General Information of the Compound
| Compound ID |
CP0213895
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| Compound Name |
Kzr-616
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| Synonyms |
(2S,3R)-N-((S)-3-(cyclopent-1-en-1-yl)-1-((R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-((S)-2-(2-morpholinoacetamido)propanamido)propanamide
(2S,3R)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
(2S,3R)N((S)3-(Cyclopent-1-en-1-yl)-1-((R)2-methyloxiran-2-yl)-1- oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-((S)2-(2- morpholinoacetamido)propanamido)propenamide
1629677-75-3
4,5-ANHYDRO-1-(1-CYCLOPENTEN-1-YL)-1,2-DIDEOXY-4-C-METHYL-2-((N-(2-(4-MORPHOLINYL)ACETYL)-L-ALANYL-(.BETA.R)-.BETA.-HYDROXY-O-METHYL-L-TYROSYL)AMINO)-D-ERYTHRO-3-PENTULOSE
4,5-Anhydro-1-(1-cyclopenten-1-yl)-1,2-dideoxy-4-C-methyl-2-((N-(2-(4-morpholinyl)acetyl)-L-alanyl-(betaR)-beta-hydroxy-O-methyl-L-tyrosyl)amino)-D-erythro-3-pentulose
AKOS040755812
BDBM50526811
CHEMBL4297468
CS-0085023
D-Erythro-3-pentulose, 4,5-anhydro-1-(1-cyclopenten-1-yl)-1,2-dideoxy-4-C-methyl-2-((N-(2-(4-morpholinyl)acetyl)-L-alanyl-(betaR)-beta-hydroxy-O-methyl-L-tyrosyl)amino)-
D-erythro-3-Pentulose, 4,5-anhydro-1-(1-cyclopenten-1-yl)-1,2-dideoxy-4-C-methyl-2-[[N-[2-(4-morpholinyl)acetyl]-L-alanyl-(betaR)-beta-hydroxy-O-methyl-L-tyrosyl]amino]-
EX-A6921
GTPL10409
HY-114419
KZR-616
KZR616
O4BT6C02M2
SCHEMBL16118957
UNII-O4BT6C02M2
ZETOMIPZOMIB [INN]
ZETOMIPZOMIB [USAN]
Zetomipzomib
compound 12 [PMID: 30380863]
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| Structure |
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| Formula |
C30H42N4O8
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| Molecular Weight |
586.686
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| Canonical SMILES |
COc1ccc(cc1)[C@@H](O)[C@H](NC(=O)[C@H](C)NC(=O)CN1CCOCC1)C(=O)N[C@@H](CC1=CCCC1)C(=O)[C@@]1(C)CO1
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| InChI |
InChI=1S/C30H42N4O8/c1-19(31-24(35)17-34-12-14-41-15-13-34)28(38)33-25(26(36)21-8-10-22(40-3)11-9-21)29(39)32-23(16-20-6-4-5-7-20)27(37)30(2)18-42-30/h6,8-11,19,23,25-26,36H,4-5,7,12-18H2,1-3H3,(H,31,35)(H,32,39)(H,33,38)/t19-,23-,25-,26+,30+/m0/s1
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| InChIKey |
GHYOCDFICYLMRF-UTIIJYGPSA-N
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| CAS |
1629677-75-3
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Map of Molecular Bioactivity Related to the Compound
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Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02583, Proteasome subunit beta type-1
Protein ID: PT06625, Proteasome subunit beta type-1
Protein ID: PT07183, Proteasome subunit beta type-10
Protein ID: PT03496, Proteasome subunit beta type-10
Protein ID: PT02579, Proteasome subunit beta type-2
Protein ID: PT06951, Proteasome subunit beta type-2
Protein ID: PT03791, Proteasome subunit beta type-5
Protein ID: PT04765, Proteasome subunit beta type-8
Protein ID: PT03838, Proteasome subunit beta type-9
Protein ID: PT06624, Proteasome subunit beta type-9
Clinical Information about the Compound