Protein Information

General Information of the Protein

Protein ID	PT01552
Protein Name	Nuclear receptor subfamily 1 group I member 2
Secondarily Protein Name	Orphan nuclear receptor PAR1 Orphan nuclear receptor PXR Pregnane X receptor Steroid and xenobiotic receptor
Gene Name	NR1I2
Secondarily Gene Name	PXR
Sequence	MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Transcription factor > Nuclear receptor > Nuclear hormone receptor subfamily 1 > Nuclear hormone receptor subfamily 1 group I > Nuclear hormone receptor subfamily 1 group I member 2
Function	Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. Show/Hide
Uniprot ID	Primary ID: O75469 Secondarily ID: Q006P5 Q008C8 Q96AC7 Q9UJ22 Q9UJ23 Q9UJ24 Q9UJ25 Q9UJ26 Q9UJ27 Q9UNW4 Show/Hide
HGNC ID	HGNC:7968
Subcellular Location	Nucleus

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000514 , DPX2

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0023108 Compound Info	(9,12,15)-linolenic acid Show/Hide	C18H30O2	1
1	EC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0084133 Compound Info	CHEBI:31524 Show/Hide	C9H11NO5	1
1	EC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0005068 Compound Info	2,6-difluoro-4-[[(1S)-1-(2-fluorophenyl)ethyl]amino]-N-(1,3-thiazol-4-yl)benzenesulfonamide Show/Hide	C17H14F3N3O2S2	1
1	EC50 = 250 nM Bioactivity Info	TI LI LO TS
CP0007586 Compound Info	5-chloro-4-[[(1S)-1-(2,5-difluorophenyl)ethyl]amino]-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide Show/Hide	C17H13ClF3N3O2S2	1
1	EC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0002464 Compound Info	5-chloro-2-fluoro-4-[[(1R)-2-methoxy-1-phenylethyl]amino]-N-(1,3-thiazol-2-yl)benzenesulfonamide Show/Hide	C18H17ClFN3O3S2	1
1	EC50 = 420 nM Bioactivity Info	TI LI LO TS
CP0004048 Compound Info	5-chloro-4-[[(1S)-1-(2,4-difluorophenyl)ethyl]amino]-2-fluoro-N-(1,3-thiazol-2-yl)benzenesulfonamide Show/Hide	C17H13ClF3N3O2S2	1
1	EC50 = 420 nM Bioactivity Info	TI LI LO TS
CP0013039 Compound Info	4-[[(1S)-1-(5-cyano-2-fluorophenyl)ethyl]amino]-2,6-difluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide Show/Hide	C18H13F3N4O2S2	1
1	EC50 = 630 nM Bioactivity Info	TI LI LO TS
CP0084134 Compound Info	ORG-6216 Show/Hide	C24H34O3	2
1	EC50 = 1600 nM Bioactivity Info	TI LI LO TS
2	EC50 = 4000 nM Bioactivity Info	TI LI LO TS
CP0337534 Compound Info	Riodipine Show/Hide	C18H19F2NO5	2
1	EC50 = 1600 nM Bioactivity Info	TI LI LO TS
2	EC50 = 4000 nM Bioactivity Info	TI LI LO TS
CP0012726 Compound Info	5-chloro-2-fluoro-4-[[(1S)-1-(2-fluoro-5-methoxyphenyl)ethyl]amino]-N-(1,3-thiazol-4-yl)benzenesulfonamide Show/Hide	C18H16ClF2N3O3S2	1
1	EC50 = 1680 nM Bioactivity Info	TI LI LO TS
CP0077818 Compound Info	CL-287389 Show/Hide	C19H19N3O6	2
1	EC50 = 1900 nM Bioactivity Info	TI LI LO TS
2	EC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0082870 Compound Info	5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C18H19Cl2NO4	2
1	EC50 = 1900 nM Bioactivity Info	TI LI LO TS
2	EC50 = 3900 nM Bioactivity Info	TI LI LO TS
CP0960351 Compound Info	2-(5-Hydroxy-2-methyl-1H-indol-3-yl)-N-((S)-1-(4-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)pentyl)propanamide Show/Hide	C30H33N5O3	1
1	EC50 = 1900 nM Bioactivity Info	TI LI LO TS
CP0010068 Compound Info	CHEBI:78886 Show/Hide	C10H14O2	2
1	EC50 = 2000 nM Bioactivity Info	TI LI LO TS
2	EC50 = 12600 nM Bioactivity Info	TI LI LO TS
CP0011265 Compound Info	2,6-difluoro-4-[[(1S)-1-(2-fluoro-5-methoxyphenyl)ethyl]amino]-N-(1,3-thiazol-4-yl)benzenesulfonamide Show/Hide	C18H16F3N3O3S2	1
