General Information of the Protein
Protein ID
PT03496
Protein Name
Proteasome subunit beta type-10
Secondarily
Protein Name
Low molecular mass protein 10
Macropain subunit MECl-1
Multicatalytic endopeptidase complex subunit MECl-1
Proteasome MECl-1
Proteasome subunit beta-2i
Gene Name
PSMB10
Secondarily
Gene Name
LMP10
MECL1
Sequence
MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGRYHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Protease
>
Threonine protease
>
Threonine protease PBT clan
>
Threonine protease T1A subfamily
Function
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.
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Uniprot ID
Primary ID:
P40306

Secondarily ID:
B2R5J4
Q5U098
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Ensembl ID
ENSG00000205220
HGNC ID
HGNC:9538
Subcellular Location
Cytoplasm
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000116 , MOLT-4
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0098995
 Compound Info 
(2S)-2-[[2-(azepan-1-yl)acetyl]amino]-4-methyl-N-[(2S)-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-4-(4-methylphenyl)-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pentanamide
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C37H52N4O5
  1
1
IC50 = 71 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0086566
 Compound Info 
(2S)-2-[[2-(azepan-1-yl)acetyl]amino]-4-methyl-N-[(2S)-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pentanamide
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C35H48N4O5
  1
1
IC50 = 97 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0213895
 Compound Info 
Kzr-616
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C30H42N4O8
  1
1
IC50 = 623 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0062987
 Compound Info 
(2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
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C31H40N4O7
  1
1
IC50 = 902 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0151829
 Compound Info 
(2S)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
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C30H42N4O7
  1
1
IC50 = 1437 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0086565
 Compound Info 
CHEMBL4441524
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C31H43N3O7
  1
1
IC50 > 25000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0403175
 Compound Info 
CHEMBL4454809
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C32H41N3O7
  1
1
IC50 > 25000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0847941
 Compound Info 
N-((R)-1-((S)-3-(1H-indol-3-yl)-1-((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-ylamino)-1-oxopropan-2-ylamino)-1-oxopropan-2-yl)-3-methyl-1H-indene-2-carboxamide
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C37H38N4O5
  1
1
IC50 > 25000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000174 , Raji
 Cell Line Info 
Cell Line ID: CL000186 , RPMI-8226
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0213895
 Compound Info 
Kzr-616
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C30H42N4O8
  1
1 IC50 = 0.131 nM
CP0261361
 Compound Info 
(2S)-N-[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]-4-methylpentanamide
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C33H47N7O5S
  1
1 IC50 = 27.5 nM
CP0086566
 Compound Info 
(2S)-2-[[2-(azepan-1-yl)acetyl]amino]-4-methyl-N-[(2S)-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pentanamide
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C35H48N4O5
  1
1 IC50 = 97 nM
CP0151829
 Compound Info 
(2S)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
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C30H42N4O7
  1
1 IC50 = 1437 nM
CP0062987
 Compound Info 
(2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
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C31H40N4O7
  2
1 IC50 = 4850 nM
2 IC50 > 10000 nM
CP0086565
 Compound Info 
CHEMBL4441524
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C31H43N3O7
  1
1 IC50 > 25000 nM
Clinical Information about the Protein
Target 1 ( Proteasome beta-10 (PS beta-10) )
Target Type Patented-recorded Target
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT07183 Proteasome subunit beta type-10 Mus musculus, Mouse
 Protein Info