Protein Information

General Information of the Protein

Protein ID	PT02585
Protein Name	Proteasome subunit beta type-5
Secondarily Protein Name	Macropain epsilon chain Multicatalytic endopeptidase complex epsilon chain Proteasome chain 6 Proteasome epsilon chain Proteasome subunit MB1 Proteasome subunit X
Gene Name	PSMB5
Secondarily Gene Name	LMPX MB1 X
Sequence	MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Protease > Threonine protease > Threonine protease PBT clan > Threonine protease T1A subfamily
Function	Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity. Show/Hide
Uniprot ID	Primary ID: P28074 Secondarily ID: B2R4N9 B4DUM9 D3DS43 E9PAV2 Q16242 Q6PEW2 Q7Z3B5 Q86T01 Q9TNN9 Show/Hide
Ensembl ID	ENSG00000100804
HGNC ID	HGNC:9542
Subcellular Location	Cytoplasm Nucleus

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000068 , A-549

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0570106 Compound Info	US10294246, Compound No. 20 Show/Hide	C16H16BN3O4	1
1	IC50 = 204 nM Bioactivity Info	TI LI LO TS
CP0550598 Compound Info	US10294246, Compound No. 92 Show/Hide	C19H20BNO5	1
1	IC50 = 222 nM Bioactivity Info	TI LI LO TS
CP0564533 Compound Info	[(1R)-2-(1-benzofuran-3-yl)-1-(3-methoxypropanoylamino)ethyl]boronic acid Show/Hide	C14H18BNO5	1
1	IC50 = 241 nM Bioactivity Info	TI LI LO TS
CP0571391 Compound Info	US10294246, Compound No. 18 Show/Hide	C16H16BN3O4	1
1	IC50 = 328 nM Bioactivity Info	TI LI LO TS
CP0564532 Compound Info	[(1R)-1-acetamido-2-(1-benzofuran-3-yl)ethyl]boronic acid Show/Hide	C12H14BNO4	1
1	IC50 = 420 nM Bioactivity Info	TI LI LO TS
CP0550601 Compound Info	[(1R)-2-(1-benzofuran-3-yl)-1-[(2-methoxyacetyl)amino]ethyl]boronic acid Show/Hide	C13H16BNO5	1
1	IC50 = 520 nM Bioactivity Info	TI LI LO TS
CP0545536 Compound Info	US10294246, Compound No. 6 Show/Hide	C18H18BNO4	1
1	IC50 = 573 nM Bioactivity Info	TI LI LO TS
CP0575635 Compound Info	US10294246, Compound No. 8 Show/Hide	C17H17BN2O4	1
1	IC50 = 646 nM Bioactivity Info	TI LI LO TS
CP0547335 Compound Info	US10294246, Compound No. 125 Show/Hide	C18H17BFNO4	1
1	IC50 = 785 nM Bioactivity Info	TI LI LO TS
CP0564529 Compound Info	[(1R)-2-(1-benzofuran-3-yl)-1-[[(2R)-oxolane-2-carbonyl]amino]ethyl]boronic acid Show/Hide	C15H18BNO5	1
1	IC50 = 817 nM Bioactivity Info	TI LI LO TS
CP0576763 Compound Info	[(1R)-2-(1-benzofuran-3-yl)-1-[(2-pyrazol-1-ylacetyl)amino]ethyl]boronic acid Show/Hide	C15H16BN3O4	1
1	IC50 = 894 nM Bioactivity Info	TI LI LO TS
CP0545538 Compound Info	[(1R)-2-(1-benzofuran-3-yl)-1-[[(1S,2R,4R)-7-oxabicyclo[2.2.1]heptane-2-carbonyl]amino]ethyl]boronic acid Show/Hide	C17H20BNO5	1
1	IC50 = 1035 nM Bioactivity Info	TI LI LO TS
CP0547336 Compound Info	[(1R)-2-(1-benzofuran-3-yl)-1-[[(3R)-oxolane-3-carbonyl]amino]ethyl]boronic acid Show/Hide	C15H18BNO5	1
1	IC50 = 1689 nM Bioactivity Info	TI LI LO TS
CP0569314 Compound Info	US10294246, Compound No. 85 Show/Hide	C18H17BClNO4	1
1	IC50 = 2062 nM Bioactivity Info	TI LI LO TS
CP0575641 Compound Info	US10294246, Compound No. 75 Show/Hide	C19H20BNO4	1