1	EC50 = 2450 nM Bioactivity Info	TI LI LO TS
CP0914177 Compound Info	(S)-2-(5-methoxy-1H-indol-3-yl)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)pentyl)acetamide Show/Hide	C29H31N5O3	1
1	EC50 = 2500 nM Bioactivity Info	TI LI LO TS
CP0166548 Compound Info	(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-benzo[f]chromen-5-yl acetate Show/Hide	C22H34O7	2
1	EC50 = 2700 nM Bioactivity Info	TI LI LO TS
2	EC50 = 7900 nM Bioactivity Info	TI LI LO TS
CP0951201 Compound Info	2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)pentyl)propanamide Show/Hide	C31H35N5O3	1
1	EC50 = 2900 nM Bioactivity Info	TI LI LO TS
CP0013887 Compound Info	5-chloro-2-fluoro-4-[[(1S)-1-pyridin-3-ylethyl]amino]-N-(1,3-thiazol-2-yl)benzenesulfonamide Show/Hide	C16H14ClFN4O2S2	1
1	EC50 = 3000 nM Bioactivity Info	TI LI LO TS
CP0055221 Compound Info	Famprofazone Show/Hide	C24H31N3O	2
1	EC50 = 3100 nM Bioactivity Info	TI LI LO TS
2	EC50 = 5100 nM Bioactivity Info	TI LI LO TS
CP0011908 Compound Info	4-[[2-(azetidin-1-ylmethyl)-6-fluorophenyl]methylamino]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide Show/Hide	C20H19ClF2N4O2S2	1
1	EC50 = 3100 nM Bioactivity Info	TI LI LO TS
CP0071702 Compound Info	BA-41166E Show/Hide	C43H58N4O12	2
1	EC50 = 3200 nM Bioactivity Info	TI LI LO TS
2	EC50 = 3500 nM Bioactivity Info	TI LI LO TS
CP0084497 Compound Info	CHEBI:31625 Show/Hide	C22H29FO4	2
1	EC50 = 3200 nM Bioactivity Info	TI LI LO TS
2	EC50 = 12600 nM Bioactivity Info	TI LI LO TS
CP0807345 Compound Info	SID144205546 Show/Hide	C41H49ClN2O9	1
1	EC50 = 3200 nM Bioactivity Info	TI LI LO TS
CP0058606 Compound Info	3-[3-(4-benzhydrylpiperazin-1-yl)propyl]-1H-benzimidazol-2-one Show/Hide	C27H30N4O	2
1	EC50 = 3500 nM Bioactivity Info	TI LI LO TS
2	EC50 = 7100 nM Bioactivity Info	TI LI LO TS
CP0154074 Compound Info	(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 3,5-dimethylbenzoate Show/Hide	C17H23NO2	2
1	EC50 = 3500 nM Bioactivity Info	TI LI LO TS
2	EC50 = 15800 nM Bioactivity Info	TI LI LO TS
CP0036175 Compound Info	1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[(2S)-3-methyl-2-{[methyl({[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl})carbamoyl]amino}butanamido]-1,6-diphenylhexan-2-yl]carbamate Show/Hide	C37H48N6O5S2	1
1	EC50 = 4000 nM Bioactivity Info	TI LI LO TS
CP0787567 Compound Info	Ecopipam hydrobromide Show/Hide	C19H21BrClNO	2
1	EC50 = 4000 nM Bioactivity Info	TI LI LO TS
2	EC50 = 12600 nM Bioactivity Info	TI LI LO TS
CP0650352 Compound Info	THIAMYLAL SODIUM Show/Hide	C12H17N2NaO2S	2
1	EC50 = 4100 nM Bioactivity Info	TI LI LO TS
2	EC50 = 6400 nM Bioactivity Info	TI LI LO TS
CP0001104 Compound Info	2,6-difluoro-4-[[2-fluoro-6-[[methyl(propan-2-yl)amino]methyl]phenyl]methylamino]-N-(1,3-thiazol-4-yl)benzenesulfonamide Show/Hide	C21H23F3N4O2S2	1
1	EC50 = 4100 nM Bioactivity Info	TI LI LO TS
CP0951199 Compound Info	(S)-2-(1H-indol-3-yl)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)pentyl)acetamide Show/Hide	C28H29N5O2	1
1	EC50 = 4400 nM Bioactivity Info	TI LI LO TS
CP0013040 Compound Info	5-chloro-4-[[2-[(2,2-dimethylazetidin-1-yl)methyl]-6-fluorophenyl]methylamino]-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide Show/Hide	C22H23ClF2N4O2S2	1
1	EC50 = 4800 nM Bioactivity Info	TI LI LO TS
CP0048240 Compound Info	BDBM50101974 Show/Hide	C24H27NO5S	2
1	EC50 = 6900 nM Bioactivity Info	TI LI LO TS
2	EC50 = 31600 nM Bioactivity Info	TI LI LO TS
CP0246675 Compound Info	Bumecaine Show/Hide	C18H28N2O	2
1	EC50 = 7000 nM Bioactivity Info	TI LI LO TS
