General Information of the Protein
Protein ID
PT07183
Protein Name
Proteasome subunit beta type-10
Secondarily
Protein Name
Low molecular mass protein 10
Macropain subunit MECl-1
Multicatalytic endopeptidase complex subunit MECl-1
Proteasome MECl-1
Proteasome subunit beta-2i
Gene Name
PSMB10
Secondarily
Gene Name
Lmp10
Mecl1
Sequence
MLKQAVEPTGGFSFENCQRNASLEHVLPGLRVPHARKTGTTIAGLVFRDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADTEMTTRMAASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLVVGGVDLNGPQLYEVHPHGSYSRLPFTALGSGQGAAVALLEDRFQPNMTLEAAQELLVEAITAGILSDLGSGGNVDACVITAGGAKLQRALSTPTEPVQRAGRYRFAPGTTPVLTREVRPLTLELLEETVQAMEVE
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Organism
Mus musculus, Mouse
Protein Classification
Enzyme
>
Hydrolase
Function
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Plays a role in determining the T-cell repertoire for an antiviral T-cell response.
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Uniprot ID
Primary ID:
O35955

Secondarily ID:
O08687
Q99KC5
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Ensembl ID
ENSG00000205220
Subcellular Location
Cytoplasm
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000160 , A20
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0086566
 Compound Info 
(2S)-2-[[2-(azepan-1-yl)acetyl]amino]-4-methyl-N-[(2S)-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pentanamide
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C35H48N4O5
  1
1
IC50 = 159 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0098995
 Compound Info 
(2S)-2-[[2-(azepan-1-yl)acetyl]amino]-4-methyl-N-[(2S)-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-4-(4-methylphenyl)-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pentanamide
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C37H52N4O5
  1
1
IC50 = 305 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0213895
 Compound Info 
Kzr-616
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C30H42N4O8
  1
1
IC50 = 522 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0062987
 Compound Info 
(2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
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C31H40N4O7
  1
1
IC50 = 699 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT03496 Proteasome subunit beta type-10 Homo sapiens, Human
 Protein Info