1	IC50 = 2098 nM Bioactivity Info	TI LI LO TS
CP0575644 Compound Info	US10294246, Compound No. 90 Show/Hide	C19H17BN2O4	1
1	IC50 = 2221 nM Bioactivity Info	TI LI LO TS
CP0575636 Compound Info	[(1R)-2-(1-benzofuran-3-yl)-1-[[(1R,2S,4S)-7-oxabicyclo[2.2.1]heptane-2-carbonyl]amino]ethyl]boronic acid Show/Hide	C17H20BNO5	1
1	IC50 = 2445 nM Bioactivity Info	TI LI LO TS
CP0564531 Compound Info	US10294246, Compound No. 105 Show/Hide	C19H19BN2O4	1
1	IC50 = 2520 nM Bioactivity Info	TI LI LO TS
CP0570105 Compound Info	US10294246, Compound No. 19 Show/Hide	C17H17BN2O4	1
1	IC50 = 2538 nM Bioactivity Info	TI LI LO TS
CP0545537 Compound Info	[(1R)-2-(1-benzofuran-3-yl)-1-[[(3S)-oxolane-3-carbonyl]amino]ethyl]boronic acid Show/Hide	C15H18BNO5	1
1	IC50 = 2996 nM Bioactivity Info	TI LI LO TS
CP0571392 Compound Info	[(1S)-2-(3,4-dimethylphenyl)-1-[(2-phenylacetyl)amino]ethyl]boronic acid Show/Hide	C18H22BNO3	1
1	IC50 = 5900 nM Bioactivity Info	TI LI LO TS
CP0571153 Compound Info	US10294246, Compound No. 132 Show/Hide	C18H19BClNO4	1
1	IC50 = 6099 nM Bioactivity Info	TI LI LO TS
CP0575637 Compound Info	US10294246, Compound No. 14 Show/Hide	C17H20BNO3	1
1	IC50 = 6287 nM Bioactivity Info	TI LI LO TS
CP0550600 Compound Info	[(1R)-3-methyl-1-[(2-phenylacetyl)amino]butyl]boronic acid Show/Hide	C13H20BNO3	1
1	IC50 = 6997 nM Bioactivity Info	TI LI LO TS
CP0572728 Compound Info	US10294246, Compound No. 126 Show/Hide	C19H19BClNO4	1
1	IC50 = 7325 nM Bioactivity Info	TI LI LO TS
CP0571152 Compound Info	[(1R)-2-(4-chlorophenyl)-1-[(2-phenylacetyl)amino]ethyl]boronic acid Show/Hide	C16H17BClNO3	1
1	IC50 = 8748 nM Bioactivity Info	TI LI LO TS
CP0577158 Compound Info	[(1R)-2-phenyl-1-[(2-phenylacetyl)amino]ethyl]boronic acid Show/Hide	C16H18BNO3	1
1	IC50 = 9565 nM Bioactivity Info	TI LI LO TS
CP0579795 Compound Info	US10294246, Compound No. 110 Show/Hide	C18H18BNO4	1
1	IC50 = 10148 nM Bioactivity Info	TI LI LO TS
CP0571390 Compound Info	US10294246, Compound No. 124 Show/Hide	C19H22BNO4	1
1	IC50 = 14000 nM Bioactivity Info	TI LI LO TS
CP0564534 Compound Info	[(1R)-2-(1-benzofuran-3-yl)-1-[[(2S)-oxolane-2-carbonyl]amino]ethyl]boronic acid Show/Hide	C15H18BNO5	1
1	IC50 = 15000 nM Bioactivity Info	TI LI LO TS
CP0575639 Compound Info	US10294246, Compound No. 73 Show/Hide	C18H17BClNO4	1
1	IC50 = 16492 nM Bioactivity Info	TI LI LO TS
CP0550599 Compound Info	US10294246, Compound No. 134 Show/Hide	C19H18BClN2O4	1
1	IC50 = 20904 nM Bioactivity Info	TI LI LO TS
CP0572727 Compound Info	[(1R)-2-(3,4-dimethylphenyl)-1-[(2-phenylacetyl)amino]ethyl]boronic acid Show/Hide	C18H22BNO3	1
1	IC50 = 24454 nM Bioactivity Info	TI LI LO TS
CP0564530 Compound Info	US10294246, Compound No. 133 Show/Hide	C18H19BClNO4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0572729 Compound Info	US10294246, Compound No. 130 Show/Hide	C20H21BN2O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0573716 Compound Info	US10294246, Compound No. 29 Show/Hide	C18H22BNO3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000187 , Calu-6