2	EC50 = 11000 nM Bioactivity Info	TI LI LO TS
CP0048232 Compound Info	A-61589 Show/Hide	C21H26O3	2
1	EC50 = 7100 nM Bioactivity Info	TI LI LO TS
2	EC50 = 28200 nM Bioactivity Info	TI LI LO TS
CP0852141 Compound Info	SID50107064 Show/Hide	C23H30ClN3O2S2	2
1	EC50 = 7100 nM Bioactivity Info	TI LI LO TS
2	EC50 = 12600 nM Bioactivity Info	TI LI LO TS
CP0086100 Compound Info	L-1633 Show/Hide	C18H23O3S-	2
1	EC50 = 8900 nM Bioactivity Info	TI LI LO TS
2	EC50 = 25100 nM Bioactivity Info	TI LI LO TS
CP0066208 Compound Info	Fungistat Show/Hide	C26H31Cl2N5O3	2
1	EC50 = 8900 nM Bioactivity Info	TI LI LO TS
2	EC50 = 14100 nM Bioactivity Info	TI LI LO TS
CP0001105 Compound Info	4-[[2-[[tert-butyl(methyl)amino]methyl]-6-fluorophenyl]methylamino]-2,6-difluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide Show/Hide	C22H25F3N4O2S2	1
1	EC50 = 9400 nM Bioactivity Info	TI LI LO TS
CP0045344 Compound Info	4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide Show/Hide	C31H33N3O6S	2
1	EC50 = 9500 nM Bioactivity Info	TI LI LO TS
2	EC50 = 14100 nM Bioactivity Info	TI LI LO TS
CP0000815 Compound Info	Rapamycin C-7, analog 4 Show/Hide	C51H79NO13	1
1	EC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0037303 Compound Info	ADD-3878 Show/Hide	C18H23NO3S	2
1	EC50 = 10000 nM Bioactivity Info	TI LI LO TS
2	EC50 = 14100 nM Bioactivity Info	TI LI LO TS
CP0068778 Compound Info	[(E)-2-chloro-1-(2,4-dichlorophenyl)ethenyl] diethyl phosphate Show/Hide	C12H14Cl3O4P	2
1	EC50 = 10000 nM Bioactivity Info	TI LI LO TS
2	EC50 = 12600 nM Bioactivity Info	TI LI LO TS
CP0150271 Compound Info	BAY-H-5757 Show/Hide	C20H22N4O6S	2
1	EC50 = 10000 nM Bioactivity Info	TI LI LO TS
2	EC50 = 15800 nM Bioactivity Info	TI LI LO TS
CP0068895 Compound Info	ethyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate Show/Hide	C22H23ClN2O2	2
1	EC50 = 10000 nM Bioactivity Info	TI LI LO TS
2	EC50 = 12600 nM Bioactivity Info	TI LI LO TS
CP0072914 Compound Info	US20230414632, Compound I-e Show/Hide	C20H24N2O6	2
1	EC50 = 10000 nM Bioactivity Info	TI LI LO TS
2	EC50 = 12600 nM Bioactivity Info	TI LI LO TS
CP0093021 Compound Info	(5-Phenylsulfanyl-1H-benzoimidazol-2-yl)-carbamic acid methyl ester Show/Hide	C15H13N3O2S	1
1	EC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0669919 Compound Info	SID56463066 Show/Hide	C32H55BrN4O	1
1	EC50 = 11200 nM Bioactivity Info	TI LI LO TS
CP0286860 Compound Info	(2Z,6Z)-2,6-bis(thiophen-2-ylmethylidene)cyclohexan-1-one Show/Hide	C16H14OS2	1
1	EC50 = 11200 nM Bioactivity Info	TI LI LO TS
CP0002465 Compound Info	4-[[2-[(2,2-dimethylazetidin-1-yl)methyl]-6-fluorophenyl]methylamino]-2,6-difluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide Show/Hide	C22H23F3N4O2S2	1
1	EC50 = 11800 nM Bioactivity Info	TI LI LO TS
CP0041351 Compound Info	2,2'-THIOBIS(4,6-DICHLOROPHENOL) Show/Hide	C12H6Cl4O2S	1
1	EC50 = 12600 nM Bioactivity Info	TI LI LO TS
CP0045801 Compound Info	(10R,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C21H30O2	2
1	EC50 = 12600 nM Bioactivity Info	TI LI LO TS
2	EC50 = 31600 nM Bioactivity Info	TI LI LO TS
CP0065655 Compound Info	4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide Show/Hide	C27H29N5O6S	2
1	EC50 = 12600 nM Bioactivity Info	TI LI LO TS
2	EC50 = 14100 nM Bioactivity Info	TI LI LO TS
CP0069705 Compound Info	CHEBI:6888 Show/Hide	C22H30O5	1
1	EC50 = 12600 nM Bioactivity Info	TI LI LO TS
CP0113904 Compound Info	CHEBI:6806 Show/Hide	C22H22N2O8	1
1	EC50 = 12600 nM Bioactivity Info	TI LI LO TS
CP0678377 Compound Info	SID50106762 Show/Hide	C23H32ClNO2	2
