General Information of the Protein
Protein ID
PT02579
Protein Name
Proteasome subunit beta type-2
Secondarily
Protein Name
Macropain subunit C7-I
Multicatalytic endopeptidase complex subunit C7-I
Proteasome component C7-I
Gene Name
PSMB2
Sequence
MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Protease
>
Threonine protease
>
Threonine protease PBT clan
>
Threonine protease T1A subfamily
Function
Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
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Uniprot ID
Primary ID:
P49721

Secondarily ID:
D3DPS0
P31145
Q9BWZ9
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Ensembl ID
ENSG00000126067
HGNC ID
HGNC:9539
Subcellular Location
Cytoplasm
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0261361
 Compound Info 
(2S)-N-[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]-4-methylpentanamide
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C33H47N7O5S
  1
1
IC50 = 2700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0128289
 Compound Info 
(2S)-N-[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]-2-[[(2S)-3-(4-aminophenyl)-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]propanoyl]amino]-4-methylpentanamide
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C36H46N8O5S
  1
1
IC50 = 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0145054
 Compound Info 
(2S)-N-[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]-2-[[(2S)-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]-3-pyridin-4-ylpropanoyl]amino]-4-methylpentanamide
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C35H44N8O5S
  1
1
IC50 = 27000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0065810
 Compound Info 
(2S)-2-[[(2S)-3-[4-(aminomethyl)phenyl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]propanoyl]amino]-N-[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]-4-methylpentanamide
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C37H48N8O5S
  1
1
IC50 = 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000018 , HL-60
 Cell Line Info 
Cell Line ID: CL000116 , MOLT-4
 Cell Line Info 
Cell Line ID: CL000482 , NCI-H929
 Cell Line Info 
Cell Line ID: CL000174 , Raji
 Cell Line Info 
Cell Line ID: CL000186 , RPMI-8226
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0261361
 Compound Info 
(2S)-N-[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]-4-methylpentanamide
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C33H47N7O5S
  2
1 IC50 = 10.8 nM
2 IC50 = 84 nM
CP0065810
 Compound Info 
(2S)-2-[[(2S)-3-[4-(aminomethyl)phenyl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]propanoyl]amino]-N-[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]-4-methylpentanamide
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C37H48N8O5S
  1
1 IC50 = 22 nM
CP0213895
 Compound Info 
Kzr-616
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C30H42N4O8
  1
1 IC50 = 28 nM
CP0128289
 Compound Info 
(2S)-N-[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]-2-[[(2S)-3-(4-aminophenyl)-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]propanoyl]amino]-4-methylpentanamide
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C36H46N8O5S
  1
1 IC50 = 47 nM
CP0145054
 Compound Info 
(2S)-N-[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]-2-[[(2S)-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]-3-pyridin-4-ylpropanoyl]amino]-4-methylpentanamide
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C35H44N8O5S
  1
1 IC50 = 51 nM
CP0086566
 Compound Info 
(2S)-2-[[2-(azepan-1-yl)acetyl]amino]-4-methyl-N-[(2S)-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pentanamide
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C35H48N4O5
  1
1 IC50 = 81 nM
CP0004620
 Compound Info 
(R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid
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C19H25BN4O4
  10
1 IC50 = 128 nM
2 IC50 = 261.1 nM
3 IC50 = 590 nM
4 IC50 = 1200 nM
5 IC50 = 1500 nM
6 IC50 = 1880 nM
7 IC50 = 1930 nM
8 IC50 = 2119 nM
9 IC50 = 3998 nM
10 IC50 > 40000 nM
CP0151829
 Compound Info 
(2S)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
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C30H42N4O7
  1
1 IC50 = 1176 nM
CP0075396
 Compound Info 
N-[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-2-oxoethyl]-3-[1,1-bis[4-[2-(azepan-1-yl)ethoxy]phenyl]but-1-en-2-yl]benzamide
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C89H150N36O12
  2
1 IC50 = 1200 nM
2 IC50 = 45000 nM
CP0045910
 Compound Info 
(S)-2-azido-N-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)-3-phenylpropanamide
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C36H42N6O5
  1
1 IC50 = 1800 nM
CP0075391
 Compound Info 
N-[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-acetamido-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-2-oxoethyl]-3-[1,1-bis[4-[2-(azepan-1-yl)ethoxy]phenyl]but-1-en-2-yl]benzamide
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C91H152N36O13
  2
1 IC50 = 3500 nM
2 IC50 > 40000 nM
CP0062987
 Compound Info 
(2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
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C31H40N4O7
  1
1 IC50 = 4700 nM
CP0086565
 Compound Info 
CHEMBL4441524
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C31H43N3O7
  1
1 IC50 > 25000 nM