| Compound ID |
Compound Name |
Compound Formula |
|
CP0003740
|
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide
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|
C17H12F9NO3S
|
1
|
| 1 |
EC50 = 8 nM
|
|
|
|
CP0423163
|
1,1,1,3,3,3-hexafluoro-2-(4-(1-((4-fluorophenyl)sulfonyl)cyclopentyl)phenyl)propan-2-ol
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|
C20H17F7O3S
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0513828
|
1,1,1,3,3,3-hexafluoro-2-[1-(4-fluorophenyl)sulfonyl-4-methyl-3,4-dihydro-2H-quinolin-6-yl]propan-2-ol
Show/Hide
|
C19H16F7NO3S
|
1
|
| 1 |
EC50 = 16 nM
|
|
|
|
CP0427318
|
1,1,1,3,3,3-hexafluoro-2-[1-(4-fluorophenyl)sulfonyl-4-methyl-2,3-dihydroquinoxalin-6-yl]propan-2-ol
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|
C18H15F7N2O3S
|
1
|
| 1 |
EC50 = 18 nM
|
|
|
|
CP0408973
|
1,1,1,3,3,3-hexafluoro-2-[4-(4-fluorophenyl)sulfonyl-2,3-dihydro-1,4-benzothiazin-7-yl]propan-2-ol
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|
C17H12F7NO3S2
|
1
|
| 1 |
EC50 = 20 nM
|
|
|
|
CP0408979
|
1,1,1,3,3,3-hexafluoro-2-[1-(4-fluorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-6-yl]propan-2-ol
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|
C18H14F7NO3S
|
1
|
| 1 |
EC50 = 25 nM
|
|
|
|
CP0427313
|
1,1,1,3,3,3-hexafluoro-2-[1-(4-fluorophenyl)sulfonyl-4,4-dimethyl-2,3-dihydroquinolin-6-yl]propan-2-ol
Show/Hide
|
C20H18F7NO3S
|
1
|
| 1 |
EC50 = 36 nM
|
|
|
|
CP0427328
|
US9771320, Example 125
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|
C21H22F4O3S
|
1
|
| 1 |
EC50 = 48 nM
|
|
|
|
CP0408982
|
methyl 2-[4-(4-fluorophenyl)sulfonyl-7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2,3-dihydro-1,4-benzothiazin-2-yl]acetate
Show/Hide
|
C20H16F7NO5S2
|
1
|
| 1 |
EC50 = 55 nM
|
|
|
|
CP0329667
|
US10550091, No. LC-51
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|
C20H19ClN4O3S
|
1
|
| 1 |
EC50 = 80 nM
|
|
|
|
CP0547635
|
US10550091, No. LC-39
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|
C19H21ClN4O3S
|
2
|
| 1 |
EC50 = 110 nM
|
|
|
| 2 |
IC50 = 4400 nM
|
|
|
|
CP0427316
|
2-[(2S)-4-(4-fluorophenyl)sulfonyl-7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2,3-dihydro-1,4-benzothiazin-2-yl]-N-(2-hydroxy-2-methylpropyl)acetamide
Show/Hide
|
C23H23F7N2O5S2
|
1
|
| 1 |
EC50 = 144 nM
|
|
|
|
CP0329674
|
US10550091, No. LC-38
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|
C20H24N4O3S
|
2
|
| 1 |
EC50 = 160 nM
|
|
|
| 2 |
IC50 = 3300 nM
|
|
|
|
CP0329676
|
US10550091, No. LC-50
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|
C21H22N4O3S
|
1
|
| 1 |
EC50 = 160 nM
|
|
|
|
CP0427315
|
2-[4-(4-fluorophenyl)sulfonyl-7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2,3-dihydro-1,4-benzothiazin-2-yl]-N-(2-hydroxy-2-methylpropyl)acetamide
Show/Hide
|
C23H23F7N2O5S2
|
1
|
| 1 |
EC50 = 175 nM
|
|
|
|
CP0071702
|
BA-41166E
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|
C43H58N4O12
|
2
|
| 1 |
EC50 = 190 nM
|
|
|
| 2 |
EC50 = 1400 nM
|
|
|
|
CP0429976
|
2-[4-(4-fluorophenyl)sulfonyl-7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2,3-dihydro-1,4-benzothiazin-2-yl]acetamide
Show/Hide
|
C19H15F7N2O4S2
|
1
|
| 1 |
EC50 = 190 nM
|
|
|
|
CP0356309
|
US10550091, No. LC-54
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|
C21H22ClN3O4S
|
1
|
| 1 |
EC50 = 200 nM
|
|
|
|
CP0511892
|
1-fluoro-4-((1-(4-(1,1,1,3,3,3-hexafluoro-2-phenoxypropan-2-yl)phenyl)cyclopentyl)sulfonyl)benzene
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|
C26H21F7O3S
|
1
|
| 1 |
EC50 = 205 nM
|
|
|
|
CP0408975
|
2-[(2R)-4-(4-fluorophenyl)sulfonyl-7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2,3-dihydro-1,4-benzothiazin-2-yl]-N-(2-hydroxy-2-methylpropyl)acetamide
Show/Hide
|
C23H23F7N2O5S2
|
1
|
| 1 |
EC50 = 228 nM
|
|
|
|
CP0551899
|
1-(2-chloro-1,1,1,3,3,3-hexafluoropropan-2-yl)-4-(1-((4-fluorophenyl)sulfonyl)cyclopentyl)benzene
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|
C20H16ClF7O2S
|
1
|
| 1 |
EC50 = 229 nM
|
|
|
|
CP0432790
|
1,1,1-trifluoro-2-(4-(1-((4-fluorophenyl)sulfonyl)cyclopentyl)phenyl)propan-2-ol Step A: 1-fluoro-4-((4-iodobenzyl)sulfonyl)benzene
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|
C20H20F4O3S
|
1
|
| 1 |
EC50 = 239 nM
|
|
|
|
CP0329669
|
4-(4-tert-butylphenyl)sulfonyl-1-(5-fluoro-2-methoxyphenyl)-5-methyltriazole
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|
C20H22FN3O3S
|
2
|
| 1 |
EC50 = 240 nM
|
|
|
| 2 |
IC50 = 700 nM
|
|
|
|
CP0427319
|
2-[4-(4-fluorophenyl)sulfonyl-7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2,3-dihydro-1,4-benzothiazin-2-yl]-N-pyridin-4-ylacetamide
Show/Hide
|
C24H18F7N3O4S2
|
1
|
| 1 |
EC50 = 250 nM
|
|
|
|
CP0329686
|
US10550091, No. LC-33
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|
C21H24ClN3O4S
|
1
|
| 1 |
EC50 = 250 nM
|
|
|
|
CP0408907
|
2-[4-(4-fluorophenyl)sulfonyl-7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2,3-dihydro-1,4-benzothiazin-2-yl]-N-(1,3,4-thiadiazol-2-yl)acetamide
Show/Hide
|
C21H15F7N4O4S3
|
1
|
| 1 |
EC50 = 254 nM
|
|
|
|
CP0271429
|
US10550091, No. LC-49
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|
C21H22N4O4S
|
2
|
| 1 |
EC50 = 260 nM
|
|
|
| 2 |
IC50 = 2400 nM
|
|
|
|
CP0329673
|
US10550091, No. LC-35
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|
C22H24ClN3O4S
|
1
|
| 1 |
EC50 = 260 nM
|
|
|
|
CP0432789
|
1,1,1,3,3,3-hexafluoro-2-(4-(1-((4-fluorophenyl)sulfonyl)cyclopentyl)phenyl)propan-2-amine
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|
C20H18F7NO2S
|
1
|
| 1 |
EC50 = 275 nM
|
|