1	EC50 = 12600 nM Bioactivity Info	TI LI LO TS
2	EC50 = 25100 nM Bioactivity Info	TI LI LO TS
CP0077813 Compound Info	(-)-demecolcine Show/Hide	C21H25NO5	1
1	EC50 = 12600 nM Bioactivity Info	TI LI LO TS
CP0294381 Compound Info	CHEBI:31550 Show/Hide	C27H41NO6S	1
1	EC50 = 12600 nM Bioactivity Info	TI LI LO TS
CP0388937 Compound Info	RIFAXIMIN Show/Hide	C43H51N3O11	1
1	EC50 = 14100 nM Bioactivity Info	TI LI LO TS
CP0783466 Compound Info	SID50112861 Show/Hide	C21H24ClN2NaO4S	2
1	EC50 = 14100 nM Bioactivity Info	TI LI LO TS
2	EC50 = 22400 nM Bioactivity Info	TI LI LO TS
CP0040193 Compound Info	(15R,19R)-15-ethyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraen-17-one Show/Hide	C19H22N2O	1
1	EC50 = 14100 nM Bioactivity Info	TI LI LO TS
CP0714309 Compound Info	indinavir sulphate Show/Hide	C36H49N5O8S	2
1	EC50 = 14100 nM Bioactivity Info	TI LI LO TS
2	EC50 = 15800 nM Bioactivity Info	TI LI LO TS
CP0951200 Compound Info	3-amino-2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)pentyl)propanamide Show/Hide	C31H36N6O3	1
1	EC50 > 15000 nM Bioactivity Info	TI LI LO TS
CP0077816 Compound Info	LASALOCID A SODIUM Show/Hide	C34H53NaO8	1
1	EC50 = 17800 nM Bioactivity Info	TI LI LO TS
CP0129175 Compound Info	8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one Show/Hide	C22H25N3O3	2
1	EC50 = 20000 nM Bioactivity Info	TI LI LO TS
2	EC50 = 35500 nM Bioactivity Info	TI LI LO TS
CP0007434 Compound Info	4-[[5-(azetidin-1-ylmethyl)-2-fluorophenyl]methylamino]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide Show/Hide	C20H19ClF2N4O2S2	1
1	EC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0011266 Compound Info	4-[[(1S)-1-[5-(azetidin-1-ylmethyl)-2-fluorophenyl]ethyl]amino]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide Show/Hide	C21H21ClF2N4O2S2	1
1	EC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0241176 Compound Info	(7R,11S)-11-methyl-7,15,17-tris(oxidanyl)-12-oxabicyclo[12.4.0]octadeca-1(14),15,17-trien-13-one Show/Hide	C18H26O5	2
1	EC50 = 23700 nM Bioactivity Info	TI LI LO TS
2	EC50 = 25100 nM Bioactivity Info	TI LI LO TS
CP0187532 Compound Info	EVRA Show/Hide	C21H29NO2	1
1	EC50 = 25100 nM Bioactivity Info	TI LI LO TS
CP0058220 Compound Info	(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate Show/Hide	C29H53NO5	1
1	EC50 = 28200 nM Bioactivity Info	TI LI LO TS
CP0382330 Compound Info	CHEBI:35001 Show/Hide	C25H38O3	2
1	EC50 = 28200 nM Bioactivity Info	TI LI LO TS
2	EC50 = 31600 nM Bioactivity Info	TI LI LO TS
CP0187528 Compound Info	4-Amino-N-(2-amino-phenyl)-benzamide Show/Hide	C13H13N3O	1
1	EC50 = 28200 nM Bioactivity Info	TI LI LO TS
CP0906813 Compound Info	3-amino-2-(5-hydroxy-2-methyl-1H-indol-3-yl)-N-((S)-1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)pentyl)propanamide Show/Hide	C30H34N6O3	1
1	EC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0960834 Compound Info	(S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)pentyl)-1-methylazetidine-3-carboxamide Show/Hide	C23H29N5O2	1
1	EC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0002228 Compound Info	(S)-2-(4,6-Dimethyl-pyrimidin-2-yloxy)-3-methoxy-3,3-diphenyl-propionic acid Show/Hide	C22H22N2O4	1
1	EC50 = 31600 nM Bioactivity Info	TI LI LO TS
CP0066002 Compound Info	A-41-304 Show/Hide	C22H29FO4	1
1	EC50 = 31600 nM Bioactivity Info	TI LI LO TS
CP0271312 Compound Info	Enzacamene Show/Hide	C18H22O	1
1	EC50 = 31600 nM Bioactivity Info	TI LI LO TS
CP0675983 Compound Info	AMLODIPINE BESYLATE Show/Hide	C26H31ClN2O8S	1