Cell Line Info

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000017 , HeLa

Cell Line Info

Cell Line ID: CL000018 , HL-60

Cell Line Info

Cell Line ID: CL000116 , MOLT-4

Cell Line Info

Cell Line ID: CL000482 , NCI-H929

Cell Line Info

Cell Line ID: CL000174 , Raji

Cell Line Info

Cell Line ID: CL000186 , RPMI-8226

Cell Line Info

Cell Line ID: CL000164 , SEM

Cell Line Info

Cell Line ID: CL000165 , SUP-B15

Cell Line Info

Cell Line ID: CL000596 , U266B1

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0004620 Compound Info	(R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid Show/Hide	C19H25BN4O4	19
1	IC50 = 0.5 nM
2	IC50 = 1.9 nM
3	IC50 = 3.2 nM
4	IC50 = 4.5 nM
5	IC50 = 4.68 nM
6	IC50 = 6 nM
7	IC50 = 6.2 nM
8	IC50 = 7 nM
9	IC50 = 7.04 nM
10	IC50 = 7.09 nM
11	IC50 = 7.9 nM
12	IC50 = 8.3 nM
13	IC50 = 10.8 nM
14	IC50 = 11 nM
15	IC50 = 140 nM
16	IC50 = 2100 nM
17	Ki = 0.55 nM
18	Ki = 0.6 nM
19	Ki = 9.8 nM
CP0213895 Compound Info	Kzr-616 Show/Hide	C30H42N4O8	1
1	IC50 = 0.688 nM
CP0045910 Compound Info	(S)-2-azido-N-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)-3-phenylpropanamide Show/Hide	C36H42N6O5	1
1	IC50 = 1 nM
CP0112227 Compound Info	(2S)-N-[(2S)-1-[(2-chlorophenyl)methylamino]-1-oxo-3-pyridin-4-ylpropan-2-yl]-N'-(2,2-dimethylpropyl)-2-[[2-(1H-indol-3-yl)-2-oxoacetyl]amino]butanediamide Show/Hide	C34H37ClN6O5	2
1	IC50 = 1.1 nM
2	IC50 = 1.2 nM
CP0001758 Compound Info	(S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic acid [(S)-1-((S)-1-formyl-3-methyl-butylcarbamoyl)-3-methyl-butyl]-amide Show/Hide	C26H41N3O5	7
1	IC50 = 1.2 nM
2	IC50 = 11 nM
3	IC50 = 25 nM
4	IC50 = 37 nM
5	Ki = 1.4 nM
6	Ki = 3.7 nM
7	Ki = 70 nM
CP0013049 Compound Info	CARFILZOMIB Show/Hide	C40H57N5O7	7
1	IC50 = 2.1 nM
2	IC50 = 5 nM
3	IC50 = 6 nM
4	IC50 = 7 nM
5	IC50 = 8.4 nM
6	IC50 = 8.6 nM
7	IC50 = 23.6 nM
CP0034167 Compound Info	[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid Show/Hide	C14H19BCl2N2O4	3
1	IC50 = 2.884 nM
2	IC50 = 3.4 nM
3	IC50 = 7.73 nM
CP0648674 Compound Info	epoxomicin Show/Hide	C28H50N4O7	2
1	IC50 = 3.7 nM
2	IC50 = 47 nM
CP0077120 Compound Info	N,N'-bis[6-[[6-[[6-[[(2S)-1-[[(2S)-1-[[(2S)-1-(benzylamino)-3-[(3R)-3-hydroxy-2-oxo-1H-indol-3-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-(4-phenylmethoxyphenyl)propan-2-yl]amino]-6-oxohexyl]amino]-6-oxohexyl]amino]-6-oxohexyl]hexanediamide Show/Hide	C116H150N16O20	2
1	IC50 = 19.1 nM
2	Ki = 10.6 nM
CP0205983 Compound Info	N'-[(2S)-1-[[(2S)-1-[[(2S)-1-(benzylamino)-3-[(3R)-3-hydroxy-2-oxo-1H-indol-3-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-(4-phenylmethoxyphenyl)propan-2-yl]-N-[6-[[6-[[6-[[6-[[6-[[(2S)-1-[[(2S)-1-[[(2S)-1-(benzylamino)-3-[(3R)-3-hydroxy-2-oxo-1H-indol-3-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-(4-phenylmethoxyphenyl)propan-2-yl]amino]-6-oxohexyl]amino]-6-oxohexyl]amino]-6-oxohexyl]amino]-6-oxohexyl]amino]-6-oxohexyl]hexanediamide Show/Hide	C110H139N15O19	2