|
|
CP0423594
|
US10550091, No. LC-24
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|
C22H27N3O4S
|
1
|
| 1 |
EC50 = 280 nM
|
|
|
|
CP0553930
|
US9771320, Example 60
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|
C28H22F7NO3S
|
1
|
| 1 |
EC50 = 303 nM
|
|
|
|
CP0271435
|
US10550091, No. LC-69
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|
C20H21ClN2O3S
|
1
|
| 1 |
EC50 = 360 nM
|
|
|
|
CP0537174
|
US9771320, Example 48
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|
C23H21F7O3S
|
1
|
| 1 |
EC50 = 371 nM
|
|
|
|
CP0408910
|
2-[4-(4-fluorophenyl)sulfonyl-7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2,3-dihydro-1,4-benzothiazin-2-yl]-1-morpholin-4-ylethanone
Show/Hide
|
C23H21F7N2O5S2
|
1
|
| 1 |
EC50 = 380 nM
|
|
|
|
CP0329681
|
1-(5-tert-butyl-2-methoxyphenyl)-4-(4-tert-butylphenyl)sulfonyl-5-methyltriazole
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|
C24H31N3O3S
|
1
|
| 1 |
EC50 = 380 nM
|
|
|
|
CP0015320
|
BAY-E-9736
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|
C21H26N2O7
|
1
|
| 1 |
EC50 = 390 nM
|
|
|
|
CP0271427
|
US10550091, No. LC-26
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|
C23H27N3O4S
|
2
|
| 1 |
EC50 = 400 nM
|
|
|
| 2 |
IC50 = 9000 nM
|
|
|
|
CP0444363
|
US10550091, No. LC-37
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|
C20H24N4O4S
|
2
|
| 1 |
EC50 = 430 nM
|
|
|
| 2 |
IC50 = 1700 nM
|
|
|
|
CP0458191
|
US9458171, 3
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|
C19H16F7NO3S
|
1
|
| 1 |
EC50 = 434 nM
|
|
|
|
CP0329683
|
(1R)-1-[3-[4-(4-tert-butylphenyl)sulfonyl-5-methyltriazol-1-yl]-4-methoxyphenyl]ethanol
Show/Hide
|
C22H27N3O4S
|
1
|
| 1 |
EC50 = 440 nM
|
|
|
|
CP0514888
|
US9771320, Example 97
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|
C27H21F9O3S
|
1
|
| 1 |
EC50 = 463 nM
|
|
|
|
CP0560214
|
US9771320, Example 59
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|
C27H22ClF7O3S
|
1
|
| 1 |
EC50 = 469 nM
|
|
|
|
CP0468597
|
US9458171, 48
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|
C21H18F7NO4S
|
1
|
| 1 |
EC50 = 480 nM
|
|
|
|
CP0130502
|
US10550091, No. LC-75
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|
C21H23ClN2O3S
|
1
|
| 1 |
EC50 = 500 nM
|
|
|
|
CP0138470
|
US10550091, No. LC-16
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|
C23H27N3O5S
|
1
|
| 1 |
EC50 = 500 nM
|
|
|
|
CP0355713
|
US10550091, No. LC-53
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|
C22H25N3O4S
|
1
|
| 1 |
EC50 = 500 nM
|
|
|
|
CP0408981
|
N-[[4-(4-fluorophenyl)sulfonyl-7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2,3-dihydro-1,4-benzothiazin-2-yl]methyl]-3-hydroxy-3-methylbutanamide
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|
C23H23F7N2O5S2
|
1
|
| 1 |
EC50 = 520 nM
|
|
|
|
CP0427332
|
US9458171, 4
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|
C19H16F7NO3S
|
1
|
| 1 |
EC50 = 520 nM
|
|
|
|
CP0487397
|
19-cyclohexyl-N-(dimethylsulfamoyl)-5-methoxy-10-(8-oxa-3-azabicyclo[3.2.1]octane-3-carbonyl)-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
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|
C35H42N4O6S
|
1
|
| 1 |
EC50 = 600 nM
|
|
|
|
CP0130499
|
US10550091, No. LC-9
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|
C21H24ClN3O4S
|
1
|
| 1 |
EC50 = 600 nM
|
|
|
|
CP0343122
|
US10550091, No. LC-11
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|
C22H27N3O4S
|
1
|
| 1 |
EC50 = 600 nM
|
|
|
|
CP0485596
|
US10550091, No. LC-29
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|
C20H21BrClN3O3S
|
1
|
| 1 |
EC50 = 600 nM
|
|
|
|
CP0490474
|
US10550091, No. LC-59
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|
C20H23N3O3S
|
2
|
| 1 |
EC50 = 600 nM
|
|
|
| 2 |
IC50 = 5000 nM
|
|
|
|
CP0559669
|
US10550091, No. LC-10
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|
C21H24BrN3O4S
|
1
|
| 1 |
EC50 = 600 nM
|
|
|
|
CP0537036
|
US9458171, 337
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|
C34H30ClF8NO6S
|
1
|
| 1 |
EC50 = 630 nM
|
|
|
|
CP0552290
|
US9458171, 171
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|
C35H33F9N2O5S
|
1
|
| 1 |
EC50 = 630 nM
|
|
|
|
CP0553928
|
US9771320, Example 58
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|
C27H22F8O3S
|
1
|
| 1 |
EC50 = 630 nM
|
|
|
|
CP0329684
|
(1S)-1-[3-[4-(4-tert-butylphenyl)sulfonyl-5-methyltriazol-1-yl]-4-methoxyphenyl]ethanol
Show/Hide
|
C22H27N3O4S
|
1
|
| 1 |
EC50 = 640 nM
|
|
|
|
CP0271430
|
US10550091, No. LC-67
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|
C21H24N2O4S
|
1
|
| 1 |
EC50 = 700 nM
|
|
|
|
CP0329677
|
US10550091, No. LC-68
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|
C21H24N2O3S
|
1
|
| 1 |
EC50 = 700 nM
|
|
|
|
CP0329685
|
US10550091, No. LC-21
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|
C22H27N3O3S
|
1
|
| 1 |
EC50 = 700 nM
|
|
|
|
CP0444366
|
US10550091, No. LC-31
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|
C22H26ClN3O3S
|
1
|
| 1 |
EC50 = 700 nM
|
|
|
|
CP0427414
|
1-fluoro-4-(1-(4-(1,1,1,3,3,3-hexafluoro-2-methylpropan-2-yl)phenyl)cyclopentylsulfonyl)benzene
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|
C21H19F7O2S
|
1
|
| 1 |
EC50 = 752 nM
|
|
|
|
CP0329675
|
US10550091, No. LC-60
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|
C19H20ClN3O3S
|
2
|
| 1 |
EC50 = 770 nM
|
|
|
| 2 |
IC50 = 10500 nM
|
|
|
|
CP0556811
|
1-(2-(benzyloxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)-4-(1-((4-fluorophenyl)sulfonyl)cyclopentyl)benzene
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|
