General Information of the Protein
Protein ID
PT00996
Protein Name
Histone deacetylase 5
Secondarily
Protein Name
Antigen NY-CO-9
Gene Name
HDAC5
Secondarily
Gene Name
KIAA0600
Sequence
MNSPNESDGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL
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Organism
Homo sapiens, Human
Protein Classification
Epigenetic regulator
>
Eraser
>
Histone deacetylase
>
HDAC class IIa
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758).
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Uniprot ID
Primary ID:
Q9UQL6

Secondarily ID:
C9JFV9
O60340
O60528
Q96DY4
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Ensembl ID
ENSG00000108840
HGNC ID
HGNC:14068
Subcellular Location
Nucleus
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000314 , HEK293T/17
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0431647
 Compound Info 
3,4-dichloro-N-[[4-(hydroxycarbamoyl)phenyl]methyl]benzamide
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C15H12Cl2N2O3
  1
1
IC50 = 3120 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0057110
 Compound Info 
4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide
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C19H23N3O3
  1
1
IC50 = 6620 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0431646
 Compound Info 
5-[2-[(3,4-dichlorobenzoyl)amino]ethyl]-N-hydroxy-1,2-oxazole-3-carboxamide
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C13H11Cl2N3O4
  1
1
IC50 = 6910 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0008777
 Compound Info 
JNJ-26481585
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C21H26N6O2
  3
1 IC50 = 3.69 nM
2 Ki = 2.1 nM
3 Ki = 4.3 nM
CP0005479
 Compound Info 
CHEBI:46024
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C17H22N2O3
  11
1 IC50 = 6 nM
2 IC50 = 8.08 nM
3 IC50 = 12.5 nM
4 IC50 = 16 nM
5 IC50 = 16.48 nM
6 IC50 = 16.5 nM
7 IC50 = 1090 nM
8 IC50 = 1400 nM
9 IC50 = 6155 nM
10 Ki = 260 nM
11 Ki = 4120 nM
CP0003580
 Compound Info 
Faridak
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C21H23N3O2
  8
1 IC50 = 7.8 nM
2 IC50 = 190 nM
3 IC50 = 195.6 nM
4 IC50 = 290 nM
5 IC50 < 300 nM
6 Ki = 0.7 nM
7 Ki = 57 nM
8 Ki = 80 nM
CP0033005
 Compound Info 
2-(2-fluorophenyl)-N-hydroxy-2-[4-[5-(trifluoromethyl)pyrimidin-2-yl]phenyl]acetamide
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C19H13F4N3O2
  1
1 IC50 = 60 nM
CP0003832
 Compound Info 
N'-hydroxy-N-phenyloctanediamide
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C14H20N2O3
  27
1 IC50 = 107.3 nM
2 IC50 = 150 nM
3 IC50 = 378 nM
4 IC50 = 380 nM
5 IC50 = 400 nM
6 IC50 = 2180 nM
7 IC50 = 2480 nM
8 IC50 = 2580 nM
9 IC50 = 3000 nM
10 IC50 = 4600 nM
11 IC50 = 8750 nM
12 IC50 = 11000 nM
13 IC50 = 13800 nM
14 IC50 = 15000 nM
15 IC50 = 18440 nM
16 IC50 = 20000 nM
17 IC50 = 27000 nM
18 IC50 = 27200 nM
19 IC50 = 41500 nM
20 IC50 > 200 nM
21 IC50 > 5000 nM
22 IC50 > 10000 nM
23 IC50 > 30000 nM
24 Ki = 33 nM
25 Ki = 36 nM
26 Ki = 3600 nM
27 Ki = 12000 nM
CP0124688
 Compound Info 
N-hydroxy-9H-fluorene-9-carboxamide
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C14H11NO2
  1
1 IC50 = 150 nM
CP0066173
 Compound Info 
N-hydroxy-2,2-diphenylacetamide
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C14H13NO2
  1
1 IC50 = 160 nM
CP0003676
 Compound Info 
N-hydroxy-2-[[2-(6-methoxypyridin-3-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl-methylamino]pyrimidine-5-carboxamide
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C23H24N8O4S
  3
1 IC50 = 406 nM
2 IC50 = 581 nM
3 IC50 = 674 nM
CP0004988
 Compound Info 
pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate
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C21H20N4O3
  3
1 IC50 = 1400 nM
2 IC50 > 10000 nM
3 IC50 > 50000 nM
CP0057110
 Compound Info 
4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide
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C19H23N3O3
  1
1 IC50 = 11700 nM
CP0016939
 Compound Info 
N-(2-aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide
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C23H20N6O
  1
1 IC50 > 10000 nM
CP0015005
 Compound Info 
S-[(E)-4-[(4Z,7S,10S)-4-ethylidene-2,5,8,12-tetraoxo-7-propan-2-yl-9-oxa-16-thia-3,6,13,18-tetrazabicyclo[13.2.1]octadeca-1(17),15(18)-dien-10-yl]but-3-enyl] octanethioate
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C29H42N4O6S2
  1
1 IC50 > 10000 nM
Clinical Information about the Protein
Target 1 ( Histone deacetylase 5 (HDAC5) )
Target Type Patented-recorded Target