Brief Information of the Cell Line and Protein
Cell Line ID: CL000081 , Jurkat E6.1
 Cell Line Info 
Synonyms
JurkatE6-1
Jurkat E6-1
Jurkat, Clone E6-1
Jurkat Clone E6-1
Jurkat (clone E6-1)
JURKAT E-6.1
JURKAT E-61
Jurkat-CloneE61
Jurkat-E6
Jurkat E6
J.E6-1
E6-1
Jurkat J6
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0367
Protein ID: PT01878 , Mitogen-activated protein kinase kinase kinase kinase 1
 Protein Info 
Gene Name MAP4K1
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID Q92918
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000081
 Cell Line Info 
 Protein ID: PT01878
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0579637
 Compound Info 
CHEMBL5081453
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C25H29ClFN5O2
  1
1
IC50 = 1200 nM
 Bioactivity Info 
   TI
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CP0572711
 Compound Info 
6-amino-3-(4-chlorospiro[1,2-dihydropyrrolo[2,3-b]pyridine-3,1'-cyclopentane]-5-yl)-2-fluoro-N,N-dimethylbenzamide
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C20H22ClFN4O
  1
1
IC50 = 1500 nM
 Bioactivity Info 
   TI
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CP0546094
 Compound Info 
6-amino-3-[(1'S,3R)-4-chloro-1'-cyano-1'-methylspiro[1,2-dihydropyrrolo[2,3-b]pyridine-3,3'-cyclopentane]-5-yl]-2-fluoro-N,N-dimethylbenzamide
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C22H23ClFN5O
  1
1
IC50 = 1700 nM
 Bioactivity Info 
   TI
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CP0568791
 Compound Info 
CHEMBL5091391
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C24H27ClFN5O2
  1
1
IC50 = 1700 nM
 Bioactivity Info 
   TI
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CP0527829
 Compound Info 
6-amino-3-[(1'S,3R)-4-chloro-1'-hydroxy-1'-methylspiro[1,2-dihydropyrrolo[2,3-b]pyridine-3,3'-cyclopentane]-5-yl]-2-fluoro-N,N-dimethylbenzamide
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C21H24ClFN4O2
  1
1
IC50 = 2000 nM
 Bioactivity Info 
   TI
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CP0527830
 Compound Info 
6-amino-3-(4-chloro-1'-hydroxy-1'-methylspiro[1,2-dihydropyrrolo[2,3-b]pyridine-3,4'-cyclohexane]-5-yl)-2-fluoro-N,N-dimethylbenzamide
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C22H26ClFN4O2
  1
1
IC50 = 3000 nM
 Bioactivity Info 
   TI
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CP0568965
 Compound Info 
6-amino-3-[(3R,3'S)-4-chloro-3'-hydroxyspiro[1,2-dihydropyrrolo[2,3-b]pyridine-3,1'-cyclopentane]-5-yl]-2-fluoro-N,N-dimethylbenzamide
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C20H22ClFN4O2
  1
1
IC50 = 5000 nM
 Bioactivity Info 
   TI
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CP0546095
 Compound Info 
(1'S,3R)-5-[4-amino-3-(dimethylcarbamoyl)-2-fluorophenyl]-4-chloro-N-methylspiro[1,2-dihydropyrrolo[2,3-b]pyridine-3,3'-cyclopentane]-1'-carboxamide
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C22H25ClFN5O2
  1
1
IC50 = 7400 nM
 Bioactivity Info 
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CP0572072
 Compound Info 
6-amino-3-(4-chloro-1'-cyano-1'-methylspiro[1,2-dihydropyrrolo[2,3-b]pyridine-3,4'-cyclohexane]-5-yl)-2-fluoro-N,N-dimethylbenzamide
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C23H25ClFN5O
  1
1
IC50 = 7900 nM
 Bioactivity Info 
   TI
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CP0568790
 Compound Info 
(1'S,3R)-5-[4-amino-3-(dimethylcarbamoyl)-2-fluorophenyl]-4-chlorospiro[1,2-dihydropyrrolo[2,3-b]pyridine-3,3'-cyclopentane]-1'-carboxamide
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C21H23ClFN5O2
  1
1
IC50 = 14000 nM
 Bioactivity Info 
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CP0955724
 Compound Info 
(+/-)-(1R*,3S*)-6-Amino-3-(4'-chloro-3-(1H-1,2,4-triazol-5-yl)-1',2'-dihydrospiro[cyclopentane-1,3'-pyrrolo[2,3-b]pyridin]-5'-yl)-2-fluoro-N,N-dimethylbenzamide
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C22H23ClFN7O
  1
1
IC50 = 15000 nM
 Bioactivity Info 
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CP0546097
 Compound Info 
(1'R,3S)-5-[4-amino-3-(dimethylcarbamoyl)-2-fluorophenyl]-4-chloro-1'-methylspiro[1,2-dihydropyrrolo[2,3-b]pyridine-3,3'-cyclopentane]-1'-carboxamide
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C22H25ClFN5O2
  1
1
IC50 > 25000 nM
 Bioactivity Info 
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