1	IC50 = 22.7 nM
2	Ki = 11.4 nM
CP0210996 Compound Info	(1R,4R,5S)-4-(2-chloroethyl)-1-[(S)-cyclohexyl(hydroxy)methyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione Show/Hide	C15H22ClNO4	1
1	IC50 = 23 nM
CP0114837 Compound Info	N'-[(2S)-1-[[(2S)-1-[[(2S)-1-(benzylamino)-3-[(3R)-3-hydroxy-2-oxo-1H-indol-3-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-(4-phenylmethoxyphenyl)propan-2-yl]-N-[6-[[6-[[6-[[(2S)-1-[[(2S)-1-[[(2S)-1-(benzylamino)-3-[(3R)-3-hydroxy-2-oxo-1H-indol-3-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-(4-phenylmethoxyphenyl)propan-2-yl]amino]-6-oxohexyl]amino]-6-oxohexyl]amino]-6-oxohexyl]hexanediamide Show/Hide	C98H117N13O17	2
1	IC50 = 25.8 nM
2	Ki = 10.3 nM
CP0127744 Compound Info	N'-[(2S)-1-[[(2S)-1-[[(2S)-1-(benzylamino)-3-[(3R)-3-hydroxy-2-oxo-1H-indol-3-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-(4-phenylmethoxyphenyl)propan-2-yl]-N-[6-[[6-[[6-[[6-[[(2S)-1-[[(2S)-1-[[(2S)-1-(benzylamino)-3-[(3R)-3-hydroxy-2-oxo-1H-indol-3-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-(4-phenylmethoxyphenyl)propan-2-yl]amino]-6-oxohexyl]amino]-6-oxohexyl]amino]-6-oxohexyl]amino]-6-oxohexyl]hexanediamide Show/Hide	C104H128N14O18	2
1	IC50 = 25.9 nM
2	Ki = 10.8 nM
CP0221835 Compound Info	(1R,4R,5S)-4-(2-chloroethyl)-1-[(S)-cyclopropyl(hydroxy)methyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione Show/Hide	C12H16ClNO4	1
1	IC50 = 28 nM
CP0086566 Compound Info	(2S)-2-[[2-(azepan-1-yl)acetyl]amino]-4-methyl-N-[(2S)-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pentanamide Show/Hide	C35H48N4O5	1
1	IC50 = 39 nM
CP0070546 Compound Info	(1R,4R,5S)-4-(3-chloropropyl)-1-[(S)-cyclohexyl(hydroxy)methyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione Show/Hide	C16H24ClNO4	1
1	IC50 = 50 nM
CP0955534 Compound Info	(S)-2-(2-(1H-indol-3-yl)-2-oxoacetamido)-N4-tert-butyl-N1-((S)-1-(naphthalen-1-ylmethylamino)-1-oxopropan-2-yl)succinamide Show/Hide	C32H35N5O5	1
1	IC50 = 59.2 nM
CP0023959 Compound Info	(-)-Epigallocatechin gallate Show/Hide	C22H18O11	1
1	IC50 = 86 nM
CP0550598 Compound Info	US10294246, Compound No. 92 Show/Hide	C19H20BNO5	1
1	IC50 = 140 nM
CP0062987 Compound Info	(2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide Show/Hide	C31H40N4O7	4
1	IC50 = 150 nM
2	IC50 = 414.8 nM
3	IC50 = 472.7 nM
4	IC50 > 1000 nM
CP0009077 Compound Info	LACTACYSTIN Show/Hide	C15H24N2O7S	4
1	IC50 = 160 nM
2	IC50 = 500 nM
3	IC50 = 4960 nM
4	IC50 = 10090 nM
CP0570106 Compound Info	US10294246, Compound No. 20 Show/Hide	C16H16BN3O4	1
1	IC50 = 230 nM