1	EC50 = 31600 nM Bioactivity Info	TI LI LO TS
CP0041772 Compound Info	4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-phthalazin-1-one Show/Hide	C22H28N2O	1
1	EC50 = 31600 nM Bioactivity Info	TI LI LO TS
CP0217342 Compound Info	Diclazuril Show/Hide	C17H9Cl3N4O2	2
1	EC50 = 31600 nM Bioactivity Info	TI LI LO TS
2	EC50 = 35500 nM Bioactivity Info	TI LI LO TS
CP0003832 Compound Info	N'-hydroxy-N-phenyloctanediamide Show/Hide	C14H20N2O3	1
1	EC50 = 35500 nM Bioactivity Info	TI LI LO TS
CP0099682 Compound Info	AS-229 Show/Hide	C9H5Cl2NO	1
1	EC50 = 39800 nM Bioactivity Info	TI LI LO TS
CP0077899 Compound Info	Anti-Lewisite Show/Hide	C3H8OS2	1
1	EC50 = 50100 nM Bioactivity Info	TI LI LO TS
CP0041554 Compound Info	Thyroxine Show/Hide	C15H11I4NO4	1
1	EC50 = 100000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000017 , HeLa

Cell Line Info

Cell Line ID: CL000063 , Hep-G2

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0003740 Compound Info	N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide Show/Hide	C17H12F9NO3S	3
1	EC50 = 50 nM
2	IC50 = 36 nM
3	IC50 = 39.81 nM
CP0357968 Compound Info	CHEBI:77317 Show/Hide	C24H42O7P2	2
1	EC50 = 60 nM
2	EC50 = 440 nM
CP0095082 Compound Info	DABRAFENIB Show/Hide	C23H20F3N5O2S2	1
1	EC50 = 87 nM
CP0071702 Compound Info	BA-41166E Show/Hide	C43H58N4O12	1
1	EC50 = 200 nM
CP0045344 Compound Info	4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide Show/Hide	C31H33N3O6S	1
1	EC50 = 710 nM
CP0000815 Compound Info	Rapamycin C-7, analog 4 Show/Hide	C51H79NO13	1
1	EC50 = 890 nM
CP0077818 Compound Info	CL-287389 Show/Hide	C19H19N3O6	1
1	EC50 = 890 nM
CP0041351 Compound Info	2,2'-THIOBIS(4,6-DICHLOROPHENOL) Show/Hide	C12H6Cl4O2S	1
1	EC50 = 1000 nM
CP0055221 Compound Info	Famprofazone Show/Hide	C24H31N3O	1
1	EC50 = 1300 nM
CP0084497 Compound Info	CHEBI:31625 Show/Hide	C22H29FO4	1
1	EC50 = 1300 nM
CP0058220 Compound Info	(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate Show/Hide	C29H53NO5	1
1	EC50 = 1600 nM
CP0087963 Compound Info	N-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-hydroxy-3-methylbutanamide Show/Hide	C23H35ClN2O4	1
1	EC50 = 1800 nM
CP0023108 Compound Info	(9,12,15)-linolenic acid Show/Hide	C18H30O2	1
1	EC50 = 2500 nM
CP0084134 Compound Info	ORG-6216 Show/Hide	C24H34O3	1
1	EC50 = 2500 nM
CP0084133 Compound Info	CHEBI:31524 Show/Hide	C9H11NO5	1
1	EC50 = 3200 nM
CP0113904 Compound Info	CHEBI:6806 Show/Hide	C22H22N2O8	1
1	EC50 = 3200 nM
CP0241176 Compound Info	(7R,11S)-11-methyl-7,15,17-tris(oxidanyl)-12-oxabicyclo[12.4.0]octadeca-1(14),15,17-trien-13-one Show/Hide	C18H26O5	1
1	EC50 = 4000 nM
CP0037303 Compound Info	ADD-3878 Show/Hide	C18H23NO3S	1
1	EC50 = 4500 nM
CP0077899 Compound Info	Anti-Lewisite Show/Hide	C3H8OS2	1
1	EC50 = 5000 nM
CP0246675 Compound Info	Bumecaine Show/Hide	C18H28N2O	1
1	EC50 = 5000 nM
CP0271312 Compound Info	Enzacamene Show/Hide	C18H22O	1
1	EC50 = 5000 nM
CP0077816 Compound Info	LASALOCID A SODIUM Show/Hide	C34H53NaO8	1
1	EC50 = 5600 nM
CP0086100 Compound Info	L-1633 Show/Hide	C18H23O3S-	1
1	EC50 = 6300 nM
CP0787567 Compound Info	Ecopipam hydrobromide Show/Hide	C19H21BrClNO	1
1	EC50 = 6300 nM
CP0082870 Compound Info	5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Show/Hide	C18H19Cl2NO4	1
1	EC50 = 7100 nM
CP0058606 Compound Info	3-[3-(4-benzhydrylpiperazin-1-yl)propyl]-1H-benzimidazol-2-one Show/Hide	C27H30N4O	1
1	EC50 = 7900 nM
CP0068778 Compound Info	[(E)-2-chloro-1-(2,4-dichlorophenyl)ethenyl] diethyl phosphate Show/Hide	C12H14Cl3O4P	1
1	EC50 = 7900 nM
