Brief Information of the Cell Line and Protein
Cell Line ID: CL000186 , RPMI-8226
 Cell Line Info 
Synonyms
RPMI 8226
RPMI.8226
RPMI8226
RPMI no. 8226
RPMI no 8226
RPMI #8226
8226
RPMI 8226/S
RPMI-8226S
RPMI8226/S
8226/S
Roswell Park Memorial Institute 8226
GM02132
GM2132
GM 2132
GM02132C
Simpson
Category Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0014
Protein ID: PT02579 , Proteasome subunit beta type-2
 Protein Info 
Gene Name PSMB2
Organism Homo sapiens, Human
Protein Classification Enzyme
Uniprot ID P49721
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000186
 Cell Line Info 
 Protein ID: PT02579
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0446747
 Compound Info 
(2S)-N-[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-3-methoxy-1-oxopropan-2-yl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]-4-methylpentanamide
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C31H43N7O6S
  1
1
IC50 = 8 nM
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CP0446750
 Compound Info 
(2S)-N-[(2S,3R)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]-4-methylpentanamide
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C31H43N7O6S
  1
1
IC50 = 8 nM
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CP0427708
 Compound Info 
(2S)-N-[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-1-oxopropan-2-yl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]-4-methylpentanamide
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C30H41N7O5S
  1
1
IC50 = 10 nM
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CP0432043
 Compound Info 
(2S)-N-[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]-4-methylpentanamide
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C30H41N7O6S
  1
1
IC50 = 11 nM
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CP0476382
 Compound Info 
N-[(2S)-1-[[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4-cyclohexyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide
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C33H49N5O5S2
  1
1
IC50 = 11 nM
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CP0536885
 Compound Info 
(2S)-2-[[(2S)-3-[4-(aminomethyl)phenyl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]propanoyl]amino]-N-[(2S)-4-cyclohexyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxobutan-2-yl]-3-methylbutanamide
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C37H51N7O5
  1
1
IC50 = 13 nM
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CP0476387
 Compound Info 
N-[(2S)-1-[[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-3-(4-cyclohexylcyclohexyl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide
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C38H57N5O5S2
  1
1
IC50 = 16 nM
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CP0508331
 Compound Info 
(2S)-N-[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]-2-[[(2S)-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-4-fluoro-4-methylpentanamide
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C33H46FN7O5S
  1
1
IC50 = 17 nM
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CP0563686
 Compound Info 
N-[(2S)-1-[[(2S)-3-(1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-2-yl)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide
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C36H53N5O5S2
  1
1
IC50 = 17 nM
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CP0423650
 Compound Info 
N-[(2S)-1-[[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide
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C32H47N5O5S2
  1
1
IC50 = 18 nM
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CP0455536
 Compound Info 
(2S)-N-[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4,4,4-trifluoro-1-oxobutan-2-yl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]-4-methylpentanamide
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C31H40F3N7O5S
  1
1
IC50 = 21 nM
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CP0446746
 Compound Info 
N-[(2S)-1-[[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]benzamide
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C31H44N4O5S
  1
1
IC50 = 23 nM
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CP0438681
 Compound Info 
(2S)-N-[2-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-2-oxoethyl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]-4-methylpentanamide
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C29H39N7O5S
  1
1
IC50 = 26 nM
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CP0553755
 Compound Info 
N-[(2S)-1-[[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-6-phenylpyridine-3-carboxamide
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C36H47N5O5S
  1
1
IC50 = 29 nM
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CP0536884
 Compound Info 
N-[(2S)-1-[[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-3-(4-methylcyclohexyl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide
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C33H49N5O5S2
  1
1
IC50 = 31 nM
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CP0446741
 Compound Info 
(2S)-N-[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methyl-2-[(2-morpholin-4-ylacetyl)amino]pentanamide
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C30H49N5O6S
  1
1
IC50 = 32 nM
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CP0476381
 Compound Info 
N-[(2S)-1-[[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide
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C32H47N5O5S2
  1
1
IC50 = 35 nM
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CP0476403