CP0574852 Compound Info	(2S)-N'-tert-butyl-N-[(2S)-1-[(4-fluoronaphthalen-1-yl)methylamino]-1-oxopropan-2-yl]-2-(3-phenylpropanoylamino)pentanediamide Show/Hide	C32H39FN4O4	1
1	IC50 = 244 nM
CP0564533 Compound Info	[(1R)-2-(1-benzofuran-3-yl)-1-(3-methoxypropanoylamino)ethyl]boronic acid Show/Hide	C14H18BNO5	1
1	IC50 = 400 nM
CP0571391 Compound Info	US10294246, Compound No. 18 Show/Hide	C16H16BN3O4	1
1	IC50 = 410 nM
CP0065730 Compound Info	tert-butyl N-[6-[[6-[[6-[[(2S)-1-[[(2S)-1-[[(2S)-1-(benzylamino)-3-[(3R)-3-hydroxy-2-oxo-1H-indol-3-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-(4-phenylmethoxyphenyl)propan-2-yl]amino]-6-oxohexyl]amino]-6-oxohexyl]amino]-6-oxohexyl]carbamate Show/Hide	C60H80N8O11	3
1	IC50 = 460 nM
2	Ki = 101 nM
3	Ki = 316 nM
CP0070550 Compound Info	(1R,4R,5S)-4-(2-chloroethyl)-1-[(1S)-1-hydroxy-2-phenylethyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione Show/Hide	C16H18ClNO4	1
1	IC50 = 500 nM
CP0547335 Compound Info	US10294246, Compound No. 125 Show/Hide	C18H17BFNO4	1
1	IC50 = 530 nM
CP0575635 Compound Info	US10294246, Compound No. 8 Show/Hide	C17H17BN2O4	1
1	IC50 = 540 nM
CP0560194 Compound Info	(2S)-N'-tert-butyl-N-[(2S)-1-[(4-fluoronaphthalen-1-yl)methylamino]-1-oxopropan-2-yl]-2-[(5-methyl-1,2-oxazole-3-carbonyl)amino]pentanediamide Show/Hide	C28H34FN5O5	1
1	IC50 = 610 nM
CP0058714 Compound Info	1-[2-[4-[1-[4-[2-(azepan-1-yl)ethoxy]phenyl]-2-phenylbut-1-enyl]phenoxy]ethyl]azepane Show/Hide	C38H50N2O2	4
1	IC50 = 640 nM
2	IC50 = 1020 nM
3	IC50 > 100000 nM
4	Ki = 580 nM
CP0576763 Compound Info	[(1R)-2-(1-benzofuran-3-yl)-1-[(2-pyrazol-1-ylacetyl)amino]ethyl]boronic acid Show/Hide	C15H16BN3O4	1
1	IC50 = 770 nM
CP0550601 Compound Info	[(1R)-2-(1-benzofuran-3-yl)-1-[(2-methoxyacetyl)amino]ethyl]boronic acid Show/Hide	C13H16BNO5	1
1	IC50 = 820 nM
CP0569314 Compound Info	US10294246, Compound No. 85 Show/Hide	C18H17BClNO4	1
1	IC50 = 860 nM
CP0545536 Compound Info	US10294246, Compound No. 6 Show/Hide	C18H18BNO4	1
1	IC50 = 900 nM
CP0151829 Compound Info	(2S)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide Show/Hide	C30H42N4O7	1
1	IC50 = 926 nM
CP0564529 Compound Info	[(1R)-2-(1-benzofuran-3-yl)-1-[[(2R)-oxolane-2-carbonyl]amino]ethyl]boronic acid Show/Hide	C15H18BNO5	1
1	IC50 = 930 nM
CP0575641 Compound Info	US10294246, Compound No. 75 Show/Hide	C19H20BNO4	1
1	IC50 = 1200 nM
CP0564532 Compound Info	[(1R)-1-acetamido-2-(1-benzofuran-3-yl)ethyl]boronic acid Show/Hide	C12H14BNO4	1
1	IC50 = 1400 nM
CP0354052 Compound Info	(2S)-N'-tert-butyl-N-[(2S)-1-[(4-fluoronaphthalen-1-yl)methylamino]-3-methoxy-1-oxopropan-2-yl]-2-[(4-methylphenyl)sulfonylamino]pentanediamide Show/Hide	C31H39FN4O6S	1
1	IC50 = 1456 nM
CP0572728 Compound Info	US10294246, Compound No. 126 Show/Hide	C19H19BClNO4	1