CP0072914 Compound Info	US20230414632, Compound I-e Show/Hide	C20H24N2O6	1
1	EC50 = 7900 nM
CP0217342 Compound Info	Diclazuril Show/Hide	C17H9Cl3N4O2	1
1	EC50 = 7900 nM
CP0048240 Compound Info	BDBM50101974 Show/Hide	C24H27NO5S	1
1	EC50 = 8900 nM
CP0065655 Compound Info	4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide Show/Hide	C27H29N5O6S	1
1	EC50 = 8900 nM
CP0068895 Compound Info	ethyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate Show/Hide	C22H23ClN2O2	1
1	EC50 = 10000 nM
CP0286860 Compound Info	(2Z,6Z)-2,6-bis(thiophen-2-ylmethylidene)cyclohexan-1-one Show/Hide	C16H14OS2	1
1	EC50 = 10000 nM
CP0041554 Compound Info	Thyroxine Show/Hide	C15H11I4NO4	1
1	EC50 = 11200 nM
CP0382330 Compound Info	CHEBI:35001 Show/Hide	C25H38O3	1
1	EC50 = 11200 nM
CP0669919 Compound Info	SID56463066 Show/Hide	C32H55BrN4O	1
1	EC50 = 11200 nM
CP0040193 Compound Info	(15R,19R)-15-ethyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraen-17-one Show/Hide	C19H22N2O	1
1	EC50 = 12600 nM
CP0045801 Compound Info	(10R,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol Show/Hide	C21H30O2	1
1	EC50 = 12600 nM
CP0048232 Compound Info	A-61589 Show/Hide	C21H26O3	1
1	EC50 = 12600 nM
CP0077813 Compound Info	(-)-demecolcine Show/Hide	C21H25NO5	1
1	EC50 = 14100 nM
CP0154074 Compound Info	(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 3,5-dimethylbenzoate Show/Hide	C17H23NO2	1
1	EC50 = 14100 nM
CP0166548 Compound Info	(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-benzo[f]chromen-5-yl acetate Show/Hide	C22H34O7	1
1	EC50 = 14100 nM
CP0337534 Compound Info	Riodipine Show/Hide	C18H19F2NO5	1
1	EC50 = 14100 nM
CP0650352 Compound Info	THIAMYLAL SODIUM Show/Hide	C12H17N2NaO2S	1
1	EC50 = 14100 nM
CP0678377 Compound Info	SID50106762 Show/Hide	C23H32ClNO2	1
1	EC50 = 14100 nM
CP0807345 Compound Info	SID144205546 Show/Hide	C41H49ClN2O9	1
1	EC50 = 15800 nM
CP0003832 Compound Info	N'-hydroxy-N-phenyloctanediamide Show/Hide	C14H20N2O3	1
1	EC50 = 25100 nM
CP0129175 Compound Info	8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one Show/Hide	C22H25N3O3	1
1	EC50 = 25100 nM
CP0675983 Compound Info	AMLODIPINE BESYLATE Show/Hide	C26H31ClN2O8S	1
1	EC50 = 28200 nM
CP0041772 Compound Info	4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-phthalazin-1-one Show/Hide	C22H28N2O	1
1	EC50 = 31600 nM
CP0294381 Compound Info	CHEBI:31550 Show/Hide	C27H41NO6S	1
1	EC50 = 31600 nM
CP0783466 Compound Info	SID50112861 Show/Hide	C21H24ClN2NaO4S	1
1	EC50 = 39800 nM
CP0329667 Compound Info	US10550091, No. LC-51 Show/Hide	C20H19ClN4O3S	1
1	IC50 = 61 nM
CP0444363 Compound Info	US10550091, No. LC-37 Show/Hide	C20H24N4O4S	1
1	IC50 = 180 nM
CP0423504 Compound Info	US10550091, No. LC-1 Show/Hide	C21H25N3O4S	1
1	IC50 = 190 nM
CP0329676 Compound Info	US10550091, No. LC-50 Show/Hide	C21H22N4O3S	1
1	IC50 = 210 nM
CP0329680 Compound Info	US10550091, No. LC-7 Show/Hide	C20H22ClN3O3S	1
1	IC50 = 250 nM
CP0355713 Compound Info	US10550091, No. LC-53 Show/Hide	C22H25N3O4S	1
1	IC50 = 260 nM
CP0329674 Compound Info	US10550091, No. LC-38 Show/Hide	C20H24N4O3S	1
1	IC50 = 280 nM
CP0271429 Compound Info	US10550091, No. LC-49 Show/Hide	C21H22N4O4S	1
1	IC50 = 300 nM
CP0329681 Compound Info	1-(5-tert-butyl-2-methoxyphenyl)-4-(4-tert-butylphenyl)sulfonyl-5-methyltriazole Show/Hide	C24H31N3O3S	1
1	IC50 = 300 nM
CP0329679 Compound Info	US10550091, No. LC-78 Show/Hide	C22H25ClN2O3S	1
1	IC50 = 350 nM
CP0423603 Compound Info	US10550091, No. LC-17 Show/Hide	C22H24N4O4S	1
1	IC50 = 360 nM
CP0130500 Compound Info	US10550091, No. LC-28 Show/Hide	C20H21Cl2N3O3S	1