 Compound Info 
(2S)-N-[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-[[(2S)-2-[(2-azidoacetyl)amino]-3-phenylpropanoyl]amino]-4-methylpentanamide
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C35H50N8O6S
  1
1
IC50 = 35 nM
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CP0476384
 Compound Info 
N-[(2S)-1-[[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide
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C35H51N5O5S2
  1
1
IC50 = 40 nM
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CP0476383
 Compound Info 
N-[(2S)-1-[[(2S)-3-(1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-1-yl)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide
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C36H53N5O5S2
  1
1
IC50 = 41 nM
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CP0446744
 Compound Info 
N-[(2S)-1-[[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-3-(4-methoxycyclohexyl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide
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C33H49N5O6S2
  1
1
IC50 = 43 nM
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CP0535352
 Compound Info 
N-[(1S)-2-[[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-cyclohexyl-2-oxoethyl]-2-methyl-1,3-thiazole-5-carboxamide
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C31H45N5O5S2
  1
1
IC50 = 47 nM
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CP0455541
 Compound Info 
N-[(2S)-1-[[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2,5-dichlorobenzamide
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C31H42Cl2N4O5S
  1
1
IC50 = 69 nM
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CP0446742
 Compound Info 
N-[(2S)-1-[[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide
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C29H43N5O5S2
  1
1
IC50 = 72 nM
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CP0446751
 Compound Info 
N-[(2S)-1-[[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-3-methoxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide
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C27H39N5O6S2
  1
1
IC50 = 72 nM
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CP0476389
 Compound Info 
(2S)-2-[[(2S)-3-[4-(aminomethyl)phenyl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]propanoyl]amino]-3-methyl-N-[(2S)-3-(4-methylcyclohexyl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]butanamide
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C37H51N7O5
  1
1
IC50 = 73 nM
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CP0446745
 Compound Info 
(2S)-N-[(2S)-3-(1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-2-[[(2S)-3-[4-(aminomethyl)phenyl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]propanoyl]amino]-3-methylbutanamide
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C40H55N7O5
  1
1
IC50 = 97 nM
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CP0438680
 Compound Info 
N-[(2S)-1-[[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]pyrazine-2-carboxamide
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C29H42N6O5S
  1
1
IC50 = 160 nM
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CP0261361
 Compound Info 
(2S)-N-[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]-4-methylpentanamide
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C33H47N7O5S
  1
1
IC50 = 170 nM
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CP0431914
 Compound Info 
N-[(2S)-1-[[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-cyclohexyl-1-oxobutan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide
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C33H49N5O5S2
  1
1
IC50 = 210 nM
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CP0476386
 Compound Info 
(2S)-N-[(2S)-3-(1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-2-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-2-[[(2S)-3-[4-(aminomethyl)phenyl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]propanoyl]amino]-3-methylbutanamide
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C40H55N7O5
  1
1
IC50 = 210 nM
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CP0476390
 Compound Info 
(2S)-N-[(2S)-4-cyclohexyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxobutan-2-yl]-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
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C32H48N4O7
  1
1
IC50 = 215 nM
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CP0446743
 Compound Info 
N-[(2S)-1-[[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]pyrazine-2-carboxamide
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C26H36N6O5S
  1
1
IC50 = 240 nM
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CP0479603
 Compound Info 
N-[(2S)-1-[[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-methoxycyclohexyl)-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide
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C33H49N5O6S2
  1
1
IC50 = 280 nM
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CP0431919
 Compound Info 
(2S)-2-[[(2S)-3-[4-(aminomethyl)phenyl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]propanoyl]amino]-N-[(2S)-3-(4-methoxycyclohexyl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-methylbutanamide
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C37H51N7O6
  1
1
IC50 = 290 nM
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CP0423623
 Compound Info 
(2S)-N-[(2S)-3-(1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
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C35H52N4O7
  1
1
