1	IC50 = 1500 nM
CP0013041 Compound Info	HPOB Show/Hide	C17H18N2O4	2
1	IC50 = 1700 nM
2	IC50 > 10000 nM
CP0229886 Compound Info	US9765054, Compound 25C Show/Hide	C14H13N3O2	1
1	IC50 = 1800 nM
CP0004475 Compound Info	RICOLINOSTAT Show/Hide	C24H27N5O3	4
1	IC50 = 7000 nM
2	IC50 > 1000 nM
3	IC50 > 5000 nM
4	IC50 > 10000 nM
CP0420778 Compound Info	US9765054, Compound 25A Show/Hide	C15H19NO2	1
1	IC50 = 9000 nM
CP0057110 Compound Info	4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide Show/Hide	C19H23N3O3	1
1	IC50 = 9390 nM
CP0561037 Compound Info	N-[(2R)-1-(dipropylamino)propan-2-yl]-4-[3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl]benzamide Show/Hide	C19H25F3N4O2	1
1	IC50 = 28000 nM
CP0396397 Compound Info	6-[[4-(benzenesulfonyl)-5-oxido-1,2,5-oxadiazol-5-ium-3-yl]oxy]-N-hydroxyhexanamide Show/Hide	C14H17N3O7S	1
1	IC50 = 30000 nM
CP0908156 Compound Info	rac-(1S,2R)-N-Hydroxy-2-phenylcyclopropanecarboxamide Show/Hide	C10H11NO2	1
1	IC50 = 51000 nM
CP0363242 Compound Info	US8609678, 2-((2-chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide [89] Show/Hide	C24H26ClN5O3	2
1	IC50 > 1000 nM
2	IC50 > 20000 nM
CP0016939 Compound Info	N-(2-aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide Show/Hide	C23H20N6O	1
1	IC50 > 10000 nM
CP0015005 Compound Info	S-[(E)-4-[(4Z,7S,10S)-4-ethylidene-2,5,8,12-tetraoxo-7-propan-2-yl-9-oxa-16-thia-3,6,13,18-tetrazabicyclo[13.2.1]octadeca-1(17),15(18)-dien-10-yl]but-3-enyl] octanethioate Show/Hide	C29H42N4O6S2	1
1	IC50 > 10000 nM
CP0717470 Compound Info	(2R,3S)-N-Hydroxy-2,3-diphenylcyclopropanecarboxamide Show/Hide	C16H15NO2	1
1	IC50 > 50000 nM
CP0264088 Compound Info	N-[(2R)-1-(dipropylamino)propan-2-yl]-4-(5-methyl-1,2,4-oxadiazol-3-yl)benzamide Show/Hide	C19H28N4O2	1
1	IC50 > 50000 nM
CP0542917 Compound Info	N-[(2R)-1-(dipropylamino)propan-2-yl]-4-(1,2,4-oxadiazol-3-yl)benzamide Show/Hide	C18H26N4O2	1
1	IC50 > 50000 nM
CP0010599 Compound Info	UF010 Show/Hide	C11H15BrN2O	1
1	IC50 > 50000 nM
CP0011696 Compound Info	N-(2-aminophenyl)-4-[1-(2-thiophen-3-ylethyl)triazol-4-yl]benzamide Show/Hide	C21H19N5OS	1
1	IC50 > 100000 nM
CP0014660 Compound Info	N-(2-aminophenyl)-5-[1-[2-(3-nitrophenyl)ethyl]triazol-4-yl]thiophene-2-carboxamide Show/Hide	C21H18N6O3S	1
1	IC50 > 100000 nM
CP0013235 Compound Info	(E)-3-[2-butyl-1-[2-(diethylamino)ethyl]benzimidazol-5-yl]-N-hydroxyprop-2-enamide Show/Hide	C20H32Cl2N4O2	1
1	Ki = 16 nM
CP0013905 Compound Info	[6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate Show/Hide	C24H27N3O4	1
1	Ki = 1050 nM

Clinical Information about the Protein

Target 1 ( Histone deacetylase 4 (HDAC4) )

Target Type	Clinical trial Target
Disease	1 Target-related Disease				1
1	Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Investigative Drug(s)	1 Investigative Drug				1
1	ST-2987	Drug Info	Investigative	Solid tumour/cancer

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han