1	IC50 = 1700 nM
CP0575644 Compound Info	US10294246, Compound No. 90 Show/Hide	C19H17BN2O4	1
1	IC50 = 1700 nM
CP0570105 Compound Info	US10294246, Compound No. 19 Show/Hide	C17H17BN2O4	1
1	IC50 = 2300 nM
CP0075396 Compound Info	N-[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-2-oxoethyl]-3-[1,1-bis[4-[2-(azepan-1-yl)ethoxy]phenyl]but-1-en-2-yl]benzamide Show/Hide	C89H150N36O12	3
1	IC50 = 2400 nM
2	IC50 = 5500 nM
3	IC50 > 50000 nM
CP0564531 Compound Info	US10294246, Compound No. 105 Show/Hide	C19H19BN2O4	1
1	IC50 = 2400 nM
CP0545538 Compound Info	[(1R)-2-(1-benzofuran-3-yl)-1-[[(1S,2R,4R)-7-oxabicyclo[2.2.1]heptane-2-carbonyl]amino]ethyl]boronic acid Show/Hide	C17H20BNO5	1
1	IC50 = 2500 nM
CP0261361 Compound Info	(2S)-N-[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]-4-methylpentanamide Show/Hide	C33H47N7O5S	2
1	IC50 = 2600 nM
2	IC50 = 5800 nM
CP0086565 Compound Info	CHEMBL4441524 Show/Hide	C31H43N3O7	1
1	IC50 = 2670 nM
CP0128289 Compound Info	(2S)-N-[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]-2-[[(2S)-3-(4-aminophenyl)-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]propanoyl]amino]-4-methylpentanamide Show/Hide	C36H46N8O5S	1
1	IC50 = 2800 nM
CP0571153 Compound Info	US10294246, Compound No. 132 Show/Hide	C18H19BClNO4	1
1	IC50 = 2900 nM
CP0114836 Compound Info	tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S)-1-(benzylamino)-3-[(3R)-3-hydroxy-2-oxo-1H-indol-3-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-(4-phenylmethoxyphenyl)propan-2-yl]carbamate Show/Hide	C42H47N5O8	3
1	IC50 = 3190 nM
2	Ki = 2430 nM
3	Ki = 5030 nM
CP0547336 Compound Info	[(1R)-2-(1-benzofuran-3-yl)-1-[[(3R)-oxolane-3-carbonyl]amino]ethyl]boronic acid Show/Hide	C15H18BNO5	1
1	IC50 = 4300 nM
CP0545537 Compound Info	[(1R)-2-(1-benzofuran-3-yl)-1-[[(3S)-oxolane-3-carbonyl]amino]ethyl]boronic acid Show/Hide	C15H18BNO5	1
1	IC50 = 5000 nM
CP0579795 Compound Info	US10294246, Compound No. 110 Show/Hide	C18H18BNO4	1
1	IC50 = 5000 nM
CP0145054 Compound Info	(2S)-N-[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]-2-[[(2S)-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]-3-pyridin-4-ylpropanoyl]amino]-4-methylpentanamide Show/Hide	C35H44N8O5S	1
1	IC50 = 5500 nM
CP0363571 Compound Info	(2S)-N'-tert-butyl-N-[(2S)-1-[(4-fluoronaphthalen-1-yl)methylamino]-1-oxopropan-2-yl]-2-[(4-methylphenyl)sulfonylamino]pentanediamide Show/Hide	C30H37FN4O5S	1
1	IC50 = 5520 nM
CP0571152 Compound Info	[(1R)-2-(4-chlorophenyl)-1-[(2-phenylacetyl)amino]ethyl]boronic acid Show/Hide	C16H17BClNO3	1
1	IC50 = 5600 nM
CP0075391 Compound Info	N-[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-acetamido-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-2-oxoethyl]-3-[1,1-bis[4-[2-(azepan-1-yl)ethoxy]phenyl]but-1-en-2-yl]benzamide Show/Hide	C91H152N36O13	3