C27H23F7O3S
|
1
|
| 1 |
EC50 = 781 nM
|
|
|
|
CP0468595
|
US9458171, 50
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|
C25H24F7NO4S
|
1
|
| 1 |
EC50 = 794 nM
|
|
|
|
CP0130504
|
US10550091, No. LC-12
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|
C23H29N3O4S
|
1
|
| 1 |
EC50 = 800 nM
|
|
|
|
CP0343125
|
US10550091, No. LC-6
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|
C20H23N3O3S
|
2
|
| 1 |
EC50 = 800 nM
|
|
|
| 2 |
IC50 = 1000 nM
|
|
|
|
CP0423588
|
US10550091, No. LC-19
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|
C21H24ClN3O3S
|
2
|
| 1 |
EC50 = 800 nM
|
|
|
| 2 |
IC50 = 2000 nM
|
|
|
|
CP0329682
|
[3-[4-(4-tert-butylphenyl)sulfonyl-5-methyltriazol-1-yl]-4-methoxyphenyl]methanol
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|
C21H25N3O4S
|
2
|
| 1 |
EC50 = 810 nM
|
|
|
| 2 |
IC50 = 2000 nM
|
|
|
|
CP0423606
|
US10550091, No. LC-23
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|
C24H31N3O3S
|
1
|
| 1 |
EC50 = 830 nM
|
|
|
|
CP0046495
|
2-(3-methoxyphenyl)-1H-quinazoline-4-thione
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|
C15H12N2OS
|
1
|
| 1 |
EC50 = 860 nM
|
|
|
|
CP0138472
|
US10550091, No. LC-22
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|
C23H29N3O3S
|
1
|
| 1 |
EC50 = 900 nM
|
|
|
|
CP0271425
|
US10550091, No. LC-13
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|
C24H31N3O4S
|
1
|
| 1 |
EC50 = 900 nM
|
|
|
|
CP0537035
|
1-[1-(4-fluorobenzenesulfonyl)cyclopentyl]-4-(1,1,1,3,3,3-hexafluoro-2-methoxypropan-2-yl)benzene
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|
C21H19F7O3S
|
1
|
| 1 |
EC50 = 920 nM
|
|
|
|
CP0245114
|
(E)-1-[6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]-N-[(3,4-dichlorophenyl)methoxy]methanimine
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|
C19H12Cl3N3OS
|
1
|
| 1 |
EC50 = 990 nM
|
|
|
|
CP0351470
|
US10550091, No. LC-71
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|
C22H26N2O3S
|
1
|
| 1 |
EC50 = 990 nM
|
|
|
|
CP0467087
|
19-cyclohexyl-N-(dimethylsulfamoyl)-5-methoxy-10-(3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C36H45N5O5S
|
1
|
| 1 |
EC50 = 1000 nM
|
|
|
|
CP0000804
|
2-[2-[2-(2,6-dichlorophenyl)propan-2-yl]-1-[2-fluoro-4-[3-fluoro-4-(hydroxymethyl)-5-methylsulfonylphenyl]phenyl]imidazol-4-yl]propan-2-ol
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|
C29H28Cl2F2N2O4S
|
1
|
| 1 |
EC50 = 1000 nM
|
|
|
|
CP0130503
|
US10550091, No. LC-77
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|
C23H28N2O3S
|
1
|
| 1 |
EC50 = 1000 nM
|
|
|
|
CP0271428
|
US10550091, No. LC-36
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|
C21H21ClN4O3S
|
2
|
| 1 |
EC50 = 1000 nM
|
|
|
| 2 |
IC50 = 3400 nM
|
|
|
|
CP0271434
|
US10550091, No. LC-8
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|
C21H24FN3O4S
|
2
|
| 1 |
EC50 = 1000 nM
|
|
|
| 2 |
IC50 = 2000 nM
|
|
|
|
CP0423589
|
US10550091, No. LC-30
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|
C21H24ClN3O3S
|
2
|
| 1 |
EC50 = 1000 nM
|
|
|
| 2 |
IC50 = 2300 nM
|
|
|
|
CP0423379
|
5-benzyl-2-(3-fluoro-2-hydroxyphenyl)-6-methyl-3-(2-phenylethyl)pyrimidin-4-one
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|
C26H23FN2O2
|
1
|
| 1 |
EC50 = 1000 nM
|
|
|
|
CP0537142
|
1-[1-(4-fluorobenzenesulfonyl)cyclopentyl]-4-(heptafluoropropan-2-yl)benzene
Show/Hide
|
C20H16F8O2S
|
1
|
| 1 |
EC50 = 1010 nM
|
|
|
|
CP0421708
|
(2S)-2-[(22S)-17-fluoro-5-(2-hydroxypropan-2-yl)-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10,12,14(33),15(20),16,18-decaen-3-yl]-2-[(2-methylpropan-2-yl)oxy]acetic acid
Show/Hide
|
C41H52FN3O6
|
1
|
| 1 |
EC50 = 1010 nM
|
|
|
|
CP0130505
|
US10550091, No. LC-14
Show/Hide
|
C22H27N3O5S
|
1
|
| 1 |
EC50 = 1050 nM
|
|
|
|
CP0426743
|
(E)-1-(6-naphthalen-2-ylimidazo[2,1-b][1,3]oxazol-5-yl)-N-[(4-phenoxyphenyl)methoxy]methanimine
Show/Hide
|
C29H21N3O3
|
1
|
| 1 |
EC50 = 1100 nM
|
|
|
|
CP0423603
|
US10550091, No. LC-17
Show/Hide
|
C22H24N4O4S
|
1
|
| 1 |
EC50 = 1100 nM
|
|
|
|
CP0556810
|
1-[3-[(3R)-3-[4-[2-[(2,6-difluorophenyl)methoxy]-1,1,1,3,3,3-hexafluoropropan-2-yl]phenyl]-3-(4-fluorophenyl)sulfonylpyrrolidine-1-carbonyl]azetidin-1-yl]ethanone
Show/Hide
|
C32H27F9N2O5S
|
1
|
| 1 |
EC50 = 1150 nM
|
|
|
|
CP0257779
|
US10550091, No. LC-76
Show/Hide
|
C23H28N2O4S
|
1
|
| 1 |
EC50 = 1200 nM
|
|
|
|
CP0329679
|
US10550091, No. LC-78
Show/Hide
|
C22H25ClN2O3S
|
1
|
| 1 |
EC50 = 1200 nM
|
|
|
|
CP0444364
|
US10550091, No. LC-72
Show/Hide
|
C21H23ClN2O3S
|
1
|
| 1 |
EC50 = 1210 nM
|
|
|
|
CP0514886
|
US9458171, 344
Show/Hide
|
C34H30F8N4O5S
|
1
|
| 1 |
EC50 = 1230 nM
|
|
|
|
CP0558676
|
US9458171, 280
Show/Hide
|
C31H27F9N2O5S
|
1
|
| 1 |
EC50 = 1250 nM
|
|
|
|
CP0537032
|
US9771320, Example 62
Show/Hide
|
C28H22F10O4S
|
1
|
| 1 |
EC50 = 1280 nM
|
|
|
|
CP0426742
|
(E)-1-[6-(4-chlorophenyl)imidazo[2,1-b][1,3]oxazol-5-yl]-N-[(3,4-dichlorophenyl)methoxy]methanimine
Show/Hide
|
C19H12Cl3N3O2
|
1
|
| 1 |
EC50 = 1300 nM
|
|
|
|
CP0329671
|
US10550091, No. LC-20
Show/Hide
|
C21H24BrN3O3S
|
1
|
| 1 |
EC50 = 1300 nM
|
|
|
|
CP0485593
|
US10550091, No. LC-58
Show/Hide
|
C20H23N3O4S
|
2
|
| 1 |
EC50 = 1400 nM
|
|
|
| 2 |
IC50 = 3400 nM
|
|
|
|
CP0564175
|
US9771320, Example 64
Show/Hide
|
C33H27F7O3S
|
1
|
| 1 |
EC50 = 1440 nM
|
|
|
|
CP0130506
|
US10550091, No. LC-27
Show/Hide
|
C22H24N4O3S
|
2
|
| 1 |
EC50 = 1600 nM
|
|
|
| 2 |
IC50 = 4000 nM
|
|
|
|
CP0490472
|
US10550091, No. LC-25
Show/Hide
|
C23H27N3O5S
|
2
|
| 1 |
EC50 = 1600 nM
|
|
|
| 2 |
IC50 = 6000 nM
|
|
|
|
CP0423583
|