1	IC50 = 400 nM
CP0130503 Compound Info	US10550091, No. LC-77 Show/Hide	C23H28N2O3S	1
1	IC50 = 400 nM
CP0138483 Compound Info	3-[4-(4-tert-butylphenyl)sulfonyl-5-methyltriazol-1-yl]-4-methoxybenzonitrile Show/Hide	C21H22N4O3S	1
1	IC50 = 400 nM
CP0329669 Compound Info	4-(4-tert-butylphenyl)sulfonyl-1-(5-fluoro-2-methoxyphenyl)-5-methyltriazole Show/Hide	C20H22FN3O3S	1
1	IC50 = 400 nM
CP0329670 Compound Info	1-(5-bromo-2-methoxyphenyl)-4-(4-tert-butylphenyl)sulfonyl-5-methyltriazole Show/Hide	C20H22BrN3O3S	1
1	IC50 = 400 nM
CP0356309 Compound Info	US10550091, No. LC-54 Show/Hide	C21H22ClN3O4S	1
1	IC50 = 400 nM
CP0485595 Compound Info	4-(4-tert-butylphenyl)sulfonyl-1-[2-methoxy-5-(trifluoromethyl)phenyl]-5-methyltriazole Show/Hide	C21H22F3N3O3S	1
1	IC50 = 410 nM
CP0329686 Compound Info	US10550091, No. LC-33 Show/Hide	C21H24ClN3O4S	1
1	IC50 = 470 nM
CP0329675 Compound Info	US10550091, No. LC-60 Show/Hide	C19H20ClN3O3S	1
1	IC50 = 480 nM
CP0343122 Compound Info	US10550091, No. LC-11 Show/Hide	C22H27N3O4S	1
1	IC50 = 500 nM
CP0490474 Compound Info	US10550091, No. LC-59 Show/Hide	C20H23N3O3S	1
1	IC50 = 500 nM
CP0547635 Compound Info	US10550091, No. LC-39 Show/Hide	C19H21ClN4O3S	1
1	IC50 = 500 nM
CP0343125 Compound Info	US10550091, No. LC-6 Show/Hide	C20H23N3O3S	1
1	IC50 = 530 nM
CP0444364 Compound Info	US10550091, No. LC-72 Show/Hide	C21H23ClN2O3S	1
1	IC50 = 550 nM
CP0485596 Compound Info	US10550091, No. LC-29 Show/Hide	C20H21BrClN3O3S	1
1	IC50 = 550 nM
CP0271428 Compound Info	US10550091, No. LC-36 Show/Hide	C21H21ClN4O3S	1
1	IC50 = 600 nM
CP0423604 Compound Info	US10550091, No. LC-18 Show/Hide	C21H24FN3O3S	1
1	IC50 = 600 nM
CP0130504 Compound Info	US10550091, No. LC-12 Show/Hide	C23H29N3O4S	1
1	IC50 = 700 nM
CP0329687 Compound Info	US10550091, No. LC-52 Show/Hide	C22H25N3O5S	1
1	IC50 = 700 nM
CP0423503 Compound Info	US10550091, No. LC-57 Show/Hide	C21H24ClN3O3S	1
1	IC50 = 700 nM
CP0423588 Compound Info	US10550091, No. LC-19 Show/Hide	C21H24ClN3O3S	1
1	IC50 = 700 nM
CP0444368 Compound Info	US10550091, No. LC-34 Show/Hide	C22H24ClN3O5S	1
1	IC50 = 700 nM
CP0559669 Compound Info	US10550091, No. LC-10 Show/Hide	C21H24BrN3O4S	1
1	IC50 = 700 nM
CP0138481 Compound Info	US10550091, No. LC-5 Show/Hide	C21H25N3O3S	1
1	IC50 = 800 nM
CP0138923 Compound Info	US10550091, No. LC-55 Show/Hide	C22H27N3O4S	1
1	IC50 = 800 nM
CP0329688 Compound Info	US10550091, No. LC-74 Show/Hide	C22H26N2O3S	1
1	IC50 = 800 nM
CP0130499 Compound Info	US10550091, No. LC-9 Show/Hide	C21H24ClN3O4S	1
1	IC50 = 900 nM
CP0130502 Compound Info	US10550091, No. LC-75 Show/Hide	C21H23ClN2O3S	1
1	IC50 = 900 nM
CP0138470 Compound Info	US10550091, No. LC-16 Show/Hide	C23H27N3O5S	1
1	IC50 = 900 nM
CP0138472 Compound Info	US10550091, No. LC-22 Show/Hide	C23H29N3O3S	1
1	IC50 = 1000 nM
CP0271425 Compound Info	US10550091, No. LC-13 Show/Hide	C24H31N3O4S	1
1	IC50 = 1000 nM
CP0423599 Compound Info	4-benzylsulfonyl-1-(2,5-dimethoxyphenyl)-5-methyltriazole Show/Hide	C18H19N3O4S	1
1	IC50 = 1000 nM
CP0423608 Compound Info	US10550091, No. LC-56 Show/Hide	C22H27N3O3S	1
1	IC50 = 1000 nM
CP0130506 Compound Info	US10550091, No. LC-27 Show/Hide	C22H24N4O3S	1
1	IC50 = 1070 nM
CP0130498 Compound Info	3-[4-(4-tert-butylphenyl)sulfonyl-5-methyltriazol-1-yl]-4-methoxybenzamide Show/Hide	C21H24N4O4S	1
1	IC50 = 1100 nM
CP0329672 Compound Info	US10550091, No. LC-32 Show/Hide	C23H28ClN3O3S	1
1	IC50 = 1100 nM
CP0329683 Compound Info	(1R)-1-[3-[4-(4-tert-butylphenyl)sulfonyl-5-methyltriazol-1-yl]-4-methoxyphenyl]ethanol Show/Hide	C22H27N3O4S	1
