| Compound ID |
Compound Name |
Compound Formula |
|
CP0568787
|
N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-5-chloro-2-fluorophenyl]-2,5-difluorobenzenesulfonamide
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|
C23H19ClF3N5O2S2
|
1
|
| 1 |
EC50 = 81.4 nM
|
|
|
|
CP0095082
|
DABRAFENIB
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|
C23H20F3N5O2S2
|
1
|
| 1 |
EC50 = 87.2 nM
|
|
|
|
CP0568750
|
N-[3-[5-(2-aminopyrimidin-4-yl)-2-morpholin-3-yl-1,3-thiazol-4-yl]-5-chloro-2-fluorophenyl]-2,5-difluorobenzenesulfonamide
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|
C23H18ClF3N6O3S2
|
1
|
| 1 |
EC50 = 2280 nM
|
|
|
|
CP0580161
|
N-[3-[5-(2-aminopyrimidin-4-yl)-2-piperidin-2-yl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,5-difluorobenzenesulfonamide
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|
C24H21F3N6O2S2
|
1
|
| 1 |
EC50 = 5160 nM
|
|
|
|
CP0579229
|
N-[3-[5-(2-aminopyrimidin-4-yl)-2-(1-cyclopropylpiperidin-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl]-2,5-difluorobenzenesulfonamide
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|
C27H25F3N6O2S2
|
1
|
| 1 |
EC50 = 6210 nM
|
|
|
|
CP0580197
|
N-[3-[5-(2-aminopyrimidin-4-yl)-2-pyrrolidin-2-yl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,5-difluorobenzenesulfonamide
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|
C23H19F3N6O2S2
|
1
|
| 1 |
EC50 = 9790 nM
|
|
|
|
CP0580198
|
N-[4-[2-(1-cyclopropylpiperidin-4-yl)-4-[3-[(2,5-difluorophenyl)sulfonylamino]-2-fluorophenyl]-1,3-thiazol-5-yl]pyrimidin-2-yl]acetamide
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|
C29H27F3N6O3S2
|
1
|
| 1 |
EC50 = 10800 nM
|
|
|
|
CP0579900
|
N-[3-[5-(2-aminopyrimidin-4-yl)-2-morpholin-3-yl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,5-difluorobenzenesulfonamide
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|
C23H19F3N6O3S2
|
1
|
| 1 |
EC50 = 11500 nM
|
|
|
|
CP0577379
|
N-[3-[5-(2-aminopyrimidin-4-yl)-2-(azetidin-2-yl)-1,3-thiazol-4-yl]-2-fluorophenyl]-2,5-difluorobenzenesulfonamide
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|
C22H17F3N6O2S2
|
1
|
| 1 |
EC50 > 30000 nM
|
|
|
|
CP0577380
|
N-[3-[5-(2-aminopyrimidin-4-yl)-2-piperazin-2-yl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,5-difluorobenzenesulfonamide
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|
C23H20F3N7O2S2
|
1
|
| 1 |
EC50 > 30000 nM
|
|
|
|
CP0577381
|
N-[3-[2-(3-aminopropyl)-5-(2-aminopyrimidin-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl]-2,5-difluorobenzenesulfonamide
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|
C22H19F3N6O2S2
|
1
|
| 1 |
EC50 > 30000 nM
|
|
|
|
CP0577935
|
N-[4-[2-(3-aminopropyl)-4-[3-[(2,5-difluorophenyl)sulfonylamino]-2-fluorophenyl]-1,3-thiazol-5-yl]pyrimidin-2-yl]acetamide
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|
C24H21F3N6O3S2
|
1
|
| 1 |
EC50 > 30000 nM
|
|
|
|
CP0579230
|
N-[3-[5-(2-aminopyrimidin-4-yl)-2-piperidin-3-yl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,5-difluorobenzenesulfonamide
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|
C24H21F3N6O2S2
|
1
|
| 1 |
EC50 > 30000 nM
|
|
|