1-(2,5-dimethoxyphenyl)-4-(4-methoxyphenyl)sulfonyl-5-methyltriazole
Show/Hide
|
C18H19N3O5S
|
1
|
| 1 |
EC50 = 1680 nM
|
|
|
|
CP0329672
|
US10550091, No. LC-32
Show/Hide
|
C23H28ClN3O3S
|
1
|
| 1 |
EC50 = 1800 nM
|
|
|
|
CP0329688
|
US10550091, No. LC-74
Show/Hide
|
C22H26N2O3S
|
1
|
| 1 |
EC50 = 1800 nM
|
|
|
|
CP0394528
|
2-[(2S)-1-(4-fluorophenyl)sulfonyl-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-3,4-dihydro-2H-quinolin-2-yl]-N-(2-hydroxy-2-methylpropyl)acetamide
Show/Hide
|
C24H25F7N2O5S
|
1
|
| 1 |
EC50 = 1830 nM
|
|
|
|
CP0329687
|
US10550091, No. LC-52
Show/Hide
|
C22H25N3O5S
|
1
|
| 1 |
EC50 = 1900 nM
|
|
|
|
CP0444368
|
US10550091, No. LC-34
Show/Hide
|
C22H24ClN3O5S
|
2
|
| 1 |
EC50 = 1900 nM
|
|
|
| 2 |
IC50 = 10000 nM
|
|
|
|
CP0043589
|
(13S,17S)-13-Methyl-7-[9-(4,4,5,5,5-pentafluoro-pentane-1-sulfinyl)-nonyl]-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
Show/Hide
|
C32H47F5O3S
|
1
|
| 1 |
EC50 = 1950 nM
|
|
|
|
CP0558700
|
10-(3-benzyl-3,6-diazabicyclo[3.1.1]heptane-6-carbonyl)-19-cyclohexyl-N-(dimethylsulfamoyl)-5-methoxy-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C41H47N5O5S
|
1
|
| 1 |
EC50 = 2000 nM
|
|
|
|
CP0389268
|
N—((S)-2-fluoro-3-hydroxy-3-methylbutyl)-2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetamide
Show/Hide
|
C25H26F8N2O5S
|
1
|
| 1 |
EC50 = 2000 nM
|
|
|
|
CP0427340
|
(�) 2-(1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)-N-(2-hydroxy-2-methylpropyl)acetamide
Show/Hide
|
C24H25F7N2O5S
|
1
|
| 1 |
EC50 = 2000 nM
|
|
|
|
CP0421596
|
(E)-1-(6-naphthalen-2-ylimidazo[2,1-b][1,3]oxazol-5-yl)-N-[[4-(trifluoromethyl)phenyl]methoxy]methanimine
Show/Hide
|
C24H16F3N3O2
|
1
|
| 1 |
EC50 = 2000 nM
|
|
|
|
CP0490471
|
1-(2,5-dimethoxyphenyl)-5-methyl-4-(4-methylphenyl)sulfonyltriazole
Show/Hide
|
C18H19N3O4S
|
1
|
| 1 |
EC50 = 2100 nM
|
|
|
|
CP0087963
|
N-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-hydroxy-3-methylbutanamide
Show/Hide
|
C23H35ClN2O4
|
1
|
| 1 |
EC50 = 2300 nM
|
|
|
|
CP0485656
|
4-(4-chlorophenyl)sulfonyl-1-(2,5-dimethoxyphenyl)-5-methyltriazole
Show/Hide
|
C17H16ClN3O4S
|
1
|
| 1 |
EC50 = 2300 nM
|
|
|
|
CP0564750
|
US9771320, Example 57
Show/Hide
|
C28H25F7O3S
|
1
|
| 1 |
EC50 = 2330 nM
|
|
|
|
CP0130498
|
3-[4-(4-tert-butylphenyl)sulfonyl-5-methyltriazol-1-yl]-4-methoxybenzamide
Show/Hide
|
C21H24N4O4S
|
1
|
| 1 |
EC50 = 2440 nM
|
|
|
|
CP0356331
|
4-(benzenesulfonyl)-1-(2,5-dimethoxyphenyl)-5-methyltriazole
Show/Hide
|
C17H17N3O4S
|
1
|
| 1 |
EC50 = 2500 nM
|
|
|
|
CP0562786
|
2-(3-fluoro-2-hydroxyphenyl)-6-methyl-5-(5-methylthiophen-2-yl)-3-(2-phenylethyl)pyrimidin-4-one
Show/Hide
|
C24H21FN2O2S
|
1
|
| 1 |
EC50 = 2500 nM
|
|
|
|
CP0056585
|
2-methyl-3-(naphthalen-1-ylcarbonyl)-1-propyl-1H-indole
Show/Hide
|
C23H21NO
|
1
|
| 1 |
EC50 = 2640 nM
|
|
|
|
CP0394525
|
2-[(2R)-1-(4-fluorophenyl)sulfonyl-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-3,4-dihydro-2H-quinolin-2-yl]-N-(2-hydroxy-2-methylpropyl)acetamide
Show/Hide
|
C24H25F7N2O5S
|
1
|
| 1 |
EC50 = 2860 nM
|
|
|
|
CP0068895
|
ethyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
Show/Hide
|
C22H23ClN2O2
|
1
|
| 1 |
EC50 = 3000 nM
|
|
|
|
CP0443320
|
19-cyclohexyl-N-(dimethylsulfamoyl)-5-methoxy-10-(8-methyl-3,8-diazabicyclo[3.2.1]octane-3-carbonyl)-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C36H45N5O5S
|
1
|
| 1 |
EC50 = 3000 nM
|
|
|
|
CP0078956
|
2-[[1-[3-(3,5-dichlorophenyl)phenyl]cyclobutyl]-[(2,2-dimethyl-3,4-dihydrochromen-6-yl)sulfonyl]amino]acetic acid
Show/Hide
|
C29H29Cl2NO5S
|
1
|
| 1 |
EC50 = 3000 nM
|
|
|
|
CP0005861
|
2-[2-[2-(2-chloro-3-fluorophenyl)propan-2-yl]-1-[4-[3-fluoro-4-(hydroxymethyl)-5-methylsulfonylphenyl]phenyl]imidazol-4-yl]propan-2-ol
Show/Hide
|
C29H29ClF2N2O4S
|
1
|
| 1 |
EC50 = 3000 nM
|
|
|
|
CP0423380
|
2-fluoro-6-[6-methyl-5-(5-methylthiophen-2-yl)-3-(2-phenylethyl)pyrazin-2-yl]phenol
Show/Hide
|
C24H21FN2OS
|
1
|
| 1 |
EC50 = 3200 nM
|
|
|
|
CP0423599
|
4-benzylsulfonyl-1-(2,5-dimethoxyphenyl)-5-methyltriazole
Show/Hide
|
C18H19N3O4S
|
1
|
| 1 |
EC50 = 3400 nM
|
|
|
|
CP0444365
|
US10550091, No. LC-15
Show/Hide
|
C23H27N3O6S
|
1
|
| 1 |
EC50 = 3400 nM
|
|
|
|
CP0483284
|
(E)-N-[(3,4-dichlorophenyl)methoxy]-1-[6-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)imidazo[2,1-b][1,3]thiazol-5-yl]methanimine
Show/Hide
|
C27H27Cl2N3OS
|
1
|
| 1 |
EC50 = 3600 nM
|
|
|
|
CP0490475
|
US10550091, No. LC-70
Show/Hide
|
C22H26N2O4S
|
1
|
| 1 |
EC50 = 4000 nM
|
|
|
|
CP0537034
|
US9458171, 335
Show/Hide
|
C35H33F8NO6S
|
1
|
| 1 |
EC50 = 4820 nM
|
|
|
|
CP0435666
|
US9458171, 12
Show/Hide
|
C26H26F7N3O5S
|
1
|
| 1 |
EC50 = 4930 nM
|
|
|
|
CP0042421
|
5-Chloro-N-cyclopropylmethyl-2-methyl-N-propyl-N''-(2,4,6-trichloro-phenyl)-pyrimidine-4,6-diamine
Show/Hide
|
C18H20Cl4N4
|
1
|
| 1 |
EC50 = 4950 nM
|
|
|
|
CP0534024
|
2-(3-fluoro-2-hydroxyphenyl)-6-methyl-3-(2-phenylethyl)-5-(5-pyridin-2-ylthiophen-2-yl)pyrimidin-4-one
Show/Hide
|
C28H22FN3O2S
|
1
|
| 1 |
EC50 = 5000 nM
|
|
|
|
CP0384357
|
US9458171, 499
Show/Hide
|
C27H27F8NO5S2
|
1
|
| 1 |
EC50 = 5200 nM
|
|
|
|
CP0553562
|
1-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-[(1S,3S)-3-hydroxycyclopentyl]urea
Show/Hide
|
C24H36ClN3O4
|
1
|
| 1 |
EC50 = 5700 nM
|
|
|
|
CP0421709
|
(2S)-2-[7-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl]-2-[(2-methylpropan-2-yl)oxy]acetic acid
Show/Hide
|
C29H30FN3O4
|
1
|
| 1 |
EC50 = 5700 nM
|
|
|
|
CP0526030
|
(E)-N-[(3,4-dichlorophenyl)methoxy]-1-(6-naphthalen-2-ylimidazo[2,1-b][1,3]oxazol-5-yl)methanimine
Show/Hide
|
C23H15Cl2N3O2
|
1
|
| 1 |