IC50 = 320 nM
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CP0535350
 Compound Info 
N-[(2S)-1-[[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-methylcyclohexyl)-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide
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C33H49N5O5S2
  1
1
IC50 = 380 nM
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CP0065810
 Compound Info 
(2S)-2-[[(2S)-3-[4-(aminomethyl)phenyl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]propanoyl]amino]-N-[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]-4-methylpentanamide
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C37H48N8O5S
  1
1
IC50 = 420 nM
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CP0455537
 Compound Info 
N-[(2S)-3-(1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-2-yl)-1-[[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide
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C36H53N5O5S2
  1
1
IC50 = 510 nM
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CP0128289
 Compound Info 
(2S)-N-[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]-2-[[(2S)-3-(4-aminophenyl)-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]propanoyl]amino]-4-methylpentanamide
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C36H46N8O5S
  1
1
IC50 = 580 nM
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CP0563687
 Compound Info 
N-[(2S)-3-(1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-1-yl)-1-[[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide
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C36H53N5O5S2
  1
1
IC50 = 2250 nM
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CP0431915
 Compound Info 
(2S)-N-[(2S)-3-(4-methoxycyclohexyl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
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C32H48N4O8
  1
1
IC50 = 2750 nM
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CP0431917
 Compound Info 
(2S)-N-[(2S)-3-(1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-2-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
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C35H52N4O7
  1
1
IC50 = 2800 nM
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CP0431920
 Compound Info 
(2S)-2-[[(2S)-3-[4-(aminomethyl)phenyl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]propanoyl]amino]-N-[(2S)-3-(2-bicyclo[2.2.1]heptanyl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-methylbutanamide
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C37H49N7O5
  1
1
IC50 = 3100 nM
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CP0427459
 Compound Info 
N-[(2S)-1-[[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-3-hydroxy-2-methylbenzamide
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C28H38N4O7S
  1
1
IC50 = 3200 nM
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CP0476380
 Compound Info 
N-[(2S)-1-[[(2S)-1-[[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-cyclohexylcyclohexyl)-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide
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C38H57N5O5S2
  1
1
IC50 = 3350 nM
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CP0572669
 Compound Info 
(2S)-2-[[(2S)-3-[4-(aminomethyl)phenyl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]propanoyl]amino]-N-[(2S)-3-(4-cyclohexylcyclohexyl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-methylbutanamide
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C42H59N7O5
  1
1
IC50 = 3600 nM
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CP0455540
 Compound Info 
(2S)-2-[[(2S)-3-[4-(aminomethyl)phenyl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]propanoyl]amino]-N-[(1S)-1-cyclohexyl-2-[(2R)-2-methyloxiran-2-yl]-2-oxoethyl]-3-methylbutanamide
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C35H47N7O5
  1
1
IC50 = 4850 nM
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CP0476388
 Compound Info 
(2S)-N-[(2S)-3-(4,4-difluorocyclohexyl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
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C31H44F2N4O7
  1
1
IC50 = 5530 nM
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CP0552317
 Compound Info 
(2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-[4-(trifluoromethyl)cyclohexyl]propan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
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C32H45F3N4O7
  1
1
IC50 = 8400 nM
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CP0455539
 Compound Info 
(2S)-N-[(2S)-3-(2-bicyclo[2.2.1]heptanyl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
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C32H46N4O7
  1
1
IC50 > 10000 nM
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CP0476385
 Compound Info 
(2S)-N-[(1S)-1-cyclohexyl-2-[(2R)-2-methyloxiran-2-yl]-2-oxoethyl]-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
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C30H44N4O7
  1
1
IC50 > 10000 nM
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CP0427458
 Compound Info 
N-[(2S)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-3-hydroxy-2-methylbenzamide
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C25H38N6O7
  1
1
IC50 = 24000 nM
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CP0482909
 Compound Info 
(2S)-N-[(2S)-3-(4-cyclohexylcyclohexyl)-1-[[(2S)-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]-4-methyl-2-[(2-morpholin-4-ylacetyl)amino]pentanamide
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C42H65N5O7
  1
1
IC50 > 100000 nM
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