Brief Information of the Compound and Protein
Compound Name
6-amino-3-(4-chloro-1'-cyano-1'-methylspiro[1,2-dihydropyrrolo[2,3-b]pyridine-3,4'-cyclohexane]-5-yl)-2-fluoro-N,N-dimethylbenzamide
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Canonical SMILES
CN(C)C(=O)c1c(N)ccc(c1F)-c1cnc2NC[C@]3(CC[C@](C)(CC3)C#N)c2c1Cl
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Compound Formula C23H25ClFN5O
Compound Structure
Protein Name
Mitogen-activated protein kinase kinase kinase kinase 1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
STE protein kinase group
>
STE protein kinase STE20 family
>
STE protein kinase KHS subfamily
Uniprot ID
Q92918
Gene Name
MAP4K1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000081 Jurkat E6.1 Homo sapiens (Human)  1
1
IC50 = 7900 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 8.4 nM