EC50 = 5900 nM
|
|
|
|
CP0329678
|
US10550091, No. LC-73
Show/Hide
|
C22H26N2O4S
|
1
|
| 1 |
EC50 = 6000 nM
|
|
|
|
CP0086396
|
FLUTRIMAZOLE
Show/Hide
|
C22H16F2N2
|
1
|
| 1 |
EC50 = 6100 nM
|
|
|
|
CP0427330
|
US9458171, 415
Show/Hide
|
C27H25ClF7NO5S
|
1
|
| 1 |
EC50 = 6440 nM
|
|
|
|
CP0423597
|
4-[1-(2,5-dimethoxyphenyl)-5-methyltriazol-4-yl]sulfonylaniline
Show/Hide
|
C17H18N4O4S
|
1
|
| 1 |
EC50 = 7000 nM
|
|
|
|
CP0526029
|
(E)-1-(6-naphthalen-2-ylimidazo[2,1-b][1,3]oxazol-5-yl)-N-phenylmethoxymethanimine
Show/Hide
|
C23H17N3O2
|
1
|
| 1 |
EC50 = 7300 nM
|
|
|
|
CP0494325
|
(3R)-N-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-hydroxybutanamide
Show/Hide
|
C22H33ClN2O4
|
1
|
| 1 |
EC50 = 7800 nM
|
|
|
|
CP0435665
|
US9458171, 11
Show/Hide
|
C27H27F7N2O5S
|
1
|
| 1 |
EC50 = 7810 nM
|
|
|
|
CP0555068
|
2-(3-fluoro-2-hydroxyphenyl)-6-methyl-3-(2-phenylethyl)-5-(5-phenylthiophen-2-yl)pyrimidin-4-one
Show/Hide
|
C29H23FN2O2S
|
1
|
| 1 |
EC50 = 8000 nM
|
|
|
|
CP0045890
|
(5R,11R)-5,11-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol
Show/Hide
|
C22H24O2
|
1
|
| 1 |
EC50 = 8600 nM
|
|
|
|
CP0380881
|
19-cyclohexyl-10-(3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-N-(dimethylsulfamoyl)-5-methoxy-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C35H43N5O5S
|
1
|
| 1 |
EC50 = 9000 nM
|
|
|
|
CP0566936
|
2-(3-fluoro-2-hydroxyphenyl)-6-methyl-5-(2-methyl-1,3-thiazol-5-yl)-3-(2-phenylethyl)pyrimidin-4-one
Show/Hide
|
C23H20FN3O2S
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0440425
|
US9458171, 386
Show/Hide
|
C27H24F9NO5S
|
1
|
| 1 |
EC50 = 10600 nM
|
|
|
|
CP0041761
|
2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethoxy]phenyl}carbonyl)-1-benzothiophen-6-ol
Show/Hide
|
C28H27NO4S
|
1
|
| 1 |
EC50 = 11710 nM
|
|
|
|
CP0490045
|
US9458171, 417
Show/Hide
|
C28H28F7NO5S
|
1
|
| 1 |
EC50 = 12600 nM
|
|
|
|
CP0555069
|
2-(3-fluoro-2-hydroxyphenyl)-5-[5-(hydroxymethyl)thiophen-2-yl]-6-methyl-3-(2-phenylethyl)pyrimidin-4-one
Show/Hide
|
C24H21FN2O3S
|
1
|
| 1 |
EC50 = 13000 nM
|
|
|
|
CP0552772
|
US9458171, 186
Show/Hide
|
C32H28F9NO5S
|
1
|
| 1 |
EC50 = 15320 nM
|
|
|
|
CP0478420
|
US9458171, 385
Show/Hide
|
C27H24F9NO5S
|
1
|
| 1 |
EC50 > 17000 nM
|
|
|
|
CP0440424
|
4-[(3R)-3-(4-fluorophenyl)sulfonyl-3-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]pyrrolidine-1-carbonyl]-4-methoxycyclohexane-1-carboxylic acid
Show/Hide
|
C28H27F8NO6S
|
1
|
| 1 |
EC50 > 18000 nM
|
|
|
|
CP0410401
|
1-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-[(1S,3R)-3-hydroxycyclopentyl]urea
Show/Hide
|
C24H36ClN3O4
|
1
|
| 1 |
EC50 = 19000 nM
|
|
|
|
CP0548402
|
US9458171, 383
Show/Hide
|
C27H24F9NO5S
|
1
|
| 1 |
EC50 > 22000 nM
|
|
|
|
CP0271432
|
4-[1-(2,5-dimethoxyphenyl)-5-methyltriazol-4-yl]sulfonylphenol
Show/Hide
|
C17H17N3O5S
|
1
|
| 1 |
EC50 = 22000 nM
|
|
|
|
CP0423170
|
US9458171, 117
Show/Hide
|
C28H27F8NO5S
|
1
|
| 1 |
EC50 > 22800 nM
|
|
|
|
CP0053909
|
1-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-(2-hydroxy-2-methylpropyl)urea
Show/Hide
|
C23H36ClN3O4
|
1
|
| 1 |
EC50 > 25000 nM
|
|
|
|
CP0379828
|
1-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-[(2S)-2-hydroxypropyl]urea
Show/Hide
|
C22H34ClN3O4
|
1
|
| 1 |
EC50 > 25000 nM
|
|
|
|
CP0533048
|
N-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-4-hydroxy-4-methylpentanamide
Show/Hide
|
C24H37ClN2O4
|
1
|
| 1 |
EC50 = 25000 nM
|
|
|
|
CP0547486
|
1-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-[(2R)-2-hydroxypropyl]urea
Show/Hide
|
C22H34ClN3O4
|
1
|
| 1 |
EC50 > 25000 nM
|
|
|
|
CP0440423
|
US9458171, 400
Show/Hide
|
C27H23F8NO5S
|
1
|
| 1 |
EC50 > 33000 nM
|
|
|
|
CP0427339
|
US9458171, 511
Show/Hide
|
C26H24F8N2O5S
|
1
|
| 1 |
EC50 > 46100 nM
|
|
|
|
CP0121866
|
BMS-791325
Show/Hide
|
C36H45N5O5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0175792
|
(8S,10R)-19-cyclohexyl-N-(dimethylsulfamoyl)-10-(3-ethyl-3,6-diazabicyclo[3.1.1]heptane-6-carbonyl)-5-methoxy-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C36H45N5O5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0246985
|
19-cyclohexyl-10-(3,6-diazabicyclo[3.1.1]heptane-6-carbonyl)-N-(dimethylsulfamoyl)-5-methoxy-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C34H41N5O5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0380880
|
19-cyclohexyl-N-(dimethylsulfamoyl)-10-(3-ethyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-5-methoxy-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C37H47N5O5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0395302
|
19-cyclohexyl-N-(dimethylsulfamoyl)-5-methoxy-10-(3-methyl-3,6-diazabicyclo[3.1.1]heptane-6-carbonyl)-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C35H43N5O5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0406404
|
19-cyclohexyl-10-[(3R,5S)-3,5-dimethylpiperazine-1-carbonyl]-N-(dimethylsulfamoyl)-5-methoxy-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C35H45N5O5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0431959
|
19-cyclohexyl-N-(dimethylsulfamoyl)-10-(3-hydroxy-3-propan-2-ylazetidine-1-carbonyl)-5-methoxy-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C35H44N4O6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0458939
|
19-cyclohexyl-N-(dimethylsulfamoyl)-10-(3-hydroxyazetidine-1-carbonyl)-5-methoxy-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C32H38N4O6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0467482
|
19-cyclohexyl-10-(3-cyclopropyl-3-hydroxyazetidine-1-carbonyl)-N-(dimethylsulfamoyl)-5-methoxy-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C35H42N4O6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0469227