1	IC50 = 1100 nM
CP0423589 Compound Info	US10550091, No. LC-30 Show/Hide	C21H24ClN3O3S	1
1	IC50 = 1200 nM
CP0329685 Compound Info	US10550091, No. LC-21 Show/Hide	C22H27N3O3S	1
1	IC50 = 1220 nM
CP0130505 Compound Info	US10550091, No. LC-14 Show/Hide	C22H27N3O5S	1
1	IC50 = 1300 nM
CP0271435 Compound Info	US10550091, No. LC-69 Show/Hide	C20H21ClN2O3S	1
1	IC50 = 1300 nM
CP0329684 Compound Info	(1S)-1-[3-[4-(4-tert-butylphenyl)sulfonyl-5-methyltriazol-1-yl]-4-methoxyphenyl]ethanol Show/Hide	C22H27N3O4S	1
1	IC50 = 1300 nM
CP0271427 Compound Info	US10550091, No. LC-26 Show/Hide	C23H27N3O4S	1
1	IC50 = 1400 nM
CP0329677 Compound Info	US10550091, No. LC-68 Show/Hide	C21H24N2O3S	1
1	IC50 = 1400 nM
CP0329682 Compound Info	[3-[4-(4-tert-butylphenyl)sulfonyl-5-methyltriazol-1-yl]-4-methoxyphenyl]methanol Show/Hide	C21H25N3O4S	1
1	IC50 = 1400 nM
CP0485593 Compound Info	US10550091, No. LC-58 Show/Hide	C20H23N3O4S	1
1	IC50 = 1400 nM
CP0444366 Compound Info	US10550091, No. LC-31 Show/Hide	C22H26ClN3O3S	1
1	IC50 = 1500 nM
CP0490472 Compound Info	US10550091, No. LC-25 Show/Hide	C23H27N3O5S	1
1	IC50 = 1500 nM
CP0351470 Compound Info	US10550091, No. LC-71 Show/Hide	C22H26N2O3S	1
1	IC50 = 1600 nM
CP0485656 Compound Info	4-(4-chlorophenyl)sulfonyl-1-(2,5-dimethoxyphenyl)-5-methyltriazole Show/Hide	C17H16ClN3O4S	1
1	IC50 = 1900 nM
CP0329678 Compound Info	US10550091, No. LC-73 Show/Hide	C22H26N2O4S	1
1	IC50 = 2000 nM
CP0356331 Compound Info	4-(benzenesulfonyl)-1-(2,5-dimethoxyphenyl)-5-methyltriazole Show/Hide	C17H17N3O4S	1
1	IC50 = 2000 nM
CP0423594 Compound Info	US10550091, No. LC-24 Show/Hide	C22H27N3O4S	1
1	IC50 = 2000 nM
CP0423606 Compound Info	US10550091, No. LC-23 Show/Hide	C24H31N3O3S	1
1	IC50 = 2000 nM
CP0257779 Compound Info	US10550091, No. LC-76 Show/Hide	C23H28N2O4S	1
1	IC50 = 2100 nM
CP0329668 Compound Info	4-[4-(2-butoxypropan-2-yl)phenyl]sulfonyl-1-(2,5-dimethoxyphenyl)-5-methyltriazole Show/Hide	C24H31N3O5S	1
1	IC50 = 2100 nM
CP0329671 Compound Info	US10550091, No. LC-20 Show/Hide	C21H24BrN3O3S	1
1	IC50 = 2200 nM
CP0444365 Compound Info	US10550091, No. LC-15 Show/Hide	C23H27N3O6S	1
1	IC50 = 2300 nM
CP0490475 Compound Info	US10550091, No. LC-70 Show/Hide	C22H26N2O4S	1
1	IC50 = 2500 nM
CP0423583 Compound Info	1-(2,5-dimethoxyphenyl)-4-(4-methoxyphenyl)sulfonyl-5-methyltriazole Show/Hide	C18H19N3O5S	1
1	IC50 = 3000 nM
CP0271430 Compound Info	US10550091, No. LC-67 Show/Hide	C21H24N2O4S	1
1	IC50 = 3080 nM
CP0547636 Compound Info	1-(2,5-dimethoxyphenyl)-4-[4-(2-methoxypropan-2-yl)phenyl]sulfonyl-5-methyltriazole Show/Hide	C21H25N3O5S	1
1	IC50 = 3700 nM
CP0490471 Compound Info	1-(2,5-dimethoxyphenyl)-5-methyl-4-(4-methylphenyl)sulfonyltriazole Show/Hide	C18H19N3O4S	1
1	IC50 = 3800 nM
CP0271434 Compound Info	US10550091, No. LC-8 Show/Hide	C21H24FN3O4S	1
1	IC50 = 4000 nM
CP0423597 Compound Info	4-[1-(2,5-dimethoxyphenyl)-5-methyltriazol-4-yl]sulfonylaniline Show/Hide	C17H18N4O4S	1
1	IC50 = 5000 nM
CP0271432 Compound Info	4-[1-(2,5-dimethoxyphenyl)-5-methyltriazol-4-yl]sulfonylphenol Show/Hide	C17H17N3O5S	1
1	IC50 = 8000 nM
CP0543498 Compound Info	2-(1H-indole-3-carbonyl)-N-methyl-1,3-thiazole-4-carboxamide Show/Hide	C14H11N3O2S	1
1	IC50 = 32100 nM

Clinical Information about the Protein

Target 1 ( Pregnane X receptor (NR1I2) )

Target Type	Literature-reported Target

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT04880	Nuclear receptor subfamily 1 group I member 2	Rattus norvegicus, Rat	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han