1	IC50 = 6000 nM
2	IC50 = 9400 nM
3	IC50 > 40000 nM
CP0575637 Compound Info	US10294246, Compound No. 14 Show/Hide	C17H20BNO3	1
1	IC50 = 6300 nM
CP0575636 Compound Info	[(1R)-2-(1-benzofuran-3-yl)-1-[[(1R,2S,4S)-7-oxabicyclo[2.2.1]heptane-2-carbonyl]amino]ethyl]boronic acid Show/Hide	C17H20BNO5	1
1	IC50 = 6500 nM
CP0571390 Compound Info	US10294246, Compound No. 124 Show/Hide	C19H22BNO4	1
1	IC50 = 7200 nM
CP0550599 Compound Info	US10294246, Compound No. 134 Show/Hide	C19H18BClN2O4	1
1	IC50 = 7400 nM
CP0211226 Compound Info	[4-[(1E,6E)-7-[4-[(2S)-2-amino-3-methylbutanoyl]oxy-3-methoxyphenyl]-3,5-dioxohepta-1,6-dienyl]-2-methoxyphenyl] (2S)-2-amino-3-methylbutanoate Show/Hide	C31H38N2O8	1
1	IC50 = 10000 nM
CP0354051 Compound Info	(2S)-N'-tert-butyl-N-[(2S)-1-[(4-fluoronaphthalen-1-yl)methylamino]-3-methoxy-1-oxopropan-2-yl]-2-[(4-methylphenyl)sulfonylamino]butanediamide Show/Hide	C30H37FN4O6S	1
1	IC50 = 13740 nM
CP0572729 Compound Info	US10294246, Compound No. 130 Show/Hide	C20H21BN2O4	1
1	IC50 = 14000 nM
CP0550600 Compound Info	[(1R)-3-methyl-1-[(2-phenylacetyl)amino]butyl]boronic acid Show/Hide	C13H20BNO3	1
1	IC50 = 15000 nM
CP0572727 Compound Info	[(1R)-2-(3,4-dimethylphenyl)-1-[(2-phenylacetyl)amino]ethyl]boronic acid Show/Hide	C18H22BNO3	1
1	IC50 = 15000 nM
CP0577158 Compound Info	[(1R)-2-phenyl-1-[(2-phenylacetyl)amino]ethyl]boronic acid Show/Hide	C16H18BNO3	1
1	IC50 = 16000 nM
CP0575639 Compound Info	US10294246, Compound No. 73 Show/Hide	C18H17BClNO4	1
1	IC50 = 20000 nM
CP0065810 Compound Info	(2S)-2-[[(2S)-3-[4-(aminomethyl)phenyl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]propanoyl]amino]-N-[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]-4-methylpentanamide Show/Hide	C37H48N8O5S	1
1	IC50 = 21000 nM
CP0564534 Compound Info	[(1R)-2-(1-benzofuran-3-yl)-1-[[(2S)-oxolane-2-carbonyl]amino]ethyl]boronic acid Show/Hide	C15H18BNO5	1
1	IC50 = 24000 nM
CP0573716 Compound Info	US10294246, Compound No. 29 Show/Hide	C18H22BNO3	1
1	IC50 = 26000 nM
CP0668235 Compound Info	1-(Quinolin-2-ylmethylene)thiosemicarbazone Show/Hide	C11H10N4S	1
1	IC50 > 10000 nM
CP0564530 Compound Info	US10294246, Compound No. 133 Show/Hide	C18H19BClNO4	1
1	IC50 > 30000 nM
CP0571392 Compound Info	[(1S)-2-(3,4-dimethylphenyl)-1-[(2-phenylacetyl)amino]ethyl]boronic acid Show/Hide	C18H22BNO3	1
1	IC50 > 30000 nM

Clinical Information about the Protein

Target 1 ( Proteasome beta-5 (PS beta-5) )

Target Type	Patented-recorded Target

Similar Protein(s) and Bioactivity Statistics

90% Identity

Protein ID	Protein Name	Protein Organism
PT03791	Proteasome subunit beta type-5	Mus musculus, Mouse	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han