|
19-cyclohexyl-N-(dimethylsulfamoyl)-5-methoxy-10-[(3R,5S)-3,4,5-trimethylpiperazine-1-carbonyl]-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C36H47N5O5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0469229
|
19-cyclohexyl-N-(dimethylsulfamoyl)-10-(3-hydroxy-3-methylazetidine-1-carbonyl)-5-methoxy-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C33H40N4O6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0481581
|
(8S,10R)-19-cyclohexyl-N-(dimethylsulfamoyl)-5-methoxy-10-(3-methyl-3,6-diazabicyclo[3.1.1]heptane-6-carbonyl)-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C35H43N5O5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0487369
|
19-cyclohexyl-N-(dimethylsulfamoyl)-10-(3-hydroxy-3-phenylazetidine-1-carbonyl)-5-methoxy-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C38H42N4O6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0547373
|
19-cyclohexyl-10-[4-(dimethylcarbamoyl)piperazine-1-carbonyl]-N-(dimethylsulfamoyl)-5-methoxy-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C36H46N6O6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0547374
|
10-[(3R,5S)-4-acetyl-3,5-dimethylpiperazine-1-carbonyl]-19-cyclohexyl-N-(dimethylsulfamoyl)-5-methoxy-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C37H47N5O6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0553620
|
19-cyclohexyl-N-(dimethylsulfamoyl)-10-[3-(4-fluorophenyl)-3-hydroxyazetidine-1-carbonyl]-5-methoxy-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C38H41FN4O6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0553621
|
(8S,10R)-19-cyclohexyl-N-(dimethylsulfamoyl)-5-methoxy-10-[(2R)-2-(methoxymethyl)morpholine-4-carbonyl]-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C35H44N4O7S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0553622
|
19-cyclohexyl-10-(3,8-diazabicyclo[3.2.1]octane-3-carbonyl)-N-(dimethylsulfamoyl)-5-methoxy-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C35H43N5O5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0553623
|
10-(4-acetylpiperazine-1-carbonyl)-19-cyclohexyl-N-(dimethylsulfamoyl)-5-methoxy-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C35H43N5O6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0406206
|
1-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-[(1R,3R)-3-hydroxycyclopentyl]urea
Show/Hide
|
C24H36ClN3O4
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0410400
|
1-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-[(1R,3S)-3-hydroxycyclopentyl]urea
Show/Hide
|
C24H36ClN3O4
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0202748
|
US9458171, 95
Show/Hide
|
C27H25F8NO5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0361647
|
US9458171, 16
Show/Hide
|
C27H26F7NO6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0427417
|
US9458171, 116
Show/Hide
|
C26H25F8N3O4S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0427418
|
US9458171, 120
Show/Hide
|
C30H29F8NO5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0427424
|
US9458171, 422
Show/Hide
|
C29H30F7NO5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0432788
|
4-[(3R)-3-(benzenesulfonyl)-3-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]pyrrolidine-1-carbonyl]cyclohexane-1-carboxylic acid
Show/Hide
|
C27H26F7NO5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0436100
|
US9458171, 119
Show/Hide
|
C29H29F8NO5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0482739
|
US9458171, 104
Show/Hide
|
C27H26F8N2O4S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0534392
|
US9458171, 97
Show/Hide
|
C28H28F7NO6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0539410
|
US9458171, 506
Show/Hide
|
C26H26F8N2O5S2
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0125809
|
US9458171, 392
Show/Hide
|
C29H27F8NO5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0136114
|
US9458171, 387
Show/Hide
|
C29H29F8NO5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0384347
|
4-[(3R)-3-(4-fluorophenyl)sulfonyl-3-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]pyrrolidine-1-carbonyl]-4-methylcyclohexane-1-carboxylic acid
Show/Hide
|
C28H27F8NO5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0384348
|
4-[(3R)-3-(4-fluorophenyl)sulfonyl-3-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]pyrrolidine-1-carbonyl]-4-(methoxymethyl)cyclohexane-1-carboxylic acid
Show/Hide
|
C29H29F8NO6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0384652
|
US9458171, 103
Show/Hide
|
C27H26F8N2O4S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0384653
|
US9458171, 494
Show/Hide
|
C26H25F8NO5S2
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0384656
|
US9458171, 402
Show/Hide
|
C28H25F8NO6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0384659
|
US9458171, 502
Show/Hide
|
C25H23F8NO6S2
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0384660
|
US9458171, 382
Show/Hide
|
C28H27F8NO5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0384661
|
4-[(3R)-3-(4-fluorophenyl)sulfonyl-3-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]pyrrolidine-1-carbonyl]-4-methylcyclohexane-1-carboxylic acid
Show/Hide
|
C28H27F8NO5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0384662
|
US9458171, 101
Show/Hide
|
C27H25F8NO6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0384663
|
US9458171, 485
Show/Hide
|
C25H23F8NO5S2
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0416603
|
US9458171, 399
Show/Hide
|
C27H23F8NO5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0416604
|
US9458171, 403
Show/Hide
|
C28H25F8NO6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0416632
|
US9458171, 396
Show/Hide
|
C29H29F8NO5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0434779
|
US9458171, 404
Show/Hide
|
C27H23F8NO5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0434781
|
US9458171, 504
Show/Hide
|
C26H25F8NO6S2
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0478422
|
US9458171, 514
Show/Hide
|
C27H27F8NO4S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0535831
|
US9458171, 517
Show/Hide
|
C26H25F8NO4S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0535853
|
US9458171, 526
Show/Hide
|
C26H25F8NO6S2
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0553126
|
US9458171, 519
Show/Hide
|
C25H22F9NO5S2
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0867529
|
US9458171, 401
Show/Hide
|
C27H25F8N5O3S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0537033
|
US9458171, 160
Show/Hide
|
C34H30F9NO6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0537173
|
US9458171, 341
Show/Hide
|
C35H33F8NO7S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0552292
|
US9458171, 294
Show/Hide
|
C31H32F7NO6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0552720
|
US9458171, 24
Show/Hide
|
C34H31F9N2O6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0553608
|
US9458171, 151
Show/Hide
|
C33H29F9N2O5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0556808
|
US9458171, 155
Show/Hide
|
C33H29F9N2O5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0556809
|
US9458171, 275
Show/Hide
|
C33H30F9N3O5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0560215
|
US9458171, 318
Show/Hide
|
C35H31F10NO7S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0560216
|
US9458171, 169
Show/Hide
|
C34H31F9N2O5S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0564087
|
US9458171, 332
Show/Hide
|
C36H36F7NO6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0564088
|
US9458171, 301
Show/Hide
|
C34H38F7NO6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0564091
|
US9458171, 251
Show/Hide
|
C33H29F9N2O6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0564749
|
US9458171, 297
Show/Hide
|
C33H36F7NO6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0570892
|
US9458171, 295
Show/Hide
|
C32H34F7NO6S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0465591
|
(2S)-2-[(22S)-17-fluoro-5-[[(2-hydroxy-2-methylpropyl)amino]methyl]-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10,12,14(33),15(20),16,18-decaen-3-yl]-2-[(2-methylpropan-2-yl)oxy]acetic acid
Show/Hide
|
C43H57FN4O6
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0557118
|
(2S)-2-[(22S)-5-[(dimethylamino)methyl]-17-fluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10,12,14(33),15(20),16,18-decaen-3-yl]-2-[(2-methylpropan-2-yl)oxy]acetic acid
Show/Hide
|
C41H53FN4O5
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0557190
|
(2S)-2-[(22S)-17-fluoro-4,22,28-trimethyl-5-[(propan-2-ylamino)methyl]-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10,12,14(33),15(20),16,18-decaen-3-yl]-2-[(2-methylpropan-2-yl)oxy]acetic acid
Show/Hide
|
C42H55FN4O5
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0451175
|
2-(3-fluoro-2-hydroxyphenyl)-6-methyl-5-(5-methyl-4-pyridin-2-ylthiophen-2-yl)-3-(2-phenylethyl)pyrimidin-4-one
Show/Hide
|
C29H24FN3O2S
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0421593
|
(E)-N-[(3,4-dichlorophenyl)methoxy]-1-[6-(4-phenylphenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methanimine
Show/Hide
|
C25H17Cl2N3OS
|
1
|
| 1 |
EC50 = 57000 nM
|
|
|
|
CP0237282
|
5-amino-3-[2-[4-[3-fluoro-4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-1-methyl-8-(1,3-thiazol-2-yl)-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C25H29FN10O3S
|
1
|
| 1 |
EC50 > 60000 nM
|
|
|
|
CP0427423
|
US9458171, 56
Show/Hide
|
C26H27F7N2O6S2
|
1
|
| 1 |
EC50 > 2470 nM
|
|
|
|
CP0487396
|
19-cyclohexyl-N-(dimethylsulfamoyl)-10-[3-hydroxy-3-(trifluoromethyl)azetidine-1-carbonyl]-5-methoxy-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Show/Hide
|
C33H37F3N4O6S
|
1
|
| 1 |
EC50 > 3000 nM
|
|
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CP0059925
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4-methoxy-2-(3-methoxyphenyl)quinazoline
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C16H14N2O2
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1
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| 1 |
EC50 > 3000 nM
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CP0180452
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2-(3-methoxyphenyl)-4-methylsulfanylquinazoline
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C16H14N2OS
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1
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| 1 |
EC50 > 3500 nM
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CP0423165
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US9458171, 79
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C26H26F7N3O5S
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1
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| 1 |
EC50 > 5140 nM
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CP0423504
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US10550091, No. LC-1
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C21H25N3O4S
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2
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| 1 |
IC50 = 24 nM
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| 2 |
IC50 = 250 nM
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CP0138483
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3-[4-(4-tert-butylphenyl)sulfonyl-5-methyltriazol-1-yl]-4-methoxybenzonitrile
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C21H22N4O3S
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2
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| 1 |
IC50 = 50 nM
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| 2 |
IC50 = 450 nM
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CP0329670
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1-(5-bromo-2-methoxyphenyl)-4-(4-tert-butylphenyl)sulfonyl-5-methyltriazole
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C20H22BrN3O3S
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2
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| 1 |
IC50 = 50 nM
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| 2 |
IC50 = 240 nM
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CP0329668
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4-[4-(2-butoxypropan-2-yl)phenyl]sulfonyl-1-(2,5-dimethoxyphenyl)-5-methyltriazole
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C24H31N3O5S
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2
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| 1 |
IC50 = 250 nM
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| 2 |
IC50 = 1350 nM
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CP0329680
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US10550091, No. LC-7
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C20H22ClN3O3S
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2
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| 1 |
IC50 = 270 nM
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| 2 |
IC50 = 310 nM
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CP0547636
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1-(2,5-dimethoxyphenyl)-4-[4-(2-methoxypropan-2-yl)phenyl]sulfonyl-5-methyltriazole
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C21H25N3O5S
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2
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| 1 |
IC50 = 400 nM
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| 2 |
IC50 = 2300 nM
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CP0138923
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US10550091, No. LC-55
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C22H27N3O4S
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1
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| 1 |
IC50 = 500 nM
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CP0423604
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US10550091, No. LC-18
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C21H24FN3O3S
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1
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| 1 |
IC50 = 700 nM
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CP0423608
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US10550091, No. LC-56
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C22H27N3O3S
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1
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| 1 |
IC50 = 800 nM
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CP0423503
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US10550091, No. LC-57
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C21H24ClN3O3S
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1
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| 1 |
IC50 = 960 nM
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CP0485595
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4-(4-tert-butylphenyl)sulfonyl-1-[2-methoxy-5-(trifluoromethyl)phenyl]-5-methyltriazole
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C21H22F3N3O3S
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1
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| 1 |
IC50 = 1010 nM
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CP0130500
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US10550091, No. LC-28
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C20H21Cl2N3O3S
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1
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| 1 |
IC50 = 1300 nM
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CP0138481
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US10550091, No. LC-5
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C21H25N3O3S
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1
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| 1 |
IC50 = 2000 nM
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CP0543193
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2-bromo-N-[2-(4-ethylphenyl)-1,3-benzoxazol-5-yl]-5-nitrobenzamide
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C22H16BrN3O4
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1
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| 1 |
IC50 = 41000 nM
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CP0362425
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2-chloro-N-[2-(4-ethylphenyl)-1,3-benzoxazol-5-yl]-5-nitrobenzamide
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C22H16ClN3O4
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1
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| 1 |
IC50 > 50000 nM
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